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Conserved domains on  [gi|2462587308|ref|XP_054201294|]
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tetratricopeptide repeat protein 14 isoform X2 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
41-205 6.84e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 71.58  E-value: 6.84e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  41 EDDFASALRKKQSASWALkcVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALEN 120
Cdd:COG0457    28 IEDYEKALELDPDDAEAL--YNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALEL 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308 121 CPTHRNARKYLCQTLVERgGQLEEeekflnAESYYKKALALDETFKDA----EDALQKLHKYmQKSLELREKQAEKEEKQ 196
Cdd:COG0457   106 DPDDAEALYNLGLALLEL-GRYDE------AIEAYERALELDPDDADAlynlGIALEKLGRY-EEALELLEKLEAAALAA 177


                  ....*....
gi 2462587308 197 KTKKIETSA 205
Cdd:COG0457   178 LLAAALGEA 186
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
41-205 6.84e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 71.58  E-value: 6.84e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  41 EDDFASALRKKQSASWALkcVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALEN 120
Cdd:COG0457    28 IEDYEKALELDPDDAEAL--YNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALEL 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308 121 CPTHRNARKYLCQTLVERgGQLEEeekflnAESYYKKALALDETFKDA----EDALQKLHKYmQKSLELREKQAEKEEKQ 196
Cdd:COG0457   106 DPDDAEALYNLGLALLEL-GRYDE------AIEAYERALELDPDDADAlynlGIALEKLGRY-EEALELLEKLEAAALAA 177


                  ....*....
gi 2462587308 197 KTKKIETSA 205
Cdd:COG0457   178 LLAAALGEA 186
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 80-161 9.31e-05

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 44.54  E-value: 9.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  80 YNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHrNARKYLCqtLvergGQLEEEEkflNAESYYKKAL 159
Cdd:cd24142    23 LQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDG-GYEKYLY--L----GQLSGGE---EALQYYEKGI 92


                  ..
gi 2462587308 160 AL 161
Cdd:cd24142    93 EI 94
TPR_11 pfam13414
TPR repeat;
67-105 1.08e-04

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 39.76  E-value: 1.08e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2462587308  67 YFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKG 105
Cdd:pfam13414   4 YYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKLG 42
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 33-181 7.88e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.38  E-value: 7.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  33 GLQSKNFSEDDFASALRKKQSASWAlkcvKIGVDYFKV--GRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKA 110
Cdd:TIGR02917 137 GLGQLELAQKSYEQALAIDPRSLYA----KLGLAQLALaeNRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELA 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308 111 IEDFELALENCPTHRNARKYLCQTLVERgGQLEEEEKFLNA---------ESYYKKALaLDETFKDAEDALQKLHKYMQK 181
Cdd:TIGR02917 213 LAAYRKAIALRPNNIAVLLALATILIEA-GEFEEAEKHADAllkkapnspLAHYLKAL-VDFQKKNYEDARETLQDALKS 290
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
41-205 6.84e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 71.58  E-value: 6.84e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  41 EDDFASALRKKQSASWALkcVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALEN 120
Cdd:COG0457    28 IEDYEKALELDPDDAEAL--YNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALEL 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308 121 CPTHRNARKYLCQTLVERgGQLEEeekflnAESYYKKALALDETFKDA----EDALQKLHKYmQKSLELREKQAEKEEKQ 196
Cdd:COG0457   106 DPDDAEALYNLGLALLEL-GRYDE------AIEAYERALELDPDDADAlynlGIALEKLGRY-EEALELLEKLEAAALAA 177


                  ....*....
gi 2462587308 197 KTKKIETSA 205
Cdd:COG0457   178 LLAAALGEA 186
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 62-187 4.34e-13

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 66.37  E-value: 4.34e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  62 KIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERGgq 141
Cdd:COG4783     9 ALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAG-- 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2462587308 142 leeeeKFLNAESYYKKALALDETFKDAEDALQKLHKYMQKSLELRE 187
Cdd:COG4783    87 -----DYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIA 127
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
63-190 3.48e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.57  E-value: 3.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  63 IGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERgGQL 142
Cdd:COG0457    14 LGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQAL-GRY 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462587308 143 EEeekflnAESYYKKALALDETFKDAEDALQKLH----------KYMQKSLELREKQA 190
Cdd:COG0457    93 EE------ALEDYDKALELDPDDAEALYNLGLALlelgrydeaiEAYERALELDPDDA 144
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 67-172 4.32e-12

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 63.49  E-value: 4.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  67 YFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLcqtlverGGQLEEEE 146
Cdd:COG4235    27 YLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLL-------GLAAFQQG 99

                          90       100
                  ....*....|....*....|....*.
gi 2462587308 147 KFLNAESYYKKALALDEtfKDAEDAL 172
Cdd:COG4235   100 DYAEAIAAWQKLLALLP--ADAPARL 123
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
41-190 9.84e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.03  E-value: 9.84e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  41 EDDFASALRKKQSASWALkcVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALEN 120
Cdd:COG0457    62 LADYEQALELDPDDAEAL--NNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALEL 139

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308 121 CPTHRNARKYLCQTLVERgGQLEEEEKFLNAESYYKKALALDETFKDAEDALQKLHKYMQKSLELREKQA 190
Cdd:COG0457   140 DPDDADALYNLGIALEKL-GRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALR 208
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 63-168 1.51e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 66.94  E-value: 1.51e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  63 IGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLvERGGQL 142
Cdd:COG3914   118 LGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNAL-QDLGRL 196

                          90       100
                  ....*....|....*....|....*.
gi 2462587308 143 EEeekflnAESYYKKALALDETFKDA 168
Cdd:COG3914   197 EE------AIAAYRRALELDPDNADA 216
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 44-176 3.81e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 63.59  E-value: 3.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  44 FASALRKKQSASWALkcVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPT 123
Cdd:COG2956    65 HQKLLERDPDRAEAL--LELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPE 142

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462587308 124 HRNArkylcqtLVERGGQLEEEEKFLNAESYYKKALALDETFKDAEDALQKLH 176
Cdd:COG2956   143 NAHA-------YCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELY 188
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 67-162 5.85e-11

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 60.74  E-value: 5.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  67 YFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERGgqleeee 146
Cdd:COG5010    64 YNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLG------- 136

                          90
                  ....*....|....*.
gi 2462587308 147 KFLNAESYYKKALALD 162
Cdd:COG5010   137 QDDEAKAALQRALGTS 152
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
67-162 3.51e-10

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 56.72  E-value: 3.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  67 YFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEdFELALENCPTHRNARKYLCQTLVERGgqleeee 146
Cdd:COG3063     2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELG------- 73

                          90
                  ....*....|....*.
gi 2462587308 147 KFLNAESYYKKALALD 162
Cdd:COG3063    74 DYDEALAYLERALELD 89
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 41-162 5.16e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 57.51  E-value: 5.16e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  41 EDDFASALRKKQSASWALkcVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALEN 120
Cdd:COG4783    24 EALLEKALELDPDNPEAF--ALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKL 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2462587308 121 CPTHRNARKYLCQTLVERGgqleeeeKFLNAESYYKKALALD 162
Cdd:COG4783   102 DPEHPEAYLRLARAYRALG-------RPDEAIAALEKALELD 136
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 64-175 7.11e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 59.74  E-value: 7.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  64 GVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERgGQLE 143
Cdd:COG2956    15 GLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKA-GLLD 93

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2462587308 144 EeekflnAESYYKKALALDEtfkDAEDALQKL 175
Cdd:COG2956    94 R------AEELLEKLLELDP---DDAEALRLL 116
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 71-190 8.70e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 61.16  E-value: 8.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  71 GRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERgGQLEEeekfln 150
Cdd:COG3914    92 GRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRL-GRLEE------ 164

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462587308 151 AESYYKKALALDETFKDAE----DALQKLHKY------MQKSLELREKQA 190
Cdd:COG3914   165 AIAALRRALELDPDNAEALnnlgNALQDLGRLeeaiaaYRRALELDPDNA 214
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
12-186 2.39e-08

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 54.54  E-value: 2.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  12 VVEFLLEKLGIDESNPPSLMRGLQSKNFSEDDFASALRKKQSASWALKCVKI----GVDYFKVGRHVDAMNEYNKALEID 87
Cdd:COG4785    24 ILLAALLFAAVLALAIALADLALALAAAALAAAALAAERIDRALALPDLAQLyyerGVAYDSLGDYDLAIADFDQALELD 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  88 KQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLvERGGQLEEeekflnAESYYKKALALD----- 162
Cdd:COG4785   104 PDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIAL-YYLGRYEL------AIADLEKALELDpndpe 176

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2462587308 163 --------ETFKDAEDALQKLHKYMQKSLELR 186
Cdd:COG4785   177 ralwlylaERKLDPEKALALLLEDWATAYLLQ 208
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
64-160 1.09e-07

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 52.61  E-value: 1.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  64 GVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTH--RNARKYLCQTLV----- 136
Cdd:COG4785   114 GLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDpeRALWLYLAERKLdpeka 193

                          90       100       110
                  ....*....|....*....|....*....|
gi 2462587308 137 ------ERGGQLEEEEKFLNAESYYKKALA 160
Cdd:COG4785   194 lallleDWATAYLLQGDTEEARELFKLALA 223
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
41-190 3.42e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.55  E-value: 3.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  41 EDDFASALRKKQSASWALkcVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALEN 120
Cdd:COG0457    96 LEDYDKALELDPDDAEAL--YNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAA 173

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308 121 cptHRNARKYLCQTLVERGGQLEEEEKFLNAESYYKKALALDETFKDAEDALQKLHKYMQKSLELREKQA 190
Cdd:COG0457   174 ---ALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALAL 240
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 41-177 4.13e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 52.69  E-value: 4.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  41 EDDFASALRKKqsASWALKCVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALEN 120
Cdd:COG3914   132 LAALRRALALN--PDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALEL 209

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462587308 121 CPTHRNARKYLCQTLVERGGqLEEEEKFLNAESYYKKALALDETF------KDAEDALQKLHK 177
Cdd:COG3914   210 DPDNADAHSNLLFALRQACD-WEVYDRFEELLAALARGPSELSPFallylpDDDPAELLALAR 271
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
84-190 5.93e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.78  E-value: 5.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  84 LEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERgGQLEEeekflnAESYYKKALALDE 163
Cdd:COG0457     1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRL-GRYEE------ALADYEQALELDP 73

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462587308 164 TFKDA----EDALQKLHKY------MQKSLELREKQA 190
Cdd:COG0457    74 DDAEAlnnlGLALQALGRYeealedYDKALELDPDDA 110
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 75-190 4.73e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.15  E-value: 4.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  75 DAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERGGQLEEEEKF------ 148
Cdd:COG4235     1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLeralal 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2462587308 149 --LNAESYYKKALALDET--FKDAEDALQKLHKYMQKSLELREKQA 190
Cdd:COG4235    81 dpDNPEALYLLGLAAFQQgdYAEAIAAWQKLLALLPADAPARLLEA 126
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
41-122 3.08e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 42.85  E-value: 3.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  41 EDDFASALRKKQSASWALkcVKIGVDYFKVGRHVDAMnEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALEN 120
Cdd:COG3063    12 EEYYEKALELDPDNADAL--NNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALEL 88


                  ..
gi 2462587308 121 CP 122
Cdd:COG3063    89 DP 90
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 41-124 7.69e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.87  E-value: 7.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  41 EDDFASALRKKQSASWALkcVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALEN 120
Cdd:COG4783    58 IVLLHEALELDPDEPEAR--LNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALEL 135


                  ....
gi 2462587308 121 CPTH 124
Cdd:COG4783   136 DPDD 139
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 80-161 9.31e-05

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 44.54  E-value: 9.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  80 YNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHrNARKYLCqtLvergGQLEEEEkflNAESYYKKAL 159
Cdd:cd24142    23 LQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDG-GYEKYLY--L----GQLSGGE---EALQYYEKGI 92


                  ..
gi 2462587308 160 AL 161
Cdd:cd24142    93 EI 94
TPR_11 pfam13414
TPR repeat;
67-105 1.08e-04

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 39.76  E-value: 1.08e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2462587308  67 YFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKG 105
Cdd:pfam13414   4 YYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKLG 42
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 63-122 2.73e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.48  E-value: 2.73e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  63 IGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCP 122
Cdd:COG5010    94 LALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 79-181 2.97e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.48  E-value: 2.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  79 EYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERgGQLEEeekflnAESYYKKA 158
Cdd:COG5010    42 LAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRS-GDKDE------AKEYYEKA 114

                          90       100
                  ....*....|....*....|...
gi 2462587308 159 LALDETFKDAEDALQKLHKYMQK 181
Cdd:COG5010   115 LALSPDNPNAYSNLAALLLSLGQ 137
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 89-185 7.36e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.79  E-value: 7.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  89 QNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERgGQLEEeekflnAESYYKKALALDETFKDA 168
Cdd:COG4783     2 ACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQL-GDLDE------AIVLLHEALELDPDEPEA 74

                          90       100
                  ....*....|....*....|....*..
gi 2462587308 169 E----DALQKLHKY------MQKSLEL 185
Cdd:COG4783    75 RlnlgLALLKAGDYdealalLEKALKL 101
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 33-181 7.88e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.38  E-value: 7.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  33 GLQSKNFSEDDFASALRKKQSASWAlkcvKIGVDYFKV--GRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKA 110
Cdd:TIGR02917 137 GLGQLELAQKSYEQALAIDPRSLYA----KLGLAQLALaeNRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELA 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308 111 IEDFELALENCPTHRNARKYLCQTLVERgGQLEEEEKFLNA---------ESYYKKALaLDETFKDAEDALQKLHKYMQK 181
Cdd:TIGR02917 213 LAAYRKAIALRPNNIAVLLALATILIEA-GEFEEAEKHADAllkkapnspLAHYLKAL-VDFQKKNYEDARETLQDALKS 290
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 45-182 3.95e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.07  E-value: 3.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  45 ASALRKKQSASWALKcvkiGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTH 124
Cdd:TIGR02917 593 AADAAPDSPEAWLML----GRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDN 668

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462587308 125 RNARKYLCQTLVErGGQLEEEEKFLNA-ESYYKKALALDE-------TFKDAEDALQKLHKYMQKS 182
Cdd:TIGR02917 669 TEAQIGLAQLLLA-AKRTESAKKIAKSlQKQHPKAALGFElegdlylRQKDYPAAIQAYRKALKRA 733
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 67-162 4.55e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.94  E-value: 4.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587308  67 YFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNarkylcqtLVERGGQLEEEE 146
Cdd:COG2956   188 YLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDL--------LLALADLLERKE 259

                          90
                  ....*....|....*.
gi 2462587308 147 KFLNAESYYKKALALD 162
Cdd:COG2956   260 GLEAALALLERQLRRH 275
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 62-124 9.66e-03

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 35.00  E-value: 9.66e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462587308  62 KIGVDYFKVGRHVDAMNEYNKALEIDK---QNVEALVARGALYATKGSLNKAIEDFELALENCPTH 124
Cdd:pfam13432   2 ALARAALRAGDYDDAAAALEAALARFPespDAAAALLLLGLAALRQGRLAEAAAAYRAALRAAPGD 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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