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Conserved domains on  [gi|2462575627|ref|XP_054199162|]
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WD repeat-containing protein 35 isoform X2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
19-184 1.47e-10

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 1.47e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575627  19 CVSWNKEQGFIACGGEDGLLKVLKLETqtddAKLRglaapsnlsmnQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVW 98
Cdd:COG2319   125 SVAFSPDGKTLASGSADGTVRLWDLAT----GKLL-----------RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575627  99 MLYKGSWIEEMinNRNKSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIwGKDLKG--IQLSHVTWSADSKVLLFGMA 176
Cdd:COG2319   190 DLATGKLLRTL--TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL-LRTLTGhsGSVRSVAFSPDGRLLASGSA 266


                  ....*...
gi 2462575627 177 NGEIHIYD 184
Cdd:COG2319   267 DGTVRLWD 274
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
19-184 1.47e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 1.47e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575627  19 CVSWNKEQGFIACGGEDGLLKVLKLETqtddAKLRglaapsnlsmnQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVW 98
Cdd:COG2319   125 SVAFSPDGKTLASGSADGTVRLWDLAT----GKLL-----------RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575627  99 MLYKGSWIEEMinNRNKSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIwGKDLKG--IQLSHVTWSADSKVLLFGMA 176
Cdd:COG2319   190 DLATGKLLRTL--TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL-LRTLTGhsGSVRSVAFSPDGRLLASGSA 266


                  ....*...
gi 2462575627 177 NGEIHIYD 184
Cdd:COG2319   267 DGTVRLWD 274
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-184 7.05e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.73  E-value: 7.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575627  19 CVSWNKEQGFIACGGEDGLLKVLKLETqtddaklrglaapsnLSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVW 98
Cdd:cd00200   140 SVAFSPDGTFVASSSQDGTIKLWDLRT---------------GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575627  99 MLYKGSWIEEMINNRNKsvVRSMSWNADGQkicivyedgAVIVGSVDGN-RIWgkDLKGIQLSH-----------VTWSA 166
Cdd:cd00200   205 DLSTGKCLGTLRGHENG--VNSVAFSPDGY---------LLASGSEDGTiRVW--DLRTGECVQtlsghtnsvtsLAWSP 271

                         170
                  ....*....|....*...
gi 2462575627 167 DSKVLLFGMANGEIHIYD 184
Cdd:cd00200   272 DGKRLASGSADGTIRIWD 289
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 121-184 9.03e-06

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 44.58  E-value: 9.03e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462575627 121 MSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQL--SHVTWSADSKVLLFGMANGEIHIYD 184
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRLNWQRVWTLSPDKEDLevTSLAWRPDGKLLAVGYSDGTVRLLD 66
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
19-184 1.47e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 1.47e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575627  19 CVSWNKEQGFIACGGEDGLLKVLKLETqtddAKLRglaapsnlsmnQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVW 98
Cdd:COG2319   125 SVAFSPDGKTLASGSADGTVRLWDLAT----GKLL-----------RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575627  99 MLYKGSWIEEMinNRNKSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIwGKDLKG--IQLSHVTWSADSKVLLFGMA 176
Cdd:COG2319   190 DLATGKLLRTL--TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL-LRTLTGhsGSVRSVAFSPDGRLLASGSA 266


                  ....*...
gi 2462575627 177 NGEIHIYD 184
Cdd:COG2319   267 DGTVRLWD 274
WD40 COG2319
WD40 repeat [General function prediction only];
19-184 1.71e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.31  E-value: 1.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575627  19 CVSWNKEQGFIACGGEDGLLKVLKLETQtddaKLRglaapsnlsmnQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVW 98
Cdd:COG2319   209 SVAFSPDGKLLASGSADGTVRLWDLATG----KLL-----------RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575627  99 MLYKGSWIEEMinNRNKSVVRSMSWNADGQKICIVYEDGAVIVGSVD-GNRIWGKDLKGIQLSHVTWSADSKVLLFGMAN 177
Cdd:COG2319   274 DLATGELLRTL--TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDD 351


                  ....*..
gi 2462575627 178 GEIHIYD 184
Cdd:COG2319   352 GTVRLWD 358
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-184 7.05e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.73  E-value: 7.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575627  19 CVSWNKEQGFIACGGEDGLLKVLKLETqtddaklrglaapsnLSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVW 98
Cdd:cd00200   140 SVAFSPDGTFVASSSQDGTIKLWDLRT---------------GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575627  99 MLYKGSWIEEMINNRNKsvVRSMSWNADGQkicivyedgAVIVGSVDGN-RIWgkDLKGIQLSH-----------VTWSA 166
Cdd:cd00200   205 DLSTGKCLGTLRGHENG--VNSVAFSPDGY---------LLASGSEDGTiRVW--DLRTGECVQtlsghtnsvtsLAWSP 271

                         170
                  ....*....|....*...
gi 2462575627 167 DSKVLLFGMANGEIHIYD 184
Cdd:cd00200   272 DGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-184 4.10e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.03  E-value: 4.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575627  19 CVSWNKEQGFIACGGEDGLLKVLKLETQTDDaklrglaapsnlsmnQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVW 98
Cdd:cd00200    14 CVAFSPDGKLLATGSGDGTIKVWDLETGELL---------------RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575627  99 MLYKGSWIEEMINnrNKSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIwGKDLKGIQ--LSHVTWSADSKVLLFGMA 176
Cdd:cd00200    79 DLETGECVRTLTG--HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC-LTTLRGHTdwVNSVAFSPDGTFVASSSQ 155


                  ....*...
gi 2462575627 177 NGEIHIYD 184
Cdd:cd00200   156 DGTIKLWD 163
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-184 6.32e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.65  E-value: 6.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575627  19 CVSWNKEQGFIACGGEDGLLKVLKLETqtddAKLRglaapsnlsmnQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVW 98
Cdd:cd00200    98 SVAFSPDGRILSSSSRDKTIKVWDVET----GKCL-----------TTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575627  99 MLYKGSWIEEMinNRNKSVVRSMSWNADGQKICivyedgaviVGSVDGN-RIWgkDLKGIQLSH-----------VTWSA 166
Cdd:cd00200   163 DLRTGKCVATL--TGHTGEVNSVAFSPDGEKLL---------SSSSDGTiKLW--DLSTGKCLGtlrghengvnsVAFSP 229

                         170
                  ....*....|....*...
gi 2462575627 167 DSKVLLFGMANGEIHIYD 184
Cdd:cd00200   230 DGYLLASGSEDGTIRVWD 247
WD40 COG2319
WD40 repeat [General function prediction only];
65-184 9.38e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.84  E-value: 9.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575627  65 QTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMinNRNKSVVRSMSWNADGQKIcivyedgavIVGSV 144
Cdd:COG2319   114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL--TGHSGAVTSVAFSPDGKLL---------ASGSD 182

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462575627 145 DGN-RIW----GKDLKGIQ-----LSHVTWSADSKVLLFGMANGEIHIYD 184
Cdd:COG2319   183 DGTvRLWdlatGKLLRTLTghtgaVRSVAFSPDGKLLASGSADGTVRLWD 232
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 65-184 1.39e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.41  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575627  65 QTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINnrNKSVVRSMSWNADGQKICIVYEDGAVIVGSV 144
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG--HTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2462575627 145 DGN---RIWGKDLKGIqlSHVTWSADSKVLLFGMANGEIHIYD 184
Cdd:cd00200    81 ETGecvRTLTGHTSYV--SSVAFSPDGRILSSSSRDKTIKVWD 121
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 121-184 9.03e-06

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 44.58  E-value: 9.03e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462575627 121 MSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQL--SHVTWSADSKVLLFGMANGEIHIYD 184
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRLNWQRVWTLSPDKEDLevTSLAWRPDGKLLAVGYSDGTVRLLD 66
WD40 COG2319
WD40 repeat [General function prediction only];
47-184 1.10e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.90  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575627  47 TDDAKLRGLAAPSNLSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMinNRNKSVVRSMSWNAD 126
Cdd:COG2319    54 GAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL--TGHTGAVRSVAFSPD 131

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462575627 127 GQKIcivyedgavIVGSVDGN-RIW----GKDLKGIQ-----LSHVTWSADSKVLLFGMANGEIHIYD 184
Cdd:COG2319   132 GKTL---------ASGSADGTvRLWdlatGKLLRTLTghsgaVTSVAFSPDGKLLASGSDDGTVRLWD 190
WD40 COG2319
WD40 repeat [General function prediction only];
28-150 1.20e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.82  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575627  28 FIACGGEDGLLKVLKLETqtddAKLRglaapsnlsmnQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIE 107
Cdd:COG2319   302 LLASGSDDGTVRLWDLAT----GKLL-----------RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR 366

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462575627 108 EMINNRNKsvVRSMSWNADGQKIcivyedgavIVGSVDGN-RIW 150
Cdd:COG2319   367 TLTGHTGA--VTSVAFSPDGRTL---------ASGSADGTvRLW 399
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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