TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462573304 1224 CDNVLAPNVTKQECCCTS-GAGWGDNCEifPCPVLGTAEFTEMC 1266
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSvGRAWGSPCE--LCPPPGTDEFRELC 44

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462573304 1400 VCSRPLVGkQTTYTECCCLY-GEAWGMQCALCPLKDSDDYAQLC 1442
Cdd:pfam00683    2 RCSNPLPG-NVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2462573304  1027 DIDECQHRHLCAHG-QCRNTEGSFQCVCDQGYRAsglGDHCE 1067
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2462573304   945 DVDECLEPNVCANG-DCSNLEGSYMCSCHKGYTrtpDHKHC 984
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|..
gi 2462573304   626 DINECQLQGVCPNG-ECLNTMGSYRCTCKIGF 656
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2462573304  1527 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1561
Cdd:smart00179    1 DIDECASGNP----CQNgGTCVNTVGSYRCECPPGY 32

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462573304  567 QCGKALPG-LSKQEDCCGTVGTSWGfNKCQKCPKKPS 602
Cdd:pfam00683    2 RCSNPLPGnVTKSECCCTSVGRAWG-SPCELCPPPGT 37

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462573304 1224 CDNVLAPNVTKQECCCTS-GAGWGDNCEifPCPVLGTAEFTEMC 1266
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSvGRAWGSPCE--LCPPPGTDEFRELC 44

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462573304 1400 VCSRPLVGkQTTYTECCCLY-GEAWGMQCALCPLKDSDDYAQLC 1442
Cdd:pfam00683    2 RCSNPLPG-NVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462573304 1109 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisadGRTCE 1150
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462573304 1027 DIDECQHRHLC-AHGQCRNTEGSFQCVCDQGYRasglGDHCE 1067
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT----GRNCE 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....
gi 2462573304  986 DIDECQQGNLCVN-GQCKNTEGSFRCTCGQGYQL 1018
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462573304   862 DIDECTQVqHLCSQG-RCENTEGSFLCICPAGFmasEEGTNCI 903
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462573304 1068 DINECLEDKSVCQR-GDCINTAGSYDCTCPDG 1098
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2462573304  1068 DINECLEDkSVCQRG-DCINTAGSYDCTCPDGFQldDNKTCQ 1108
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGYT--DGRNCE 39

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462573304  862 DIDECTQVQHLCSQ-GRCENTEGSFLCICPAG 892
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2462573304  862 DIDECTQvQHLCS-QGRCENTEGSFLCICPAGFmaseEGTNCI 903
Cdd:cd00054      1 DIDECAS-GNPCQnGGTCVNTVGSYRCSCPPGY----TGRNCE 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462573304 1527 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1561
Cdd:cd00054      1 DIDECASGNP----CQNgGTCVNTVGSYRCSCPPGY 32

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462573304  567 QCGKALPG-LSKQEDCCGTVGTSWGfNKCQKCPKKPS 602
Cdd:pfam00683    2 RCSNPLPGnVTKSECCCTSVGRAWG-SPCELCPPPGT 37

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....
gi 2462573304  904 DVDECLRPDVCGEGH-CVNTVGAFRCEyCDSGYR 936
Cdd:cd00054      1 DIDECASGNPCQNGGtCVNTVGSYRCS-CPPGYT 33

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462573304 1027 DIDEC-QHRHLC-AHGQCRNTEGSFQCVCDQG 1056
Cdd:pfam07645    1 DVDECaTGTHNCpANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462573304  986 DIDECQQG-NLC-VNGQCKNTEGSFRCTCGQG 1015
Cdd:pfam07645    1 DVDECATGtHNCpANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain;

                            10        20
                    ....*....|....*....|....*...
gi 2462573304  1332 DMDECQDPSSCIDG-QCVNTEGSYNCFC 1358
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCEC 28

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462573304 1224 CDNVLAPNVTKQECCCTS-GAGWGDNCEifPCPVLGTAEFTEMC 1266
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSvGRAWGSPCE--LCPPPGTDEFRELC 44

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462573304 1400 VCSRPLVGkQTTYTECCCLY-GEAWGMQCALCPLKDSDDYAQLC 1442
Cdd:pfam00683    2 RCSNPLPG-NVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462573304 1109 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisadGRTCE 1150
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462573304 1027 DIDECQHRHLC-AHGQCRNTEGSFQCVCDQGYRasglGDHCE 1067
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT----GRNCE 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....
gi 2462573304  986 DIDECQQGNLCVN-GQCKNTEGSFRCTCGQGYQL 1018
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462573304   862 DIDECTQVqHLCSQG-RCENTEGSFLCICPAGFmasEEGTNCI 903
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462573304 1068 DINECLEDKSVCQR-GDCINTAGSYDCTCPDG 1098
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2462573304  1068 DINECLEDkSVCQRG-DCINTAGSYDCTCPDGFQldDNKTCQ 1108
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGYT--DGRNCE 39

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462573304  862 DIDECTQVQHLCSQ-GRCENTEGSFLCICPAG 892
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2462573304  862 DIDECTQvQHLCS-QGRCENTEGSFLCICPAGFmaseEGTNCI 903
Cdd:cd00054      1 DIDECAS-GNPCQnGGTCVNTVGSYRCSCPPGY----TGRNCE 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462573304 1527 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1561
Cdd:cd00054      1 DIDECASGNP----CQNgGTCVNTVGSYRCSCPPGY 32

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462573304  567 QCGKALPG-LSKQEDCCGTVGTSWGfNKCQKCPKKPS 602
Cdd:pfam00683    2 RCSNPLPGnVTKSECCCTSVGRAWG-SPCELCPPPGT 37

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462573304 1527 DVNECDELNNrmsLC-KNAKCINTDGSYKCLCLPG 1560
Cdd:pfam07645    1 DVDECATGTH---NCpANTVCVNTIGSFECRCPDG 32

Epidermal growth factor-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 2462573304   629 ECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPT 661
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462573304  626 DINEC-QLQGVCP-NGECLNTMGSYRCTCKIG 655
Cdd:pfam07645    1 DVDECaTGTHNCPaNTVCVNTIGSFECRCPDG 32

Epidermal growth factor-like domain;

                            10        20
                    ....*....|....*....|....*....
gi 2462573304   948 ECLEPNVCANGDCSNLEGSYMCSCHKGYT 976
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYT 29

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.

                           10        20
                   ....*....|....*....|..
gi 2462573304 1133 HCVCQQGFSISADGRTCEDVNE 1154
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462573304  856 QQRKCVDIDECTQVQHLCSQGrCENTEGSFLCICPAGFMASEEG 899
Cdd:cd01475    180 QGKICVVPDLCATLSHVCQQV-CISTPGSYLCACTEGYALLEDN 222

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462573304  986 DIDECQQG-NLC-VNGQCKNTEGSFRCTCGQG 1015
Cdd:pfam07645    1 DVDECATGtHNCpANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF domain;

                           10        20
                   ....*....|....*....|....*....
gi 2462573304  945 DVDECLEP-NVC-ANGDCSNLEGSYMCSC 971
Cdd:pfam07645    1 DVDECATGtHNCpANTVCVNTIGSFECRC 29