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Conserved domains on  [gi|2462570000|ref|XP_054196457|]
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MIT domain-containing protein 1 isoform X3 [Homo sapiens]

Protein Classification

BREX system Lon protease-like protein BrxL( domain architecture ID 10119420)

BREX system Lon protease-like protein BrxL is part of the phage resistance system BREX (BacteRiophage EXclusion) that employs a defense strategy involving DNA methylation of the host cell and blocking phage DNA replication

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIT_C super family cl02780
MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and ...
 125-217 4.01e-48

MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown.


The actual alignment was detected with superfamily member pfam16565:

Pssm-ID: 470673  Cd Length: 137  Bit Score: 155.76  E-value: 4.01e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570000 125 GFSYESLFREYLNETVTEVWIEDPYIRHTHQGI----------------------------EQVQQSRGLQEIEESLRSH 176
Cdd:pfam16565   1 GYSYESLFGPYLDGTATEITIEDPYIRAPHQIRnlvrfcellvkkcgnlkkihlltgedeeNLDQQLDNLEELKDSLASR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2462570000 177 GVLLEVQYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQTGF 217
Cdd:pfam16565  81 GVTLTVEFSSTLHDREIRFDNGWIIKIGRGLDYFKKPESKF 121
MIT_1 cd02683
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 35-111 3.66e-42

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.


:

Pssm-ID: 239146  Cd Length: 77  Bit Score: 138.71  E-value: 3.66e-42
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462570000  35 PQSTAAATVLKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKKYLDQEKEDG 111
Cdd:cd02683     1 SLELAAKEVLKRAVELDQEGRFQEALVCYQEGIDLLMQVLKGTKDEAKKKNLRQKISEYMDRAEAIKKRLDQEKEDG 77
 
Name Accession Description Interval E-value
MIT_C pfam16565
Phospholipase D-like domain at C-terminus of MIT; MIT_C is the C-terminal domain of ...
 125-217 4.01e-48

Phospholipase D-like domain at C-terminus of MIT; MIT_C is the C-terminal domain of MIT-containing proteins, pfam04212. It contains an unanticipated phospholipase d fold (PLD fold) that binds avidly to phosphoinositide-containing membranes. It is conserved in eukaryotes, though not fungi and plants, and some bacteria.


Pssm-ID: 465180  Cd Length: 137  Bit Score: 155.76  E-value: 4.01e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570000 125 GFSYESLFREYLNETVTEVWIEDPYIRHTHQGI----------------------------EQVQQSRGLQEIEESLRSH 176
Cdd:pfam16565   1 GYSYESLFGPYLDGTATEITIEDPYIRAPHQIRnlvrfcellvkkcgnlkkihlltgedeeNLDQQLDNLEELKDSLASR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2462570000 177 GVLLEVQYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQTGF 217
Cdd:pfam16565  81 GVTLTVEFSSTLHDREIRFDNGWIIKIGRGLDYFKKPESKF 121
MIT_C cd02685
MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and ...
 122-217 4.13e-45

MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown.


Pssm-ID: 239148  Cd Length: 148  Bit Score: 148.54  E-value: 4.13e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570000 122 NATGFSYESLFREYLNETVTEVWIEDPYIRHTHQ------GIEQV----------------------QQSRGLQEIEESL 173
Cdd:cd02685     1 NATGFSYDRLFGPYLDDGVTEITVEDPYIRNFHQirnflrFCELVvkppcelkyihlvtgededngkQQIEALEEIKQSL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462570000 174 RSHGVLLEVQYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQTGF 217
Cdd:cd02685    81 ASHGVEFTWEFSDTIHDREIRTDNGWIIKIGRGLDYFKPPEGKF 124
MIT_1 cd02683
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 35-111 3.66e-42

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.


Pssm-ID: 239146  Cd Length: 77  Bit Score: 138.71  E-value: 3.66e-42
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462570000  35 PQSTAAATVLKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKKYLDQEKEDG 111
Cdd:cd02683     1 SLELAAKEVLKRAVELDQEGRFQEALVCYQEGIDLLMQVLKGTKDEAKKKNLRQKISEYMDRAEAIKKRLDQEKEDG 77
MIT smart00745
Microtubule Interacting and Trafficking molecule domain;
33-106 2.03e-19

Microtubule Interacting and Trafficking molecule domain;


Pssm-ID: 197854  Cd Length: 77  Bit Score: 79.66  E-value: 2.03e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462570000   33 QDPQSTAAATVLKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKKYLDQ 106
Cdd:smart00745   1 TRDYLSKAKELISKALKADEAGNYEEALELYKKAIEYLLEGIKVESDSKRREALKAKAAEYLDRAEEIKKSLLE 74
MIT pfam04212
MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric ...
 39-102 9.91e-17

MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric three-helix bundle and binds ESCRT-III (endosomal sorting complexes required for transport) substrates.


Pssm-ID: 461228  Cd Length: 66  Bit Score: 72.19  E-value: 9.91e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462570000  39 AAATVLKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKK 102
Cdd:pfam04212   3 KALELVKKAVEEDNAGNYEEALELYKEALDYLLLALKETKNEERRELLRAKIAEYLERAEELKE 66
 
Name Accession Description Interval E-value
MIT_C pfam16565
Phospholipase D-like domain at C-terminus of MIT; MIT_C is the C-terminal domain of ...
 125-217 4.01e-48

Phospholipase D-like domain at C-terminus of MIT; MIT_C is the C-terminal domain of MIT-containing proteins, pfam04212. It contains an unanticipated phospholipase d fold (PLD fold) that binds avidly to phosphoinositide-containing membranes. It is conserved in eukaryotes, though not fungi and plants, and some bacteria.


Pssm-ID: 465180  Cd Length: 137  Bit Score: 155.76  E-value: 4.01e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570000 125 GFSYESLFREYLNETVTEVWIEDPYIRHTHQGI----------------------------EQVQQSRGLQEIEESLRSH 176
Cdd:pfam16565   1 GYSYESLFGPYLDGTATEITIEDPYIRAPHQIRnlvrfcellvkkcgnlkkihlltgedeeNLDQQLDNLEELKDSLASR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2462570000 177 GVLLEVQYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQTGF 217
Cdd:pfam16565  81 GVTLTVEFSSTLHDREIRFDNGWIIKIGRGLDYFKKPESKF 121
MIT_C cd02685
MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and ...
 122-217 4.13e-45

MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown.


Pssm-ID: 239148  Cd Length: 148  Bit Score: 148.54  E-value: 4.13e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570000 122 NATGFSYESLFREYLNETVTEVWIEDPYIRHTHQ------GIEQV----------------------QQSRGLQEIEESL 173
Cdd:cd02685     1 NATGFSYDRLFGPYLDDGVTEITVEDPYIRNFHQirnflrFCELVvkppcelkyihlvtgededngkQQIEALEEIKQSL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462570000 174 RSHGVLLEVQYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQTGF 217
Cdd:cd02685    81 ASHGVEFTWEFSDTIHDREIRTDNGWIIKIGRGLDYFKPPEGKF 124
MIT_1 cd02683
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 35-111 3.66e-42

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.


Pssm-ID: 239146  Cd Length: 77  Bit Score: 138.71  E-value: 3.66e-42
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462570000  35 PQSTAAATVLKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKKYLDQEKEDG 111
Cdd:cd02683     1 SLELAAKEVLKRAVELDQEGRFQEALVCYQEGIDLLMQVLKGTKDEAKKKNLRQKISEYMDRAEAIKKRLDQEKEDG 77
MIT cd02656
MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain ...
 39-108 1.31e-19

MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar sorting proteins and others. The molecular function of the MIT domain is unclear.


Pssm-ID: 239121  Cd Length: 75  Bit Score: 80.43  E-value: 1.31e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570000  39 AAATVLKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKKYLDQEK 108
Cdd:cd02656     5 QAKELIKQAVKEDEDGNYEEALELYKEALDYLLQALKAEKEPKLRKLLRKKVKEYLDRAEFLKELLKKQK 74
MIT smart00745
Microtubule Interacting and Trafficking molecule domain;
33-106 2.03e-19

Microtubule Interacting and Trafficking molecule domain;


Pssm-ID: 197854  Cd Length: 77  Bit Score: 79.66  E-value: 2.03e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462570000   33 QDPQSTAAATVLKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKKYLDQ 106
Cdd:smart00745   1 TRDYLSKAKELISKALKADEAGNYEEALELYKKAIEYLLEGIKVESDSKRREALKAKAAEYLDRAEEIKKSLLE 74
MIT pfam04212
MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric ...
 39-102 9.91e-17

MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric three-helix bundle and binds ESCRT-III (endosomal sorting complexes required for transport) substrates.


Pssm-ID: 461228  Cd Length: 66  Bit Score: 72.19  E-value: 9.91e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462570000  39 AAATVLKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKK 102
Cdd:pfam04212   3 KALELVKKAVEEDNAGNYEEALELYKEALDYLLLALKETKNEERRELLRAKIAEYLERAEELKE 66
MIT_VPS4 cd02678
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 45-108 3.26e-12

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in intracellular protein transport proteins of the AAA-ATPase family. The molecular function of the MIT domain is unclear.


Pssm-ID: 239141  Cd Length: 75  Bit Score: 60.36  E-value: 3.26e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462570000  45 KRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKKYLDQEK 108
Cdd:cd02678    11 KKAIEEDNAGNYEEALRLYQHALEYFMHALKYEKNPKSKESIRAKCTEYLDRAEKLKEYLAKKE 74
MIT_SNX15 cd02677
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT ...
 40-100 4.74e-09

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.


Pssm-ID: 239140  Cd Length: 75  Bit Score: 51.96  E-value: 4.74e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462570000  40 AATVLKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENI 100
Cdd:cd02677     6 AAELIRLALEKEEEGDYEAAFEFYRAGVDLLLKGVQGDSSPERREAVKRKIAEYLKRAEEI 66
MIT_2 cd02684
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 40-104 4.58e-04

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with an n-terminal serine/threonine kinase domain. The molecular function of the MIT domain is unclear.


Pssm-ID: 239147  Cd Length: 75  Bit Score: 37.88  E-value: 4.58e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462570000  40 AATVLKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKKYL 104
Cdd:cd02684     6 AIALVVQAVKKDQRGDAAAALSLYCSALQYFVPALHYETDAQRKEALRQKVLQYVSRAEELKALI 70
MIT_AAA_Arch cd02682
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 47-102 4.61e-04

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in mostly archaebacterial AAA-ATPases. The molecular function of the MIT domain is unclear.


Pssm-ID: 239145  Cd Length: 75  Bit Score: 37.89  E-value: 4.61e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462570000  47 AVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKK 102
Cdd:cd02682    13 AVKAEKEGNAEDAITNYKKAIEVLSQIVKNYPDSPTRLIYEQMINEYKRRIEVLEK 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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