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Conserved domains on  [gi|2462514419|ref|XP_054195111|]
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volume-regulated anion channel subunit LRRC8C isoform X4 [Homo sapiens]

Protein Classification

Pannexin_like and LRR domain-containing protein( domain architecture ID 12117038)

Pannexin_like and LRR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-291 1.35e-166

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


:

Pssm-ID: 463622  Cd Length: 345  Bit Score: 483.66  E-value: 1.35e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419   1 MQDKIICLPKRVQPAQNHSSLSNVSQAVASTTPLPPPKPSPANPITvEMKGLKTDLDLQQYSFINQMCYERALHWYAKYF 80
Cdd:pfam12534  48 TQDKVVCLPCLESPPSTASLDDSYANSLSPTQSAPTVSSPSASMIP-EPKGRKTNLDRQQYVFINQVCYEKALHWYSKYF 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419  81 PYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEVSGEDSEEKD--NRKNNMN-----RSNTIQ 153
Cdd:pfam12534 127 PYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSILGKCFDSPWTTRALSETSGEDSEEKKqrLEGNTVLpkvssSSSLSS 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 154 SGPEGSLVNSQSLKSIPEKFVVD-KSTAGALDKKEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAY 232
Cdd:pfam12534 207 SDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSY 286

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462514419 233 NSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTL 291
Cdd:pfam12534 287 TSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
535-725 8.84e-35

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 137.37  E-value: 8.84e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 535 LNNLKKMTNLTELELVHCDleriphAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTVLKLWHNSITYIPEHIKKLTS 614
Cdd:COG4886    89 LTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 615 LERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSL 694
Cdd:COG4886   161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2462514419 695 SVLsPKIGNLLFLSYLDVKGNHFEILPPELG 725
Cdd:COG4886   241 TDL-PELGNLTNLEELDLSNNQLTDLPPLAN 270
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 465-575 4.42e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 4.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 465 GLRNLEELYLVGSLshdISRNVTLESLRDLKSLKILS--IKSNVSKI--PQAVVDVSSHLQKMCIHNDgtKLVMLNNLKK 540
Cdd:cd21340    66 NLVNLKKLYLGGNR---ISVVEGLENLTNLEELHIENqrLPPGEKLTfdPRSLAALSNSLRVLNISGN--NIDSLEPLAP 140

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2462514419 541 MTNLTELELVHCDLERIP---HAVFSLLSLQELDLKEN 575
Cdd:cd21340   141 LRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGN 178
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-291 1.35e-166

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 483.66  E-value: 1.35e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419   1 MQDKIICLPKRVQPAQNHSSLSNVSQAVASTTPLPPPKPSPANPITvEMKGLKTDLDLQQYSFINQMCYERALHWYAKYF 80
Cdd:pfam12534  48 TQDKVVCLPCLESPPSTASLDDSYANSLSPTQSAPTVSSPSASMIP-EPKGRKTNLDRQQYVFINQVCYEKALHWYSKYF 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419  81 PYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEVSGEDSEEKD--NRKNNMN-----RSNTIQ 153
Cdd:pfam12534 127 PYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSILGKCFDSPWTTRALSETSGEDSEEKKqrLEGNTVLpkvssSSSLSS 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 154 SGPEGSLVNSQSLKSIPEKFVVD-KSTAGALDKKEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAY 232
Cdd:pfam12534 207 SDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSY 286

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462514419 233 NSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTL 291
Cdd:pfam12534 287 TSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
535-725 8.84e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 137.37  E-value: 8.84e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 535 LNNLKKMTNLTELELVHCDleriphAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTVLKLWHNSITYIPEHIKKLTS 614
Cdd:COG4886    89 LTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 615 LERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSL 694
Cdd:COG4886   161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2462514419 695 SVLsPKIGNLLFLSYLDVKGNHFEILPPELG 725
Cdd:COG4886   241 TDL-PELGNLTNLEELDLSNNQLTDLPPLAN 270
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 538-717 4.89e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.04  E-value: 4.89e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 538 LKKMTNLTeleLVHCDLERIPhaVFSLL-SLQELDLKENNLKSIEeivSFQHLRKLTVLKLWHNSITYIpEHIKKLTSLE 616
Cdd:cd21340     1 LKRITHLY---LNDKNITKID--NLSLCkNLKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLK 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 617 RLSFSHNKIEVLpSHLFLCNKIRYLDLSYNDIrfiPPE----------IGVLQSLQYFSITCNKVESLpDELYFCKKLKT 686
Cdd:cd21340    72 KLYLGGNRISVV-EGLENLTNLEELHIENQRL---PPGekltfdprslAALSNSLRVLNISGNNIDSL-EPLAPLRNLEQ 146

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2462514419 687 LKIGKN---SLSVLSPKIGNLLFLSYLDVKGNHF 717
Cdd:cd21340   147 LDASNNqisDLEELLDLLSSWPSLRELDLTGNPV 180
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 394-730 3.73e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.88  E-value: 3.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 394 FEITELQSLK-LEIIKNVM---IPATIAQLDNLQELSLHQ--CSVKIHSAALSFLKenlkVLSVKFDDMR---ELPPWMY 464
Cdd:PLN00113  230 YEIGGLTSLNhLDLVYNNLtgpIPSSLGNLKNLQYLFLYQnkLSGPIPPSIFSLQK----LISLDLSDNSlsgEIPELVI 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 465 GLRNLEELYLvgsLSHDISRNVTlESLRDLKSLKILSIKSN--VSKIPQavvdvssHLQKmciHNDGTKLVMLNN----- 537
Cdd:PLN00113  306 QLQNLEILHL---FSNNFTGKIP-VALTSLPRLQVLQLWSNkfSGEIPK-------NLGK---HNNLTVLDLSTNnltge 371

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 538 ----LKKMTNLTELELVHCDLE-RIPHAVFSLLSLQELDLKENNLkSIEEIVSFQHLRKLTVLKLWHNSIT-YIPEHIKK 611
Cdd:PLN00113  372 ipegLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSF-SGELPSEFTKLPLVYFLDISNNNLQgRINSRKWD 450

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 612 LTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNKVES-LPDELYFCKKLKTLKI 689
Cdd:PLN00113  451 MPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLDL 530

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 2462514419 690 GKNSLSVLSP-KIGNLLFLSYLDVKGNHFE-ILPPELGDCRAL 730
Cdd:PLN00113  531 SHNQLSGQIPaSFSEMPVLSQLDLSQNQLSgEIPKNLGNVESL 573
LRR_8 pfam13855
Leucine rich repeat;
590-648 2.24e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.24e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462514419 590 RKLTVLKLWHNSITYI-PEHIKKLTSLERLSFSHNKIEVLPSHLFLC-NKIRYLDLSYNDI 648
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 465-575 4.42e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 4.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 465 GLRNLEELYLVGSLshdISRNVTLESLRDLKSLKILS--IKSNVSKI--PQAVVDVSSHLQKMCIHNDgtKLVMLNNLKK 540
Cdd:cd21340    66 NLVNLKKLYLGGNR---ISVVEGLENLTNLEELHIENqrLPPGEKLTfdPRSLAALSNSLRVLNISGN--NIDSLEPLAP 140

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2462514419 541 MTNLTELELVHCDLERIP---HAVFSLLSLQELDLKEN 575
Cdd:cd21340   141 LRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGN 178
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 378-686 8.30e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 39.86  E-value: 8.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419  378 RLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSvkihsaalsflkenlkvlsvkfdDMR 457
Cdd:PLN03210   615 KLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCS-----------------------SLV 671

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419  458 ELPPWMYGLRNLEELylvgslshDISRNVTLESLR---DLKSLKILSIkSNVSKIpQAVVDVSSHLQKMCIhnDGTKLVM 534
Cdd:PLN03210   672 ELPSSIQYLNKLEDL--------DMSRCENLEILPtgiNLKSLYRLNL-SGCSRL-KSFPDISTNISWLDL--DETAIEE 739

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419  535 LNNLKKMTNLTELELVHCDLERIPHAVFSLL--------SLQELDLkeNNLKSIEEI-VSFQHLRKLTVLKLWH-NSITY 604
Cdd:PLN03210   740 FPSNLRLENLDELILCEMKSEKLWERVQPLTplmtmlspSLTRLFL--SDIPSLVELpSSIQNLHKLEHLEIENcINLET 817

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419  605 IPEHIkKLTSLERLSFSH-NKIEVLPShlfLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFS-ITCNKVESLPDELYFCK 682
Cdd:PLN03210   818 LPTGI-NLESLESLDLSGcSRLRTFPD---ISTNISDLNLSRTGIEEVPWWIEKFSNLSFLDmNGCNNLQRVSLNISKLK 893


                   ....
gi 2462514419  683 KLKT 686
Cdd:PLN03210   894 HLET 897
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-291 1.35e-166

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 483.66  E-value: 1.35e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419   1 MQDKIICLPKRVQPAQNHSSLSNVSQAVASTTPLPPPKPSPANPITvEMKGLKTDLDLQQYSFINQMCYERALHWYAKYF 80
Cdd:pfam12534  48 TQDKVVCLPCLESPPSTASLDDSYANSLSPTQSAPTVSSPSASMIP-EPKGRKTNLDRQQYVFINQVCYEKALHWYSKYF 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419  81 PYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEVSGEDSEEKD--NRKNNMN-----RSNTIQ 153
Cdd:pfam12534 127 PYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSILGKCFDSPWTTRALSETSGEDSEEKKqrLEGNTVLpkvssSSSLSS 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 154 SGPEGSLVNSQSLKSIPEKFVVD-KSTAGALDKKEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAY 232
Cdd:pfam12534 207 SDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSY 286

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462514419 233 NSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTL 291
Cdd:pfam12534 287 TSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
535-725 8.84e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 137.37  E-value: 8.84e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 535 LNNLKKMTNLTELELVHCDleriphAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTVLKLWHNSITYIPEHIKKLTS 614
Cdd:COG4886    89 LTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 615 LERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSL 694
Cdd:COG4886   161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2462514419 695 SVLsPKIGNLLFLSYLDVKGNHFEILPPELG 725
Cdd:COG4886   241 TDL-PELGNLTNLEELDLSNNQLTDLPPLAN 270
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
468-732 1.98e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 124.66  E-value: 1.98e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 468 NLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTEL 547
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 548 ELVHCDLerIPHAVFSLLSLQELDLKENNlksieeivSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEV 627
Cdd:COG4886    81 LLSLLLL--GLTDLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTD 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 628 LPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFL 707
Cdd:COG4886   151 LPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230

                         250       260
                  ....*....|....*....|....*
gi 2462514419 708 SYLDVKGNHFEILpPELGDCRALKR 732
Cdd:COG4886   231 ETLDLSNNQLTDL-PELGNLTNLEE 254
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
351-724 1.25e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.41  E-value: 1.25e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 351 NKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQC 430
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 431 SVKIHSAALSFLKENLKVLSVKFDDMRELppwmYGLRNLEELYLVGSLSHDISrnvtlESLRDLKSLKILSIKSN-VSKI 509
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELDLSGNEEL----SNLTNLESLDLSGNQLTDLP-----EELANLTNLKELDLSNNqLTDL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 510 PqavvdvsshlqkmcihndgtklvmlNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEivSFQHL 589
Cdd:COG4886   152 P-------------------------EPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE--PLGNL 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 590 RKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPShLFLCNKIRYLDLSYNDIRFIPPEIGvLQSLQYFSITCN 669
Cdd:COG4886   205 TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPLAN-LTNLKTLDLSNN 282

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462514419 670 KVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPEL 724
Cdd:COG4886   283 QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTL 337
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
309-711 1.32e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.08  E-value: 1.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 309 QETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSG 388
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 389 LPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKeNLKVLSVKFDDMRELPPWMYGLRN 468
Cdd:COG4886    82 LSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLT-NLKELDLSNNQLTDLPEPLGNLTN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 469 LEELYLVGSLSHDISrnvtlESLRDLKSLKILSIKSN-VSKIPQAvvdvsshlqkmcihndgtklvmlnnLKKMTNLTEL 547
Cdd:COG4886   161 LKSLDLSNNQLTDLP-----EELGNLTNLKELDLSNNqITDLPEP-------------------------LGNLTNLEEL 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 548 ELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIvsfQHLRKLTVLKLWHNSITYIPEhIKKLTSLERLSFSHNKIEV 627
Cdd:COG4886   211 DLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPEL---GNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTD 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 628 LP-SHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLF 706
Cdd:COG4886   287 LKlKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLL 366


                  ....*
gi 2462514419 707 LSYLD 711
Cdd:COG4886   367 LTLGL 371
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 538-717 4.89e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.04  E-value: 4.89e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 538 LKKMTNLTeleLVHCDLERIPhaVFSLL-SLQELDLKENNLKSIEeivSFQHLRKLTVLKLWHNSITYIpEHIKKLTSLE 616
Cdd:cd21340     1 LKRITHLY---LNDKNITKID--NLSLCkNLKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLK 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 617 RLSFSHNKIEVLpSHLFLCNKIRYLDLSYNDIrfiPPE----------IGVLQSLQYFSITCNKVESLpDELYFCKKLKT 686
Cdd:cd21340    72 KLYLGGNRISVV-EGLENLTNLEELHIENQRL---PPGekltfdprslAALSNSLRVLNISGNNIDSL-EPLAPLRNLEQ 146

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2462514419 687 LKIGKN---SLSVLSPKIGNLLFLSYLDVKGNHF 717
Cdd:cd21340   147 LDASNNqisDLEELLDLLSSWPSLRELDLTGNPV 180
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 394-730 3.73e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.88  E-value: 3.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 394 FEITELQSLK-LEIIKNVM---IPATIAQLDNLQELSLHQ--CSVKIHSAALSFLKenlkVLSVKFDDMR---ELPPWMY 464
Cdd:PLN00113  230 YEIGGLTSLNhLDLVYNNLtgpIPSSLGNLKNLQYLFLYQnkLSGPIPPSIFSLQK----LISLDLSDNSlsgEIPELVI 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 465 GLRNLEELYLvgsLSHDISRNVTlESLRDLKSLKILSIKSN--VSKIPQavvdvssHLQKmciHNDGTKLVMLNN----- 537
Cdd:PLN00113  306 QLQNLEILHL---FSNNFTGKIP-VALTSLPRLQVLQLWSNkfSGEIPK-------NLGK---HNNLTVLDLSTNnltge 371

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 538 ----LKKMTNLTELELVHCDLE-RIPHAVFSLLSLQELDLKENNLkSIEEIVSFQHLRKLTVLKLWHNSIT-YIPEHIKK 611
Cdd:PLN00113  372 ipegLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSF-SGELPSEFTKLPLVYFLDISNNNLQgRINSRKWD 450

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 612 LTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNKVES-LPDELYFCKKLKTLKI 689
Cdd:PLN00113  451 MPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLDL 530

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 2462514419 690 GKNSLSVLSP-KIGNLLFLSYLDVKGNHFE-ILPPELGDCRAL 730
Cdd:PLN00113  531 SHNQLSGQIPaSFSEMPVLSQLDLSQNQLSgEIPKNLGNVESL 573
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 496-748 1.85e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.40  E-value: 1.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 496 SLKILSIKSNV--SKIPQAVVDVSShLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLE-RIPHAVFSLLSLQELDL 572
Cdd:PLN00113  165 SLKVLDLGGNVlvGKIPNSLTNLTS-LEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDL 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 573 KENNLkSIEEIVSFQHLRKLTVLKLWHNSIT-YIPEHIKKLTSLERLSFSHNKIE-VLPSHLFLCNKIRYLDLSYNDIR- 649
Cdd:PLN00113  244 VYNNL-TGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTg 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 650 FIPPEIGVLQSLQYFSITCNKVE-SLPDELYFCKKLKTLKIGKNSLSVLSPKI----GNL----LFLSYLDVKgnhfeiL 720
Cdd:PLN00113  323 KIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGEIPEGlcssGNLfkliLFSNSLEGE------I 396

                         250       260
                  ....*....|....*....|....*...
gi 2462514419 721 PPELGDCRALKRAGLvVEDALFETLPSD 748
Cdd:PLN00113  397 PKSLGACRSLRRVRL-QDNSFSGELPSE 423
LRR_8 pfam13855
Leucine rich repeat;
590-648 2.24e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.24e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462514419 590 RKLTVLKLWHNSITYI-PEHIKKLTSLERLSFSHNKIEVLPSHLFLC-NKIRYLDLSYNDI 648
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 556-731 4.81e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.78  E-value: 4.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 556 RIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSIT-YIPEhiKKLTSLERLSFSHNKIE-VLPSHLF 633
Cdd:PLN00113   84 KISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTgSIPR--GSIPNLETLDLSNNMLSgEIPNDIG 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 634 LCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNK-VESLPDELYFCKKLKTLKIGKNSLSVLSPK-IGNLLFLSYL 710
Cdd:PLN00113  162 SFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGYNNLSGEIPYeIGGLTSLNHL 241

                         170       180
                  ....*....|....*....|..
gi 2462514419 711 D-VKGNHFEILPPELGDCRALK 731
Cdd:PLN00113  242 DlVYNNLTGPIPSSLGNLKNLQ 263
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
534-754 4.84e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 56.63  E-value: 4.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 534 MLNNLKKmtNLTELELVHCDLERIPHAVFSllSLQELDLKENNLKSIEEIVSfQHLRKLTVLKlwhNSITYIPEHIKKlt 613
Cdd:PRK15370  172 MRDCLKN--NKTELRLKILGLTTIPACIPE--QITTLILDNNELKSLPENLQ-GNIKTLYANS---NQLTSIPATLPD-- 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 614 SLERLSFSHNKIEVLPSHLflcnkiryldlsyndirfipPeigvlQSLQYFSITCNKVESLPDELyfCKKLKTLKIGKNS 693
Cdd:PRK15370  242 TIQEMELSINRITELPERL--------------------P-----SALQSLDLFHNKISCLPENL--PEELRYLSVYDNS 294

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462514419 694 LSVLSPKIGNllFLSYLDVKGNHFEILPPELgdcrALKRAGLVVEDALFETLPSDVREQMK 754
Cdd:PRK15370  295 IRTLPAHLPS--GITHLNVQSNSLTALPETL----PPGLKTLEAGENALTSLPASLPPELQ 349
LRR_8 pfam13855
Leucine rich repeat;
542-602 1.29e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 1.29e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462514419 542 TNLTELELVHCDLERIPHAVFS-LLSLQELDLKENNLKSIEEiVSFQHLRKLTVLKLWHNSI 602
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
566-625 5.14e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 5.14e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462514419 566 SLQELDLKENNLKSIEEiVSFQHLRKLTVLKLWHNSITYI-PEHIKKLTSLERLSFSHNKI 625
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDD-GAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 466-640 9.81e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.17  E-value: 9.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 466 LRNLEELYLvgslSH-DISRnvtLESLRDLKSLKILsiksnvskipqavvdvssHLQKMCIhndgtklVMLNNLKKMTNL 544
Cdd:cd21340    45 LTNLTHLYL----QNnQIEK---IENLENLVNLKKL------------------YLGGNRI-------SVVEGLENLTNL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 545 TELelvHCDLERI---------PHAVFSLL-SLQELDLKENNLKSIEEivsFQHLRKLTVLKLWHNSITYIPE---HIKK 611
Cdd:cd21340    93 EEL---HIENQRLppgekltfdPRSLAALSnSLRVLNISGNNIDSLEP---LAPLRNLEQLDASNNQISDLEElldLLSS 166

                         170       180
                  ....*....|....*....|....*....
gi 2462514419 612 LTSLERLSFSHNKIevlpshlflCNKIRY 640
Cdd:cd21340   167 WPSLRELDLTGNPV---------CKKPKY 186
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
402-678 1.47e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.62  E-value: 1.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 402 LKLEIIKNVMIPATIAQ------LDNLQELSLHQCsvkihsaalsfLKENLKVLSVKFDDMRELPPWMYGlrNLEELylv 475
Cdd:PRK15370  183 LRLKILGLTTIPACIPEqittliLDNNELKSLPEN-----------LQGNIKTLYANSNQLTSIPATLPD--TIQEM--- 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 476 gslshDISRNVTLESLRDLKS-LKILSIKSN-VSKIPQAVVDvssHLQKMCIHNdgtklvmlNNLKKMTnltelelvhcd 553
Cdd:PRK15370  247 -----ELSINRITELPERLPSaLQSLDLFHNkISCLPENLPE---ELRYLSVYD--------NSIRTLP----------- 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 554 lERIPHavfsllSLQELDLKENNLKSIEEIVSFQhlrkLTVLKLWHNSITYIPEHIKKltSLERLSFSHNKIEVLPSHlf 633
Cdd:PRK15370  300 -AHLPS------GITHLNVQSNSLTALPETLPPG----LKTLEAGENALTSLPASLPP--ELQVLDVSKNQITVLPET-- 364

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2462514419 634 LCNKIRYLDLSYNDIRFIPPEIGVlqSLQYFSITCNKVESLPDEL 678
Cdd:PRK15370  365 LPPTITTLDVSRNALTNLPENLPA--ALQIMQASRNNLVRLPESL 407
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 535-696 3.89e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 50.17  E-value: 3.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 535 LNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNL--KSIEEIVS-FQHLRKLTVLKLWHNSIT-----YIP 606
Cdd:COG5238   178 QNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIgdEGAEILAEaLKGNKSLTTLDLSNNQIGdegviALA 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 607 EHIKKLTSLERLSFSHNKIEV-----LPSHLFLCNKIRYLDLSYNDIRFiPPEIGVLQSLQ-----------YFSITCNK 670
Cdd:COG5238   258 EALKNNTTVETLYLSGNQIGAegaiaLAKALQGNTTLTSLDLSVNRIGD-EGAIALAEGLQgnktlhtlnlaYNGIGAQG 336

                         170       180
                  ....*....|....*....|....*.
gi 2462514419 671 VESLPDELYFCKKLKTLKIGKNSLSV 696
Cdd:COG5238   337 AIALAKALQENTTLHSLDLSDNQIGD 362
PLN03150 PLN03150
hypothetical protein; Provisional
 557-623 4.70e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 4.70e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462514419 557 IPHAVFSLLSLQELDLKENNLKSieEI-VSFQHLRKLTVLKLWHNSIT-YIPEHIKKLTSLERLSFSHN 623
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRG--NIpPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGN 500
LRR_8 pfam13855
Leucine rich repeat;
659-717 2.57e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 2.57e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462514419 659 QSLQYFSITCNKVESLPDE-LYFCKKLKTLKIGKNSLSVLSPK-IGNLLFLSYLDVKGNHF 717
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 465-575 4.42e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 4.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419 465 GLRNLEELYLVGSLshdISRNVTLESLRDLKSLKILS--IKSNVSKI--PQAVVDVSSHLQKMCIHNDgtKLVMLNNLKK 540
Cdd:cd21340    66 NLVNLKKLYLGGNR---ISVVEGLENLTNLEELHIENqrLPPGEKLTfdPRSLAALSNSLRVLNISGN--NIDSLEPLAP 140

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2462514419 541 MTNLTELELVHCDLERIP---HAVFSLLSLQELDLKEN 575
Cdd:cd21340   141 LRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGN 178
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 378-686 8.30e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 39.86  E-value: 8.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419  378 RLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSvkihsaalsflkenlkvlsvkfdDMR 457
Cdd:PLN03210   615 KLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCS-----------------------SLV 671

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419  458 ELPPWMYGLRNLEELylvgslshDISRNVTLESLR---DLKSLKILSIkSNVSKIpQAVVDVSSHLQKMCIhnDGTKLVM 534
Cdd:PLN03210   672 ELPSSIQYLNKLEDL--------DMSRCENLEILPtgiNLKSLYRLNL-SGCSRL-KSFPDISTNISWLDL--DETAIEE 739

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419  535 LNNLKKMTNLTELELVHCDLERIPHAVFSLL--------SLQELDLkeNNLKSIEEI-VSFQHLRKLTVLKLWH-NSITY 604
Cdd:PLN03210   740 FPSNLRLENLDELILCEMKSEKLWERVQPLTplmtmlspSLTRLFL--SDIPSLVELpSSIQNLHKLEHLEIENcINLET 817

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462514419  605 IPEHIkKLTSLERLSFSH-NKIEVLPShlfLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFS-ITCNKVESLPDELYFCK 682
Cdd:PLN03210   818 LPTGI-NLESLESLDLSGcSRLRTFPD---ISTNISDLNLSRTGIEEVPWWIEKFSNLSFLDmNGCNNLQRVSLNISKLK 893


                   ....
gi 2462514419  683 KLKT 686
Cdd:PLN03210   894 HLET 897
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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