|
Name |
Accession |
Description |
Interval |
E-value |
| zf-C2H2_11 |
pfam16622 |
zinc-finger C2H2-type; Zinc-finger of C2H2 type found in higher eukaryotes. |
1190-1216 |
8.24e-10 |
|
zinc-finger C2H2-type; Zinc-finger of C2H2 type found in higher eukaryotes.
:
Pssm-ID: 465205 Cd Length: 27 Bit Score: 54.74 E-value: 8.24e-10
10 20
....*....|....*....|....*..
gi 2462511785 1190 GAQQCLDCGLCFASPGSLSRHRFISHK 1216
Cdd:pfam16622 1 STCQCLLCGLCFTSQGSLSRHLFIVHK 27
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
111-351 |
1.58e-06 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 53.02 E-value: 1.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 111 TAAASAGDGPGVPAQASDHGLPPPdiSVVSVIVKNTVCPEQSEALAGGSAGDGAQAAGVTKEGPVGPHRMQNgfgSPEPS 190
Cdd:PHA03247 2763 TAGPPAPAPPAAPAAGPPRRLTRP--AVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPT---SAQPT 2837
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 191 LPGTPHSPAPPS---------GGTWKEKGMEGKT----------PLDLFAHFGPEPGDHSDPLPPSAPSPTREGALTPPP 251
Cdd:PHA03247 2838 APPPPPGPPPPSlplggsvapGGDVRRRPPSRSPaakpaaparpPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPP 2917
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 252 FPSSFE--LAQENGPGMQPPVSSPPLGALKQESCSPH-HPQVLAQQGSGSSPKATDIPASASPPPVAGVPFFKQSPGHQS 328
Cdd:PHA03247 2918 QPQPQPppPPQPQPPPPPPPRPQPPLAPTTDPAGAGEpSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLT 2997
|
250 260
....*....|....*....|....*
gi 2462511785 329 PLASPKVP--VCQPLKEEDDDEGPV 351
Cdd:PHA03247 2998 GHSLSRVSswASSLALHEETDPPPV 3022
|
|
| zf-C2H2_8 super family |
cl25789 |
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem. |
852-934 |
4.63e-03 |
|
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
The actual alignment was detected with superfamily member pfam15909:
Pssm-ID: 464935 [Multi-domain] Cd Length: 98 Bit Score: 37.78 E-value: 4.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 852 PICPMAFKSGPSAHAHLYSQHPSFQTQQAKLiYKCAM--CDTVFTHKPLLSSHFDQHLLPQRVsvFKCPSCPLLFAQKRT 929
Cdd:pfam15909 5 PGCCLSFPSVRDLAQHLRTHCPPTQSLEGKL-FRCSAlsCTETFPSMQELVAHSKLHYKPNRY--FKCENCLLRFRTHRS 81
|
....*
gi 2462511785 930 MLEHL 934
Cdd:pfam15909 82 LFKHL 86
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| zf-C2H2_11 |
pfam16622 |
zinc-finger C2H2-type; Zinc-finger of C2H2 type found in higher eukaryotes. |
1190-1216 |
8.24e-10 |
|
zinc-finger C2H2-type; Zinc-finger of C2H2 type found in higher eukaryotes.
Pssm-ID: 465205 Cd Length: 27 Bit Score: 54.74 E-value: 8.24e-10
10 20
....*....|....*....|....*..
gi 2462511785 1190 GAQQCLDCGLCFASPGSLSRHRFISHK 1216
Cdd:pfam16622 1 STCQCLLCGLCFTSQGSLSRHLFIVHK 27
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
111-351 |
1.58e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 53.02 E-value: 1.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 111 TAAASAGDGPGVPAQASDHGLPPPdiSVVSVIVKNTVCPEQSEALAGGSAGDGAQAAGVTKEGPVGPHRMQNgfgSPEPS 190
Cdd:PHA03247 2763 TAGPPAPAPPAAPAAGPPRRLTRP--AVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPT---SAQPT 2837
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 191 LPGTPHSPAPPS---------GGTWKEKGMEGKT----------PLDLFAHFGPEPGDHSDPLPPSAPSPTREGALTPPP 251
Cdd:PHA03247 2838 APPPPPGPPPPSlplggsvapGGDVRRRPPSRSPaakpaaparpPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPP 2917
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 252 FPSSFE--LAQENGPGMQPPVSSPPLGALKQESCSPH-HPQVLAQQGSGSSPKATDIPASASPPPVAGVPFFKQSPGHQS 328
Cdd:PHA03247 2918 QPQPQPppPPQPQPPPPPPPRPQPPLAPTTDPAGAGEpSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLT 2997
|
250 260
....*....|....*....|....*
gi 2462511785 329 PLASPKVP--VCQPLKEEDDDEGPV 351
Cdd:PHA03247 2998 GHSLSRVSswASSLALHEETDPPPV 3022
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
129-336 |
2.76e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 45.53 E-value: 2.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 129 HGLPPPDISVVSVIVKNTVCPEQSEALAGGSAGDGAQAAGVTKEGPVGPHRMQngfgsPEPSLP-GTPHSPAPPSggtwk 207
Cdd:pfam03154 291 HPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQ-----PLPPAPlSMPHIKPPPT----- 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 208 ekgmegkTPLDLFahfgPEPGDHSDPLPPSAPSPTREGALTPPPfPSSFELAQEngPGMQPPVSSPPLGALKQES----C 283
Cdd:pfam03154 361 -------TPIPQL----PNPQSHKHPPHLSGPSPFQMNSNLPPP-PALKPLSSL--STHHPPSAHPPPLQLMPQSqqlpP 426
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 2462511785 284 SPHHPQVLAQQGSGSSPKATDIPASASPPPVAGVPFFKQS--PGHQSPLASPKVP 336
Cdd:pfam03154 427 PPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPfvPGGPPPITPPSGP 481
|
|
| zf-C2H2_8 |
pfam15909 |
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem. |
852-934 |
4.63e-03 |
|
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
Pssm-ID: 464935 [Multi-domain] Cd Length: 98 Bit Score: 37.78 E-value: 4.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 852 PICPMAFKSGPSAHAHLYSQHPSFQTQQAKLiYKCAM--CDTVFTHKPLLSSHFDQHLLPQRVsvFKCPSCPLLFAQKRT 929
Cdd:pfam15909 5 PGCCLSFPSVRDLAQHLRTHCPPTQSLEGKL-FRCSAlsCTETFPSMQELVAHSKLHYKPNRY--FKCENCLLRFRTHRS 81
|
....*
gi 2462511785 930 MLEHL 934
Cdd:pfam15909 82 LFKHL 86
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| zf-C2H2_11 |
pfam16622 |
zinc-finger C2H2-type; Zinc-finger of C2H2 type found in higher eukaryotes. |
1190-1216 |
8.24e-10 |
|
zinc-finger C2H2-type; Zinc-finger of C2H2 type found in higher eukaryotes.
Pssm-ID: 465205 Cd Length: 27 Bit Score: 54.74 E-value: 8.24e-10
10 20
....*....|....*....|....*..
gi 2462511785 1190 GAQQCLDCGLCFASPGSLSRHRFISHK 1216
Cdd:pfam16622 1 STCQCLLCGLCFTSQGSLSRHLFIVHK 27
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
111-351 |
1.58e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 53.02 E-value: 1.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 111 TAAASAGDGPGVPAQASDHGLPPPdiSVVSVIVKNTVCPEQSEALAGGSAGDGAQAAGVTKEGPVGPHRMQNgfgSPEPS 190
Cdd:PHA03247 2763 TAGPPAPAPPAAPAAGPPRRLTRP--AVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPT---SAQPT 2837
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 191 LPGTPHSPAPPS---------GGTWKEKGMEGKT----------PLDLFAHFGPEPGDHSDPLPPSAPSPTREGALTPPP 251
Cdd:PHA03247 2838 APPPPPGPPPPSlplggsvapGGDVRRRPPSRSPaakpaaparpPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPP 2917
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 252 FPSSFE--LAQENGPGMQPPVSSPPLGALKQESCSPH-HPQVLAQQGSGSSPKATDIPASASPPPVAGVPFFKQSPGHQS 328
Cdd:PHA03247 2918 QPQPQPppPPQPQPPPPPPPRPQPPLAPTTDPAGAGEpSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLT 2997
|
250 260
....*....|....*....|....*
gi 2462511785 329 PLASPKVP--VCQPLKEEDDDEGPV 351
Cdd:PHA03247 2998 GHSLSRVSswASSLALHEETDPPPV 3022
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
129-336 |
2.76e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 45.53 E-value: 2.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 129 HGLPPPDISVVSVIVKNTVCPEQSEALAGGSAGDGAQAAGVTKEGPVGPHRMQngfgsPEPSLP-GTPHSPAPPSggtwk 207
Cdd:pfam03154 291 HPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQ-----PLPPAPlSMPHIKPPPT----- 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 208 ekgmegkTPLDLFahfgPEPGDHSDPLPPSAPSPTREGALTPPPfPSSFELAQEngPGMQPPVSSPPLGALKQES----C 283
Cdd:pfam03154 361 -------TPIPQL----PNPQSHKHPPHLSGPSPFQMNSNLPPP-PALKPLSSL--STHHPPSAHPPPLQLMPQSqqlpP 426
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 2462511785 284 SPHHPQVLAQQGSGSSPKATDIPASASPPPVAGVPFFKQS--PGHQSPLASPKVP 336
Cdd:pfam03154 427 PPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPfvPGGPPPITPPSGP 481
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
157-388 |
3.99e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 45.16 E-value: 3.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 157 GGSAGDGAQAAGVTKEGPVGPHRMQNGfgsPEPSLPGTPHSPAPPSGGTWKEKGmegKTPLDLFAHFGPEPGDH-SDPLP 235
Cdd:PHA03307 44 VSDSAELAAVTVVAGAAACDRFEPPTG---PPPGPGTEAPANESRSTPTWSLST---LAPASPAREGSPTPPGPsSPDPP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 236 PSAPSPTREGALTPPPFPSSFELAQENGPGMQPPVSSPPLGALKQESCSPHHPQVLAQQGSGSSPKATDIPASASPPPVA 315
Cdd:PHA03307 118 PPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPST 197
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462511785 316 GVPFFKQSPGHQSPLASPKVPVCQPLKEEDDDEGPVDKSSPGSPQSPSSGAEAADEDSNDSPASSSSRPLKVR 388
Cdd:PHA03307 198 PPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIW 270
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
86-415 |
5.83e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 44.54 E-value: 5.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 86 SGPEENEGPGGPGKPEPGVGSES-----------------EDTAAASAGD-----GPGVPAQASDHGLPPPDISvvsviv 143
Cdd:PHA03247 2501 GGPPDPDAPPAPSRLAPAILPDEpvgepvhprmltwirglEELASDDAGDpppplPPAAPPAAPDRSVPPPRPA------ 2574
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 144 kntvcPEQSEALAGGSAG-DGAQAAGVTKEGPVGPHRMQNGFGSPEPSLPGTPHSPAPPSGGTWKEKGMEGKTPldlfAH 222
Cdd:PHA03247 2575 -----PRPSEPAVTSRARrPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPP----PT 2645
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 223 FGPEPGDHSDPLPPSAPSPTREGALTPPPFPSSfELAQENGPGMQPPVSS----------PPLGALKQESCSPHHPQVLA 292
Cdd:PHA03247 2646 VPPPERPRDDPAPGRVSRPRRARRLGRAAQASS-PPQRPRRRAARPTVGSltsladppppPPTPEPAPHALVSATPLPPG 2724
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 293 QQGSGSSPKATdiPASASPPPVAGVPffkQSPGHQSPLASPKVPV--CQPLKEEDDDEGPVDKSSPGSPQSPSSGAEAAD 370
Cdd:PHA03247 2725 PAAARQASPAL--PAAPAPPAVPAGP---ATPGGPARPARPPTTAgpPAPAPPAAPAAGPPRRLTRPAVASLSESRESLP 2799
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 2462511785 371 EDSNDSPASSSSRPLKVRIKTIKTSCGNITRTVTQVPSDPDPPAP 415
Cdd:PHA03247 2800 SPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG 2844
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
192-337 |
1.42e-03 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 43.14 E-value: 1.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 192 PGTPHSPAPPSGGTWKEKGMEGktpldlfaHFGPEPGDHSdPLPPSAPSPTREGALTPPPFPssfelAQENGPGMQPPVS 271
Cdd:PTZ00449 511 PEGPEASGLPPKAPGDKEGEEG--------EHEDSKESDE-PKEGGKPGETKEGEVGKKPGP-----AKEHKPSKIPTLS 576
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462511785 272 SPPLGALKqescsPHHPQVLAQQGSGSSPKATDIPASASPPPVAGVPFFKQSPGHQSPLASPKVPV 337
Cdd:PTZ00449 577 KKPEFPKD-----PKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPP 637
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
106-329 |
1.52e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 42.83 E-value: 1.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 106 SESEDTAAASAGDGPGVPAQASDHGLPPPDISVVSVIVKNTVCPEQSEALAGGSAGDGAQAAGVTKEGPVGPHRM-QNGF 184
Cdd:pfam03154 156 SDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLiQQTP 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 185 GSPEPSLPgTPHSPAPPSggtwkekgMEGKTPLDLFAHFGPEPGDHSdPLPPsAPSPTREG------ALTPPPFPSSFEL 258
Cdd:pfam03154 236 TLHPQRLP-SPHPPLQPM--------TQPPPPSQVSPQPLPQPSLHG-QMPP-MPHSLQTGpshmqhPVPPQPFPLTPQS 304
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462511785 259 AQENGPgmqppvSSPPLGALKQESCSPHHPQVLAQQGSGSSPKATDIPASA------SPPPVAGVPFFKQSPGHQSP 329
Cdd:pfam03154 305 SQSQVP------PGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPlsmphiKPPPTTPIPQLPNPQSHKHP 375
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
161-330 |
2.02e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 42.45 E-value: 2.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 161 GDGAQAAGVTKEGPVGPHRMQNGFGSPEPSLPgTPHSPAPPSGGTWKEKGMEGKtPLDLFAHFGPEPgdhsdPLPPSAPS 240
Cdd:pfam03154 118 GESSDGRSVNDEGSSDPKDIDQDNRSTSPSIP-SPQDNESDSDSSAQQQILQTQ-PPVLQAQSGAAS-----PPSPPPPG 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 241 PTREGALTPPPFPSSFelaqengpgmqPPVSSPPLGALKQESCSPHHPQVLAQQGSG------SSPKATDIPASASPPPV 314
Cdd:pfam03154 191 TTQAATAGPTPSAPSV-----------PPQGSPATSQPPNQTQSTAAPHTLIQQTPTlhpqrlPSPHPPLQPMTQPPPPS 259
|
170
....*....|....*.
gi 2462511785 315 AGVPFFKQSPGHQSPL 330
Cdd:pfam03154 260 QVSPQPLPQPSLHGQM 275
|
|
| zf-C2H2_8 |
pfam15909 |
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem. |
852-934 |
4.63e-03 |
|
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
Pssm-ID: 464935 [Multi-domain] Cd Length: 98 Bit Score: 37.78 E-value: 4.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 852 PICPMAFKSGPSAHAHLYSQHPSFQTQQAKLiYKCAM--CDTVFTHKPLLSSHFDQHLLPQRVsvFKCPSCPLLFAQKRT 929
Cdd:pfam15909 5 PGCCLSFPSVRDLAQHLRTHCPPTQSLEGKL-FRCSAlsCTETFPSMQELVAHSKLHYKPNRY--FKCENCLLRFRTHRS 81
|
....*
gi 2462511785 930 MLEHL 934
Cdd:pfam15909 82 LFKHL 86
|
|
| TALPID3 |
pfam15324 |
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ... |
186-333 |
6.76e-03 |
|
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.
Pssm-ID: 434634 [Multi-domain] Cd Length: 1288 Bit Score: 41.03 E-value: 6.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 186 SPEPSLPGTPHSPA--------PPSggTWKEKGMEGKTPLDLFAHFGPEPGDHSDPL-PPSA---PSPTREGALTPPPFP 253
Cdd:pfam15324 990 TPQPTPPCSPPSPLkepspvktPDS--SPCVSEHDFFPVKEIPPEKGADTGPAVSLViTPTVtpiATPPPAATPTPPLSE 1067
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 254 SSFELAQENGPGMQPPVSSPPLgALKQESCSP-----HHPQVLAQQGSGSSPKATDIPAS-ASPPPVAGVPFFKQSPghq 327
Cdd:pfam15324 1068 NSIDKLKSPSPELPKPWEDSDL-PLEEENPNSeqeelHPRAVVMSVARDEEPESVVLPASpPEPKPLAPPPLGAAPP--- 1143
|
....*.
gi 2462511785 328 SPLASP 333
Cdd:pfam15324 1144 SPPQSP 1149
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
174-318 |
7.03e-03 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 40.83 E-value: 7.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 174 PVGPHRMQngfGSPEPSLPGTPHSPAPPSGGTWKEK-----------GMEGKTPLDLFAHFG-------PE----PGDHS 231
Cdd:PTZ00449 642 PSSPERPE---GPKIIKSPKPPKSPKPPFDPKFKEKfyddyldaaakSKETKTTVVLDESFEsilketlPEtpgtPFTTP 718
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511785 232 DPLPPSAPSpTREGALTPP-------PFPSSFELAQENGPGM--QPPVSSPPLGALKQEScspHHPQVLAQQGSGSSP-K 301
Cdd:PTZ00449 719 RPLPPKLPR-DEEFPFEPIgdpdaeqPDDIEFFTPPEEERTFfhETPADTPLPDILAEEF---KEEDIHAETGEPDEAmK 794
|
170
....*....|....*..
gi 2462511785 302 ATDIPASASPPPVAGVP 318
Cdd:PTZ00449 795 RPDSPSEHEDKPPGDHP 811
|
|
| |
