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Conserved domains on  [gi|2462509962|ref|XP_054192949|]
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denticleless protein homolog isoform X1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
5-329 2.47e-39

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 149.68  E-value: 2.47e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962   5 LAVANEEGFVRLYNTESQsfrkKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSV 84
Cdd:COG2319   135 LASGSADGTVRLWDLATG----KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962  85 AFSKFEKAVFcTGGRDGNIMVWDTrcnkkdgfyrqvnqisgahntsdkqtpskpkkkQNSKGLAPSVDFQQSVTVVLF-Q 163
Cdd:COG2319   211 AFSPDGKLLA-SGSADGTVRLWDL---------------------------------ATGKLLRTLTGHSGSVRSVAFsP 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962 164 DENTLVSAGAvDGIIKVWDLRknytayrqepiasksflyPGSSTRKLGY-----SSLILDSTGSTLFANCTDDNIYMFNM 238
Cdd:COG2319   257 DGRLLASGSA-DGTVRLWDLA------------------TGELLRTLTGhsggvNSVAFSPDGKLLASGSDDGTVRLWDL 317

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962 239 TGLKtsPVAIFNGHQNSTFYVksSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTvLLGHSQEVTSVCWCPsDFTKIATCS 318
Cdd:COG2319   318 ATGK--LLRTLTGHTGAVRSV--AFSPDGKTLASGSDDGTVRLWDLATGELLRT-LTGHTGAVTSVAFSP-DGRTLASGS 391

                         330
                  ....*....|.
gi 2462509962 319 DDNTLKIWRLN 329
Cdd:COG2319   392 ADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
5-329 2.47e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 149.68  E-value: 2.47e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962   5 LAVANEEGFVRLYNTESQsfrkKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSV 84
Cdd:COG2319   135 LASGSADGTVRLWDLATG----KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962  85 AFSKFEKAVFcTGGRDGNIMVWDTrcnkkdgfyrqvnqisgahntsdkqtpskpkkkQNSKGLAPSVDFQQSVTVVLF-Q 163
Cdd:COG2319   211 AFSPDGKLLA-SGSADGTVRLWDL---------------------------------ATGKLLRTLTGHSGSVRSVAFsP 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962 164 DENTLVSAGAvDGIIKVWDLRknytayrqepiasksflyPGSSTRKLGY-----SSLILDSTGSTLFANCTDDNIYMFNM 238
Cdd:COG2319   257 DGRLLASGSA-DGTVRLWDLA------------------TGELLRTLTGhsggvNSVAFSPDGKLLASGSDDGTVRLWDL 317

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962 239 TGLKtsPVAIFNGHQNSTFYVksSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTvLLGHSQEVTSVCWCPsDFTKIATCS 318
Cdd:COG2319   318 ATGK--LLRTLTGHTGAVRSV--AFSPDGKTLASGSDDGTVRLWDLATGELLRT-LTGHTGAVTSVAFSP-DGRTLASGS 391

                         330
                  ....*....|.
gi 2462509962 319 DDNTLKIWRLN 329
Cdd:COG2319   392 ADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-327 9.85e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 144.79  E-value: 9.85e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962   3 HVLAVANEEGFVRLYNTESQSFrKKCFKEwmaHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLK 82
Cdd:cd00200    22 KLLATGSGDGTIKVWDLETGEL-LRTLKG---HTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVS 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962  83 SVAFSKFEKaVFCTGGRDGNIMVWDTRCNKkdgfyrQVNQISGaHNtsdkqtpskpkkkqnskglapsvdfqQSVTVVLF 162
Cdd:cd00200    98 SVAFSPDGR-ILSSSSRDKTIKVWDVETGK------CLTTLRG-HT--------------------------DWVNSVAF 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962 163 QDENTLVSAGAVDGIIKVWDLRKNYTAYRqepiasksflYPGSstrKLGYSSLILDSTGSTLFANCTDDNIYMFNMTGLK 242
Cdd:cd00200   144 SPDGTFVASSSQDGTIKLWDLRTGKCVAT----------LTGH---TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962 243 TspVAIFNGHQNSTFYVksSLSPDDQFLVSGSSDEAAYIWKVSTpWQPPTVLLGHSQEVTSVCWCPsDFTKIATCSDDNT 322
Cdd:cd00200   211 C--LGTLRGHENGVNSV--AFSPDGYLLASGSEDGTIRVWDLRT-GECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGT 284


                  ....*
gi 2462509962 323 LKIWR 327
Cdd:cd00200   285 IRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 287-326 1.24e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.24e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462509962  287 PWQPPTVLLGHSQEVTSVCWCPsDFTKIATCSDDNTLKIW 326
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
288-326 2.56e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 2.56e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2462509962 288 WQPPTVLLGHSQEVTSVCWCPSDfTKIATCSDDNTLKIW 326
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 169-336 2.96e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.47  E-value: 2.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962 169 VSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFlypgsstrklgysSLILDSTGSTLFANCTDDNiymfnmtglKTSPVAI 248
Cdd:PLN00181  548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVW-------------SIDYSSADPTLLASGSDDG---------SVKLWSI 605

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962 249 FNGHQNSTFYVKSSLS----PDD--QFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCpsDFTKIATCSDDNT 322
Cdd:PLN00181  606 NQGVSIGTIKTKANICcvqfPSEsgRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFV--DSSTLVSSSTDNT 683

                         170
                  ....*....|....*..
gi 2462509962 323 LKIWRLN---RGLEEKP 336
Cdd:PLN00181  684 LKLWDLSmsiSGINETP 700
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
5-329 2.47e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 149.68  E-value: 2.47e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962   5 LAVANEEGFVRLYNTESQsfrkKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSV 84
Cdd:COG2319   135 LASGSADGTVRLWDLATG----KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962  85 AFSKFEKAVFcTGGRDGNIMVWDTrcnkkdgfyrqvnqisgahntsdkqtpskpkkkQNSKGLAPSVDFQQSVTVVLF-Q 163
Cdd:COG2319   211 AFSPDGKLLA-SGSADGTVRLWDL---------------------------------ATGKLLRTLTGHSGSVRSVAFsP 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962 164 DENTLVSAGAvDGIIKVWDLRknytayrqepiasksflyPGSSTRKLGY-----SSLILDSTGSTLFANCTDDNIYMFNM 238
Cdd:COG2319   257 DGRLLASGSA-DGTVRLWDLA------------------TGELLRTLTGhsggvNSVAFSPDGKLLASGSDDGTVRLWDL 317

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962 239 TGLKtsPVAIFNGHQNSTFYVksSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTvLLGHSQEVTSVCWCPsDFTKIATCS 318
Cdd:COG2319   318 ATGK--LLRTLTGHTGAVRSV--AFSPDGKTLASGSDDGTVRLWDLATGELLRT-LTGHTGAVTSVAFSP-DGRTLASGS 391

                         330
                  ....*....|.
gi 2462509962 319 DDNTLKIWRLN 329
Cdd:COG2319   392 ADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-327 9.85e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 144.79  E-value: 9.85e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962   3 HVLAVANEEGFVRLYNTESQSFrKKCFKEwmaHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLK 82
Cdd:cd00200    22 KLLATGSGDGTIKVWDLETGEL-LRTLKG---HTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVS 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962  83 SVAFSKFEKaVFCTGGRDGNIMVWDTRCNKkdgfyrQVNQISGaHNtsdkqtpskpkkkqnskglapsvdfqQSVTVVLF 162
Cdd:cd00200    98 SVAFSPDGR-ILSSSSRDKTIKVWDVETGK------CLTTLRG-HT--------------------------DWVNSVAF 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962 163 QDENTLVSAGAVDGIIKVWDLRKNYTAYRqepiasksflYPGSstrKLGYSSLILDSTGSTLFANCTDDNIYMFNMTGLK 242
Cdd:cd00200   144 SPDGTFVASSSQDGTIKLWDLRTGKCVAT----------LTGH---TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962 243 TspVAIFNGHQNSTFYVksSLSPDDQFLVSGSSDEAAYIWKVSTpWQPPTVLLGHSQEVTSVCWCPsDFTKIATCSDDNT 322
Cdd:cd00200   211 C--LGTLRGHENGVNSV--AFSPDGYLLASGSEDGTIRVWDLRT-GECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGT 284


                  ....*
gi 2462509962 323 LKIWR 327
Cdd:cd00200   285 IRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
3-333 9.62e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 139.28  E-value: 9.62e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962   3 HVLAVANEEGFVRLYNTESqsfrKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLK 82
Cdd:COG2319    91 RLLASASADGTVRLWDLAT----GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVT 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962  83 SVAFSKFEKAVFcTGGRDGNIMVWDTRcnkkDGfyRQVNQISGaHntsdkqtpskpkkkqnskglapsvdfQQSVTVVLF 162
Cdd:COG2319   167 SVAFSPDGKLLA-SGSDDGTVRLWDLA----TG--KLLRTLTG-H--------------------------TGAVRSVAF 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962 163 -QDENTLVSAGAvDGIIKVWDLRknytayRQEPIASksflYPGSSTrklGYSSLILDSTGSTLFANCTDDNIYMFNMTGL 241
Cdd:COG2319   213 sPDGKLLASGSA-DGTVRLWDLA------TGKLLRT----LTGHSG---SVRSVAFSPDGRLLASGSADGTVRLWDLATG 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962 242 KtsPVAIFNGHQNSTFYVksSLSPDDQFLVSGSSDEAAYIWKVSTPwQPPTVLLGHSQEVTSVCWCPsDFTKIATCSDDN 321
Cdd:COG2319   279 E--LLRTLTGHSGGVNSV--AFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDG 352

                         330
                  ....*....|..
gi 2462509962 322 TLKIWRLNRGLE 333
Cdd:COG2319   353 TVRLWDLATGEL 364
WD40 COG2319
WD40 repeat [General function prediction only];
35-331 4.30e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.79  E-value: 4.30e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962  35 HWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVFcTGGRDGNIMVWDTRcnkkD 114
Cdd:COG2319    77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLA-SGSADGTVRLWDLA----T 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962 115 GfyRQVNQISGaHntsdkqtpskpkkkqnskglapsvdfQQSVTVVLF-QDENTLVSAGAvDGIIKVWDLRKNytayrqE 193
Cdd:COG2319   152 G--KLLRTLTG-H--------------------------SGAVTSVAFsPDGKLLASGSD-DGTVRLWDLATG------K 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962 194 PIASksflYPGSSTRKlgySSLILDSTGSTLFANCTDDNIYMFNMTGLKtsPVAIFNGHQNSTFYVksSLSPDDQFLVSG 273
Cdd:COG2319   196 LLRT----LTGHTGAV---RSVAFSPDGKLLASGSADGTVRLWDLATGK--LLRTLTGHSGSVRSV--AFSPDGRLLASG 264

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462509962 274 SSDEAAYIWKVSTpWQPPTVLLGHSQEVTSVCWCPsDFTKIATCSDDNTLKIWRLNRG 331
Cdd:COG2319   265 SADGTVRLWDLAT-GELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATG 320
WD40 COG2319
WD40 repeat [General function prediction only];
34-331 3.12e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.54  E-value: 3.12e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962  34 AHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVFcTGGRDGNIMVWDTrcnkk 113
Cdd:COG2319    34 GLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLA-SASADGTVRLWDL----- 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962 114 dgfyrqvnqisgahntsdkqtpskpkkkQNSKGLAPSVDFQQSVTVVLF-QDENTLVSAGAvDGIIKVWDLRknytayRQ 192
Cdd:COG2319   108 ----------------------------ATGLLLRTLTGHTGAVRSVAFsPDGKTLASGSA-DGTVRLWDLA------TG 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962 193 EPIASksflYPGSSTRklgYSSLILDSTGSTLFANCTDDNIYMFNMTGLKtsPVAIFNGHQNStfyVKS-SLSPDDQFLV 271
Cdd:COG2319   153 KLLRT----LTGHSGA---VTSVAFSPDGKLLASGSDDGTVRLWDLATGK--LLRTLTGHTGA---VRSvAFSPDGKLLA 220

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962 272 SGSSDEAAYIWKVSTPwQPPTVLLGHSQEVTSVCWCPsDFTKIATCSDDNTLKIWRLNRG 331
Cdd:COG2319   221 SGSADGTVRLWDLATG-KLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATG 278
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 70-331 3.13e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.41  E-value: 3.13e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962  70 LIGTCKGHQCSLKSVAFSKfEKAVFCTGGRDGNIMVWDTrcNKKDGFYRQVNQISGAhntsdkqtpskpkkkqnskglap 149
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDL--ETGELLRTLKGHTGPV----------------------- 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962 150 svdfqqsVTVVLFQDENTLVSAGAvDGIIKVWDLRKNYTAYRQEpiasksflypgsstrklGYSSLILD---STGSTLFA 226
Cdd:cd00200    55 -------RDVAASADGTYLASGSS-DKTIRLWDLETGECVRTLT-----------------GHTSYVSSvafSPDGRILS 109

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962 227 NCTDDN-IYMFNMTglKTSPVAIFNGHQNStfyVKS-SLSPDDQFLVSGSSDEAAYIWKVSTpWQPPTVLLGHSQEVTSV 304
Cdd:cd00200   110 SSSRDKtIKVWDVE--TGKCLTTLRGHTDW---VNSvAFSPDGTFVASSSQDGTIKLWDLRT-GKCVATLTGHTGEVNSV 183

                         250       260
                  ....*....|....*....|....*..
gi 2462509962 305 CWCPsDFTKIATCSDDNTLKIWRLNRG 331
Cdd:cd00200   184 AFSP-DGEKLLSSSSDGTIKLWDLSTG 209
WD40 COG2319
WD40 repeat [General function prediction only];
4-109 9.23e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.96  E-value: 9.23e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962   4 VLAVANEEGFVRLYNTESqsfrKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKS 83
Cdd:COG2319   302 LLASGSDDGTVRLWDLAT----GKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTS 377

                          90       100
                  ....*....|....*....|....*.
gi 2462509962  84 VAFSKFEKAVFcTGGRDGNIMVWDTR 109
Cdd:COG2319   378 VAFSPDGRTLA-SGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 287-326 1.24e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.24e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462509962  287 PWQPPTVLLGHSQEVTSVCWCPsDFTKIATCSDDNTLKIW 326
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
288-326 2.56e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 2.56e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2462509962 288 WQPPTVLLGHSQEVTSVCWCPSDfTKIATCSDDNTLKIW 326
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 169-336 2.96e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.47  E-value: 2.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962 169 VSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFlypgsstrklgysSLILDSTGSTLFANCTDDNiymfnmtglKTSPVAI 248
Cdd:PLN00181  548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVW-------------SIDYSSADPTLLASGSDDG---------SVKLWSI 605

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962 249 FNGHQNSTFYVKSSLS----PDD--QFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCpsDFTKIATCSDDNT 322
Cdd:PLN00181  606 NQGVSIGTIKTKANICcvqfPSEsgRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFV--DSSTLVSSSTDNT 683

                         170
                  ....*....|....*..
gi 2462509962 323 LKIWRLN---RGLEEKP 336
Cdd:PLN00181  684 LKLWDLSmsiSGINETP 700
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 57-321 3.99e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.09  E-value: 3.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962  57 DQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGfyrqvnQISGAHNTSDKQTPS 136
Cdd:PLN00181  554 EGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIG------TIKTKANICCVQFPS 627

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962 137 KPKKK---------------QNSK-GLAPSVDFQQSVTVVLFQDENTLVSAgAVDGIIKVWDLRknytayrqepiasksf 200
Cdd:PLN00181  628 ESGRSlafgsadhkvyyydlRNPKlPLCTMIGHSKTVSYVRFVDSSTLVSS-STDNTLKLWDLS---------------- 690

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509962 201 lypgsstrklgysslildstgstlfanctddniymFNMTGLKTSPVAIFNGHQNSTFYVksSLSPDDQFLVSGSSDEAAY 280
Cdd:PLN00181  691 -----------------------------------MSISGINETPLHSFMGHTNVKNFV--GLSVSDGYIATGSETNEVF 733

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462509962 281 IWKVSTPWQPPTVLLGH------------SQEVTSVCWCPSDFTKIATCSDDN 321
Cdd:PLN00181  734 VYHKAFPMPVLSYKFKTidpvsglevddaSQFISSVCWRGQSSTLVAANSTGN 786
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 293-335 1.13e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.71  E-value: 1.13e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2462509962 293 VLLGHSQEVTSVCWCPsDFTKIATCSDDNTLKIWRLNRGLEEK 335
Cdd:cd00200     4 TLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLR 45
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 68-107 2.19e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 2.19e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462509962   68 GELIGTCKGHQCSLKSVAFSKFEKaVFCTGGRDGNIMVWD 107
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
68-107 1.24e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 1.24e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2462509962  68 GELIGTCKGHQCSLKSVAFSKFEKaVFCTGGRDGNIMVWD 107
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 26-64 1.59e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.59e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2462509962   26 KKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWD 64
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
26-64 2.69e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 2.69e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2462509962  26 KKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWD 64
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 244-283 6.32e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 6.32e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462509962  244 SPVAIFNGHQNSTFYVksSLSPDDQFLVSGSSDEAAYIWK 283
Cdd:smart00320   3 ELLKTLKGHTGPVTSV--AFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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