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Conserved domains on  [gi|2462506294|ref|XP_054191179|]
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WD repeat-containing protein 47 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
613-924 2.97e-53

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.28  E-value: 2.97e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 613 TQAVRAVAFHPAGGLYAVGSNSKTLRVcaypdvIDPSAHETPKQPvvrfkrnKHHKGSIYCVAWSPCGQLLATGSNDKYV 692
Cdd:COG2319    78 TAAVLSVAFSPDGRLLASASADGTVRL------WDLATGLLLRTL-------TGHTGAVRSVAFSPDGKTLASGSADGTV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 693 KVLPFNAETCNATVSGpdlefsmHDGTIRDLAFmegpeSG-GAILISAGAgDCNIYTTDCQRGQGLHALSGHTGHILALy 771
Cdd:COG2319   145 RLWDLATGKLLRTLTG-------HSGAVTSVAF-----SPdGKLLASGSD-DGTVRLWDLATGKLLRTLTGHTGAVRSV- 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 772 TWS--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHP 849
Cdd:COG2319   211 AFSpdGKLLASGSADGTVRLWDLATGKLLR----TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG 286

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462506294 850 HSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ-GDLTKQLPimvvgEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 924
Cdd:COG2319   287 HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLT-----GHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 45-102 9.53e-13

C-terminal to LisH motif; Alpha-helical motif of unknown function.


:

Pssm-ID: 128914  Cd Length: 58  Bit Score: 63.74  E-value: 9.53e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462506294   45 FSDDMLFLRQLILDGQWDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMS 102
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNSKLEFELRKQKFLELVRQGKLEE 58
LisH_TPL super family cl39307
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 13-40 2.63e-05

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


The actual alignment was detected with superfamily member pfam17814:

Pssm-ID: 375350  Cd Length: 30  Bit Score: 41.61  E-value: 2.63e-05
                          10        20
                  ....*....|....*....|....*...
gi 2462506294  13 EIIKLILDFLNSKKLHISMLALEKESGV 40
Cdd:pfam17814   3 DVVRLILQFLKENGLHRTLQALQTESGV 30
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
613-924 2.97e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.28  E-value: 2.97e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 613 TQAVRAVAFHPAGGLYAVGSNSKTLRVcaypdvIDPSAHETPKQPvvrfkrnKHHKGSIYCVAWSPCGQLLATGSNDKYV 692
Cdd:COG2319    78 TAAVLSVAFSPDGRLLASASADGTVRL------WDLATGLLLRTL-------TGHTGAVRSVAFSPDGKTLASGSADGTV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 693 KVLPFNAETCNATVSGpdlefsmHDGTIRDLAFmegpeSG-GAILISAGAgDCNIYTTDCQRGQGLHALSGHTGHILALy 771
Cdd:COG2319   145 RLWDLATGKLLRTLTG-------HSGAVTSVAF-----SPdGKLLASGSD-DGTVRLWDLATGKLLRTLTGHTGAVRSV- 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 772 TWS--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHP 849
Cdd:COG2319   211 AFSpdGKLLASGSADGTVRLWDLATGKLLR----TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG 286

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462506294 850 HSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ-GDLTKQLPimvvgEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 924
Cdd:COG2319   287 HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLT-----GHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 613-924 5.14e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 181.38  E-value: 5.14e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 613 TQAVRAVAFHPAGGLYAVGSNSKTLRVCaypDVIDPSAHETPKQpvvrfkrnkhHKGSIYCVAWSPCGQLLATGSNDKYV 692
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVW---DLETGELLRTLKG----------HTGPVRDVAASADGTYLASGSSDKTI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 693 KVLPFNAETCNATVSGpdlefsmHDGTIRDLAFMEGPEsggaiLISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-Y 771
Cdd:cd00200    76 RLWDLETGECVRTLTG-------HTSYVSSVAFSPDGR-----ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVaF 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 772 TWSGWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHS 851
Cdd:cd00200   144 SPDGTFVASSSQDGTIKLWDLRTGKCVA----TLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHE 219

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462506294 852 SDVRSVRFSPGAHYLLTGSYDMKIKVTDLQgdltKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 924
Cdd:cd00200   220 NGVNSVAFSPDGYLLASGSEDGTIRVWDLR----TGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 45-102 9.53e-13

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 63.74  E-value: 9.53e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462506294   45 FSDDMLFLRQLILDGQWDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMS 102
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNSKLEFELRKQKFLELVRQGKLEE 58
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 665-694 1.76e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.76e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462506294  665 KHHKGSIYCVAWSPCGQLLATGSNDKYVKV 694
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKL 38
WD40 pfam00400
WD domain, G-beta repeat;
665-694 1.59e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 1.59e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462506294 665 KHHKGSIYCVAWSPCGQLLATGSNDKYVKV 694
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
LisH_TPL pfam17814
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 13-40 2.63e-05

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


Pssm-ID: 375350  Cd Length: 30  Bit Score: 41.61  E-value: 2.63e-05
                          10        20
                  ....*....|....*....|....*...
gi 2462506294  13 EIIKLILDFLNSKKLHISMLALEKESGV 40
Cdd:pfam17814   3 DVVRLILQFLKENGLHRTLQALQTESGV 30
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 9-42 3.39e-03

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 35.87  E-value: 3.39e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2462506294    9 VKEVEIIKLILDFLNSKKLHISMLALEKESGVIN 42
Cdd:smart00667   1 ISRSELNRLILEYLLRNGYEETAETLQKESGLSL 34
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
613-924 2.97e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.28  E-value: 2.97e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 613 TQAVRAVAFHPAGGLYAVGSNSKTLRVcaypdvIDPSAHETPKQPvvrfkrnKHHKGSIYCVAWSPCGQLLATGSNDKYV 692
Cdd:COG2319    78 TAAVLSVAFSPDGRLLASASADGTVRL------WDLATGLLLRTL-------TGHTGAVRSVAFSPDGKTLASGSADGTV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 693 KVLPFNAETCNATVSGpdlefsmHDGTIRDLAFmegpeSG-GAILISAGAgDCNIYTTDCQRGQGLHALSGHTGHILALy 771
Cdd:COG2319   145 RLWDLATGKLLRTLTG-------HSGAVTSVAF-----SPdGKLLASGSD-DGTVRLWDLATGKLLRTLTGHTGAVRSV- 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 772 TWS--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHP 849
Cdd:COG2319   211 AFSpdGKLLASGSADGTVRLWDLATGKLLR----TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG 286

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462506294 850 HSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ-GDLTKQLPimvvgEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 924
Cdd:COG2319   287 HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLT-----GHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
613-924 1.89e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 188.97  E-value: 1.89e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 613 TQAVRAVAFHPAGGLYAVGSNSKTLRVCaypDVIDPSAHETPKqpvvrfkrnkHHKGSIYCVAWSPCGQLLATGSNDKYV 692
Cdd:COG2319   120 TGAVRSVAFSPDGKTLASGSADGTVRLW---DLATGKLLRTLT----------GHSGAVTSVAFSPDGKLLASGSDDGTV 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 693 KVLPFNAETCNATVSGpdlefsmHDGTIRDLAFmeGPEsgGAILISAGAgDCNIYTTDCQRGQGLHALSGHTGHILALyT 772
Cdd:COG2319   187 RLWDLATGKLLRTLTG-------HTGAVRSVAF--SPD--GKLLASGSA-DGTVRLWDLATGKLLRTLTGHSGSVRSV-A 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 773 WS--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPH 850
Cdd:COG2319   254 FSpdGRLLASGSADGTVRLWDLATGELLR----TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH 329

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462506294 851 SSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGdltkQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 924
Cdd:COG2319   330 TGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT----GELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 613-924 5.14e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 181.38  E-value: 5.14e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 613 TQAVRAVAFHPAGGLYAVGSNSKTLRVCaypDVIDPSAHETPKQpvvrfkrnkhHKGSIYCVAWSPCGQLLATGSNDKYV 692
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVW---DLETGELLRTLKG----------HTGPVRDVAASADGTYLASGSSDKTI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 693 KVLPFNAETCNATVSGpdlefsmHDGTIRDLAFMEGPEsggaiLISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-Y 771
Cdd:cd00200    76 RLWDLETGECVRTLTG-------HTSYVSSVAFSPDGR-----ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVaF 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 772 TWSGWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHS 851
Cdd:cd00200   144 SPDGTFVASSSQDGTIKLWDLRTGKCVA----TLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHE 219

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462506294 852 SDVRSVRFSPGAHYLLTGSYDMKIKVTDLQgdltKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 924
Cdd:cd00200   220 NGVNSVAFSPDGYLLASGSEDGTIRVWDLR----TGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
613-882 1.13e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 172.40  E-value: 1.13e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 613 TQAVRAVAFHPAGGLYAVGSNSKTLRVCaypDVIDPsahetpkQPVVRFKrnkHHKGSIYCVAWSPCGQLLATGSNDKYV 692
Cdd:COG2319   162 SGAVTSVAFSPDGKLLASGSDDGTVRLW---DLATG-------KLLRTLT---GHTGAVRSVAFSPDGKLLASGSADGTV 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 693 KVLPFNAETCNATVSGpdlefsmHDGTIRDLAFMegpeSGGAILISAGAgDCNIYTTDCQRGQGLHALSGHTGHILALyT 772
Cdd:COG2319   229 RLWDLATGKLLRTLTG-------HSGSVRSVAFS----PDGRLLASGSA-DGTVRLWDLATGELLRTLTGHSGGVNSV-A 295

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 773 WS--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPH 850
Cdd:COG2319   296 FSpdGKLLASGSDDGTVRLWDLATGKLLR----TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH 371

                         250       260       270
                  ....*....|....*....|....*....|..
gi 2462506294 851 SSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQG 882
Cdd:COG2319   372 TGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 667-924 2.71e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 162.12  E-value: 2.71e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 667 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATVSGpdlefsmHDGTIRDLAFMEgpeSGGAILISAGAGDCNI 746
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG-------HTGPVRDVAASA---DGTYLASGSSDKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 747 YttDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDLRVPSCVrvvgTTFHGTGSAVASVAVDPSGRLLA 825
Cdd:cd00200    78 W--DLETGECVRTLTGHTSYVSSVaFSPDGRILSSSSRDKTIKVWDVETGKCL----TTLRGHTDWVNSVAFSPDGTFVA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 826 TGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ-GDLTKQLPimvvgEHKDKVIQCR 904
Cdd:cd00200   152 SSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLStGKCLGTLR-----GHENGVNSVA 226

                         250       260
                  ....*....|....*....|
gi 2462506294 905 WHTQDLSFLSSSADRTVTLW 924
Cdd:cd00200   227 FSPDGYLLASGSEDGTIRVW 246
WD40 COG2319
WD40 repeat [General function prediction only];
613-924 4.52e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 162.00  E-value: 4.52e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 613 TQAVRAVAFHPAGGLYAVGSNSKTLRVcaypdvidpsaheTPKQPVVRFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYV 692
Cdd:COG2319    36 AAAVASLAASPDGARLAAGAGDLTLLL-------------LDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTV 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 693 KVLPFNAETCNATVSGpdlefsmHDGTIRDLAFmegpESGGAILISAGAgDCNIYTTDCQRGQGLHALSGHTGHILALyT 772
Cdd:COG2319   103 RLWDLATGLLLRTLTG-------HTGAVRSVAF----SPDGKTLASGSA-DGTVRLWDLATGKLLRTLTGHSGAVTSV-A 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 773 WS--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPH 850
Cdd:COG2319   170 FSpdGKLLASGSDDGTVRLWDLATGKLLR----TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGH 245

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462506294 851 SSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLpimvVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 924
Cdd:COG2319   246 SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRT----LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 606-837 6.52e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 126.30  E-value: 6.52e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 606 CINILED-TQAVRAVAFHPAGGLYAVGSNSKTLRVcaypdvidpsaHETPK-QPVVRFKrnkHHKGSIYCVAWSPCGQLL 683
Cdd:cd00200    85 CVRTLTGhTSYVSSVAFSPDGRILSSSSRDKTIKV-----------WDVETgKCLTTLR---GHTDWVNSVAFSPDGTFV 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 684 ATGSNDKYVKVLPFNAETCNATvsgpdleFSMHDGTIRDLAFMEgpeSGGAILISAGAGDCNIYttDCQRGQGLHALSGH 763
Cdd:cd00200   151 ASSSQDGTIKLWDLRTGKCVAT-------LTGHTGEVNSVAFSP---DGEKLLSSSSDGTIKLW--DLSTGKCLGTLRGH 218

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462506294 764 TGHILAL-YTWSGWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYD 837
Cdd:cd00200   219 ENGVNSVaFSPDGYLLASGSEDGTIRVWDLRTGECVQ----TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
612-840 3.67e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 3.67e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 612 DTQAVRAVAFHPAGGLYAVGSNSKTLRVCaypDVidpsaheTPKQPVVRFkrnKHHKGSIYCVAWSPCGQLLATGSNDKY 691
Cdd:COG2319   245 HSGSVRSVAFSPDGRLLASGSADGTVRLW---DL-------ATGELLRTL---TGHSGGVNSVAFSPDGKLLASGSDDGT 311

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 692 VKVlpFNAETcnatvsgpdlefsmhdgtirdlafmegpesggailisagagdcniyttdcqrGQGLHALSGHTGHILALy 771
Cdd:COG2319   312 VRL--WDLAT----------------------------------------------------GKLLRTLTGHTGAVRSV- 336

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462506294 772 TWS--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRG 840
Cdd:COG2319   337 AFSpdGKTLASGSDDGTVRLWDLATGELLR----TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 603-791 4.96e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.41  E-value: 4.96e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 603 QFVCINILED-TQAVRAVAFHPAGGLYAVGSNSKTLRVCaypdviDPSAHETpkqpvvrFKRNKHHKGSIYCVAWSPCGQ 681
Cdd:cd00200   124 TGKCLTTLRGhTDWVNSVAFSPDGTFVASSSQDGTIKLW------DLRTGKC-------VATLTGHTGEVNSVAFSPDGE 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 682 LLATGSNDKYVKVLPFNAETCNATVSGpdlefsmHDGTIRDLAFMEGPEsggaiLISAGAGDCNIYTTDCQRGQGLHALS 761
Cdd:cd00200   191 KLLSSSSDGTIKLWDLSTGKCLGTLRG-------HENGVNSVAFSPDGY-----LLASGSEDGTIRVWDLRTGECVQTLS 258

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2462506294 762 GHTGHILALyTWS--GWMIASGSQDKTVRFWD 791
Cdd:cd00200   259 GHTNSVTSL-AWSpdGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 804-924 2.62e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.54  E-value: 2.62e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462506294 804 TFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQgd 883
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE-- 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2462506294 884 lTKQLPIMVVGeHKDKVIQCRWHTQDLSFLSSSADRTVTLW 924
Cdd:cd00200    82 -TGECVRTLTG-HTSYVSSVAFSPDGRILSSSSRDKTIKVW 120
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 45-102 9.53e-13

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 63.74  E-value: 9.53e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462506294   45 FSDDMLFLRQLILDGQWDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMS 102
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNSKLEFELRKQKFLELVRQGKLEE 58
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 850-928 7.01e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.28  E-value: 7.01e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462506294 850 HSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLtkqlPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLWTYNG 928
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE----LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 665-694 1.76e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.76e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462506294  665 KHHKGSIYCVAWSPCGQLLATGSNDKYVKV 694
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKL 38
WD40 pfam00400
WD domain, G-beta repeat;
665-694 1.59e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 1.59e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462506294 665 KHHKGSIYCVAWSPCGQLLATGSNDKYVKV 694
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 841-879 2.44e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 2.44e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2462506294  841 GRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTD 879
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
841-879 8.10e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 8.10e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2462506294 841 GRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTD 879
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 754-791 1.44e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.44e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462506294  754 GQGLHALSGHTGHILALyTWS--GWMIASGSQDKTVRFWD 791
Cdd:smart00320   2 GELLKTLKGHTGPVTSV-AFSpdGKYLASGSDDGTIKLWD 40
LisH_TPL pfam17814
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 13-40 2.63e-05

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


Pssm-ID: 375350  Cd Length: 30  Bit Score: 41.61  E-value: 2.63e-05
                          10        20
                  ....*....|....*....|....*...
gi 2462506294  13 EIIKLILDFLNSKKLHISMLALEKESGV 40
Cdd:pfam17814   3 DVVRLILQFLKENGLHRTLQALQTESGV 30
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 799-854 7.52e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.57  E-value: 7.52e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462506294 799 RVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDV 854
Cdd:pfam12894  28 RVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLI 83
WD40 pfam00400
WD domain, G-beta repeat;
757-791 9.06e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 9.06e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2462506294 757 LHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWD 791
Cdd:pfam00400   4 LKTLEGHTGSVTSLaFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 804-837 1.36e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.36e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2462506294  804 TFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYD 837
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
803-837 1.88e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.88e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2462506294 803 TTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYD 837
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 9-42 3.39e-03

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 35.87  E-value: 3.39e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2462506294    9 VKEVEIIKLILDFLNSKKLHISMLALEKESGVIN 42
Cdd:smart00667   1 ISRSELNRLILEYLLRNGYEETAETLQKESGLSL 34
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 889-924 4.19e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 4.19e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462506294  889 PIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 924
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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