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Conserved domains on  [gi|2462499803|ref|XP_054189396|]
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testis-specific Y-encoded protein 4 isoform X2 [Homo sapiens]

Protein Classification

NAP domain-containing protein( domain architecture ID 1637)

NAP domain-containing protein similar to Homo sapiens protein testis-specific Y-encoded protein and nucleosome assembly protein 1-like

CATH:  3.30.1120.90
Gene Ontology:  GO:0042393|GO:0003682|GO:0006334
PubMed:  16936827
SCOP:  4003454

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00007 super family cl08298
(NAP-L) nucleosome assembly protein -L; Provisional
 132-197 5.22e-12

(NAP-L) nucleosome assembly protein -L; Provisional


The actual alignment was detected with superfamily member PTZ00008:

Pssm-ID: 471807  Cd Length: 185  Bit Score: 63.29  E-value: 5.22e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462499803 132 ARKAFSRQReKMERRRKPHLDRRGAVIQSVPGFWANVIANHPQMSAlITDEDEDMLSYMVSLEVEE 197
Cdd:PTZ00008    8 AKEQMNIQR-QFDEKKKPLFEKRQEIIEKIPGFWADTLRRHPALSY-LVPEDIDILEHLKKIDLED 71
NAP super family cl47614
Nucleosome assembly protein (NAP); NAP proteins are involved in moving histones into the ...
 171-231 6.50e-09

Nucleosome assembly protein (NAP); NAP proteins are involved in moving histones into the nucleus, nucleosome assembly and chromatin fluidity. They affect the transcription of many genes.


The actual alignment was detected with superfamily member pfam00956:

Pssm-ID: 460010  Cd Length: 203  Bit Score: 54.87  E-value: 6.50e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462499803 171 NHPQMSALITDEDEDMLSYMVSLEVEEEKHPvhlckiMLF-----FRSNPYFQNKVITKEYLVNIT 231
Cdd:pfam00956  41 NLPLLSEMITERDEPALKHLKDIKIEYPLDE------PGFtlefhFAPNPYFTNTVLTKTYYYQDE 100
 
Name Accession Description Interval E-value
PTZ00008 PTZ00008
(NAP-S) nucleosome assembly protein-S; Provisional
 132-197 5.22e-12

(NAP-S) nucleosome assembly protein-S; Provisional


Pssm-ID: 185394  Cd Length: 185  Bit Score: 63.29  E-value: 5.22e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462499803 132 ARKAFSRQReKMERRRKPHLDRRGAVIQSVPGFWANVIANHPQMSAlITDEDEDMLSYMVSLEVEE 197
Cdd:PTZ00008    8 AKEQMNIQR-QFDEKKKPLFEKRQEIIEKIPGFWADTLRRHPALSY-LVPEDIDILEHLKKIDLED 71
NAP pfam00956
Nucleosome assembly protein (NAP); NAP proteins are involved in moving histones into the ...
 171-231 6.50e-09

Nucleosome assembly protein (NAP); NAP proteins are involved in moving histones into the nucleus, nucleosome assembly and chromatin fluidity. They affect the transcription of many genes.


Pssm-ID: 460010  Cd Length: 203  Bit Score: 54.87  E-value: 6.50e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462499803 171 NHPQMSALITDEDEDMLSYMVSLEVEEEKHPvhlckiMLF-----FRSNPYFQNKVITKEYLVNIT 231
Cdd:pfam00956  41 NLPLLSEMITERDEPALKHLKDIKIEYPLDE------PGFtlefhFAPNPYFTNTVLTKTYYYQDE 100
 
Name Accession Description Interval E-value
PTZ00008 PTZ00008
(NAP-S) nucleosome assembly protein-S; Provisional
 132-197 5.22e-12

(NAP-S) nucleosome assembly protein-S; Provisional


Pssm-ID: 185394  Cd Length: 185  Bit Score: 63.29  E-value: 5.22e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462499803 132 ARKAFSRQReKMERRRKPHLDRRGAVIQSVPGFWANVIANHPQMSAlITDEDEDMLSYMVSLEVEE 197
Cdd:PTZ00008    8 AKEQMNIQR-QFDEKKKPLFEKRQEIIEKIPGFWADTLRRHPALSY-LVPEDIDILEHLKKIDLED 71
PTZ00007 PTZ00007
(NAP-L) nucleosome assembly protein -L; Provisional
 109-226 3.66e-10

(NAP-L) nucleosome assembly protein -L; Provisional


Pssm-ID: 240226 [Multi-domain]  Cd Length: 337  Bit Score: 59.81  E-value: 3.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462499803 109 MTPES--ALEELLAVQVELEPVNAQARKAFSRQREKMERRRKPHLDRRGAVIQ----------SVPGFWANVIANHPQMS 176
Cdd:PTZ00007   35 LTDEQreTLKKLQLLQKEFDDLEVEYNAELRKLRSKYEDLYNPIYDKRKEALVqnggaeigtpGLPQFWLTAMKNNNTLG 114

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462499803 177 ALITDEDEDMLSYMVSLEVE-EEKHPVHLCKIMLFFRSNPYFQNKVITKEY 226
Cdd:PTZ00007  115 SAIEEHDEPILSYLSDISCEyTEPNKQEGFILVFTFAPNPFFSNTVLTKTY 165
NAP pfam00956
Nucleosome assembly protein (NAP); NAP proteins are involved in moving histones into the ...
 171-231 6.50e-09

Nucleosome assembly protein (NAP); NAP proteins are involved in moving histones into the nucleus, nucleosome assembly and chromatin fluidity. They affect the transcription of many genes.


Pssm-ID: 460010  Cd Length: 203  Bit Score: 54.87  E-value: 6.50e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462499803 171 NHPQMSALITDEDEDMLSYMVSLEVEEEKHPvhlckiMLF-----FRSNPYFQNKVITKEYLVNIT 231
Cdd:pfam00956  41 NLPLLSEMITERDEPALKHLKDIKIEYPLDE------PGFtlefhFAPNPYFTNTVLTKTYYYQDE 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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