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Conserved domains on  [gi|2462496865|ref|XP_054188991|]
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cell cycle checkpoint protein RAD17 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
rad24 TIGR00602
checkpoint protein rad24; All proteins in this family for which functions are known are ...
 2-641 0e+00

checkpoint protein rad24; All proteins in this family for which functions are known are involved in DNA damage tolerance (likely cell cycle checkpoints).This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


:

Pssm-ID: 129690 [Multi-domain]  Cd Length: 637  Bit Score: 1003.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865   2 NQVTDWVDPSFDDFLECSGVSTITATSLGVNNSSHRRKNGPSTLessrFPARKRGNLSsLEQIYGLENSKEYLSENEPWV 81
Cdd:TIGR00602   1 MDVTDWVKPSFDDFLLSSLISTITKWSLSRPTSSHRRKNSPSTD----IHARKRGFLS-LEQDTGLELSSENLDGNEPWV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865  82 DKYKPETQHELAVHKKKIEEVETWLKAQVLERQPKQggsILLITGPPGCGKTTTLKILSKEHGIQVQEWINPVLPDFQKD 161
Cdd:TIGR00602  76 EKYKPETQHELAVHKKKIEEVETWLKAQVLENAPKR---ILLITGPSGCGKSTTIKILSKELGIQVQEWSNPTLPDFQKN 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 162 DFKGMFNTESSFHMFpyQSQIAVFKEFLLRATkyNKLQMLGDDLRTDKKIILVEDLPNQFYRDSHTLHEVLR-KYVRIGR 240
Cdd:TIGR00602 153 DHKVTLSLESCFSNF--QSQIEVFSEFLLRAT--NKLQMLGDDLMTDKKIILVEDLPNQFYRDTRALHEILRwKYVSIGR 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 241 CPLIFIISDSLSGDNNQ-RLLFP------KEIQEECSISNISFNPVAPTIMMKFLNRIVTIEANKNGGKITVPDKTSLEL 313
Cdd:TIGR00602 229 CPLVFIITESLEGDNNQrRLLFPaetimnKEILEEPRVSNISFNPIAPTIMKKFLNRIVTIEAKKNGEKIKVPKKTSVEL 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 314 LCQGCSGDIRSAINSLQFSSSKGenNLRPRKKGMSLKSDAVLSKSKRRKKPDRVFENQEVQAIGGKDVSLFLFRALGKIL 393
Cdd:TIGR00602 309 LCQGCSGDIRSAINSLQFSSSKS--GSLPIKKRMSTKSDAHASKSKIKGKHSSNNENQEIQALGGKDVSLFLFRALGKIL 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 394 YCKRASLTELDSPRLPSHLSEYERDTLLVEPEEVVEMSHMPGD-LFNLYLHQNYIDFFMEIDDIVRASEFLSFADILSGD 472
Cdd:TIGR00602 387 YCKRATLNELDSPRLPSHLSELSRDTLMVGPEEVVEMSHMPGDkTFNLYSHQNYNDFFVEFDDEVKASEFLNFADILSGD 466

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 473 WNTRSLLREYSTSIATRGVMHSNKARGYAHCQGGGSSFRPLHKPQWFLINKKYRENCLAAKALF--PDFCLPALCLQTQL 550
Cdd:TIGR00602 467 WNTRSLLREYSTSSARRGVMHSNKARGIAHCQGGKSSFRPLHKPQWFLISKKYRENCLAAKALFkvEDFCLPADCLQTQL 546

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 551 LPYLALLTIPMRNQAQISFIQDIGRLPLKRHFGRLKMEALTDREHGMIDPDSGDEAQLNGGHSAEESLGEPTQATVPETW 630
Cdd:TIGR00602 547 LPYLALDTIPMRNDAQISFIDDLGRLPLKRDFRRLKMEALTDREVGMIDPDSGDEETSFGDDPAVESDSDPSQAAGPETW 626

                         650
                  ....*....|.
gi 2462496865 631 SLPLSQNSASE 641
Cdd:TIGR00602 627 SLPDSDNSLSE 637
 
Name Accession Description Interval E-value
rad24 TIGR00602
checkpoint protein rad24; All proteins in this family for which functions are known are ...
 2-641 0e+00

checkpoint protein rad24; All proteins in this family for which functions are known are involved in DNA damage tolerance (likely cell cycle checkpoints).This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129690 [Multi-domain]  Cd Length: 637  Bit Score: 1003.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865   2 NQVTDWVDPSFDDFLECSGVSTITATSLGVNNSSHRRKNGPSTLessrFPARKRGNLSsLEQIYGLENSKEYLSENEPWV 81
Cdd:TIGR00602   1 MDVTDWVKPSFDDFLLSSLISTITKWSLSRPTSSHRRKNSPSTD----IHARKRGFLS-LEQDTGLELSSENLDGNEPWV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865  82 DKYKPETQHELAVHKKKIEEVETWLKAQVLERQPKQggsILLITGPPGCGKTTTLKILSKEHGIQVQEWINPVLPDFQKD 161
Cdd:TIGR00602  76 EKYKPETQHELAVHKKKIEEVETWLKAQVLENAPKR---ILLITGPSGCGKSTTIKILSKELGIQVQEWSNPTLPDFQKN 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 162 DFKGMFNTESSFHMFpyQSQIAVFKEFLLRATkyNKLQMLGDDLRTDKKIILVEDLPNQFYRDSHTLHEVLR-KYVRIGR 240
Cdd:TIGR00602 153 DHKVTLSLESCFSNF--QSQIEVFSEFLLRAT--NKLQMLGDDLMTDKKIILVEDLPNQFYRDTRALHEILRwKYVSIGR 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 241 CPLIFIISDSLSGDNNQ-RLLFP------KEIQEECSISNISFNPVAPTIMMKFLNRIVTIEANKNGGKITVPDKTSLEL 313
Cdd:TIGR00602 229 CPLVFIITESLEGDNNQrRLLFPaetimnKEILEEPRVSNISFNPIAPTIMKKFLNRIVTIEAKKNGEKIKVPKKTSVEL 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 314 LCQGCSGDIRSAINSLQFSSSKGenNLRPRKKGMSLKSDAVLSKSKRRKKPDRVFENQEVQAIGGKDVSLFLFRALGKIL 393
Cdd:TIGR00602 309 LCQGCSGDIRSAINSLQFSSSKS--GSLPIKKRMSTKSDAHASKSKIKGKHSSNNENQEIQALGGKDVSLFLFRALGKIL 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 394 YCKRASLTELDSPRLPSHLSEYERDTLLVEPEEVVEMSHMPGD-LFNLYLHQNYIDFFMEIDDIVRASEFLSFADILSGD 472
Cdd:TIGR00602 387 YCKRATLNELDSPRLPSHLSELSRDTLMVGPEEVVEMSHMPGDkTFNLYSHQNYNDFFVEFDDEVKASEFLNFADILSGD 466

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 473 WNTRSLLREYSTSIATRGVMHSNKARGYAHCQGGGSSFRPLHKPQWFLINKKYRENCLAAKALF--PDFCLPALCLQTQL 550
Cdd:TIGR00602 467 WNTRSLLREYSTSSARRGVMHSNKARGIAHCQGGKSSFRPLHKPQWFLISKKYRENCLAAKALFkvEDFCLPADCLQTQL 546

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 551 LPYLALLTIPMRNQAQISFIQDIGRLPLKRHFGRLKMEALTDREHGMIDPDSGDEAQLNGGHSAEESLGEPTQATVPETW 630
Cdd:TIGR00602 547 LPYLALDTIPMRNDAQISFIDDLGRLPLKRDFRRLKMEALTDREVGMIDPDSGDEETSFGDDPAVESDSDPSQAAGPETW 626

                         650
                  ....*....|.
gi 2462496865 631 SLPLSQNSASE 641
Cdd:TIGR00602 627 SLPDSDNSLSE 637
Rad17 pfam03215
Rad17 P-loop domain;
72-259 6.26e-93

Rad17 P-loop domain;


Pssm-ID: 367398 [Multi-domain]  Cd Length: 186  Bit Score: 285.70  E-value: 6.26e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865  72 EYLSENEPWVDKYKPETQHELAVHKKKIEEVETWLKAQVLERQPKqggSILLITGPPGCGKTTTLKILSKEHGIQVQEWI 151
Cdd:pfam03215   1 INDDGGEQWYEKYKPNCLEQLAVHKRKIKDVQEWLDAMFLENAKH---RILLISGPSGCGKSTVIKELSKELGPKYREWS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 152 NPVL---PDFQKDDFKGMFNTESSFhmfpyQSQIAVFKEFLLRATKYNKLQMLGDDLRTDKKIILVEDLPNQFYRDSHTL 228
Cdd:pfam03215  78 NPTSfrsPPNQVTDFRGDCIVNSRF-----LSQMESFSEFELKGARYLVMQKRGKNAQGNKKLILIEDLPNVFHIDTRRF 152

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2462496865 229 HEVLRKYVRIGRC-PLIFIIS--DSLSGDNNQRL 259
Cdd:pfam03215 153 QQVIRQWLYSSEPlPLIICITecEILEGDNNQRK 186
PRK04195 PRK04195
replication factor C large subunit; Provisional
 79-500 2.34e-19

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 91.52  E-value: 2.34e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865  79 PWVDKYKPETQHELAVHKKKIEEVETWLKAQvLERQPKQGgsiLLITGPPGCGKTTTLKILSKEHGIQVQEwINPvlPDF 158
Cdd:PRK04195    3 PWVEKYRPKTLSDVVGNEKAKEQLREWIESW-LKGKPKKA---LLLYGPPGVGKTSLAHALANDYGWEVIE-LNA--SDQ 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 159 QKDDfkgmfntessfhmfpyqsqiaVFKEFLLRATKYNKLqmlgddLRTDKKIILVEDLPNQFYR-DSHTLHEVLrKYVR 237
Cdd:PRK04195   76 RTAD---------------------VIERVAGEAATSGSL------FGARRKLILLDEVDGIHGNeDRGGARAIL-ELIK 127

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 238 IGRCPLIFIISDSLSgdnnqrlLFPKEIQEECSIsnISFNPVAPTIMMKFLNRIVTIEanknggKITVPDKTsLELLCQG 317
Cdd:PRK04195  128 KAKQPIILTANDPYD-------PSLRELRNACLM--IEFKRLSTRSIVPVLKRICRKE------GIECDDEA-LKEIAER 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 318 CSGDIRSAINSLQfSSSKGENNLrprkkgmslksdavlskskrrkkpdrvfENQEVQAIGGKDVSLFLFRALGKIL---Y 394
Cdd:PRK04195  192 SGGDLRSAINDLQ-AIAEGYGKL----------------------------TLEDVKTLGRRDREESIFDALDAVFkarN 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 395 CKRA--SLTELDsprlpshlseyerdtllVEPEEVVEmshmpgdlfnlYLHQN----YIDffmeIDDIVRASEFLSFADI 468
Cdd:PRK04195  243 ADQAleASYDVD-----------------EDPDDLIE-----------WIDENipkeYDD----PEDIARAYDALSRADI 290

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 2462496865 469 LSG------DWntrSLLReYSTSIATRGV--MHSNKARGY 500
Cdd:PRK04195  291 FLGrvkrtqNY---DLWR-YASDLMTAGValAKEKKKRGF 326
HLD_clamp_RarA cd18139
helical lid domain of recombination factor protein RarA; Recombination factor RarA ...
 281-343 3.85e-09

helical lid domain of recombination factor protein RarA; Recombination factor RarA (Replication associated recombination gene/protein A, also known as MgsA (Maintenance of genome stability A) or Mgs1 in yeast and WRNIP1 in mammals) is a member of the clamp-loader clade of the AAA+ superfamily. It functions as a tetramer. RarA co-localize with the replication fork throughout the cell cycle and may play a role in the rescue of stalled replication forks.


Pssm-ID: 350841 [Multi-domain]  Cd Length: 75  Bit Score: 53.40  E-value: 3.85e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462496865 281 PTIMMKFLNRIVTIEANKNGGKITVPDKtSLELLCQGCSGDIRSAINSLQFSSSKGENNLRPR 343
Cdd:cd18139     3 EEDLEKLLKRALEDKERGGDRKVTIDDE-ALELLAEAADGDARSALNLLELAVLSAEEDGGIV 64
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
 119-189 7.05e-07

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 49.73  E-value: 7.05e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462496865 119 GSILLITGPPGCGKTTTLKILSKEHGiqVQEWINPVLPdfqKDDFKGMFNTESsfhmFPYQSQIAVFKEFL 189
Cdd:COG4088     4 PMLLILTGPPGSGKTTFAKALAQRLY--AEGIAVALLH---SDDFRRFLVNES----FPKETYEEVVEDVR 65
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 119-142 1.95e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 42.36  E-value: 1.95e-04
                           10        20
                   ....*....|....*....|....
gi 2462496865  119 GSILLITGPPGCGKTTTLKILSKE 142
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARE 25
 
Name Accession Description Interval E-value
rad24 TIGR00602
checkpoint protein rad24; All proteins in this family for which functions are known are ...
 2-641 0e+00

checkpoint protein rad24; All proteins in this family for which functions are known are involved in DNA damage tolerance (likely cell cycle checkpoints).This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129690 [Multi-domain]  Cd Length: 637  Bit Score: 1003.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865   2 NQVTDWVDPSFDDFLECSGVSTITATSLGVNNSSHRRKNGPSTLessrFPARKRGNLSsLEQIYGLENSKEYLSENEPWV 81
Cdd:TIGR00602   1 MDVTDWVKPSFDDFLLSSLISTITKWSLSRPTSSHRRKNSPSTD----IHARKRGFLS-LEQDTGLELSSENLDGNEPWV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865  82 DKYKPETQHELAVHKKKIEEVETWLKAQVLERQPKQggsILLITGPPGCGKTTTLKILSKEHGIQVQEWINPVLPDFQKD 161
Cdd:TIGR00602  76 EKYKPETQHELAVHKKKIEEVETWLKAQVLENAPKR---ILLITGPSGCGKSTTIKILSKELGIQVQEWSNPTLPDFQKN 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 162 DFKGMFNTESSFHMFpyQSQIAVFKEFLLRATkyNKLQMLGDDLRTDKKIILVEDLPNQFYRDSHTLHEVLR-KYVRIGR 240
Cdd:TIGR00602 153 DHKVTLSLESCFSNF--QSQIEVFSEFLLRAT--NKLQMLGDDLMTDKKIILVEDLPNQFYRDTRALHEILRwKYVSIGR 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 241 CPLIFIISDSLSGDNNQ-RLLFP------KEIQEECSISNISFNPVAPTIMMKFLNRIVTIEANKNGGKITVPDKTSLEL 313
Cdd:TIGR00602 229 CPLVFIITESLEGDNNQrRLLFPaetimnKEILEEPRVSNISFNPIAPTIMKKFLNRIVTIEAKKNGEKIKVPKKTSVEL 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 314 LCQGCSGDIRSAINSLQFSSSKGenNLRPRKKGMSLKSDAVLSKSKRRKKPDRVFENQEVQAIGGKDVSLFLFRALGKIL 393
Cdd:TIGR00602 309 LCQGCSGDIRSAINSLQFSSSKS--GSLPIKKRMSTKSDAHASKSKIKGKHSSNNENQEIQALGGKDVSLFLFRALGKIL 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 394 YCKRASLTELDSPRLPSHLSEYERDTLLVEPEEVVEMSHMPGD-LFNLYLHQNYIDFFMEIDDIVRASEFLSFADILSGD 472
Cdd:TIGR00602 387 YCKRATLNELDSPRLPSHLSELSRDTLMVGPEEVVEMSHMPGDkTFNLYSHQNYNDFFVEFDDEVKASEFLNFADILSGD 466

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 473 WNTRSLLREYSTSIATRGVMHSNKARGYAHCQGGGSSFRPLHKPQWFLINKKYRENCLAAKALF--PDFCLPALCLQTQL 550
Cdd:TIGR00602 467 WNTRSLLREYSTSSARRGVMHSNKARGIAHCQGGKSSFRPLHKPQWFLISKKYRENCLAAKALFkvEDFCLPADCLQTQL 546

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 551 LPYLALLTIPMRNQAQISFIQDIGRLPLKRHFGRLKMEALTDREHGMIDPDSGDEAQLNGGHSAEESLGEPTQATVPETW 630
Cdd:TIGR00602 547 LPYLALDTIPMRNDAQISFIDDLGRLPLKRDFRRLKMEALTDREVGMIDPDSGDEETSFGDDPAVESDSDPSQAAGPETW 626

                         650
                  ....*....|.
gi 2462496865 631 SLPLSQNSASE 641
Cdd:TIGR00602 627 SLPDSDNSLSE 637
Rad17 pfam03215
Rad17 P-loop domain;
72-259 6.26e-93

Rad17 P-loop domain;


Pssm-ID: 367398 [Multi-domain]  Cd Length: 186  Bit Score: 285.70  E-value: 6.26e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865  72 EYLSENEPWVDKYKPETQHELAVHKKKIEEVETWLKAQVLERQPKqggSILLITGPPGCGKTTTLKILSKEHGIQVQEWI 151
Cdd:pfam03215   1 INDDGGEQWYEKYKPNCLEQLAVHKRKIKDVQEWLDAMFLENAKH---RILLISGPSGCGKSTVIKELSKELGPKYREWS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 152 NPVL---PDFQKDDFKGMFNTESSFhmfpyQSQIAVFKEFLLRATKYNKLQMLGDDLRTDKKIILVEDLPNQFYRDSHTL 228
Cdd:pfam03215  78 NPTSfrsPPNQVTDFRGDCIVNSRF-----LSQMESFSEFELKGARYLVMQKRGKNAQGNKKLILIEDLPNVFHIDTRRF 152

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2462496865 229 HEVLRKYVRIGRC-PLIFIIS--DSLSGDNNQRL 259
Cdd:pfam03215 153 QQVIRQWLYSSEPlPLIICITecEILEGDNNQRK 186
PRK04195 PRK04195
replication factor C large subunit; Provisional
 79-500 2.34e-19

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 91.52  E-value: 2.34e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865  79 PWVDKYKPETQHELAVHKKKIEEVETWLKAQvLERQPKQGgsiLLITGPPGCGKTTTLKILSKEHGIQVQEwINPvlPDF 158
Cdd:PRK04195    3 PWVEKYRPKTLSDVVGNEKAKEQLREWIESW-LKGKPKKA---LLLYGPPGVGKTSLAHALANDYGWEVIE-LNA--SDQ 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 159 QKDDfkgmfntessfhmfpyqsqiaVFKEFLLRATKYNKLqmlgddLRTDKKIILVEDLPNQFYR-DSHTLHEVLrKYVR 237
Cdd:PRK04195   76 RTAD---------------------VIERVAGEAATSGSL------FGARRKLILLDEVDGIHGNeDRGGARAIL-ELIK 127

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 238 IGRCPLIFIISDSLSgdnnqrlLFPKEIQEECSIsnISFNPVAPTIMMKFLNRIVTIEanknggKITVPDKTsLELLCQG 317
Cdd:PRK04195  128 KAKQPIILTANDPYD-------PSLRELRNACLM--IEFKRLSTRSIVPVLKRICRKE------GIECDDEA-LKEIAER 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 318 CSGDIRSAINSLQfSSSKGENNLrprkkgmslksdavlskskrrkkpdrvfENQEVQAIGGKDVSLFLFRALGKIL---Y 394
Cdd:PRK04195  192 SGGDLRSAINDLQ-AIAEGYGKL----------------------------TLEDVKTLGRRDREESIFDALDAVFkarN 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 395 CKRA--SLTELDsprlpshlseyerdtllVEPEEVVEmshmpgdlfnlYLHQN----YIDffmeIDDIVRASEFLSFADI 468
Cdd:PRK04195  243 ADQAleASYDVD-----------------EDPDDLIE-----------WIDENipkeYDD----PEDIARAYDALSRADI 290

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 2462496865 469 LSG------DWntrSLLReYSTSIATRGV--MHSNKARGY 500
Cdd:PRK04195  291 FLGrvkrtqNY---DLWR-YASDLMTAGValAKEKKKRGF 326
HLD_clamp_RarA cd18139
helical lid domain of recombination factor protein RarA; Recombination factor RarA ...
 281-343 3.85e-09

helical lid domain of recombination factor protein RarA; Recombination factor RarA (Replication associated recombination gene/protein A, also known as MgsA (Maintenance of genome stability A) or Mgs1 in yeast and WRNIP1 in mammals) is a member of the clamp-loader clade of the AAA+ superfamily. It functions as a tetramer. RarA co-localize with the replication fork throughout the cell cycle and may play a role in the rescue of stalled replication forks.


Pssm-ID: 350841 [Multi-domain]  Cd Length: 75  Bit Score: 53.40  E-value: 3.85e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462496865 281 PTIMMKFLNRIVTIEANKNGGKITVPDKtSLELLCQGCSGDIRSAINSLQFSSSKGENNLRPR 343
Cdd:cd18139     3 EEDLEKLLKRALEDKERGGDRKVTIDDE-ALELLAEAADGDARSALNLLELAVLSAEEDGGIV 64
PRK12402 PRK12402
replication factor C small subunit 2; Reviewed
 80-338 6.52e-07

replication factor C small subunit 2; Reviewed


Pssm-ID: 237090 [Multi-domain]  Cd Length: 337  Bit Score: 51.91  E-value: 6.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865  80 WVDKYKPETQHELAVHkkkiEEVETWLKAQVLERQPKQggsiLLITGPPGCGKTTTLKILSKE-HGiqvQEWINPvLPDF 158
Cdd:PRK12402    5 WTEKYRPALLEDILGQ----DEVVERLSRAVDSPNLPH----LLVQGPPGSGKTAAVRALARElYG---DPWENN-FTEF 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 159 QKDDFKGMFNTESS----FHMF------PYQSQIAVFKEFLLRATKYNKLQmlgddlrTDKKIILV---EDLPNQFyrdS 225
Cdd:PRK12402   73 NVADFFDQGKKYLVedprFAHFlgtdkrIRSSKIDNFKHVLKEYASYRPLS-------ADYKTILLdnaEALREDA---Q 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 226 HTLHEVLRKYVRIGRcpliFIISDSlsgdNNQRLLFPkeIQEECsiSNISFNPVAPTIMMKFLNRIVTIEanknggKITV 305
Cdd:PRK12402  143 QALRRIMEQYSRTCR----FIIATR----QPSKLIPP--IRSRC--LPLFFRAPTDDELVDVLESIAEAE------GVDY 204

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2462496865 306 PDKtSLELLCQGCSGDIRSAINSLQFSSSKGEN 338
Cdd:PRK12402  205 DDD-GLELIAYYAGGDLRKAILTLQTAALAAGE 236
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
 119-189 7.05e-07

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 49.73  E-value: 7.05e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462496865 119 GSILLITGPPGCGKTTTLKILSKEHGiqVQEWINPVLPdfqKDDFKGMFNTESsfhmFPYQSQIAVFKEFL 189
Cdd:COG4088     4 PMLLILTGPPGSGKTTFAKALAQRLY--AEGIAVALLH---SDDFRRFLVNES----FPKETYEEVVEDVR 65
HLD_clamp_RFC cd18140
helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein ...
 284-338 1.30e-05

helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein clamp loader complex that forms a stable ATP-dependent complex with the sliding clamp, PCNA, which binds specifically to primed DNA. RFC subunits belong to the clamp loader clade of the AAA+ superfamily.


Pssm-ID: 350842 [Multi-domain]  Cd Length: 63  Bit Score: 43.29  E-value: 1.30e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462496865 284 MMKFLNRIVTIEanknggKITVPDKtSLELLCQGCSGDIRSAINSLQFSSSKGEN 338
Cdd:cd18140     6 IVKRLREICKKE------GVKIDEE-ALEAIAEKSEGDMRKAINDLQAAAAGGGV 53
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 96-142 6.23e-05

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 45.67  E-value: 6.23e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462496865  96 KKKIEEVETWLKAQVLERQ---PKQGGSILLiTGPPGCGKTTTLKILSKE 142
Cdd:COG0464   166 KEELRELVALPLKRPELREeygLPPPRGLLL-YGPPGTGKTLLARALAGE 214
dNK pfam01712
Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2. ...
 124-182 1.01e-04

Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2.7.1.74, guanosine EC:2.7.1.113, adenosine EC:2.7.1.76 and thymidine kinase EC:2.7.1.21 (which also phosphorylates deoxyuridine and deoxycytosine.) These enzymes catalyze the production of deoxynucleotide 5'-monophosphate from a deoxynucleoside. Using ATP and yielding ADP in the process.


Pssm-ID: 396326  Cd Length: 201  Bit Score: 43.85  E-value: 1.01e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462496865 124 ITGPPGCGKTTTLKILSKEHGIQ-----VQEWINPVLPDFQKdDFKG---MFNTESSFHMFPYQSQI 182
Cdd:pfam01712   3 IEGNIGAGKSTLTKILSKRLGFKvfeepVDRWTNPYLDKFYK-DPSRwsfALQTYFLNSRFKQQLEA 68
AAA_18 pfam13238
AAA domain;
123-224 1.15e-04

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 42.42  E-value: 1.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 123 LITGPPGCGKTTTLKILSKEHGIQvqewinpvlpDFQKDDFKGMFNTESSFHmfpyqsQIAVFKEFLLRATKYNKLQMLG 202
Cdd:pfam13238   2 LITGTPGVGKTTLAKELSKRLGFG----------DNVRDLALENGLVLGDDP------ETRESKRLDEDKLDRLLDLLEE 65

                          90       100
                  ....*....|....*....|..
gi 2462496865 203 DDLRTDKKIILVEDLPNQFYRD 224
Cdd:pfam13238  66 NAALEEGGNLIIDGHLAELEPE 87
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 119-142 1.95e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 42.36  E-value: 1.95e-04
                           10        20
                   ....*....|....*....|....
gi 2462496865  119 GSILLITGPPGCGKTTTLKILSKE 142
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARE 25
rfc PRK00440
replication factor C small subunit; Reviewed
 76-338 2.05e-04

replication factor C small subunit; Reviewed


Pssm-ID: 234763 [Multi-domain]  Cd Length: 319  Bit Score: 44.09  E-value: 2.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865  76 ENEPWVDKYKPETQHELAVHkkkiEEVETWLKAQVLERQ-PKqggsiLLITGPPGCGKTTTLKILSKEhgiqvqewinpV 154
Cdd:PRK00440    3 MEEIWVEKYRPRTLDEIVGQ----EEIVERLKSYVKEKNmPH-----LLFAGPPGTGKTTAALALARE-----------L 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 155 LPDFQKDDFKGMfNTESsfhmfpyQSQIAV----FKEFLlratkynKLQMLGDdlrTDKKIILVeDLPNQFYRDS-HTLH 229
Cdd:PRK00440   63 YGEDWRENFLEL-NASD-------ERGIDVirnkIKEFA-------RTAPVGG---APFKIIFL-DEADNLTSDAqQALR 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 230 EVLRKYVRIGRcpliFIISDSLSgdnnQRLLFPkeIQEECSIsnISFNPVAPTIMMKFLNRIVTIEanknggKITVPDKt 309
Cdd:PRK00440  124 RTMEMYSQNTR----FILSCNYS----SKIIDP--IQSRCAV--FRFSPLKKEAVAERLRYIAENE------GIEITDD- 184

                         250       260
                  ....*....|....*....|....*....
gi 2462496865 310 SLELLCQGCSGDIRSAINSLQFSSSKGEN 338
Cdd:PRK00440  185 ALEAIYYVSEGDMRKAINALQAAAATGKE 213
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 106-142 2.77e-04

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 41.75  E-value: 2.77e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2462496865 106 LKAQVLERQPKQGGSILLITGPPGCGKTTTLKILSKE 142
Cdd:cd00009     6 AIEALREALELPPPKNLLLYGPPGTGKTTLARAIANE 42
PLN03025 PLN03025
replication factor C subunit; Provisional
 79-142 4.62e-04

replication factor C subunit; Provisional


Pssm-ID: 178596 [Multi-domain]  Cd Length: 319  Bit Score: 42.79  E-value: 4.62e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462496865  79 PWVDKYKPETQHELAVHKKKIEevetwlKAQVLERqpkqGGSI--LLITGPPGCGKTTTLKILSKE 142
Cdd:PLN03025    2 PWVEKYRPTKLDDIVGNEDAVS------RLQVIAR----DGNMpnLILSGPPGTGKTTSILALAHE 57
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 122-147 1.18e-03

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 39.50  E-value: 1.18e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462496865 122 LLITGPPGCGKTTTLKILSKEHGIQV 147
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPF 26
Fap7 COG1936
Broad-specificity NMP kinase [Nucleotide transport and metabolism];
121-147 1.69e-03

Broad-specificity NMP kinase [Nucleotide transport and metabolism];


Pssm-ID: 441539 [Multi-domain]  Cd Length: 173  Bit Score: 39.80  E-value: 1.69e-03
                          10        20
                  ....*....|....*....|....*..
gi 2462496865 121 ILLITGPPGCGKTTTLKILSKEHGIQV 147
Cdd:COG1936     2 RIAITGTPGTGKTTVAKLLAERLGLEV 28
AAA_28 pfam13521
AAA domain;
124-147 2.25e-03

AAA domain;


Pssm-ID: 433278 [Multi-domain]  Cd Length: 164  Bit Score: 39.17  E-value: 2.25e-03
                          10        20
                  ....*....|....*....|....
gi 2462496865 124 ITGPPGCGKTTTLKILSKEHGIQV 147
Cdd:pfam13521   4 ITGGPSTGKTTLAEALAARFGYPV 27
ABC_ATPase cd00267
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ...
 119-140 2.41e-03

ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213179 [Multi-domain]  Cd Length: 157  Bit Score: 39.15  E-value: 2.41e-03
                          10        20
                  ....*....|....*....|..
gi 2462496865 119 GSILLITGPPGCGKTTTLKILS 140
Cdd:cd00267    25 GEIVALVGPNGSGKSTLLRAIA 46
DEXSc_RecD-like cd17933
DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1. ...
 118-147 2.66e-03

DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1.11.5, Exonuclease V) complex. It is the alpha chain of the complex and functions as a 3'-5' helicase. The RecBCD enzyme is both a helicase that unwinds, or separates the strands of DNA, and a nuclease that makes single-stranded nicks in DNA. RecD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350691 [Multi-domain]  Cd Length: 155  Bit Score: 39.07  E-value: 2.66e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2462496865 118 GGSILLITGPPGCGKTTTLK---ILSKEHGIQV 147
Cdd:cd17933    11 RNRVSVLTGGAGTGKTTTLKallAALEAEGKRV 43
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 92-147 3.01e-03

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 38.80  E-value: 3.01e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462496865  92 LAVHKKKIEEVETWLKAQVLERQPKQGgsILLItGPPGCGKTTTLKILSKEHGIQV 147
Cdd:cd19481     2 KASLREAVEAPRRGSRLRRYGLGLPKG--ILLY-GPPGTGKTLLAKALAGELGLPL 54
44 PHA02544
clamp loader, small subunit; Provisional
 69-147 3.64e-03

clamp loader, small subunit; Provisional


Pssm-ID: 222866 [Multi-domain]  Cd Length: 316  Bit Score: 39.97  E-value: 3.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865  69 NSKEYLsenepWVDKYKPETQHE--LAVHKKKIeevetwLKAQVlerqpKQGG--SILLITGPPGCGKTTTLKILSKEHG 144
Cdd:PHA02544    5 NPNEFM-----WEQKYRPSTIDEciLPAADKET------FKSIV-----KKGRipNMLLHSPSPGTGKTTVAKALCNEVG 68


                  ...
gi 2462496865 145 IQV 147
Cdd:PHA02544   69 AEV 71
PRK04182 PRK04182
cytidylate kinase; Provisional
 121-145 3.85e-03

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 39.02  E-value: 3.85e-03
                          10        20
                  ....*....|....*....|....*
gi 2462496865 121 ILLITGPPGCGKTTTLKILSKEHGI 145
Cdd:PRK04182    2 IITISGPPGSGKTTVARLLAEKLGL 26
AAA_22 pfam13401
AAA domain;
116-146 4.08e-03

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 37.71  E-value: 4.08e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2462496865 116 KQGGSILLITGPPGCGKTTTLKILSKEHGIQ 146
Cdd:pfam13401   2 RFGAGILVLTGESGTGKTTLLRRLLEQLPEV 32
AAA_17 pfam13207
AAA domain;
125-147 4.31e-03

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 37.99  E-value: 4.31e-03
                          10        20
                  ....*....|....*....|...
gi 2462496865 125 TGPPGCGKTTTLKILSKEHGIQV 147
Cdd:pfam13207   1 TGVPGSGKTTQLKKLAEKLGFPH 23
ABC_tran pfam00005
ABC transporter; ABC transporters for a large family of proteins responsible for translocation ...
 119-143 4.47e-03

ABC transporter; ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains.


Pssm-ID: 394964 [Multi-domain]  Cd Length: 150  Bit Score: 38.01  E-value: 4.47e-03
                          10        20
                  ....*....|....*....|....*
gi 2462496865 119 GSILLITGPPGCGKTTTLKILSKEH 143
Cdd:pfam00005  11 GEILALVGPNGAGKSTLLKLIAGLL 35
PulE COG2804
Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell ...
 113-153 4.66e-03

Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442055 [Multi-domain]  Cd Length: 561  Bit Score: 40.18  E-value: 4.66e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462496865 113 RQPkQGgsILLITGPPGCGKTTTL------------KILSKE-------HGI-QVQewINP 153
Cdd:COG2804   310 RRP-HG--IILVTGPTGSGKTTTLyaalnelntperNIITVEdpveyqlPGInQVQ--VNP 365
ABCD_peroxisomal_ALDP cd03223
ATP-binding cassette domain of peroxisomal transporter, subfamily D; Peroxisomal ATP-binding ...
 116-140 6.92e-03

ATP-binding cassette domain of peroxisomal transporter, subfamily D; Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed during fatty acid beta-oxidation. To communicate with the cytoplasm and mitochondria, peroxisomes need dedicated proteins to transport such hydrophilic molecules across their membranes. X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ALD gene, which encodes ALDP (adrenoleukodystrophy protein ), a peroxisomal integral membrane protein that is a member of the ATP-binding cassette (ABC) transporter protein family. The disease is characterized by a striking and unpredictable variation in phenotypic expression. Phenotypes include the rapidly progressive childhood cerebral form (CCALD), the milder adult form, adrenomyeloneuropathy (AMN), and variants without neurologic involvement (i.e. asymptomatic).


Pssm-ID: 213190 [Multi-domain]  Cd Length: 166  Bit Score: 37.90  E-value: 6.92e-03
                          10        20
                  ....*....|....*....|....*
gi 2462496865 116 KQGGSiLLITGPPGCGKTTTLKILS 140
Cdd:cd03223    25 KPGDR-LLITGPSGTGKSSLFRALA 48
PRK10247 PRK10247
putative ABC transporter ATP-binding protein YbbL; Provisional
 117-140 7.82e-03

putative ABC transporter ATP-binding protein YbbL; Provisional


Pssm-ID: 182331 [Multi-domain]  Cd Length: 225  Bit Score: 38.54  E-value: 7.82e-03
                          10        20
                  ....*....|....*....|....
gi 2462496865 117 QGGSILLITGPPGCGKTTTLKILS 140
Cdd:PRK10247   31 RAGEFKLITGPSGCGKSTLLKIVA 54
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 108-249 8.77e-03

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 37.48  E-value: 8.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496865 108 AQVLERQPKQGGSILLITGPPGCGKTTTLKILSKEHGIQvqewinpvlpdfqkddfKGMFNTESSFHMFPYQSQIAVFKE 187
Cdd:pfam13191  13 LDALDRVRSGRPPSVLLTGEAGTGKTTLLRELLRALERD-----------------GGYFLRGKCDENLPYSPLLEALTR 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462496865 188 FLLRATKYNKLQMLGDDLRTDKKIILVEDLPNQFYRDSHTLHEVLRKYVRIGRC---PLIFIISD 249
Cdd:pfam13191  76 EGLLRQLLDELESSLLEAWRAALLEALAPVPELPGDLAERLLDLLLRLLDLLARgerPLVLVLDD 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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