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Conserved domains on  [gi|2462494698|ref|XP_054186916|]
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voltage-gated chloride channel TMC4 isoform X5 [Homo sapiens]

Protein Classification

transmembrane channel-like protein( domain architecture ID 10544697)

transmembrane channel-like protein may function as an ion channel, transporter, or modifier

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMC pfam07810
TMC domain; These sequences are similar to a region conserved amongst various protein products ...
 309-419 8.29e-33

TMC domain; These sequences are similar to a region conserved amongst various protein products of the transmembrane channel-like (TMC) gene family, such as Transmembrane channel-like protein 3 and EVIN2 - this region is termed the TMC domain. Mutations in these genes are implicated in a number of human conditions, such as deafness and epidermodysplasia verruciformis. TMC proteins are thought to have important cellular roles, and may be modifiers of ion channels or transporters.


:

Pssm-ID: 462275  Cd Length: 111  Bit Score: 121.10  E-value: 8.29e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462494698 309 CWETVLGQEMYKLLLFDLLTVLAVALLIQFPRKLLCGLCPGALGRLAGTQEFQVPDEVLGLIYAQTVVWVGSFFCPLLPL 388
Cdd:pfam07810   1 CWETYVGQELYKLVIFDFLVTLLVTLLVEFPRKLLVRKCNGCLEKLLGKQEFDIAKNVLDLIYNQTLCWLGLFFSPLLPL 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2462494698 389 LNTVKFLLLFYLKKLTLFSTCSPAARTFRAS 419
Cdd:pfam07810  81 INVIKLFILFYVKKFSLLYNCQPPSRPFRAS 111
 
Name Accession Description Interval E-value
TMC pfam07810
TMC domain; These sequences are similar to a region conserved amongst various protein products ...
 309-419 8.29e-33

TMC domain; These sequences are similar to a region conserved amongst various protein products of the transmembrane channel-like (TMC) gene family, such as Transmembrane channel-like protein 3 and EVIN2 - this region is termed the TMC domain. Mutations in these genes are implicated in a number of human conditions, such as deafness and epidermodysplasia verruciformis. TMC proteins are thought to have important cellular roles, and may be modifiers of ion channels or transporters.


Pssm-ID: 462275  Cd Length: 111  Bit Score: 121.10  E-value: 8.29e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462494698 309 CWETVLGQEMYKLLLFDLLTVLAVALLIQFPRKLLCGLCPGALGRLAGTQEFQVPDEVLGLIYAQTVVWVGSFFCPLLPL 388
Cdd:pfam07810   1 CWETYVGQELYKLVIFDFLVTLLVTLLVEFPRKLLVRKCNGCLEKLLGKQEFDIAKNVLDLIYNQTLCWLGLFFSPLLPL 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2462494698 389 LNTVKFLLLFYLKKLTLFSTCSPAARTFRAS 419
Cdd:pfam07810  81 INVIKLFILFYVKKFSLLYNCQPPSRPFRAS 111
 
Name Accession Description Interval E-value
TMC pfam07810
TMC domain; These sequences are similar to a region conserved amongst various protein products ...
 309-419 8.29e-33

TMC domain; These sequences are similar to a region conserved amongst various protein products of the transmembrane channel-like (TMC) gene family, such as Transmembrane channel-like protein 3 and EVIN2 - this region is termed the TMC domain. Mutations in these genes are implicated in a number of human conditions, such as deafness and epidermodysplasia verruciformis. TMC proteins are thought to have important cellular roles, and may be modifiers of ion channels or transporters.


Pssm-ID: 462275  Cd Length: 111  Bit Score: 121.10  E-value: 8.29e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462494698 309 CWETVLGQEMYKLLLFDLLTVLAVALLIQFPRKLLCGLCPGALGRLAGTQEFQVPDEVLGLIYAQTVVWVGSFFCPLLPL 388
Cdd:pfam07810   1 CWETYVGQELYKLVIFDFLVTLLVTLLVEFPRKLLVRKCNGCLEKLLGKQEFDIAKNVLDLIYNQTLCWLGLFFSPLLPL 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2462494698 389 LNTVKFLLLFYLKKLTLFSTCSPAARTFRAS 419
Cdd:pfam07810  81 INVIKLFILFYVKKFSLLYNCQPPSRPFRAS 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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