NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462630681|ref|XP_054183630|]
View 

tafazzin isoform X10 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 41-172 4.30e-23

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


:

Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 90.79  E-value: 4.30e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462630681  41 SHFFSLGKCVPVCRGDGV-YQKGMDFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIGRLIAEChlNPIILPLWHVGMN 119
Cdd:cd07989    64 GWLLRLLGAIPIDRGNGRsAREALREAIEALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEA--GVPIVPVAISGTW 141

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462630681 120 DVLPnsPPYFPRFGQKITVLIGKPFSAlpvlerlrAENKSAVEMRKALTDFIQ 172
Cdd:cd07989   142 GSLP--KGKKLPRPGRVTVRIGEPIPP--------EGLELAEEDRKELREKVR 184
 
Name Accession Description Interval E-value
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 41-172 4.30e-23

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 90.79  E-value: 4.30e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462630681  41 SHFFSLGKCVPVCRGDGV-YQKGMDFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIGRLIAEChlNPIILPLWHVGMN 119
Cdd:cd07989    64 GWLLRLLGAIPIDRGNGRsAREALREAIEALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEA--GVPIVPVAISGTW 141

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462630681 120 DVLPnsPPYFPRFGQKITVLIGKPFSAlpvlerlrAENKSAVEMRKALTDFIQ 172
Cdd:cd07989   142 GSLP--KGKKLPRPGRVTVRIGEPIPP--------EGLELAEEDRKELREKVR 184
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 24-116 2.22e-18

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 76.93  E-value: 2.22e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462630681  24 PRRTPAAADICFTKeLHSHFFSLGKCVPVCRGD-GVYQKGMDFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIGRLIA 102
Cdd:pfam01553  41 PLVFVAKKELFDIP-LVGWLMRLLGCIFIDRKNrKDAAGTLEYLVELLREGKLVVIFPEGTRSREGELLPFKKGAFRLAI 119

                          90
                  ....*....|....
gi 2462630681 103 EchLNPIILPLWHV 116
Cdd:pfam01553 120 E--AGVPIVPVAIS 131
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 20-118 3.75e-18

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 76.24  E-value: 3.75e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462630681   20 PPALPRRTPAAADICFTKELHSHFFSLGKCVPVCRGDG-VYQKGMDFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIG 98
Cdd:smart00563  21 PRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGrKARAALREAVELLKEGEWLLIFPEGTRSRPGKLLPFKKGAA 100

                           90       100
                   ....*....|....*....|
gi 2462630681   99 RLIAECHlnPIILPLWHVGM 118
Cdd:smart00563 101 RLALEAG--VPIVPVAIRGT 118
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 22-186 3.59e-13

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 65.03  E-value: 3.59e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462630681  22 ALPRRTP--AAADIcFTKELHSHFFSLGKCVPVCRGDGVY-QKGMDFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIG 98
Cdd:COG0204    63 ALPRPVRfvAKKEL-FKIPLLGWLLRALGAIPVDRSKRRAaLRALRQAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAA 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462630681  99 RLIAECHLnPIIlPLWHVGMNDVLPnsPPYFPRFGqKITVLIGKPFSAlpvlERLRAENksavemRKALTDFIQEEFQHL 178
Cdd:COG0204   142 RLALEAGV-PIV-PVAIDGTERALP--KGFLPRPG-KVTVRIGPPIDP----SDLEGED------RRELAERLRAAIEAL 206


                  ....*...
gi 2462630681 179 KTQAEQLH 186
Cdd:COG0204   207 LAELRAEA 214
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 43-188 7.03e-06

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 45.69  E-value: 7.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462630681   43 FFSLGKCVPVCRGDgvyQKGM-DFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIgRLIAECHLNPIIlP-----LW-- 114
Cdd:PRK08633   483 FFKLFGVIPISSGG---SKESlEFIRKALDDGEVVCIFPEGAITRNGQLNEFKRGF-ELIVKGTDVPII-PfyirgLWgs 557

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462630681  115 -----HVGMNDVLPNSPPYfprfgqKITVLIGKPfsaLPvlerlraENKSAVEMRKALTDFIQEEFQHLKTQAEQLHNH 188
Cdd:PRK08633   558 ifsraSGKFLWRWPTRIPY------PVTVAFGKP---MP-------AHSTAHEVKQAVFELSFDSWKSRKEALPPLAEA 620
 
Name Accession Description Interval E-value
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 41-172 4.30e-23

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 90.79  E-value: 4.30e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462630681  41 SHFFSLGKCVPVCRGDGV-YQKGMDFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIGRLIAEChlNPIILPLWHVGMN 119
Cdd:cd07989    64 GWLLRLLGAIPIDRGNGRsAREALREAIEALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEA--GVPIVPVAISGTW 141

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462630681 120 DVLPnsPPYFPRFGQKITVLIGKPFSAlpvlerlrAENKSAVEMRKALTDFIQ 172
Cdd:cd07989   142 GSLP--KGKKLPRPGRVTVRIGEPIPP--------EGLELAEEDRKELREKVR 184
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 24-116 2.22e-18

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 76.93  E-value: 2.22e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462630681  24 PRRTPAAADICFTKeLHSHFFSLGKCVPVCRGD-GVYQKGMDFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIGRLIA 102
Cdd:pfam01553  41 PLVFVAKKELFDIP-LVGWLMRLLGCIFIDRKNrKDAAGTLEYLVELLREGKLVVIFPEGTRSREGELLPFKKGAFRLAI 119

                          90
                  ....*....|....
gi 2462630681 103 EchLNPIILPLWHV 116
Cdd:pfam01553 120 E--AGVPIVPVAIS 131
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 20-118 3.75e-18

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 76.24  E-value: 3.75e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462630681   20 PPALPRRTPAAADICFTKELHSHFFSLGKCVPVCRGDG-VYQKGMDFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIG 98
Cdd:smart00563  21 PRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGrKARAALREAVELLKEGEWLLIFPEGTRSRPGKLLPFKKGAA 100

                           90       100
                   ....*....|....*....|
gi 2462630681   99 RLIAECHlnPIILPLWHVGM 118
Cdd:smart00563 101 RLALEAG--VPIVPVAIRGT 118
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 22-186 3.59e-13

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 65.03  E-value: 3.59e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462630681  22 ALPRRTP--AAADIcFTKELHSHFFSLGKCVPVCRGDGVY-QKGMDFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIG 98
Cdd:COG0204    63 ALPRPVRfvAKKEL-FKIPLLGWLLRALGAIPVDRSKRRAaLRALRQAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAA 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462630681  99 RLIAECHLnPIIlPLWHVGMNDVLPnsPPYFPRFGqKITVLIGKPFSAlpvlERLRAENksavemRKALTDFIQEEFQHL 178
Cdd:COG0204   142 RLALEAGV-PIV-PVAIDGTERALP--KGFLPRPG-KVTVRIGPPIDP----SDLEGED------RRELAERLRAAIEAL 206


                  ....*...
gi 2462630681 179 KTQAEQLH 186
Cdd:COG0204   207 LAELRAEA 214
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 43-188 7.03e-06

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 45.69  E-value: 7.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462630681   43 FFSLGKCVPVCRGDgvyQKGM-DFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIgRLIAECHLNPIIlP-----LW-- 114
Cdd:PRK08633   483 FFKLFGVIPISSGG---SKESlEFIRKALDDGEVVCIFPEGAITRNGQLNEFKRGF-ELIVKGTDVPII-PfyirgLWgs 557

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462630681  115 -----HVGMNDVLPNSPPYfprfgqKITVLIGKPfsaLPvlerlraENKSAVEMRKALTDFIQEEFQHLKTQAEQLHNH 188
Cdd:PRK08633   558 ifsraSGKFLWRWPTRIPY------PVTVAFGKP---MP-------AHSTAHEVKQAVFELSFDSWKSRKEALPPLAEA 620
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 43-169 1.18e-03

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 38.16  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462630681  43 FFSLGKCVPVCRGDGVYQKG-MDFILEKL-NHGDWVHIFPEGKVNMSSEF-LRFKWGIGRLIAECHLNpiILPLwhvgmn 119
Cdd:cd06551    69 FFTRLGAFSVDRDSPRSAAKsLKYVARLLsKPGSVVWIFPEGTRTRRDKRpLQFKPGVAHLAEKAGVP--IVPV------ 140

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462630681 120 dVLPNSPPYFPRFGQkITVLIGKPfsalPVLERLRAENKSAVEMRKALTD 169
Cdd:cd06551   141 -ALRYTFELFEQFPE-IFVRIGPP----IPYAETALGEELAAELANRLTR 184
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 29-162 2.51e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 37.24  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462630681  29 AAADIcFTKELHSHFFSLGKCVPVCR---------GDGVYQKGMDFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIGR 99
Cdd:cd07992    58 AKADL-FKNPLIGWLLESFGAIPVYRpkdlarggiGKISNAAVFDAVGEALKAGGAIGIFPEGGSHDRPRLLPLKAGAAR 136

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462630681 100 LIAECHLNPII-LPLWHVGMNdvlpnsppYF--PRFGQKITVLIGKPFSALP--VLERLRAENKSAVE 162
Cdd:cd07992   137 MALEALEAGQKdVKIVPVGLN--------YEdkSRFRSRVLVEFGKPISVSAfeEAEASRDVEKKLIN 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH