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Conserved domains on  [gi|2462629168|ref|XP_054182892|]
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protein FAM156A/FAM156B isoform X1 [Homo sapiens]

Protein Classification

PGC7_Stella domain-containing protein( domain architecture ID 10634677)

PGC7_Stella domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PGC7_Stella pfam15549
PGC7/Stella/Dppa3 domain; The domain belongs to a fast evolving family known only from the ...
 1-170 1.19e-70

PGC7/Stella/Dppa3 domain; The domain belongs to a fast evolving family known only from the placental mammals. The PGC7/Stella/Dppa3 protein protects imprinted regions from demethylation post-fertilization. This suggests that it might bind methylated DNA sequences directly. The conserved core includes a postively charged helical segment and a C-terminal CXCXXC motif that is predicted to chelate a metal ion. Most placental mammals contain 3-6 paralogs of this domain family. The CXCXXC motif is also conserved in a subset of fungal MBD4-like proteins.


:

Pssm-ID: 464759  Cd Length: 166  Bit Score: 212.47  E-value: 1.19e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629168   1 MDPLQKRNPASPSKSSPMTAAETSQEGPAPSQPSYSEQPMMGLSNLSPGPGPSQAVPLPEGLLRQRYREEKTLEERRWER 80
Cdd:pfam15549   1 MDPLQKWDPMLISESSQMATEEDSQAVSAASQPSSSETLVKGLSNLTLNPGPSLPAPLPEGLLQQQMREEKTLQQRRWER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629168  81 LEFLQRKKAFLRHVRRRHRDHMAPYAVGREARISPLGDRSQNRFRCECRYCQSHRPNLSGIPGESNraphPSSWETLVQG 160
Cdd:pfam15549  81 TLLSQRKKAFLRHIRRRRLDHMAPYPVEREQRISPSGDRAQNRFRCLCRYCQSHRPNISGMSGERN----PSSWETLVQG 156

                         170
                  ....*....|
gi 2462629168 161 LSGLTLSLGT 170
Cdd:pfam15549 157 LSGLNLSLGT 166
PGC7_Stella super family cl21352
PGC7/Stella/Dppa3 domain; The domain belongs to a fast evolving family known only from the ...
 144-204 4.56e-07

PGC7/Stella/Dppa3 domain; The domain belongs to a fast evolving family known only from the placental mammals. The PGC7/Stella/Dppa3 protein protects imprinted regions from demethylation post-fertilization. This suggests that it might bind methylated DNA sequences directly. The conserved core includes a postively charged helical segment and a C-terminal CXCXXC motif that is predicted to chelate a metal ion. Most placental mammals contain 3-6 paralogs of this domain family. The CXCXXC motif is also conserved in a subset of fungal MBD4-like proteins.


The actual alignment was detected with superfamily member pfam15549:

Pssm-ID: 464759  Cd Length: 166  Bit Score: 47.99  E-value: 4.56e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462629168 144 ESNRAPHPSSWETLVQGLSGLTLSLGTNQPGPLPEAALQPQETEEKRQRERQQESKIMFQR 204
Cdd:pfam15549  26 AVSAASQPSSSETLVKGLSNLTLNPGPSLPAPLPEGLLQQQMREEKTLQQRRWERTLLSQR 86
 
Name Accession Description Interval E-value
PGC7_Stella pfam15549
PGC7/Stella/Dppa3 domain; The domain belongs to a fast evolving family known only from the ...
 1-170 1.19e-70

PGC7/Stella/Dppa3 domain; The domain belongs to a fast evolving family known only from the placental mammals. The PGC7/Stella/Dppa3 protein protects imprinted regions from demethylation post-fertilization. This suggests that it might bind methylated DNA sequences directly. The conserved core includes a postively charged helical segment and a C-terminal CXCXXC motif that is predicted to chelate a metal ion. Most placental mammals contain 3-6 paralogs of this domain family. The CXCXXC motif is also conserved in a subset of fungal MBD4-like proteins.


Pssm-ID: 464759  Cd Length: 166  Bit Score: 212.47  E-value: 1.19e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629168   1 MDPLQKRNPASPSKSSPMTAAETSQEGPAPSQPSYSEQPMMGLSNLSPGPGPSQAVPLPEGLLRQRYREEKTLEERRWER 80
Cdd:pfam15549   1 MDPLQKWDPMLISESSQMATEEDSQAVSAASQPSSSETLVKGLSNLTLNPGPSLPAPLPEGLLQQQMREEKTLQQRRWER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629168  81 LEFLQRKKAFLRHVRRRHRDHMAPYAVGREARISPLGDRSQNRFRCECRYCQSHRPNLSGIPGESNraphPSSWETLVQG 160
Cdd:pfam15549  81 TLLSQRKKAFLRHIRRRRLDHMAPYPVEREQRISPSGDRAQNRFRCLCRYCQSHRPNISGMSGERN----PSSWETLVQG 156

                         170
                  ....*....|
gi 2462629168 161 LSGLTLSLGT 170
Cdd:pfam15549 157 LSGLNLSLGT 166
PGC7_Stella pfam15549
PGC7/Stella/Dppa3 domain; The domain belongs to a fast evolving family known only from the ...
 144-204 4.56e-07

PGC7/Stella/Dppa3 domain; The domain belongs to a fast evolving family known only from the placental mammals. The PGC7/Stella/Dppa3 protein protects imprinted regions from demethylation post-fertilization. This suggests that it might bind methylated DNA sequences directly. The conserved core includes a postively charged helical segment and a C-terminal CXCXXC motif that is predicted to chelate a metal ion. Most placental mammals contain 3-6 paralogs of this domain family. The CXCXXC motif is also conserved in a subset of fungal MBD4-like proteins.


Pssm-ID: 464759  Cd Length: 166  Bit Score: 47.99  E-value: 4.56e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462629168 144 ESNRAPHPSSWETLVQGLSGLTLSLGTNQPGPLPEAALQPQETEEKRQRERQQESKIMFQR 204
Cdd:pfam15549  26 AVSAASQPSSSETLVKGLSNLTLNPGPSLPAPLPEGLLQQQMREEKTLQQRRWERTLLSQR 86
 
Name Accession Description Interval E-value
PGC7_Stella pfam15549
PGC7/Stella/Dppa3 domain; The domain belongs to a fast evolving family known only from the ...
 1-170 1.19e-70

PGC7/Stella/Dppa3 domain; The domain belongs to a fast evolving family known only from the placental mammals. The PGC7/Stella/Dppa3 protein protects imprinted regions from demethylation post-fertilization. This suggests that it might bind methylated DNA sequences directly. The conserved core includes a postively charged helical segment and a C-terminal CXCXXC motif that is predicted to chelate a metal ion. Most placental mammals contain 3-6 paralogs of this domain family. The CXCXXC motif is also conserved in a subset of fungal MBD4-like proteins.


Pssm-ID: 464759  Cd Length: 166  Bit Score: 212.47  E-value: 1.19e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629168   1 MDPLQKRNPASPSKSSPMTAAETSQEGPAPSQPSYSEQPMMGLSNLSPGPGPSQAVPLPEGLLRQRYREEKTLEERRWER 80
Cdd:pfam15549   1 MDPLQKWDPMLISESSQMATEEDSQAVSAASQPSSSETLVKGLSNLTLNPGPSLPAPLPEGLLQQQMREEKTLQQRRWER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629168  81 LEFLQRKKAFLRHVRRRHRDHMAPYAVGREARISPLGDRSQNRFRCECRYCQSHRPNLSGIPGESNraphPSSWETLVQG 160
Cdd:pfam15549  81 TLLSQRKKAFLRHIRRRRLDHMAPYPVEREQRISPSGDRAQNRFRCLCRYCQSHRPNISGMSGERN----PSSWETLVQG 156

                         170
                  ....*....|
gi 2462629168 161 LSGLTLSLGT 170
Cdd:pfam15549 157 LSGLNLSLGT 166
PGC7_Stella pfam15549
PGC7/Stella/Dppa3 domain; The domain belongs to a fast evolving family known only from the ...
 144-204 4.56e-07

PGC7/Stella/Dppa3 domain; The domain belongs to a fast evolving family known only from the placental mammals. The PGC7/Stella/Dppa3 protein protects imprinted regions from demethylation post-fertilization. This suggests that it might bind methylated DNA sequences directly. The conserved core includes a postively charged helical segment and a C-terminal CXCXXC motif that is predicted to chelate a metal ion. Most placental mammals contain 3-6 paralogs of this domain family. The CXCXXC motif is also conserved in a subset of fungal MBD4-like proteins.


Pssm-ID: 464759  Cd Length: 166  Bit Score: 47.99  E-value: 4.56e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462629168 144 ESNRAPHPSSWETLVQGLSGLTLSLGTNQPGPLPEAALQPQETEEKRQRERQQESKIMFQR 204
Cdd:pfam15549  26 AVSAASQPSSSETLVKGLSNLTLNPGPSLPAPLPEGLLQQQMREEKTLQQRRWERTLLSQR 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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