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Conserved domains on  [gi|2462585793|ref|XP_054182051|]
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THO complex subunit 5 homolog isoform X3 [Homo sapiens]

Protein Classification

THO complex subunit 5( domain architecture ID 582274)

THO complex subunit 5 is a component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA

Gene Ontology:  GO:0003729|GO:0006406|GO:0000347|GO:0008380|GO:0006397
TCDB:  3.A.22

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FmiP_Thoc5 super family cl24222
Fms-interacting protein/Thoc5; This entry carries part of the crucial 144 N-terminal residues ...
 1-113 1.74e-45

Fms-interacting protein/Thoc5; This entry carries part of the crucial 144 N-terminal residues of the FmiP (Fms interacting protein). A member of the THO (suppressors of the transcriptional defects of hpr1delta by overexpression) complex which is a subcomplex of the transcription/export (TREX) complex. It is essential for the binding of the protein to the cytoplasmic domain of activated Fms-molecules in M-CSF induced haematopoietic differentiation of macrophages. Fmip is also known as THOC5 (THO complex subunit 5) a 683 amino acids long protein which contains a nuclear localization sequence (NLS), a leucine zipper and a PEST like sequence (aa. 303-319) that carries three ataxia-telangiectasia mutated (ATM) kinase specific phosphorylation sites. The C-terminus contains a THOC1 binding site. The level of FMIP/Thoc5 expression might form a threshold that determines whether cells differentiate into macrophages or into granulocytes.


The actual alignment was detected with superfamily member pfam09766:

Pssm-ID: 462889  Cd Length: 347  Bit Score: 158.24  E-value: 1.74e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585793   1 MLKRHPLSVMLDLKCKDDSVLHLTFYYLMNLNIMTVKAKVTTAMelitpiSAGDLLSPDSVLSCLYPGDHGKKTPNPANQ 80
Cdd:pfam09766 241 LLKPHPLSVELTIKCKDDTKLKLQFRYLPKLNIVTVKAQLTLDS------SAGDLLSDESLLSNLFPGDTGLESPNPANK 314

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2462585793  81 YQFDKVGILTLSDYVLELGHPYLWVQKLGGLHF 113
Cdd:pfam09766 315 YQLQNLGLDEFNDNFSELGKPYKWAQRLCGLDF 347
 
Name Accession Description Interval E-value
FmiP_Thoc5 pfam09766
Fms-interacting protein/Thoc5; This entry carries part of the crucial 144 N-terminal residues ...
 1-113 1.74e-45

Fms-interacting protein/Thoc5; This entry carries part of the crucial 144 N-terminal residues of the FmiP (Fms interacting protein). A member of the THO (suppressors of the transcriptional defects of hpr1delta by overexpression) complex which is a subcomplex of the transcription/export (TREX) complex. It is essential for the binding of the protein to the cytoplasmic domain of activated Fms-molecules in M-CSF induced haematopoietic differentiation of macrophages. Fmip is also known as THOC5 (THO complex subunit 5) a 683 amino acids long protein which contains a nuclear localization sequence (NLS), a leucine zipper and a PEST like sequence (aa. 303-319) that carries three ataxia-telangiectasia mutated (ATM) kinase specific phosphorylation sites. The C-terminus contains a THOC1 binding site. The level of FMIP/Thoc5 expression might form a threshold that determines whether cells differentiate into macrophages or into granulocytes.


Pssm-ID: 462889  Cd Length: 347  Bit Score: 158.24  E-value: 1.74e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585793   1 MLKRHPLSVMLDLKCKDDSVLHLTFYYLMNLNIMTVKAKVTTAMelitpiSAGDLLSPDSVLSCLYPGDHGKKTPNPANQ 80
Cdd:pfam09766 241 LLKPHPLSVELTIKCKDDTKLKLQFRYLPKLNIVTVKAQLTLDS------SAGDLLSDESLLSNLFPGDTGLESPNPANK 314

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2462585793  81 YQFDKVGILTLSDYVLELGHPYLWVQKLGGLHF 113
Cdd:pfam09766 315 YQLQNLGLDEFNDNFSELGKPYKWAQRLCGLDF 347
 
Name Accession Description Interval E-value
FmiP_Thoc5 pfam09766
Fms-interacting protein/Thoc5; This entry carries part of the crucial 144 N-terminal residues ...
 1-113 1.74e-45

Fms-interacting protein/Thoc5; This entry carries part of the crucial 144 N-terminal residues of the FmiP (Fms interacting protein). A member of the THO (suppressors of the transcriptional defects of hpr1delta by overexpression) complex which is a subcomplex of the transcription/export (TREX) complex. It is essential for the binding of the protein to the cytoplasmic domain of activated Fms-molecules in M-CSF induced haematopoietic differentiation of macrophages. Fmip is also known as THOC5 (THO complex subunit 5) a 683 amino acids long protein which contains a nuclear localization sequence (NLS), a leucine zipper and a PEST like sequence (aa. 303-319) that carries three ataxia-telangiectasia mutated (ATM) kinase specific phosphorylation sites. The C-terminus contains a THOC1 binding site. The level of FMIP/Thoc5 expression might form a threshold that determines whether cells differentiate into macrophages or into granulocytes.


Pssm-ID: 462889  Cd Length: 347  Bit Score: 158.24  E-value: 1.74e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585793   1 MLKRHPLSVMLDLKCKDDSVLHLTFYYLMNLNIMTVKAKVTTAMelitpiSAGDLLSPDSVLSCLYPGDHGKKTPNPANQ 80
Cdd:pfam09766 241 LLKPHPLSVELTIKCKDDTKLKLQFRYLPKLNIVTVKAQLTLDS------SAGDLLSDESLLSNLFPGDTGLESPNPANK 314

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2462585793  81 YQFDKVGILTLSDYVLELGHPYLWVQKLGGLHF 113
Cdd:pfam09766 315 YQLQNLGLDEFNDNFSELGKPYKWAQRLCGLDF 347
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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