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Conserved domains on  [gi|2462581687|ref|XP_054180054|]
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protein sel-1 homolog 2 isoform X14 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11434433)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
2-284 3.32e-36

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 131.20  E-value: 3.32e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581687   2 AFIGKMYLEGNAAVPQNNATAFKYFSMAASKGNAIGLHGLGLLYFHGKGVPLNYAEALKYFQKAAEKGWPDAQFQLGFMY 81
Cdd:COG0790    30 AAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEKAAEQGDAEAQYNLGLMY 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581687  82 YSGSGIWKDYKLAFKYFYLASQSGQPLAIYYLAKMYATGTGVVRSCRTAVELYKgvcelghwaekfltayfaykdgdids 161
Cdd:COG0790   110 EEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYR-------------------------- 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581687 162 slvqyallaemgyevaqsnsafileskkanilekekmypmalllwnRAAIQGNAFARVKIGDYHYYGYGTKKDYQTAATH 241
Cdd:COG0790   164 ----------------------------------------------KAAEQGDADAQYNLGVLYENGRGVPKDPAKALEW 197

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2462581687 242 YSIAANKyHNAQAMFNLAYMYEHGLGITKDIHLARRLYDMAAQ 284
Cdd:COG0790   198 YRKAAEQ-GDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAE 239
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
2-284 3.32e-36

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 131.20  E-value: 3.32e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581687   2 AFIGKMYLEGNAAVPQNNATAFKYFSMAASKGNAIGLHGLGLLYFHGKGVPLNYAEALKYFQKAAEKGWPDAQFQLGFMY 81
Cdd:COG0790    30 AAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEKAAEQGDAEAQYNLGLMY 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581687  82 YSGSGIWKDYKLAFKYFYLASQSGQPLAIYYLAKMYATGTGVVRSCRTAVELYKgvcelghwaekfltayfaykdgdids 161
Cdd:COG0790   110 EEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYR-------------------------- 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581687 162 slvqyallaemgyevaqsnsafileskkanilekekmypmalllwnRAAIQGNAFARVKIGDYHYYGYGTKKDYQTAATH 241
Cdd:COG0790   164 ----------------------------------------------KAAEQGDADAQYNLGVLYENGRGVPKDPAKALEW 197

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2462581687 242 YSIAANKyHNAQAMFNLAYMYEHGLGITKDIHLARRLYDMAAQ 284
Cdd:COG0790   198 YRKAAEQ-GDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAE 239
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 252-284 1.92e-06

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 44.09  E-value: 1.92e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2462581687  252 AQAMFNLAYMYEHGLGITKDIHLARRLYDMAAQ 284
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAE 33
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 252-284 2.37e-06

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 43.66  E-value: 2.37e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2462581687 252 AQAMFNLAYMYEHGLGITKDIHLARRLYDMAAQ 284
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAE 33
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
2-284 3.32e-36

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 131.20  E-value: 3.32e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581687   2 AFIGKMYLEGNAAVPQNNATAFKYFSMAASKGNAIGLHGLGLLYFHGKGVPLNYAEALKYFQKAAEKGWPDAQFQLGFMY 81
Cdd:COG0790    30 AAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEKAAEQGDAEAQYNLGLMY 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581687  82 YSGSGIWKDYKLAFKYFYLASQSGQPLAIYYLAKMYATGTGVVRSCRTAVELYKgvcelghwaekfltayfaykdgdids 161
Cdd:COG0790   110 EEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYR-------------------------- 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581687 162 slvqyallaemgyevaqsnsafileskkanilekekmypmalllwnRAAIQGNAFARVKIGDYHYYGYGTKKDYQTAATH 241
Cdd:COG0790   164 ----------------------------------------------KAAEQGDADAQYNLGVLYENGRGVPKDPAKALEW 197

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2462581687 242 YSIAANKyHNAQAMFNLAYMYEHGLGITKDIHLARRLYDMAAQ 284
Cdd:COG0790   198 YRKAAEQ-GDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAE 239
TPR COG0790
TPR repeat [General function prediction only];
1-142 8.37e-36

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 130.43  E-value: 8.37e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581687   1 MAFIGKMYLEGNAaVPQNNATAFKYFSMAASKGNAIGLHGLGLLYFHGKGVPLNYAEALKYFQKAAEKGWPDAQFQLGFM 80
Cdd:COG0790    66 QYNLGLMYAEGRG-VPKDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLL 144

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462581687  81 YYSGSGIWKDYKLAFKYFYLASQSGQPLAIYYLAKMYATGTGVVRSCRTAVELYKGVCELGH 142
Cdd:COG0790   145 YLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGD 206
TPR COG0790
TPR repeat [General function prediction only];
1-140 4.63e-35

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 128.12  E-value: 4.63e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581687   1 MAFIGKMYLEGNAaVPQNNATAFKYFSMAASKGNAIGLHGLGLLYFHGKGVPLNYAEALKYFQKAAEKGWPDAQFQLGFM 80
Cdd:COG0790   102 QYNLGLMYEEGLG-VPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVL 180

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581687  81 YYSGSGIWKDYKLAFKYFYLASQSGQPLAIYYLAKMYATGTGVVRSCRTAVELYKGVCEL 140
Cdd:COG0790   181 YENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
162-284 7.53e-13

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 67.26  E-value: 7.53e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581687 162 SLVQYALLAEMGYEVAQSNSAFILESKKANILEKEKMYPMALLLWNRAAIQGNAFARVKIGDYHYYGYGTKKDYQTAATH 241
Cdd:COG0790    10 AAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEW 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2462581687 242 YSIAANKyHNAQAMFNLAYMYEHGLGITKDIHLARRLYDMAAQ 284
Cdd:COG0790    90 FEKAAEQ-GDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAE 131
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 252-284 1.92e-06

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 44.09  E-value: 1.92e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2462581687  252 AQAMFNLAYMYEHGLGITKDIHLARRLYDMAAQ 284
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAE 33
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 252-284 2.37e-06

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 43.66  E-value: 2.37e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2462581687 252 AQAMFNLAYMYEHGLGITKDIHLARRLYDMAAQ 284
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAE 33
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 71-105 2.76e-06

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 43.32  E-value: 2.76e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462581687   71 PDAQFQLGFMYYSGSGIWKDYKLAFKYFYLASQSG 105
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 35-69 4.16e-06

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 42.93  E-value: 4.16e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462581687   35 AIGLHGLGLLYFHGKGVPLNYAEALKYFQKAAEKG 69
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 35-69 1.02e-05

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 41.74  E-value: 1.02e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2462581687  35 AIGLHGLGLLYFHGKGVPLNYAEALKYFQKAAEKG 69
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
TPR COG0790
TPR repeat [General function prediction only];
195-284 5.10e-05

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 44.15  E-value: 5.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581687 195 KEKMYPMALLLWNRAAIQGNAFARVKIGDYHYYGYGTKKDYQTAATHYSIAANKYHNAQAMFNLAYMYEHGLGITKDIHL 274
Cdd:COG0790     6 AAAAAAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEK 85

                          90
                  ....*....|
gi 2462581687 275 ARRLYDMAAQ 284
Cdd:COG0790    86 ALEWFEKAAE 95
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 107-142 1.13e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 39.08  E-value: 1.13e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462581687  107 PLAIYYLAKMYATGTGVVRSCRTAVELYKGVCELGH 142
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 71-105 2.49e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 37.89  E-value: 2.49e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2462581687  71 PDAQFQLGFMYYSGSGIWKDYKLAFKYFYLASQSG 105
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 215-250 4.04e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 34.46  E-value: 4.04e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462581687  215 AFARVKIGDYHYYGYGTKKDYQTAATHYSIAANKYH 250
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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