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Conserved domains on  [gi|2462580841|ref|XP_054179649|]
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zinc finger protein 64 isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
3-28 2.00e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.00e-05
                          10        20
                  ....*....|....*....|....*.
gi 2462580841   3 DMERHLKIHTGDKPHKCEVCGKCFSR 28
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
213-237 1.13e-04

C2H2-type zinc-finger domain;


:

Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 39.07  E-value: 1.13e-04
                          10        20
                  ....*....|....*....|....*
gi 2462580841 213 FKCNYCSFDTKQPSNLSKHMKKFHG 237
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
32-53 1.17e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.17e-04
                          10        20
                  ....*....|....*....|..
gi 2462580841  32 LKTHMRCHTGVKPYKCKTCDYA 53
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKS 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
115-134 1.82e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.82e-04
                          10        20
                  ....*....|....*....|
gi 2462580841 115 DLKRHMRVHSGEKPFKCEFC 134
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPEC 20
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
45-68 1.01e-03

C2H2-type zinc-finger domain;


:

Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 36.37  E-value: 1.01e-03
                          10        20
                  ....*....|....*....|....
gi 2462580841  45 YKCKTCDYAAADSSSLNKHLRIHS 68
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHT 24
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 69-153 1.72e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580841  69 DERPFKCQI--CPYASRNSSQLTVH-LRSHtgdapfqcwlCSAKFKISSDLKRHMRVHSGEKPFKCEFCNVRCTMKGNLK 145
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHmLHGH----------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ....*...
gi 2462580841 146 SHirIKHS 153
Cdd:COG5189   416 YH--RKHS 421
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
157-179 2.84e-03

C2H2-type zinc-finger domain;


:

Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 35.22  E-value: 2.84e-03
                          10        20
                  ....*....|....*....|...
gi 2462580841 157 FKCPHCDFLGDSKATLRKHSRVH 179
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKH 23
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
127-292 6.43e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 6.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580841 127 KPFKCEFCNVRCTMKGNLKSHIRIKHsgnnfkcphcdflgdskatlrkHSRVHQSEHPEKCSECSYSCSSKAALRIHERI 206
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSVN----------------------HSGESLKPFSCPYSLCGKLFSRNDALKRHILL 345

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580841 207 HCTDRPFKCNYCSFDTKQPSNL-------------SKHMKKFHGDMVKTEALERKDTGRQSSRQVAKLDAKKSFHCDICD 273
Cdd:COG5048   346 HTSISPAKEKLLNSSSKFSPLLnneppqslqqykdLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCS 425

                         170
                  ....*....|....*....
gi 2462580841 274 ASFMREDSLRSHKRQHSEY 292
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNH 444
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
3-28 2.00e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.00e-05
                          10        20
                  ....*....|....*....|....*.
gi 2462580841   3 DMERHLKIHTGDKPHKCEVCGKCFSR 28
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
213-237 1.13e-04

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 39.07  E-value: 1.13e-04
                          10        20
                  ....*....|....*....|....*
gi 2462580841 213 FKCNYCSFDTKQPSNLSKHMKKFHG 237
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
32-53 1.17e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.17e-04
                          10        20
                  ....*....|....*....|..
gi 2462580841  32 LKTHMRCHTGVKPYKCKTCDYA 53
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKS 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
115-134 1.82e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.82e-04
                          10        20
                  ....*....|....*....|
gi 2462580841 115 DLKRHMRVHSGEKPFKCEFC 134
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPEC 20
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
45-68 1.01e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 36.37  E-value: 1.01e-03
                          10        20
                  ....*....|....*....|....
gi 2462580841  45 YKCKTCDYAAADSSSLNKHLRIHS 68
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHT 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 69-153 1.72e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580841  69 DERPFKCQI--CPYASRNSSQLTVH-LRSHtgdapfqcwlCSAKFKISSDLKRHMRVHSGEKPFKCEFCNVRCTMKGNLK 145
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHmLHGH----------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ....*...
gi 2462580841 146 SHirIKHS 153
Cdd:COG5189   416 YH--RKHS 421
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
157-179 2.84e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 35.22  E-value: 2.84e-03
                          10        20
                  ....*....|....*....|...
gi 2462580841 157 FKCPHCDFLGDSKATLRKHSRVH 179
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
127-292 6.43e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 6.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580841 127 KPFKCEFCNVRCTMKGNLKSHIRIKHsgnnfkcphcdflgdskatlrkHSRVHQSEHPEKCSECSYSCSSKAALRIHERI 206
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSVN----------------------HSGESLKPFSCPYSLCGKLFSRNDALKRHILL 345

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580841 207 HCTDRPFKCNYCSFDTKQPSNL-------------SKHMKKFHGDMVKTEALERKDTGRQSSRQVAKLDAKKSFHCDICD 273
Cdd:COG5048   346 HTSISPAKEKLLNSSSKFSPLLnneppqslqqykdLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCS 425

                         170
                  ....*....|....*....
gi 2462580841 274 ASFMREDSLRSHKRQHSEY 292
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNH 444
zf-H2C2_2 pfam13465
Zinc-finger double domain;
59-84 7.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.07e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462580841  59 SLNKHLRIHSDERPFKCQICPYASRN 84
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
ZnF_C2H2 smart00355
zinc finger;
17-39 7.64e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 33.98  E-value: 7.64e-03
                           10        20
                   ....*....|....*....|...
gi 2462580841   17 HKCEVCGKCFSRKDKLKTHMRCH 39
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
3-28 2.00e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.00e-05
                          10        20
                  ....*....|....*....|....*.
gi 2462580841   3 DMERHLKIHTGDKPHKCEVCGKCFSR 28
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
213-237 1.13e-04

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 39.07  E-value: 1.13e-04
                          10        20
                  ....*....|....*....|....*
gi 2462580841 213 FKCNYCSFDTKQPSNLSKHMKKFHG 237
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
32-53 1.17e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.17e-04
                          10        20
                  ....*....|....*....|..
gi 2462580841  32 LKTHMRCHTGVKPYKCKTCDYA 53
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKS 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
115-134 1.82e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.82e-04
                          10        20
                  ....*....|....*....|
gi 2462580841 115 DLKRHMRVHSGEKPFKCEFC 134
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPEC 20
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
45-68 1.01e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 36.37  E-value: 1.01e-03
                          10        20
                  ....*....|....*....|....
gi 2462580841  45 YKCKTCDYAAADSSSLNKHLRIHS 68
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHT 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 69-153 1.72e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580841  69 DERPFKCQI--CPYASRNSSQLTVH-LRSHtgdapfqcwlCSAKFKISSDLKRHMRVHSGEKPFKCEFCNVRCTMKGNLK 145
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHmLHGH----------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ....*...
gi 2462580841 146 SHirIKHS 153
Cdd:COG5189   416 YH--RKHS 421
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 17-37 2.32e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.32e-03
                          10        20
                  ....*....|....*....|.
gi 2462580841  17 HKCEVCGKCFSRKDKLKTHMR 37
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLR 21
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
157-179 2.84e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 35.22  E-value: 2.84e-03
                          10        20
                  ....*....|....*....|...
gi 2462580841 157 FKCPHCDFLGDSKATLRKHSRVH 179
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
8-132 5.41e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 5.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580841   8 LKIHTG--DKPHKC--EVCGKCFSRKDKLKTHMRCHTGVKPYKCKTCDYAAADSSSLNK----HLRIHSDERPFKCQICP 79
Cdd:COG5048   311 SVNHSGesLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDLKNDKKSETL 390

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580841  80 YASRNS-----SQLTVHLRSHTGDAP--FQCWLCSAKFKISSDLKRHMRVHSGEKPFKCE 132
Cdd:COG5048   391 SNSCIRnfkrdSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
127-292 6.43e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 6.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580841 127 KPFKCEFCNVRCTMKGNLKSHIRIKHsgnnfkcphcdflgdskatlrkHSRVHQSEHPEKCSECSYSCSSKAALRIHERI 206
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSVN----------------------HSGESLKPFSCPYSLCGKLFSRNDALKRHILL 345

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580841 207 HCTDRPFKCNYCSFDTKQPSNL-------------SKHMKKFHGDMVKTEALERKDTGRQSSRQVAKLDAKKSFHCDICD 273
Cdd:COG5048   346 HTSISPAKEKLLNSSSKFSPLLnneppqslqqykdLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCS 425

                         170
                  ....*....|....*....
gi 2462580841 274 ASFMREDSLRSHKRQHSEY 292
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNH 444
zf-H2C2_2 pfam13465
Zinc-finger double domain;
59-84 7.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.07e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462580841  59 SLNKHLRIHSDERPFKCQICPYASRN 84
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
ZnF_C2H2 smart00355
zinc finger;
17-39 7.64e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 33.98  E-value: 7.64e-03
                           10        20
                   ....*....|....*....|...
gi 2462580841   17 HKCEVCGKCFSRKDKLKTHMRCH 39
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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