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Conserved domains on  [gi|2462580839|ref|XP_054179648|]
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zinc finger protein 64 isoform X4 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
116-547 1.12e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 1.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580839 116 DKPHKCEVCGKCFSRKDKLKTHMRCHTGVKPYKC--KTCDYAAADSSSLNKHLRIHSderpfkcqicpYASRNSSQLTVH 193
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHH-----------NNPSDLNSKSLP 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580839 194 LRSHTASELDDDVPkanclSTESTDTPKAPVITLPSEAREQMATLGERT---FNCCYPGCHFKTVHGMKDLDRHLRIHTG 270
Cdd:COG5048   100 LSNSKASSSSLSSS-----SSNSNDNNLLSSHSLPPSSRDPQLPDLLSIsnlRNNPLPGNNSSSVNTPQSNSLHPPLPAN 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580839 271 DKPHKCEFCDKCFSRKDNLtmhmrcHTSVKPHKCHLCDYAAVDSSSLKKHLRIHSDE-----RPYKCQLCPYASRNSSQL 345
Cdd:COG5048   175 SLSKDPSSNLSLLISSNVS------TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSslpltTNSQLSPKSLLSQSPSSL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580839 346 TVHLRSHTGDTPFQCWLCSAKFKISSDLKRHMIVHSG-EKPFKCEFCDVRCTMKANLKSHIRIKHTfkclhcafqgrDRA 424
Cdd:COG5048   249 SSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVNH-----------SGE 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580839 425 DLLEHSrlhqadhpekCPE--CSYSCSSAAALRVHSRVHCKDRPFKCDFCSFDTKRPSSLAK------------HVDKVH 490
Cdd:COG5048   318 SLKPFS----------CPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqqykdlKNDKKS 387

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462580839 491 RDEAKTENRAPLGKEGLREGSSQHVAKivTQRAFRCETCGASFVRDDSLRCHKKQHS 547
Cdd:COG5048   388 ETLSNSCIRNFKRDSNLSLHIITHLSF--RPYNCKNPPCSKSFNRHYNLIPHKKIHT 442
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
116-547 1.12e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 1.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580839 116 DKPHKCEVCGKCFSRKDKLKTHMRCHTGVKPYKC--KTCDYAAADSSSLNKHLRIHSderpfkcqicpYASRNSSQLTVH 193
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHH-----------NNPSDLNSKSLP 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580839 194 LRSHTASELDDDVPkanclSTESTDTPKAPVITLPSEAREQMATLGERT---FNCCYPGCHFKTVHGMKDLDRHLRIHTG 270
Cdd:COG5048   100 LSNSKASSSSLSSS-----SSNSNDNNLLSSHSLPPSSRDPQLPDLLSIsnlRNNPLPGNNSSSVNTPQSNSLHPPLPAN 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580839 271 DKPHKCEFCDKCFSRKDNLtmhmrcHTSVKPHKCHLCDYAAVDSSSLKKHLRIHSDE-----RPYKCQLCPYASRNSSQL 345
Cdd:COG5048   175 SLSKDPSSNLSLLISSNVS------TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSslpltTNSQLSPKSLLSQSPSSL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580839 346 TVHLRSHTGDTPFQCWLCSAKFKISSDLKRHMIVHSG-EKPFKCEFCDVRCTMKANLKSHIRIKHTfkclhcafqgrDRA 424
Cdd:COG5048   249 SSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVNH-----------SGE 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580839 425 DLLEHSrlhqadhpekCPE--CSYSCSSAAALRVHSRVHCKDRPFKCDFCSFDTKRPSSLAK------------HVDKVH 490
Cdd:COG5048   318 SLKPFS----------CPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqqykdlKNDKKS 387

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462580839 491 RDEAKTENRAPLGKEGLREGSSQHVAKivTQRAFRCETCGASFVRDDSLRCHKKQHS 547
Cdd:COG5048   388 ETLSNSCIRNFKRDSNLSLHIITHLSF--RPYNCKNPPCSKSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
260-285 6.04e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 6.04e-05
                          10        20
                  ....*....|....*....|....*.
gi 2462580839 260 DLDRHLRIHTGDKPHKCEFCDKCFSR 285
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
116-547 1.12e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 1.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580839 116 DKPHKCEVCGKCFSRKDKLKTHMRCHTGVKPYKC--KTCDYAAADSSSLNKHLRIHSderpfkcqicpYASRNSSQLTVH 193
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHH-----------NNPSDLNSKSLP 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580839 194 LRSHTASELDDDVPkanclSTESTDTPKAPVITLPSEAREQMATLGERT---FNCCYPGCHFKTVHGMKDLDRHLRIHTG 270
Cdd:COG5048   100 LSNSKASSSSLSSS-----SSNSNDNNLLSSHSLPPSSRDPQLPDLLSIsnlRNNPLPGNNSSSVNTPQSNSLHPPLPAN 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580839 271 DKPHKCEFCDKCFSRKDNLtmhmrcHTSVKPHKCHLCDYAAVDSSSLKKHLRIHSDE-----RPYKCQLCPYASRNSSQL 345
Cdd:COG5048   175 SLSKDPSSNLSLLISSNVS------TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSslpltTNSQLSPKSLLSQSPSSL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580839 346 TVHLRSHTGDTPFQCWLCSAKFKISSDLKRHMIVHSG-EKPFKCEFCDVRCTMKANLKSHIRIKHTfkclhcafqgrDRA 424
Cdd:COG5048   249 SSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVNH-----------SGE 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580839 425 DLLEHSrlhqadhpekCPE--CSYSCSSAAALRVHSRVHCKDRPFKCDFCSFDTKRPSSLAK------------HVDKVH 490
Cdd:COG5048   318 SLKPFS----------CPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqqykdlKNDKKS 387

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462580839 491 RDEAKTENRAPLGKEGLREGSSQHVAKivTQRAFRCETCGASFVRDDSLRCHKKQHS 547
Cdd:COG5048   388 ETLSNSCIRNFKRDSNLSLHIITHLSF--RPYNCKNPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
108-482 4.87e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 4.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580839 108 RHLKIHTGDKPHKCEV--CGKCFSRKDKLKTHMRCHTGVKPYKCKTCDYAAADSSSLNKHLRIHS-DERPFKCQICPYAS 184
Cdd:COG5048    51 RHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSnSNDNNLLSSHSLPP 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580839 185 RNSSQLTVHLRSHTASELDDDVPKANCLSTESTDTPKAPVITLPseareqmatlgertfnccypgCHFKTVHGMKDLDRH 264
Cdd:COG5048   131 SSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN---------------------SLSKDPSSNLSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580839 265 LRIHTGDKPHKCEFCDKCFSRKDNLTMHMRCHTSVKPHKCHLCDYAAVDSSSLKKHLRIHSDERPYKCQLCPYASR---- 340
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLptas 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580839 341 --NSSQLTVHLRSHTG-DTPFQCWLCSAKFKISSDLKRHM--IVHSGE--KPFKC--EFCDVRCTMKANLKSHIRIkHTF 411
Cdd:COG5048   270 sqSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILL-HTS 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580839 412 KCLHCA--------FQGRDRADLLEHSRLHQADHPEKCPECSYSCSSAAALR-----VHSRVHCKDRP--FKCDFCSFDT 476
Cdd:COG5048   349 ISPAKEkllnssskFSPLLNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRdsnlsLHIITHLSFRPynCKNPPCSKSF 428


                  ....*.
gi 2462580839 477 KRPSSL 482
Cdd:COG5048   429 NRHYNL 434
zf-H2C2_2 pfam13465
Zinc-finger double domain;
260-285 6.04e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 6.04e-05
                          10        20
                  ....*....|....*....|....*.
gi 2462580839 260 DLDRHLRIHTGDKPHKCEFCDKCFSR 285
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
258-389 1.58e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580839 258 MKDLDRHLR--IHTG--DKPHKC--EFCDKCFSRKDNLTMHMRCHTSVKPHKCHLCDYAAVDSSSLKK----HLRIHSDE 327
Cdd:COG5048   302 SSPLTRHLRsvNHSGesLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDL 381

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462580839 328 RPYKCQLCPYASRNS-----SQLTVHLRSHTGDTP--FQCWLCSAKFKISSDLKRHMIVHSGEKPFKCE 389
Cdd:COG5048   382 KNDKKSETLSNSCIRnfkrdSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 326-409 3.11e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 3.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580839 326 DERPYKCQL--CPYASRNSSQLTVH-LRSHtgdtpfqcwlCSAKFKISSDLKRHMIVHSGEKPFKCEFCDVRCTMKANLK 402
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHmLHGH----------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ....*..
gi 2462580839 403 SHIRIKH 409
Cdd:COG5189   416 YHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
105-130 3.20e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.20e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462580839 105 DMERHLKIHTGDKPHKCEVCGKCFSR 130
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
134-155 1.65e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.65e-03
                          10        20
                  ....*....|....*....|..
gi 2462580839 134 LKTHMRCHTGVKPYKCKTCDYA 155
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKS 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
145-315 2.30e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580839 145 KPYKCKTCDYAAADSSSLNKHLR--IHSDE--RPFKC--QICPYASRNSSQLTVHLRSHTaselddDVPKANCLSTESTD 218
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT------SISPAKEKLLNSSS 361

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580839 219 TPKAPVITLPSEAREQMATL-GERTFNCCYPGC--HFKTVHGMKdldRHLRIHTGDKPHKCEF--CDKCFSRKDNLTMHM 293
Cdd:COG5048   362 KFSPLLNNEPPQSLQQYKDLkNDKKSETLSNSCirNFKRDSNLS---LHIITHLSFRPYNCKNppCSKSFNRHYNLIPHK 438

                         170       180
                  ....*....|....*....|..
gi 2462580839 294 RCHTSVKPHKCHLCDYAAVDSS 315
Cdd:COG5048   439 KIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
372-396 3.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.66e-03
                          10        20
                  ....*....|....*....|....*
gi 2462580839 372 DLKRHMIVHSGEKPFKCEFCDVRCT 396
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
288-310 7.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.35e-03
                          10        20
                  ....*....|....*....|...
gi 2462580839 288 NLTMHMRCHTSVKPHKCHLCDYA 310
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKS 23
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
147-170 9.05e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 34.06  E-value: 9.05e-03
                          10        20
                  ....*....|....*....|....
gi 2462580839 147 YKCKTCDYAAADSSSLNKHLRIHS 170
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHT 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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