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Conserved domains on  [gi|2462579627|ref|XP_054179060|]
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COMM domain-containing protein 7 isoform X6 [Homo sapiens]

Protein Classification

COMM domain-containing protein( domain architecture ID 4715)

COMM (copper metabolism gene MURR1) domain-containing protein is involved in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd super family cl06336
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 19-150 1.22e-63

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


The actual alignment was detected with superfamily member cd04755:

Pssm-ID: 471425  Cd Length: 180  Bit Score: 192.66  E-value: 1.22e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462579627  19 MQQLNQLGA-QFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGSLRSIVKSLLLVPNGALKKSLTAKQVQADFIT 97
Cdd:cd04755     1 IQNLNQLSEqQFSRLTEILFEFLLEPKESERLLNQLDEFAGENGISLGPLKNIVKSILLVPNGALKRNLTAEQLREDLIQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462579627  98 LGLSEEKATYFSEK-----------------------------------------------LKLVVKKGNQTENVYIELT 130
Cdd:cd04755    81 LGLSEEKASYFSEQwkqhystlsrsavgqtlmvnqlvdmewkfgvtagsselqkvgsiflqLKLVVRKGNQTENVYMELT 160

                         170       180
                  ....*....|....*....|
gi 2462579627 131 LPQFYSFLHEMERVRTSMEC 150
Cdd:cd04755   161 LPQFYSFLHEMERAKASLEC 180
 
Name Accession Description Interval E-value
Commd7 cd04755
COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of ...
 19-150 1.22e-63

COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240103  Cd Length: 180  Bit Score: 192.66  E-value: 1.22e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462579627  19 MQQLNQLGA-QFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGSLRSIVKSLLLVPNGALKKSLTAKQVQADFIT 97
Cdd:cd04755     1 IQNLNQLSEqQFSRLTEILFEFLLEPKESERLLNQLDEFAGENGISLGPLKNIVKSILLVPNGALKRNLTAEQLREDLIQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462579627  98 LGLSEEKATYFSEK-----------------------------------------------LKLVVKKGNQTENVYIELT 130
Cdd:cd04755    81 LGLSEEKASYFSEQwkqhystlsrsavgqtlmvnqlvdmewkfgvtagsselqkvgsiflqLKLVVRKGNQTENVYMELT 160

                         170       180
                  ....*....|....*....|
gi 2462579627 131 LPQFYSFLHEMERVRTSMEC 150
Cdd:cd04755   161 LPQFYSFLHEMERAKASLEC 180
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 112-144 3.19e-03

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 34.45  E-value: 3.19e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2462579627 112 LKLVVKKGNQ-TENVYIELTLPQFYSFLHEMERV 144
Cdd:pfam07258  31 LELKLSDGDGsSEEVTFELSKEQLQDLLNELEEA 64
 
Name Accession Description Interval E-value
Commd7 cd04755
COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of ...
 19-150 1.22e-63

COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240103  Cd Length: 180  Bit Score: 192.66  E-value: 1.22e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462579627  19 MQQLNQLGA-QFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGSLRSIVKSLLLVPNGALKKSLTAKQVQADFIT 97
Cdd:cd04755     1 IQNLNQLSEqQFSRLTEILFEFLLEPKESERLLNQLDEFAGENGISLGPLKNIVKSILLVPNGALKRNLTAEQLREDLIQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462579627  98 LGLSEEKATYFSEK-----------------------------------------------LKLVVKKGNQTENVYIELT 130
Cdd:cd04755    81 LGLSEEKASYFSEQwkqhystlsrsavgqtlmvnqlvdmewkfgvtagsselqkvgsiflqLKLVVRKGNQTENVYMELT 160

                         170       180
                  ....*....|....*....|
gi 2462579627 131 LPQFYSFLHEMERVRTSMEC 150
Cdd:cd04755   161 LPQFYSFLHEMERAKASLEC 180
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 111-148 3.59e-05

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 39.98  E-value: 3.59e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2462579627 111 KLKLVVKKGNQTENVYIELTLPQFYSFLHEMERVRTSM 148
Cdd:cd04748    50 QLKLQVGDNNSSEKICFEMTKEELQNFLNKLKKIKAQL 87
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 112-144 3.19e-03

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 34.45  E-value: 3.19e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2462579627 112 LKLVVKKGNQ-TENVYIELTLPQFYSFLHEMERV 144
Cdd:pfam07258  31 LELKLSDGDGsSEEVTFELSKEQLQDLLNELEEA 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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