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Conserved domains on  [gi|2462568658|ref|XP_054178585|]
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zinc finger protein 461 isoform X1 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 12142358)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
200-388 1.84e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 1.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568658 200 KPYECKQCGKAFIRGFQLTEHLR--LHTGE--KPYECKE--CGKTFRHRSHLTIHQRIHTGEKPYECRECgkafsyHSSF 273
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLL------NSSS 361

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568658 274 SHHQKIHSgkkpyechecgkafcDGLQLTLHQRIHTGEKPYEC--KECGKTFRQCSHLKRHQRIHTGEKPHECM--ICGK 349
Cdd:COG5048   362 KFSPLLNN---------------EPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSK 426

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2462568658 350 AFRLHSHLIQHQRIHTGEKPYECkECGKAFSYHSSFSHH 388
Cdd:COG5048   427 SFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
160-185 4.63e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.63e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462568658 160 ELTLHQRIHTGEKPYECKECGKAFRQ 185
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
200-388 1.84e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 1.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568658 200 KPYECKQCGKAFIRGFQLTEHLR--LHTGE--KPYECKE--CGKTFRHRSHLTIHQRIHTGEKPYECRECgkafsyHSSF 273
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLL------NSSS 361

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568658 274 SHHQKIHSgkkpyechecgkafcDGLQLTLHQRIHTGEKPYEC--KECGKTFRQCSHLKRHQRIHTGEKPHECM--ICGK 349
Cdd:COG5048   362 KFSPLLNN---------------EPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSK 426

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2462568658 350 AFRLHSHLIQHQRIHTGEKPYECkECGKAFSYHSSFSHH 388
Cdd:COG5048   427 SFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
328-351 8.72e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.72e-04
                          10        20
                  ....*....|....*....|....
gi 2462568658 328 HLKRHQRIHTGEKPHECMICGKAF 351
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
160-185 4.63e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.63e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462568658 160 ELTLHQRIHTGEKPYECKECGKAFRQ 185
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
200-388 1.84e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 1.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568658 200 KPYECKQCGKAFIRGFQLTEHLR--LHTGE--KPYECKE--CGKTFRHRSHLTIHQRIHTGEKPYECRECgkafsyHSSF 273
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLL------NSSS 361

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568658 274 SHHQKIHSgkkpyechecgkafcDGLQLTLHQRIHTGEKPYEC--KECGKTFRQCSHLKRHQRIHTGEKPHECM--ICGK 349
Cdd:COG5048   362 KFSPLLNN---------------EPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSK 426

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2462568658 350 AFRLHSHLIQHQRIHTGEKPYECkECGKAFSYHSSFSHH 388
Cdd:COG5048   427 SFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
340-436 3.08e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 3.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568658 340 KPHECMICGKAFRLHSHLIQHQRIHTGEKPYEC--KECGKAFSYHSSFSHHQRIHSGKKPYQCGKAFNHRLQLNLHQTLH 417
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90
                  ....*....|....*....
gi 2462568658 418 TGEKPVRFPLLPPHPSLAS 436
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPP 130
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
144-293 9.77e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 9.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568658 144 KRYECNECGKAFNYGSELTLHQR--IHTGE--KPYECKE--CGKAFRQRSQLTQHQRLHTGEKPYECKQC-------GKA 210
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568658 211 FIRGFQLTEHLRLHTGEKPYEC--KECGKTFRHRSHLTIHQRIHTGEKPYECR--ECGKAFSYHSSFSHHQKIHSGKKPY 286
Cdd:COG5048   368 NNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447


                  ....*..
gi 2462568658 287 ECHECGK 293
Cdd:COG5048   448 LCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
102-434 1.08e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568658 102 NTPCLFKQQTIQNGDKCNECKECWKAFVHCSQLK-HLRIHNGEKRYECNECGKAFNYG--SELTLHQRIHTGEKPYE--- 175
Cdd:COG5048    17 SSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTrHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLnsk 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568658 176 --------------------------CKECGKAFRQRSQLTQHQRLHTGEKPYECKQCGKAFIRGFQ------------- 216
Cdd:COG5048    97 slplsnskasssslsssssnsndnnlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnslhpplpansl 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568658 217 ---------LTEHLRLHTGEKPYECKECGKTFRHRSHLTIHQRIHTGEKPYECRECGKAFSYH------SSFSHHQKIHS 281
Cdd:COG5048   177 skdpssnlsLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSS 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568658 282 GKKPYECHECGKAFCDGLQLTLHQRIHTG-EKPYECKECGKTFRQCSHLKRHQR--IHTGE--KPHEC--MICGKAFRLH 354
Cdd:COG5048   257 ASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRN 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568658 355 SHLIQHQRIHTGEKPYECKECGKAFSY--------HSSFSHHQRIHSGKKPYQ----CGKAFNHRLQLNLHQTLHTGEKP 422
Cdd:COG5048   337 DALKRHILLHTSISPAKEKLLNSSSKFspllnnepPQSLQQYKDLKNDKKSETlsnsCIRNFKRDSNLSLHIITHLSFRP 416

                         410
                  ....*....|..
gi 2462568658 423 VRFPLLPPHPSL 434
Cdd:COG5048   417 YNCKNPPCSKSF 428
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
256-400 1.88e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 1.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568658 256 KPYECRECGKAFSYHSSFSHHQ--KIHSGK--KPYECHE--CGKAFCDGLQLTLHQRIHTGEKPYECK--ECGKTFRQCS 327
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568658 328 HLKRHQRIH-----TGEKPHEC-MICGKAFRLHSHLIQHQRI-HTGEKPYECK--ECGKAFSYHSSFSHHQRIHSGKKPY 398
Cdd:COG5048   368 NNEPPQSLQqykdlKNDKKSETlSNSCIRNFKRDSNLSLHIItHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447


                  ..
gi 2462568658 399 QC 400
Cdd:COG5048   448 LC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
328-351 8.72e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.72e-04
                          10        20
                  ....*....|....*....|....
gi 2462568658 328 HLKRHQRIHTGEKPHECMICGKAF 351
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
356-381 1.21e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.21e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462568658 356 HLIQHQRIHTGEKPYECKECGKAFSY 381
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 310-388 3.04e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 3.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568658 310 GEKPYECK--ECGKTFRQCSHLKRHQRI-HTGEKPHEcmicgkafrlHSHLIQHQRIHTGEKPYECKECGKAF------S 380
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHE----------NPSPEKMNIFSAKDKPYRCEVCDKRYknlnglK 415


                  ....*...
gi 2462568658 381 YHSSFSHH 388
Cdd:COG5189   416 YHRKHSHD 423
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
137-276 4.04e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 4.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568658 137 LRIHNGE--KRYECNE--CGKAFNYGSELTLHQRIHTGEKPYECK--ECGKAFRQRS-----QLTQHQRLHTGEKPYEC- 204
Cdd:COG5048   311 SVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETl 390

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462568658 205 -KQCGKAFIRGFQLTEHLRLHTGEKPYECK--ECGKTFRHRSHLTIHQRIHTGEKPYECRECGKaFSYHSSFSHH 276
Cdd:COG5048   391 sNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
244-269 4.28e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.28e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462568658 244 HLTIHQRIHTGEKPYECRECGKAFSY 269
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
160-185 4.63e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.63e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462568658 160 ELTLHQRIHTGEKPYECKECGKAFRQ 185
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 314-336 6.70e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 6.70e-03
                          10        20
                  ....*....|....*....|...
gi 2462568658 314 YECKECGKTFRQCSHLKRHQRIH 336
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
189-213 7.64e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.64e-03
                          10        20
                  ....*....|....*....|....*
gi 2462568658 189 LTQHQRLHTGEKPYECKQCGKAFIR 213
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
301-325 8.52e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.52e-03
                          10        20
                  ....*....|....*....|....*
gi 2462568658 301 LTLHQRIHTGEKPYECKECGKTFRQ 325
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 230-252 9.54e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.43  E-value: 9.54e-03
                          10        20
                  ....*....|....*....|...
gi 2462568658 230 YECKECGKTFRHRSHLTIHQRIH 252
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
217-241 9.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 9.58e-03
                          10        20
                  ....*....|....*....|....*
gi 2462568658 217 LTEHLRLHTGEKPYECKECGKTFRH 241
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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