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Conserved domains on  [gi|2462567471|ref|XP_054178004|]
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zinc finger protein 225 isoform X2 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
119-551 2.31e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.89  E-value: 2.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 119 KLYNCDVCGKEFNQSSHLQIHQRIHTGEKPFKC--EQCGKGFSRRSGLYVHRKLHTGVKPHICEKCGKAFihDSQLQEHQ 196
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLS--NSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 197 RIHTGEKPFKCDICCK-----SFRSRANLNRHSMVHMREKPFRcdTCGKSFGLKSALNSHRMVHTGEkrykcEECGKRFI 271
Cdd:COG5048   110 LSSSSSNSNDNNLLSShslppSSRDPQLPDLLSISNLRNNPLP--GNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 272 YRQDLYKHQIDHTGEKPYNCKECGKSFRWASGLSRHVRVHSgETTFKCEECGKGFYTNSQRYSHQRAHSgekPYRCEECG 351
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSS---SDSSSSAS 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 352 KGYKRRLDLDFHQRVHrgekpynckecgksfGWASCLLNHQRIhsgEKPFKCEECGKRFTQNSQLYTHRR--VHSGE--K 427
Cdd:COG5048   259 ESPRSSLPTASSQSSS---------------PNESDSSSEKGF---SLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslK 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 428 PFKCEE--CGKRFTQNSQLYSHRRVHTGVKPYKC--EECGKGFNSKFNLDMHQRVH-----TGERPYNC--KECGKSFSR 496
Cdd:COG5048   321 PFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKR 400

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462567471 497 ASSILNHKRLH--GDEKPFKCEECGKRFTENSQLHSHQRVHTGEKPYKCEKCGKSFR 551
Cdd:COG5048   401 DSNLSLHIITHlsFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
119-551 2.31e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.89  E-value: 2.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 119 KLYNCDVCGKEFNQSSHLQIHQRIHTGEKPFKC--EQCGKGFSRRSGLYVHRKLHTGVKPHICEKCGKAFihDSQLQEHQ 196
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLS--NSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 197 RIHTGEKPFKCDICCK-----SFRSRANLNRHSMVHMREKPFRcdTCGKSFGLKSALNSHRMVHTGEkrykcEECGKRFI 271
Cdd:COG5048   110 LSSSSSNSNDNNLLSShslppSSRDPQLPDLLSISNLRNNPLP--GNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 272 YRQDLYKHQIDHTGEKPYNCKECGKSFRWASGLSRHVRVHSgETTFKCEECGKGFYTNSQRYSHQRAHSgekPYRCEECG 351
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSS---SDSSSSAS 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 352 KGYKRRLDLDFHQRVHrgekpynckecgksfGWASCLLNHQRIhsgEKPFKCEECGKRFTQNSQLYTHRR--VHSGE--K 427
Cdd:COG5048   259 ESPRSSLPTASSQSSS---------------PNESDSSSEKGF---SLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslK 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 428 PFKCEE--CGKRFTQNSQLYSHRRVHTGVKPYKC--EECGKGFNSKFNLDMHQRVH-----TGERPYNC--KECGKSFSR 496
Cdd:COG5048   321 PFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKR 400

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462567471 497 ASSILNHKRLH--GDEKPFKCEECGKRFTENSQLHSHQRVHTGEKPYKCEKCGKSFR 551
Cdd:COG5048   401 DSNLSLHIITHlsFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 126-167 1.19e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 41.00  E-value: 1.19e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2462567471 126 CGKEFNQSSHLQIHQRIHTgekpFKCEQCGKGFSRRSGLYVH 167
Cdd:cd20908     7 CDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
192-216 1.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.06e-03
                          10        20
                  ....*....|....*....|....*
gi 2462567471 192 LQEHQRIHTGEKPFKCDICCKSFRS 216
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
119-551 2.31e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.89  E-value: 2.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 119 KLYNCDVCGKEFNQSSHLQIHQRIHTGEKPFKC--EQCGKGFSRRSGLYVHRKLHTGVKPHICEKCGKAFihDSQLQEHQ 196
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLS--NSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 197 RIHTGEKPFKCDICCK-----SFRSRANLNRHSMVHMREKPFRcdTCGKSFGLKSALNSHRMVHTGEkrykcEECGKRFI 271
Cdd:COG5048   110 LSSSSSNSNDNNLLSShslppSSRDPQLPDLLSISNLRNNPLP--GNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 272 YRQDLYKHQIDHTGEKPYNCKECGKSFRWASGLSRHVRVHSgETTFKCEECGKGFYTNSQRYSHQRAHSgekPYRCEECG 351
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSS---SDSSSSAS 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 352 KGYKRRLDLDFHQRVHrgekpynckecgksfGWASCLLNHQRIhsgEKPFKCEECGKRFTQNSQLYTHRR--VHSGE--K 427
Cdd:COG5048   259 ESPRSSLPTASSQSSS---------------PNESDSSSEKGF---SLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslK 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 428 PFKCEE--CGKRFTQNSQLYSHRRVHTGVKPYKC--EECGKGFNSKFNLDMHQRVH-----TGERPYNC--KECGKSFSR 496
Cdd:COG5048   321 PFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKR 400

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462567471 497 ASSILNHKRLH--GDEKPFKCEECGKRFTENSQLHSHQRVHTGEKPYKCEKCGKSFR 551
Cdd:COG5048   401 DSNLSLHIITHlsFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
34-503 1.47e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.95  E-value: 1.47e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471  34 SMVNSFQFSKQDDMPCQVDAGLSIIHVRQKPSEgrTCKKSFSDVSVLDLHQQLQSREKSHTC--DECGKSFCYSSALRIH 111
Cdd:COG5048     5 SSQSSSSNNSVLSSTPKSTLKSLSNAPRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRH 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 112 QR-VHMGEKLYNCDVCGKEFNQSSHLQIHQRIHTGEKPFKCEQCGKGFSRRSGLYVHRKLHTGVKPHICEKCGKAFIHDS 190
Cdd:COG5048    83 LRtHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTP 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 191 QLQEHqrIHTGEKPFKCDICCKSFRSRANLNRHSMVhmreKPFRCDTCGKSFGLKSALNSHRMVHTGEKRYKCEECGKRF 270
Cdd:COG5048   163 QSNSL--HPPLPANSLSKDPSSNLSLLISSNVSTSI----PSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLS 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 271 IYRQDLYKHQidhTGEKPYNCKECGKSFR---------WASGLSRHVRVHSGETT-FKCEECGKGFYTNSQRYSHQRA-- 338
Cdd:COG5048   237 PKSLLSQSPS---SLSSSDSSSSASESPRsslptassqSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSvn 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 339 HSGEkpyrceecgkgykrrldldfhqrvhrGEKPYNCKE--CGKSFGWASCLLNHQRIHSGEKPFKC--EECGKRFTQNS 414
Cdd:COG5048   314 HSGE--------------------------SLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 415 -----QLYTHRRVHSGEKPFKCE--ECGKRFTQNSQLYSHRRVHTGVKP--YKCEECGKGFNSKFNLDMHQRVHTGERPY 485
Cdd:COG5048   368 nneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         490
                  ....*....|....*...
gi 2462567471 486 NCkeCGKSFSRASSILNH 503
Cdd:COG5048   448 LC--SILKSFRRDLDLSN 463
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
15-224 2.51e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 2.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471  15 LFSHQTWEQISSDLtrfqDSMVNSFQFSKQDDMPCQVDAGLSIIHVRQKPS-EGRTCKKSFSDVSVLDLH-QQLQSREKS 92
Cdd:COG5048   214 SSSDQNLENSSSSL----PLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESpRSSLPTASSQSSSPNESDsSSEKGFSLP 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471  93 HTCDECGKSFCYSSALRIHQR--VHMGEKL--YNCDV--CGKEFNQSSHLQIHQRIHTGEKPFKC--------------- 151
Cdd:COG5048   290 IKSKQCNISFSRSSPLTRHLRsvNHSGESLkpFSCPYslCGKLFSRNDALKRHILLHTSISPAKEkllnssskfspllnn 369

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 152 ----------------------EQCGKGFSRRSGLYVHRKLHTGVKPH--ICEKCGKAFIHDSQLQEHQRIHTGEKPFKC 207
Cdd:COG5048   370 eppqslqqykdlkndkksetlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449

                         250
                  ....*....|....*..
gi 2462567471 208 dICCKSFRSRANLNRHS 224
Cdd:COG5048   450 -SILKSFRRDLDLSNHG 465
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 285-367 4.87e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 4.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 285 GEKPYNCK--ECGKSFRWASGLSRHvRVHSgettfkceECGKGFYTNSQRYSHQRAHSGEKPYRCEECGKGYKRRLDLDF 362
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*
gi 2462567471 363 HqRVH 367
Cdd:COG5189   417 H-RKH 420
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 341-424 1.05e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 1.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 341 GEKPYRCE--ECGKGYKRRLDLDFHqRVHrgekpyncKECGKSFGWASCLLNHQRIHSGEKPFKCEECGKRFTQNSQLYT 418
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 2462567471 419 HRRvHS 424
Cdd:COG5189   417 HRK-HS 421
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 126-167 1.19e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 41.00  E-value: 1.19e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2462567471 126 CGKEFNQSSHLQIHQRIHTgekpFKCEQCGKGFSRRSGLYVH 167
Cdd:cd20908     7 CDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
287-564 1.43e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 287 KPYNCKECGKSFRWASGLSRHVRVHSGETTFKC--EECGKGFYTNSQRYSHQRAHSGEKPYRCEECGKG--YKRRLDLDF 362
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 363 HQRVH--RGEKPYNCKECGKSFGWASCLLnHQRIHSGEKPFK--------------------CEECGKRFTQNSQLYTHR 420
Cdd:COG5048   112 SSSSNsnDNNLLSSHSLPPSSRDPQLPDL-LSISNLRNNPLPgnnsssvntpqsnslhpplpANSLSKDPSSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 421 RVHSGEKPFKCEECGKRFTQNSQLYSHRRVHTGVKPYKCEECGkgFNSKFNLDMHQRVHTGErPYNCKECGKSFSRASSI 500
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS--QLSPKSLLSQSPSSLSS-SDSSSSASESPRSSLPT 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 501 LNHKRLHGDE----------KPFKCEECGKRFTENSQLHSHQR--VHTGE--KPYKC--EKCGKSFRWASTHLTHQRLHS 564
Cdd:COG5048   268 ASSQSSSPNEsdsssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 426-564 1.69e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 426 EKPFKCEECGKRFTQNSQLY----SHRRVHTGVKPYKCE--ECGKGFNSKFNLDMHqrvhtgerpynckecgksfsrass 499
Cdd:COG5189   315 KLPCTNSSSNGKLAHGGERNidtpSRMLKVKDGKPYKCPveGCNKKYKNQNGLKYH------------------------ 370

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462567471 500 ilnhkRLHGdekpfkceECGKRFTENSQLHSHQRVHTGEKPYKCEKCGKSFRwASTHLTHQRLHS 564
Cdd:COG5189   371 -----MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYK-NLNGLKYHRKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
130-307 2.36e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 2.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 130 FNQSSHLQIHQRIHTG-EKPFKCEQCGKGFSRRSGLYVHR--KLHTG--VKPHIC--EKCGKAFIHDSQLQEHQRIHTGE 202
Cdd:COG5048   270 SQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGesLKPFSCpySLCGKLFSRNDALKRHILLHTSI 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567471 203 KPFKC--DICCKSFRSRANLNRHSMVHMR-----EKPFRCD--TCGKSFGLKSALNSHRMVHT--GEKRYKCEECGKRFI 271
Cdd:COG5048   350 SPAKEklLNSSSKFSPLLNNEPPQSLQQYkdlknDKKSETLsnSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFN 429

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2462567471 272 YRQDLYKHQIDHTGEKPYNCkECGKSFRWASGLSRH 307
Cdd:COG5048   430 RHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
192-216 1.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.06e-03
                          10        20
                  ....*....|....*....|....*
gi 2462567471 192 LQEHQRIHTGEKPFKCDICCKSFRS 216
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
135-160 1.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.11e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462567471 135 HLQIHQRIHTGEKPFKCEQCGKGFSR 160
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
471-496 1.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.53e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462567471 471 NLDMHQRVHTGERPYNCKECGKSFSR 496
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
388-412 2.74e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.74e-03
                          10        20
                  ....*....|....*....|....*
gi 2462567471 388 LLNHQRIHSGEKPFKCEECGKRFTQ 412
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 397-448 3.55e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.55e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462567471 397 GEKPFKCE--ECGKRFTQNSQLYTHRR-------------------VHSGEKPFKCEECGKRFTQNSQLYSHR 448
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 210-279 4.04e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 37.01  E-value: 4.04e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462567471 210 CCKSFRSRANLNRHSMVH------MREKPFRCD--TCGKSFGLKSALNSHRMVHTGEKRY-KCEECGKRFIYRQDLYKH 279
Cdd:pfam15909   7 CCLSFPSVRDLAQHLRTHcpptqsLEGKLFRCSalSCTETFPSMQELVAHSKLHYKPNRYfKCENCLLRFRTHRSLFKH 85
zf-H2C2_2 pfam13465
Zinc-finger double domain;
416-440 5.40e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.40e-03
                          10        20
                  ....*....|....*....|....*
gi 2462567471 416 LYTHRRVHSGEKPFKCEECGKRFTQ 440
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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