BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198  94 NWQASKPTVQERFAFLFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLAL 173
Cdd:cd18281     1 NWQASKTTVKERFAFLFNNETLSDVHFIVGKGDNEQRIPAHKFVLSIGSAVFDAMFNGGMATTSAEIELPDVEPAAFLAL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2462566198 174 LKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 220
Cdd:cd18281    81 LRFLYSDEVQIGPETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198 287 QARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWSEAECQRQQLQVTPENRR 366
Cdd:cd18523    12 QARLFDEPQLASLCLENIDKNTSDAINAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWAEAECQRQQLQVTPENKR 91

                          90
                  ....*....|....*
gi 2462566198 367 KVLGKALGLIRFPLM 381
Cdd:cd18523    92 KVLGKALSLIRFPLM 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198  94 NWQASKPTVQERFAFLFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLAL 173
Cdd:cd18281     1 NWQASKTTVKERFAFLFNNETLSDVHFIVGKGDNEQRIPAHKFVLSIGSAVFDAMFNGGMATTSAEIELPDVEPAAFLAL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2462566198 174 LKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 220
Cdd:cd18281    81 LRFLYSDEVQIGPETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198 287 QARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWSEAECQRQQLQVTPENRR 366
Cdd:cd18523    12 QARLFDEPQLASLCLENIDKNTSDAINAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWAEAECQRQQLQVTPENKR 91

                          90
                  ....*....|....*
gi 2462566198 367 KVLGKALGLIRFPLM 381
Cdd:cd18523    92 KVLGKALSLIRFPLM 106

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198  117 DVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMA-TTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYT 195
Cdd:smart00225   1 DVTLVVG----GKKFHAHKAVLAAHSPYFKALFSSDFKeSDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLEL 76

                           90       100
                   ....*....|....*....|.
gi 2462566198  196 AKKYAVPALEAHCVEFLKKNL 216
Cdd:smart00225  77 ADYLQIPGLVELCEEFLLKLL 97

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198 288 ARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGI-REVRLFNAVVRWseaecqrqqLQVTPENRR 366
Cdd:pfam07707   8 ADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVpSEEEVFEAVIRW---------VKHDVERRK 78

                          90
                  ....*....|....*.
gi 2462566198 367 KVLGKALGLIRFPLMT 382
Cdd:pfam07707  79 KHLPELLSAVRLPLLS 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198  94 NWQASKPTVQERFAFLFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLAL 173
Cdd:cd18281     1 NWQASKTTVKERFAFLFNNETLSDVHFIVGKGDNEQRIPAHKFVLSIGSAVFDAMFNGGMATTSAEIELPDVEPAAFLAL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2462566198 174 LKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 220
Cdd:cd18281    81 LRFLYSDEVQIGPETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127

PHR domain; This domain is called PHR as it was original found in the proteins PAM, highwire and RPM. This domain can be duplicated in the highwire, PFAM and PRM sequence. The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198 434 NRFQQVESRWGYSGTS-DRIRFSVNKRIFVVGFGLYGSIHGPTDYQVNIQIIHTD----SNTVLGQNDTGFSCDGSASTF 508
Cdd:pfam08005   1 NRFQSTGGGWGYSGGSpDAIRFSVDRDIFLVGFGLYGSIGGPADYSVKIELIDGErwesLGEVLGENDTTFSSDGSNDIF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462566198 509 RVMFKEPVEVLPNVNYTACATLKGPDSHYGTKGLRKVTHESpttgaKTCFTFCYAAGNNNGTSVEDGQIPEVIFY 583
Cdd:pfam08005  81 RVLFDEPVEIEPNVKYTASAKIKGPSSYYGTNGLREVTCDG-----GVTFQFSSSSLSNNGTSVNRGQIPELLYY 150

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198 287 QARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWSEAECQRQQLQVTPENRR 366
Cdd:cd18523    12 QARLFDEPQLASLCLENIDKNTSDAINAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWAEAECQRQQLQVTPENKR 91

                          90
                  ....*....|....*
gi 2462566198 367 KVLGKALGLIRFPLM 381
Cdd:cd18523    92 KVLGKALSLIRFPLM 106

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein specifically expressed in skeletal muscle. It interacts with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. It may serve as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198 287 QARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWSEAECQRQQLQVTPENRR 366
Cdd:cd18522    12 QARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDLDTLCAVLERDTLSIRESRLFGAVVRWAEAECQRQQLPVTSENKQ 91

                          90
                  ....*....|....*.
gi 2462566198 367 KVLGKALGLIRFPLMT 382
Cdd:cd18522    92 KVLGKALSLIRFPLMT 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198 109 LFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPET 188
Cdd:cd18349     2 MFNNELMADVHFIVGPPGASQRVPAHKYVLAVGSSVFYAMFYGDLAEVKSEIHIPDVEPAAFLILLKYMYSDEIDLEADT 81

                          90       100
                  ....*....|....*....|....*...
gi 2462566198 189 VMTTLYTAKKYAVPALEAHCVEFLKKNL 216
Cdd:cd18349    82 VLATLYAAKKYIVPALAKACVNFLETSL 109

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This subfamily includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198 287 QARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWSEAECQRQQLQVTPENRR 366
Cdd:cd18488    12 QSRLFEEPELMQRCWEVIDAQAELALKSEGFTEIDYKTLESILRRETLNAKESVVFEAALRWAEAECQRRGLEPTPENKR 91

                  ....
gi 2462566198 367 KVLG 370
Cdd:cd18488    92 KVLG 95

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also called lens BTB domain protein, is a BTB-domain-containing Kelch-like protein that is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198 287 QARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWSEAECQRQQLQVTPENRR 366
Cdd:cd18525    12 QSRLFEEPELTQRCWEVIDAQAELALKSEGFCEIDQQTLEIILTRETLNTKEVVVFEAVLNWAEAECKRQGLPPTARNKR 91

                  ....
gi 2462566198 367 KVLG 370
Cdd:cd18525    92 NVLG 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198 115 LCDVHFLVGKglssQRIPAHRFVLAVGSAVFDAMFNGGMAT-TSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTL 193
Cdd:cd18186     1 LCDVTLVVGG----REFPAHRAVLAARSPYFRAMFSSGMKEsSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELL 76

                  ....*.
gi 2462566198 194 YTAKKY 199
Cdd:cd18186    77 AAADKL 82

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198  117 DVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMA-TTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYT 195
Cdd:smart00225   1 DVTLVVG----GKKFHAHKAVLAAHSPYFKALFSSDFKeSDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLEL 76

                           90       100
                   ....*....|....*....|.
gi 2462566198  196 AKKYAVPALEAHCVEFLKKNL 216
Cdd:smart00225  77 ADYLQIPGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198 112 NEVLCDVHFLVgkglSSQRIPAHRFVLAVGSAVFDAMFNGGMATTST-EIELPDVEPAAFLALLKFLYSDEVQIGPETVM 190
Cdd:cd18237    18 QKTLCDVILIV----EGREIKAHRVVLAAASHFFHLMFTSNMTESKSsEVELKDAEPDIIELLVEFAYTARISVNSNNVQ 93

                          90       100       110
                  ....*....|....*....|....*....|
gi 2462566198 191 TTLYTAKKYAVPALEAHCVEFLKKNLRADN 220
Cdd:cd18237    94 SLLDAANQYQIEPVKKMCVDFLKEQLDASN 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198  99 KPTVQERFAFLFNNEVLCDVHFLVGKglssQRIPAHRFVLAVGSAVFDAMF--NGGMATTSTEIELpdVEP----AAFLA 172
Cdd:cd18292     1 SREFLQDIAQLYNNEELSDIVLRVGG----KVFHAHRLILAKSSDVFRVMLsnDWWSESKQSEIEL--VEDpecaAVFEK 74

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2462566198 173 LLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEF 211
Cdd:cd18292    75 FLRYLYTGQISVNLETALPLLMLADKYNVTDLKQLCVDF 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198 115 LCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGM-ATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTL 193
Cdd:cd18234     1 LCDVILIAG----DRRIPAHRLVLSAVSDYFAAMFTNDVrEATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLL 76

                          90       100
                  ....*....|....*....|....*..
gi 2462566198 194 YTAKKYAVPALEAHCVEFLKKNLRADN 220
Cdd:cd18234    77 ATACLLQLSEVVEACCGFLMKQLHPSN 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198 116 CDVHFLVGKglssQRIPAHRFVLAVGSAVFDAMFNGGMATTSTE-IELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLY 194
Cdd:cd18256    21 CDVQLQVGM----ELFSVHRLVLAASSPYFAALFAGGMSESSKDvVQIHGVEPDIFHILLDFIYTGVVEVTVSNVQELLV 96

                          90       100
                  ....*....|....*....|....*..
gi 2462566198 195 TAKKYAVPALEAHCVEFLKKNLRADNA 221
Cdd:cd18256    97 AADMLQLTEVVEICCEFLKGQLHPSNC 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198 106 FAFLFNNEVLCDVHFLV-GKglssqRIPAHRFVLAVGSAVFDAMFNGGMATTS-TEIELPDVEPAAFLALLKFLYS---D 180
Cdd:cd18297     3 DPHYVNNPEMSDVTFLVeGR-----PFYAHKIVLVTASDRFKSMLSSGSTEAQtPVIEIPDIRYDIFQLMMQYLYTggvE 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2462566198 181 EVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 220
Cdd:cd18297    78 SLDVAQDDALELLRAASFFQLDGLKRHCEILLSQQIDLDN 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198 112 NEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTS-TEIELPDVEPAAFLALLKFLYSDEVQIGPETVM 190
Cdd:cd18248    18 SQQLCDVTLKVKYQDPKEEFMAHKVVLASSSPYFKAMFTSGLRECGmEVVPIEGVHPCVMSRLIEFAYTASISVGEKCVL 97

                          90       100
                  ....*....|....*....|....*.
gi 2462566198 191 TTLYTAKKYAVPALEAHCVEFLKKNL 216
Cdd:cd18248    98 HVLPGAVMYQMDSVVKACCDFLEQQL 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198 106 FAFLFNNEVLCDVHFLVgkglSSQRIPAHRFVLAVGSAVFDAMFNGGMATTST-EIELPDVEPAAFLALLKFLYSDEVQI 184
Cdd:cd18280     5 FGALLESEEGADVTFNV----DGEKFRAHKLVLAARSPVFRSMLFGPMREENEgEIVIEDVEPPVFKALLHFIYKDELPD 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2462566198 185 GPE----------TVMTT--LYTAKKYAVPALEAHC 208
Cdd:cd18280    81 DVEpagsdsssldTTMAQhlLAAADRYALERLRLLC 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198 109 LFNNEVLCDVHFLVGKglssQRIPAHRFVLAVGSAVFDamfNGGMATTStEIELPDVEPAAFLALLKFLYSDEVQIG--P 186
Cdd:cd18303    12 LFDKELYSDITIKLAD----KSIPAHKFVLAARSEKWS---NENLASTN-ELDLSDISYEVVLALLRWLYTDELDLTldD 83

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2462566198 187 ETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 220
Cdd:cd18303    84 EFLLELMKAAKRFQLTDLVERCERALMSSVNVDN 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198 109 LFNNEVLCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMATT-STEIELPDVEPAAFLALLKFLYSDEVQIGPE 187
Cdd:cd18259    26 LRSNPKLSDVTLLVG----GREFPCHRSVLALCSHYFNAMFTGDFVESiSARVEIKDVDPAVMESLIDFAYTGKLTINQG 101

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2462566198 188 TVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 220
Cdd:cd18259   102 NVEALIRTSNRLQFPTVRKVCSRYLQQQIDATN 134

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198 109 LFNNEVLCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMA-TTSTEIELPDVEPAAFLALLKFLYSDEVQIGPE 187
Cdd:cd18279    12 LWENSRFTDCCLCVG----GQEFQAHKAILAARSPVFSAMFEHEMEeSKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDK 87

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2462566198 188 TVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 220
Cdd:cd18279    88 MADDLLAAADKYALERLKVMCEDALCSNLSVEN 120

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198 109 LFNNEVLCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGG-MATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPE 187
Cdd:cd18286    11 LFLNGEDSDITIKVD----GKTFKAHRCILCARSSYFAAMLSGSwAESNSSEITLTGVSHAAVSFVLLFIYGGVLDLPDD 86

                          90
                  ....*....|....*...
gi 2462566198 188 TVMTTL-YTAKKYAVPAL 204
Cdd:cd18286    87 VNLGELlSLADMYGLDGL 104

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198 288 ARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWSEAEcqrqqlQVTPENRRK 367
Cdd:cd14822    13 ASLYSLDDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSFCAPEVDIFNAVRRWCEHN------PDSKEDAKE 86

                          90
                  ....*....|....*...
gi 2462566198 368 VlgkaLGLIRFPLMTIEE 385
Cdd:cd14822    87 I----LEAVRLPLMSLTE 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198 115 LCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMATTST-EIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTL 193
Cdd:cd18257    18 LCDVVLRVG----DVKIHAHKVVLASCSPYFKAMFTGNLSEKENsEVEFQCIDETALQAIVEYAYTGTVFISQATVESLL 93

                          90       100
                  ....*....|....*....|....*
gi 2462566198 194 YTAKKYAVPALEAHCVEFLKKNLRA 218
Cdd:cd18257    94 PAANLLQIKLVLKECCDFLESQLDP 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566198 132 PAHRFVLAVGSAVFDAMFNGGMA-TTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVE 210
Cdd:cd18340    40 PCHRLVLAACSPYFRAMFLSDLEeSKKREIVLEDVDPDVMGKILHYIYTSEIEITEQNVQDIFAAANMFQIPSIFTVCVS 119

                          90
                  ....*....|
gi 2462566198 211 FLKKNLRADN 220
Cdd:cd18340   120 FLQKRLCLSN 129