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Conserved domains on  [gi|2462565812|ref|XP_054177188|]
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urokinase plasminogen activator surface receptor isoform X9 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_uPAR_rpt2 cd23557
second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 111-199 3.11e-35

second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


:

Pssm-ID: 467087  Cd Length: 85  Bit Score: 120.89  E-value: 3.11e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565812 111 RSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQegeeGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFL 190
Cdd:cd23557     1 RSRYLECYSCGSSDMSCERGRLTSLQCRGPQDQCVDVTTHGSL----ERPKSERRLKGCGTLPGCPGSLGFHNNDTFHLL 76


                  ....*....
gi 2462565812 191 KCCNTTKCN 199
Cdd:cd23557    77 KCCNSSLCN 85
TFP_LU_ECD_uPAR_rpt1 cd23556
first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 23-100 1.03e-20

first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


:

Pssm-ID: 467086  Cd Length: 79  Bit Score: 82.89  E-value: 1.03e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462565812  23 LRCMQCKTNGDCRVEE-CALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQ 100
Cdd:cd23556     1 LRCYSCKSNGDCRVEEvCALGQDLCRTTVMTLWEEGEELELVVKGCDVSGKTNASSSYRTGLNINSLQETVCSSDLCNQ 79
 
Name Accession Description Interval E-value
TFP_LU_ECD_uPAR_rpt2 cd23557
second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 111-199 3.11e-35

second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467087  Cd Length: 85  Bit Score: 120.89  E-value: 3.11e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565812 111 RSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQegeeGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFL 190
Cdd:cd23557     1 RSRYLECYSCGSSDMSCERGRLTSLQCRGPQDQCVDVTTHGSL----ERPKSERRLKGCGTLPGCPGSLGFHNNDTFHLL 76


                  ....*....
gi 2462565812 191 KCCNTTKCN 199
Cdd:cd23557    77 KCCNSSLCN 85
TFP_LU_ECD_uPAR_rpt1 cd23556
first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 23-100 1.03e-20

first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467086  Cd Length: 79  Bit Score: 82.89  E-value: 1.03e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462565812  23 LRCMQCKTNGDCRVEE-CALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQ 100
Cdd:cd23556     1 LRCYSCKSNGDCRVEEvCALGQDLCRTTVMTLWEEGEELELVVKGCDVSGKTNASSSYRTGLNINSLQETVCSSDLCNQ 79
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 115-203 4.00e-16

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 71.03  E-value: 4.00e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565812  115 LECISC-GSSDMSCERGRHqslqCRSPEEQCLDVVTHWIQEGeegrpKDDRHLRGCGYLPGCPGSNGFHNNDTFHFLK-- 191
Cdd:smart00134   1 LQCYSCtGNPDSSCSSEEE----CRSPDDVCLTVVAEVISDS-----RGSVVYKGCATSPICPGSHGYEINLTIAFLKvs 71

                           90
                   ....*....|..
gi 2462565812  192 CCNTTKCNEGPS 203
Cdd:smart00134  72 CCQTDLCNAAGP 83
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 25-99 4.08e-08

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 49.07  E-value: 4.08e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462565812  25 CMQCK--TNGDCRVE-ECALGQDLCRTTIVRLWEEGEELELVEKSCTHSeKTNRTLSYRTGLKITSLTEVVCGLDLCN 99
Cdd:pfam00021   1 CYSCLgvSNEDCLSEvTCPLSDGQCVTTTLELPEGNLRGTVVSKGCARS-SCPRLLSDFINGGIISVSESCCQSDLCN 77
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 23-101 2.63e-07

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 47.14  E-value: 2.63e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565812   23 LRCMQCKTNGD--CRVEE-CALGQDLCRTTIVRlWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCN 99
Cdd:smart00134   1 LQCYSCTGNPDssCSSEEeCRSPDDVCLTVVAE-VISDSRGSVVYKGCATSPICPGSHGYEINLTIAFLKVSCCQTDLCN 79


                   ..
gi 2462565812  100 QG 101
Cdd:smart00134  80 AA 81
 
Name Accession Description Interval E-value
TFP_LU_ECD_uPAR_rpt2 cd23557
second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 111-199 3.11e-35

second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467087  Cd Length: 85  Bit Score: 120.89  E-value: 3.11e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565812 111 RSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQegeeGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFL 190
Cdd:cd23557     1 RSRYLECYSCGSSDMSCERGRLTSLQCRGPQDQCVDVTTHGSL----ERPKSERRLKGCGTLPGCPGSLGFHNNDTFHLL 76


                  ....*....
gi 2462565812 191 KCCNTTKCN 199
Cdd:cd23557    77 KCCNSSLCN 85
TFP_LU_ECD_uPAR_rpt1 cd23556
first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 23-100 1.03e-20

first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467086  Cd Length: 79  Bit Score: 82.89  E-value: 1.03e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462565812  23 LRCMQCKTNGDCRVEE-CALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQ 100
Cdd:cd23556     1 LRCYSCKSNGDCRVEEvCALGQDLCRTTVMTLWEEGEELELVVKGCDVSGKTNASSSYRTGLNINSLQETVCSSDLCNQ 79
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 115-203 4.00e-16

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 71.03  E-value: 4.00e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565812  115 LECISC-GSSDMSCERGRHqslqCRSPEEQCLDVVTHWIQEGeegrpKDDRHLRGCGYLPGCPGSNGFHNNDTFHFLK-- 191
Cdd:smart00134   1 LQCYSCtGNPDSSCSSEEE----CRSPDDVCLTVVAEVISDS-----RGSVVYKGCATSPICPGSHGYEINLTIAFLKvs 71

                           90
                   ....*....|..
gi 2462565812  192 CCNTTKCNEGPS 203
Cdd:smart00134  72 CCQTDLCNAAGP 83
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 25-99 4.08e-08

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 49.07  E-value: 4.08e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462565812  25 CMQCK--TNGDCRVE-ECALGQDLCRTTIVRLWEEGEELELVEKSCTHSeKTNRTLSYRTGLKITSLTEVVCGLDLCN 99
Cdd:pfam00021   1 CYSCLgvSNEDCLSEvTCPLSDGQCVTTTLELPEGNLRGTVVSKGCARS-SCPRLLSDFINGGIISVSESCCQSDLCN 77
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 23-101 2.63e-07

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 47.14  E-value: 2.63e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565812   23 LRCMQCKTNGD--CRVEE-CALGQDLCRTTIVRlWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCN 99
Cdd:smart00134   1 LQCYSCTGNPDssCSSEEeCRSPDDVCLTVVAE-VISDSRGSVVYKGCATSPICPGSHGYEINLTIAFLKVSCCQTDLCN 79


                   ..
gi 2462565812  100 QG 101
Cdd:smart00134  80 AA 81
TFP_LU_ECD_uPAR_rpt3 cd23558
third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 115-201 1.45e-03

third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


Pssm-ID: 467088  Cd Length: 93  Bit Score: 36.99  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565812 115 LECISC-GSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKddrhLRGCGYLPGCPGS----NGFHNNDTFHf 189
Cdd:cd23558     8 IQCYSCnGNSTHGCSSEETSKVRCRGPQTQCLEATGTTAHGGKNQSYM----VKGCATPSMCQSTalslNQVLNSADVR- 82

                          90
                  ....*....|..
gi 2462565812 190 lkCCNTTKCNEG 201
Cdd:cd23558    83 --CCNGSLCNNG 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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