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Conserved domains on  [gi|2462565314|ref|XP_054176945|]
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zinc finger protein 470 isoform X1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204378)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0003700|GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217
PubMed:  22803940|8183940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
23-83 9.00e-33

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 120.39  E-value: 9.00e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462565314   23 VTFTDVAIDFSQDEWEWLNLAQRSLYKKVMLENYRNLVSVGLCISKPDVISLLEQEKDPWV 83
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
254-669 2.02e-17

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 85.52  E-value: 2.02e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 254 KPYECIECGKAFSQSAHLAQHQRIHTGEKPFECT--ECGKAFSQNAHLVQHQRVHTGEKPY-QCKQCNKAFSQLAHlaqh 330
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASS---- 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 331 qrvhtgekpYECIECGKAFSDCSSLAHHRRIHTGKRPYECIDCGKAFRQNASLIRHRRYYHTGEKPF------DCIDCGK 404
Cdd:COG5048   108 ---------SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNslhpplPANSLSK 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 405 AFTDHIGLIQHKRIHTGERPYKCNVCGKAFSHGSSLTVHQRIHTGEKPYECNICekAFSHRGSLTLHQRVHTGEK--PYE 482
Cdd:COG5048   179 DPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSdsSSS 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 483 CKECG------KAFRQSTHLAHHQRIHTG-EKPYECKECSKTFSQNAHLAQHQ--KIHTGE--KPYECKE--CGKAFSQI 549
Cdd:COG5048   257 ASESPrsslptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRN 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 550 AHLVQHQRVHTGEKPYECI--ECGKAFSDGSY-----LVQHQRLHSGKRPYECL--ECGKAFRQRASLICHQRCHTGEKP 620
Cdd:COG5048   337 DALKRHILLHTSISPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRP 416

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462565314 621 YECN--VCGKAFSHRKSLTLHQRIHTGEKPYECkECSKAFSQVAHLTLHKR 669
Cdd:COG5048   417 YNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
663-688 7.07e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.07e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462565314 663 HLTLHKRIHTGERPYECKECGKAFRQ 688
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
23-83 9.00e-33

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 120.39  E-value: 9.00e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462565314   23 VTFTDVAIDFSQDEWEWLNLAQRSLYKKVMLENYRNLVSVGLCISKPDVISLLEQEKDPWV 83
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 22-63 2.04e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.22  E-value: 2.04e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2462565314  22 SVTFTDVAIDFSQDEWEWLNLAQRSLYKKVMLENYRNLVSVG 63
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
254-669 2.02e-17

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 85.52  E-value: 2.02e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 254 KPYECIECGKAFSQSAHLAQHQRIHTGEKPFECT--ECGKAFSQNAHLVQHQRVHTGEKPY-QCKQCNKAFSQLAHlaqh 330
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASS---- 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 331 qrvhtgekpYECIECGKAFSDCSSLAHHRRIHTGKRPYECIDCGKAFRQNASLIRHRRYYHTGEKPF------DCIDCGK 404
Cdd:COG5048   108 ---------SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNslhpplPANSLSK 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 405 AFTDHIGLIQHKRIHTGERPYKCNVCGKAFSHGSSLTVHQRIHTGEKPYECNICekAFSHRGSLTLHQRVHTGEK--PYE 482
Cdd:COG5048   179 DPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSdsSSS 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 483 CKECG------KAFRQSTHLAHHQRIHTG-EKPYECKECSKTFSQNAHLAQHQ--KIHTGE--KPYECKE--CGKAFSQI 549
Cdd:COG5048   257 ASESPrsslptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRN 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 550 AHLVQHQRVHTGEKPYECI--ECGKAFSDGSY-----LVQHQRLHSGKRPYECL--ECGKAFRQRASLICHQRCHTGEKP 620
Cdd:COG5048   337 DALKRHILLHTSISPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRP 416

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462565314 621 YECN--VCGKAFSHRKSLTLHQRIHTGEKPYECkECSKAFSQVAHLTLHKR 669
Cdd:COG5048   417 YNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNHGK 466
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 23-61 4.55e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.89  E-value: 4.55e-17
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2462565314  23 VTFTDVAIDFSQDEWEWLNLAQRSLYKKVMLENYRNLVS 61
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 395-447 1.62e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 43.70  E-value: 1.62e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462565314 395 KPFdCIDCGKAFTDHIGLIQHKRIHTgerpYKCNVCGKAFSHGSSLTVH-QRIH 447
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
270-295 1.36e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.36e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462565314 270 HLAQHQRIHTGEKPFECTECGKAFSQ 295
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
663-688 7.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.07e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462565314 663 HLTLHKRIHTGERPYECKECGKAFRQ 688
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
23-83 9.00e-33

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 120.39  E-value: 9.00e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462565314   23 VTFTDVAIDFSQDEWEWLNLAQRSLYKKVMLENYRNLVSVGLCISKPDVISLLEQEKDPWV 83
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 22-63 2.04e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.22  E-value: 2.04e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2462565314  22 SVTFTDVAIDFSQDEWEWLNLAQRSLYKKVMLENYRNLVSVG 63
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
254-669 2.02e-17

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 85.52  E-value: 2.02e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 254 KPYECIECGKAFSQSAHLAQHQRIHTGEKPFECT--ECGKAFSQNAHLVQHQRVHTGEKPY-QCKQCNKAFSQLAHlaqh 330
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASS---- 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 331 qrvhtgekpYECIECGKAFSDCSSLAHHRRIHTGKRPYECIDCGKAFRQNASLIRHRRYYHTGEKPF------DCIDCGK 404
Cdd:COG5048   108 ---------SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNslhpplPANSLSK 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 405 AFTDHIGLIQHKRIHTGERPYKCNVCGKAFSHGSSLTVHQRIHTGEKPYECNICekAFSHRGSLTLHQRVHTGEK--PYE 482
Cdd:COG5048   179 DPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSdsSSS 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 483 CKECG------KAFRQSTHLAHHQRIHTG-EKPYECKECSKTFSQNAHLAQHQ--KIHTGE--KPYECKE--CGKAFSQI 549
Cdd:COG5048   257 ASESPrsslptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRN 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 550 AHLVQHQRVHTGEKPYECI--ECGKAFSDGSY-----LVQHQRLHSGKRPYECL--ECGKAFRQRASLICHQRCHTGEKP 620
Cdd:COG5048   337 DALKRHILLHTSISPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRP 416

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462565314 621 YECN--VCGKAFSHRKSLTLHQRIHTGEKPYECkECSKAFSQVAHLTLHKR 669
Cdd:COG5048   417 YNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNHGK 466
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 23-61 4.55e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.89  E-value: 4.55e-17
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2462565314  23 VTFTDVAIDFSQDEWEWLNLAQRSLYKKVMLENYRNLVS 61
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
310-695 5.18e-17

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 84.36  E-value: 5.18e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 310 KPYQCKQCNKAFSQLAHLAQHQRVHTGEKPYEC--IECGKAFSDCSSLAHHRRIHTGKRPYECIDCGKAFRQNASLIRHR 387
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 388 RYYHTGEKPFDCIDCGKAFT------------DHIGLIQHKRIHTGERPYKC----------NVCGKAFSHGSSLTVHQR 445
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSsrdpqlpdllsiSNLRNNPLPGNNSSSVNTPQsnslhpplpaNSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 446 IHTGEKPYECNICEKAFSHRGSLTLHQRVHTGEKPYECKECGKAFRQSTHLAHHQRIHTGEKPYECKECSKTFSQNAHLA 525
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 526 QHQKIHTGE-------KPYECKECGKAFSQIAHLVQHQR--VHTGE--KPYEC--IECGKAFSDGSYLVQHQRLHSGKRP 592
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 593 YEC--LECGKAFRQ-----RASLICHQRCHTGEKPYECNV--CGKAFSHRKSLTLHQRIHTGEKPYECKECSKAFSQVAH 663
Cdd:COG5048   352 AKEklLNSSSKFSPllnnePPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRH 431

                         410       420       430
                  ....*....|....*....|....*....|....
gi 2462565314 664 LTL--HKRIHTGERPYECkECGKAFRQSVHLAHH 695
Cdd:COG5048   432 YNLipHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
217-611 2.92e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 2.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 217 KHKQDRGEKKLLKCNDCEKIFSKISTLTLHQRIHTGEKPYEC--IECGKAFSQSAHLAQHQRIHTGEKPFEC-------- 286
Cdd:COG5048    23 TLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNskslplsn 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 287 --------TECGKAFSQNAHLVQHQRVHTGEKP-------------YQCKQCNKAFSQ----LAHLAQHQRVHTGEKPYE 341
Cdd:COG5048   103 skasssslSSSSSNSNDNNLLSSHSLPPSSRDPqlpdllsisnlrnNPLPGNNSSSVNtpqsNSLHPPLPANSLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 342 CIecgkafsdcSSLAHHRRIHTGKRPYECIDCGKAFRQNASLIRHRRYYHTGEKPFDCIDCGKAFTDhIGLIQHKRIHTG 421
Cdd:COG5048   183 NL---------SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSL-LSQSPSSLSSSD 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 422 ERPYKCNVCGKAFSH-GSSLTVHQRIHTGE-----KPYECNICEKAFSHRGSLTLHQR--VHTGE--KPYECKE--CGKA 489
Cdd:COG5048   253 SSSSASESPRSSLPTaSSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKL 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 490 FRQSTHLAHHQRIHTGEKPYECK--ECSKTFSQNAH-----LAQHQKIHTGEKPYEC--KECGKAFSQIAHLVQHQRVHT 560
Cdd:COG5048   333 FSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHL 412

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462565314 561 GEKPYEC--IECGKAFSDGSYLVQHQRLHSGKRPYEClECGKAFRQRASLICH 611
Cdd:COG5048   413 SFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
189-386 9.35e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 9.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 189 IKQIFPMEERIFNFH-TDKKSLKTHSVVKKHKQDRGEKKLL-KCNDCEKIFSKISTLTLHQR--IHTGE--KPYECIE-- 260
Cdd:COG5048   249 SSSDSSSSASESPRSsLPTASSQSSSPNESDSSSEKGFSLPiKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYsl 328

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 261 CGKAFSQSAHLAQHQRIHTGEKPFEC--TECGKAFSQNAHLVQHQRVH-----TGEKPYQC--KQCNKAFSQLAHLAQHQ 331
Cdd:COG5048   329 CGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHI 408

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462565314 332 RVHTGEKPYEC--IECGKAFSDCSSLAHHRRIHTGKRPYECIDCGKaFRQNASLIRH 386
Cdd:COG5048   409 ITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
365-699 1.21e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 1.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 365 KRPYECIDCGKAFRQNASLIRHRRyYHTGEKPFDCID--CGKAFTDHIGLIQHKRIHTGERPYKCNvcgKAFSHGSSLTV 442
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIR-SHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKAS 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 443 H-QRIHTGEKPYECNICEK---AFSHRGSLT--LHQRVHTGEKPYE-CKECGKAFRQSTHLAHhqrihtgekPYECKECS 515
Cdd:COG5048   107 SsSLSSSSSNSNDNNLLSShslPPSSRDPQLpdLLSISNLRNNPLPgNNSSSVNTPQSNSLHP---------PLPANSLS 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 516 KTFSQNAHLAQHQKIHTGEKPYECKECGKAFSQIAHLVQHQRVHTGEKPYECIECGKAFSDGSYLVQHQRLHSGKRPYEC 595
Cdd:COG5048   178 KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 596 LEC-----GKAFRQRASLIC-----HQRCHTgekPYECNVCGKAFSHRKSLTLHQR--IHTGE--KPYECKE--CSKAFS 659
Cdd:COG5048   258 SESprsslPTASSQSSSPNEsdsssEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFS 334

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 2462565314 660 QVAHLTLHKRIHTGERPYECK--ECGKAFRQSVHLAHHQRIH 699
Cdd:COG5048   335 RNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQ 376
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 395-447 1.62e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 43.70  E-value: 1.62e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462565314 395 KPFdCIDCGKAFTDHIGLIQHKRIHTgerpYKCNVCGKAFSHGSSLTVH-QRIH 447
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
270-295 1.36e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.36e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462565314 270 HLAQHQRIHTGEKPFECTECGKAFSQ 295
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
523-548 1.49e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.49e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462565314 523 HLAQHQKIHTGEKPYECKECGKAFSQ 548
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 433-529 3.36e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 3.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 433 AFSHGSSLTVH---QRIHT-GEKPYECNI--CEKAFSHRGSLTLHqRVHtgekpyecKECGKAFRQSTHLAHHQRIHTGE 506
Cdd:COG5189   326 KLAHGGERNIDtpsRMLKVkDGKPYKCPVegCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKD 396

                          90       100
                  ....*....|....*....|...
gi 2462565314 507 KPYECKECSKTFSQNAHLAQHQK 529
Cdd:COG5189   397 KPYRCEVCDKRYKNLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
326-350 4.73e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.73e-04
                          10        20
                  ....*....|....*....|....*
gi 2462565314 326 HLAQHQRVHTGEKPYECIECGKAFS 350
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
412-436 5.42e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.42e-04
                          10        20
                  ....*....|....*....|....*
gi 2462565314 412 LIQHKRIHTGERPYKCNVCGKAFSH 436
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
551-575 5.64e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.64e-04
                          10        20
                  ....*....|....*....|....*
gi 2462565314 551 HLVQHQRVHTGEKPYECIECGKAFS 575
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
663-688 7.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.07e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462565314 663 HLTLHKRIHTGERPYECKECGKAFRQ 688
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
635-660 8.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.35e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462565314 635 SLTLHQRIHTGEKPYECKECSKAFSQ 660
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
243-267 9.03e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.03e-04
                          10        20
                  ....*....|....*....|....*
gi 2462565314 243 LTLHQRIHTGEKPYECIECGKAFSQ 267
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
298-323 9.68e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.68e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462565314 298 HLVQHQRVHTGEKPYQCKQCNKAFSQ 323
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
423-704 1.05e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 423 RPYKCNVCGKAFSHGSSLTVHQRIHTGEKPYECN--ICEKAFSHRGSLTLHQRVHTGEKPYECKECGKAFRQSThlAHHQ 500
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKA--SSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 501 RIHTGEKP-YECKECSKTFSQNAHLAQH----QKIHTGEKPYE-CKECGKAFSQIAHL-VQHQRVHTGEKPYeciecgka 573
Cdd:COG5048   110 LSSSSSNSnDNNLLSSHSLPPSSRDPQLpdllSISNLRNNPLPgNNSSSVNTPQSNSLhPPLPANSLSKDPS-------- 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 574 fSDGSYLVQHQRLHSGKRPYECLECGKAFRQRASLIcHQRCHTGEKPYECNVCGKAFSHRKSLTLHQRIHTGEKPYECKE 653
Cdd:COG5048   182 -SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSS-DQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 654 CSKAFSQVAHLTLHKRIHTGER-------PYECKECGKAFRQSVHLAHHQR--IHTGESS 704
Cdd:COG5048   260 SPRSSLPTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGESL 319
zf-H2C2_2 pfam13465
Zinc-finger double domain;
467-492 1.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.78e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462565314 467 SLTLHQRVHTGEKPYECKECGKAFRQ 492
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 461-560 1.93e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 461 AFSHRGSLTL----HQRVHTGEKPYECK--ECGKAFRQSTHLAHHqRIHtgekpyecKECSKTFSQNAHLAQHQKIHTGE 534
Cdd:COG5189   326 KLAHGGERNIdtpsRMLKVKDGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKD 396

                          90       100
                  ....*....|....*....|....*.
gi 2462565314 535 KPYECKECGKAFSQIAHLVQHqRVHT 560
Cdd:COG5189   397 KPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
439-464 1.98e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.98e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462565314 439 SLTVHQRIHTGEKPYECNICEKAFSH 464
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
499-520 2.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.08e-03
                          10        20
                  ....*....|....*....|..
gi 2462565314 499 HQRIHTGEKPYECKECSKTFSQ 520
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 359-448 2.57e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 2.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462565314 359 RRIHT-GKRPYEC--IDCGKAFRQNASLIRHRRYYHtgekpfdcidCGKAFTDHIGLIQHKRIHTGERPYKCNVCGKAFS 435
Cdd:COG5189   340 RMLKVkDGKPYKCpvEGCNKKYKNQNGLKYHMLHGH----------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYK 409

                          90
                  ....*....|...
gi 2462565314 436 HGSSLTVHqRIHT 448
Cdd:COG5189   410 NLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
611-632 3.90e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.90e-03
                          10        20
                  ....*....|....*....|..
gi 2462565314 611 HQRCHTGEKPYECNVCGKAFSH 632
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 310-380 7.53e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 7.53e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462565314 310 KPYqCKQCNKAFSQLAHLAQHQRvhtgEKPYECIECGKAFSDCSSLAHH-RRIHtgKRPYECIDCGKAFRQN 380
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHcLQVH--KETLTKVPNALPGRDD 65
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 481-503 7.87e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.87e-03
                          10        20
                  ....*....|....*....|...
gi 2462565314 481 YECKECGKAFRQSTHLAHHQRIH 503
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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