tetraspanin-16 isoform X2 [Homo sapiens]
Protein Classification
tetraspanin family protein( domain architecture ID 11992924)
tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| tetraspanin_LEL super family | cl02781 | Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ... |
115-179 | 3.30e-15 | ||||
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins. The actual alignment was detected with superfamily member cd03156: Pssm-ID: 351888 Cd Length: 114 Bit Score: 68.71 E-value: 3.30e-15
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| Tetraspanin | pfam00335 | Tetraspanin family; |
19-204 | 3.98e-08 | ||||
Tetraspanin family; : Pssm-ID: 459767 Cd Length: 183 Bit Score: 51.17 E-value: 3.98e-08
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| Name | Accession | Description | Interval | E-value | ||||
| uroplakin_I_like_LEL | cd03156 | Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ... |
115-179 | 3.30e-15 | ||||
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression. Pssm-ID: 239409 Cd Length: 114 Bit Score: 68.71 E-value: 3.30e-15
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| Tetraspanin | pfam00335 | Tetraspanin family; |
19-204 | 3.98e-08 | ||||
Tetraspanin family; Pssm-ID: 459767 Cd Length: 183 Bit Score: 51.17 E-value: 3.98e-08
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| Name | Accession | Description | Interval | E-value | ||||
| uroplakin_I_like_LEL | cd03156 | Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ... |
115-179 | 3.30e-15 | ||||
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression. Pssm-ID: 239409 Cd Length: 114 Bit Score: 68.71 E-value: 3.30e-15
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| CD151_like_LEL | cd03155 | Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ... |
115-178 | 1.76e-11 | ||||
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization. Pssm-ID: 239408 [Multi-domain] Cd Length: 110 Bit Score: 58.51 E-value: 1.76e-11
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| CD63_LEL | cd03166 | Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins ... |
115-167 | 1.11e-10 | ||||
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD63 is present in platelets, neutrophils, and endothelial cells, amongst others. In platelets it associates with the integrin alphaIIBbeta3 and may modulate alphaIIbbeta3-dependent cytoskeletal reorganization. Pssm-ID: 239419 Cd Length: 99 Bit Score: 56.33 E-value: 1.11e-10
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| TM4SF8_like_LEL | cd03163 | Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. ... |
115-173 | 5.45e-10 | ||||
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 8 (TM4SF8) or Tspan-3 and related proteins. Tspan-3 has been reported to form a complex with integrin beta1 and OSP/claudin-11, which may be involved in oligodendrocyte proliferation and migration. Pssm-ID: 239416 Cd Length: 105 Bit Score: 54.74 E-value: 5.45e-10
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| TM4SF2_6_like_LEL | cd03161 | Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. ... |
115-172 | 3.68e-08 | ||||
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 2 (TM4SF2) or Tspan-7, transmembrane 4 superfamily 6 (TM4SF6) or Tspan-6, and related proteins. TM4SF2 has been identified as involved in some forms of X-linked mental retardation. Pssm-ID: 239414 Cd Length: 104 Bit Score: 49.67 E-value: 3.68e-08
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| Tetraspanin | pfam00335 | Tetraspanin family; |
19-204 | 3.98e-08 | ||||
Tetraspanin family; Pssm-ID: 459767 Cd Length: 183 Bit Score: 51.17 E-value: 3.98e-08
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| tetraspanin_LEL | cd03127 | Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ... |
115-171 | 2.06e-07 | ||||
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins. Pssm-ID: 239401 [Multi-domain] Cd Length: 90 Bit Score: 47.11 E-value: 2.06e-07
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| NET-5_like_LEL | cd03165 | Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. ... |
114-171 | 2.32e-07 | ||||
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human tetraspan NET-5. Pssm-ID: 239418 [Multi-domain] Cd Length: 98 Bit Score: 47.36 E-value: 2.32e-07
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| CD37_CD82_like_LEL | cd03160 | Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ... |
115-171 | 1.23e-05 | ||||
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology. Pssm-ID: 239413 Cd Length: 117 Bit Score: 42.76 E-value: 1.23e-05
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