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Conserved domains on  [gi|2462564074|ref|XP_054176338|]
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fms-related tyrosine kinase 3 ligand isoform X6 [Homo sapiens]

Protein Classification

Flt3_lig domain-containing protein( domain architecture ID 10502990)

Flt3_lig domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Flt3_lig pfam02947
flt3 ligand; The flt3 ligand is a short chain cytokine with a 4 helical bundle fold.
 29-141 5.34e-72

flt3 ligand; The flt3 ligand is a short chain cytokine with a 4 helical bundle fold.


:

Pssm-ID: 460760  Cd Length: 131  Bit Score: 215.41  E-value: 5.34e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564074  29 DCSFQHSPISSDFAVKIRELSDYLLQDYPVTVASNLQDEELCGGLWRLVLAQRWMERLKTVAGSKMQGLLERVNTEIHFV 108
Cdd:pfam02947   1 DCAFSHSPISSDFKVKIHNLSDYLLQDYPVTVAVNLQDDELCKELWHLVLAQRWMERLKTVAGSKLQELLEKVNTEIHFV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462564074 109 TKCAFQ------------------ETSEQLVALKPWITRQNFSRCLELQCQ 141
Cdd:pfam02947  81 TSCDFQplpsclrfvqtnishllqDTSAQLLALKPKITRRNFSRCLELRCQ 131
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 138-227 1.91e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 38.98  E-value: 1.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564074 138 LQCQPGAPRPQSPGPAACGALTWPRPHPGEDTEAHRGESPARGCIAWTQRKLA------RGRSLPwAPLIPSPEWRQRQN 211
Cdd:pfam03154 174 LQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAphtliqQTPTLH-PQRLPSPHPPLQPM 252

                          90
                  ....*....|....*.
gi 2462564074 212 PAPAPLTQLCTKPLSP 227
Cdd:pfam03154 253 TQPPPPSQVSPQPLPQ 268
 
Name Accession Description Interval E-value
Flt3_lig pfam02947
flt3 ligand; The flt3 ligand is a short chain cytokine with a 4 helical bundle fold.
 29-141 5.34e-72

flt3 ligand; The flt3 ligand is a short chain cytokine with a 4 helical bundle fold.


Pssm-ID: 460760  Cd Length: 131  Bit Score: 215.41  E-value: 5.34e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564074  29 DCSFQHSPISSDFAVKIRELSDYLLQDYPVTVASNLQDEELCGGLWRLVLAQRWMERLKTVAGSKMQGLLERVNTEIHFV 108
Cdd:pfam02947   1 DCAFSHSPISSDFKVKIHNLSDYLLQDYPVTVAVNLQDDELCKELWHLVLAQRWMERLKTVAGSKLQELLEKVNTEIHFV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462564074 109 TKCAFQ------------------ETSEQLVALKPWITRQNFSRCLELQCQ 141
Cdd:pfam02947  81 TSCDFQplpsclrfvqtnishllqDTSAQLLALKPKITRRNFSRCLELRCQ 131
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 138-227 1.91e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 38.98  E-value: 1.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564074 138 LQCQPGAPRPQSPGPAACGALTWPRPHPGEDTEAHRGESPARGCIAWTQRKLA------RGRSLPwAPLIPSPEWRQRQN 211
Cdd:pfam03154 174 LQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAphtliqQTPTLH-PQRLPSPHPPLQPM 252

                          90
                  ....*....|....*.
gi 2462564074 212 PAPAPLTQLCTKPLSP 227
Cdd:pfam03154 253 TQPPPPSQVSPQPLPQ 268
 
Name Accession Description Interval E-value
Flt3_lig pfam02947
flt3 ligand; The flt3 ligand is a short chain cytokine with a 4 helical bundle fold.
 29-141 5.34e-72

flt3 ligand; The flt3 ligand is a short chain cytokine with a 4 helical bundle fold.


Pssm-ID: 460760  Cd Length: 131  Bit Score: 215.41  E-value: 5.34e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564074  29 DCSFQHSPISSDFAVKIRELSDYLLQDYPVTVASNLQDEELCGGLWRLVLAQRWMERLKTVAGSKMQGLLERVNTEIHFV 108
Cdd:pfam02947   1 DCAFSHSPISSDFKVKIHNLSDYLLQDYPVTVAVNLQDDELCKELWHLVLAQRWMERLKTVAGSKLQELLEKVNTEIHFV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462564074 109 TKCAFQ------------------ETSEQLVALKPWITRQNFSRCLELQCQ 141
Cdd:pfam02947  81 TSCDFQplpsclrfvqtnishllqDTSAQLLALKPKITRRNFSRCLELRCQ 131
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 138-227 1.91e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 38.98  E-value: 1.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564074 138 LQCQPGAPRPQSPGPAACGALTWPRPHPGEDTEAHRGESPARGCIAWTQRKLA------RGRSLPwAPLIPSPEWRQRQN 211
Cdd:pfam03154 174 LQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAphtliqQTPTLH-PQRLPSPHPPLQPM 252

                          90
                  ....*....|....*.
gi 2462564074 212 PAPAPLTQLCTKPLSP 227
Cdd:pfam03154 253 TQPPPPSQVSPQPLPQ 268
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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