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Conserved domains on  [gi|2462564004|ref|XP_054176303|]
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protein capicua homolog isoform X13 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HMG-box_CIC-like cd21990
high mobility group (HMG)-box found in protein capicua (CIC) and similar proteins; CIC is a ...
 1108-1185 2.23e-59

high mobility group (HMG)-box found in protein capicua (CIC) and similar proteins; CIC is a transcriptional repressor which plays a role in the development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, CIC is involved in brain development.


:

Pssm-ID: 438806 [Multi-domain]  Cd Length: 78  Bit Score: 198.45  E-value: 2.23e-59
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462564004 1108 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKK 1185
Cdd:cd21990      1 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPEEKQKYHDLAFQVKEAHFKAHPDWKWCSKDRKK 78
DUF4819 pfam16090
Domain of unknown function (DUF4819); This presumed domain is functionally uncharacterized. ...
 252-346 1.32e-24

Domain of unknown function (DUF4819); This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is typically between 82 and 99 amino acids in length.


:

Pssm-ID: 465014  Cd Length: 84  Bit Score: 99.68  E-value: 1.32e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004  252 DVVLDATPPPGALVVGTAVCTCV----EPGVAAYREGVVVEVATKPAAYKVRLSPGPSSqpglpgslpqppqplhrepEE 327
Cdd:pfam16090    1 DVILDASPSLSDVAVGTRVCVRLdpglEGGENVYREGVVVEVNNKPVRYVVKVSGGDEA-------------------KG 61

                           90
                   ....*....|....*....
gi 2462564004  328 AVWVARSSLRLLRPPWEPE 346
Cdd:pfam16090   62 GVWVKRADLRLLRPPWWDE 80
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 1765-2184 9.64e-09

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 61.49  E-value: 9.64e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1765 PAPTTSIRFTLPPGTSTngkvlaATAPTPGIPILQSVPSAPPPKAQSVSPVQAPPPGGSAQLLPGKVLVPLAAPSMSVRG 1844
Cdd:PHA03247  2627 PPPSPSPAANEPDPHPP------PTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLAD 2700

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1845 GGAGQPLPLVSPPFSVPVQNGAQPPSKIIQLTPVPVSTPSGLVPPLSPATLPGPTSQPQKVLLPSSTRITYVQSAGGHAL 1924
Cdd:PHA03247  2701 PPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPP 2780

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1925 PLGTSPASSQAGTVTSYGPTSSvalgftslGPSGPAFVQPLLSAGQAPLLAPGqvGVSPVPSPQLPPACAAPGGPVITAF 2004
Cdd:PHA03247  2781 RRLTRPAVASLSESRESLPSPW--------DPADPPAAVLAPAAALPPAASPA--GPLPPPTSAQPTAPPPPPGPPPPSL 2850

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 2005 -YSGSPAPTSSAPLAQPSQAPPSlvyTVATSTTPPAATIlpkgppapatatpapTSPFPSATgsmTYSLVAPKAQRPSPK 2083
Cdd:PHA03247  2851 pLGGSVAPGGDVRRRPPSRSPAA---KPAAPARPPVRRL---------------ARPAVSRS---TESFALPPDQPERPP 2909

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 2084 APQkvkaaIASIPVGSFEAGASGRPGPAPRQPLEPGPVREP---TAPESELEGQPTPPAPPPLPETWTPTARSSPPLPPP 2160
Cdd:PHA03247  2910 QPQ-----APPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPttdPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAP 2984

                          410       420
                   ....*....|....*....|....
gi 2462564004 2161 AEErTSAKGPETMASKFPSSSSDW 2184
Cdd:PHA03247  2985 SRE-APASSTPPLTGHSLSRVSSW 3007
dnaA super family cl42516
chromosomal replication initiator protein DnaA;
871-1046 3.88e-04

chromosomal replication initiator protein DnaA;


The actual alignment was detected with superfamily member PRK14086:

Pssm-ID: 455861 [Multi-domain]  Cd Length: 617  Bit Score: 45.97  E-value: 3.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004  871 VPPAAPTAVAQPMPAFGLASSPFQPVAFHPSPAALLPVLVPSSY----TSHPAPKKEVIMGRPGTvWtnvePRSVAVFPW 946
Cdd:PRK14086    93 GEPAPPPPHARRTSEPELPRPGRRPYEGYGGPRADDRPPGLPRQdqlpTARPAYPAYQQRPEPGA-W----PRAADDYGW 167

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004  947 HSlvPFLAPSQPDPSVQPSEAQQPASH---PVASNQSKEPAESAAVAHERP----PGGTGSADPERPPGA-----TCPES 1014
Cdd:PRK14086   168 QQ--QRLGFPPRAPYASPASYAPEQERdrePYDAGRPEYDQRRRDYDHPRPdwdrPRRDRTDRPEPPPGAghvhrGGPGP 245

                          170       180       190
                   ....*....|....*....|....*....|..
gi 2462564004 1015 PGPGPPHPLGVVESGKGPPPTTEEEASGPPGE 1046
Cdd:PRK14086   246 PERDDAPVVPIRPSAPGPLAAQPAPAPGPGEP 277
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 743-1105 5.80e-04

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.55  E-value: 5.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004  743 DSLDSGVDSVSHTPTPSTPAGFRAVSPAVPFSRSRQPSPLLLLPPPAGLTSDPGPSVRRVPAVQRDSPVIVRNPDVPLPS 822
Cdd:PHA03307    12 EAAAEGGEFFPRPPATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWS 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004  823 KFPGEVGTAGEVRAGGPGRGCRETPVPPGVASGKPGLPPPLPAPVPITVPPAAPTAVAQPMPAFGLASSPFQPVAFHPSP 902
Cdd:PHA03307    92 LSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQ 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004  903 AALLPVLVPSSYTSHPAPKKEVIMGRPGTVWTNVEPRsvavfPWHSLVPFLAPSQPDPSVQPSEAQQPASHPVASNQSKE 982
Cdd:PHA03307   172 AALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPR-----RSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSG 246

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004  983 PAESAAVAHERPPGGTGSADPERPPGATCPESPGPGPPHPLGVVESGKGPPPTTEEEASGPPGEPRLDSETESDHDDAFL 1062
Cdd:PHA03307   247 CGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSS 326

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 2462564004 1063 SIMSPEIQLPLPPGKRRTQSLSALPKERDSSSEKDGRSPNKRE 1105
Cdd:PHA03307   327 SSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRP 369
 
Name Accession Description Interval E-value
HMG-box_CIC-like cd21990
high mobility group (HMG)-box found in protein capicua (CIC) and similar proteins; CIC is a ...
 1108-1185 2.23e-59

high mobility group (HMG)-box found in protein capicua (CIC) and similar proteins; CIC is a transcriptional repressor which plays a role in the development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, CIC is involved in brain development.


Pssm-ID: 438806 [Multi-domain]  Cd Length: 78  Bit Score: 198.45  E-value: 2.23e-59
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462564004 1108 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKK 1185
Cdd:cd21990      1 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPEEKQKYHDLAFQVKEAHFKAHPDWKWCSKDRKK 78
DUF4819 pfam16090
Domain of unknown function (DUF4819); This presumed domain is functionally uncharacterized. ...
 252-346 1.32e-24

Domain of unknown function (DUF4819); This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is typically between 82 and 99 amino acids in length.


Pssm-ID: 465014  Cd Length: 84  Bit Score: 99.68  E-value: 1.32e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004  252 DVVLDATPPPGALVVGTAVCTCV----EPGVAAYREGVVVEVATKPAAYKVRLSPGPSSqpglpgslpqppqplhrepEE 327
Cdd:pfam16090    1 DVILDASPSLSDVAVGTRVCVRLdpglEGGENVYREGVVVEVNNKPVRYVVKVSGGDEA-------------------KG 61

                           90
                   ....*....|....*....
gi 2462564004  328 AVWVARSSLRLLRPPWEPE 346
Cdd:pfam16090   62 GVWVKRADLRLLRPPWWDE 80
HMG smart00398
high mobility group;
1108-1177 9.62e-19

high mobility group;


Pssm-ID: 197700 [Multi-domain]  Cd Length: 70  Bit Score: 82.36  E-value: 9.62e-19
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004  1108 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWK 1177
Cdd:smart00398    1 KPKRPMSAFMLFSQENRAKIKAENPDLSNAEISKKLGERWKLLSEEEKAPYEEKAKKDKERYEEEMPEYK 70
HMG_box pfam00505
HMG (high mobility group) box;
1109-1176 4.54e-17

HMG (high mobility group) box;


Pssm-ID: 459837 [Multi-domain]  Cd Length: 68  Bit Score: 77.65  E-value: 4.54e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462564004 1109 IRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDW 1176
Cdd:pfam00505    1 PKRPMSAFFLFSKEQRAKLKAENPGLKNAEISKILGEKWKALSEEEKKPYEEKAEKEKARYEKEHPEY 68
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1765-2184 9.64e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 61.49  E-value: 9.64e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1765 PAPTTSIRFTLPPGTSTngkvlaATAPTPGIPILQSVPSAPPPKAQSVSPVQAPPPGGSAQLLPGKVLVPLAAPSMSVRG 1844
Cdd:PHA03247  2627 PPPSPSPAANEPDPHPP------PTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLAD 2700

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1845 GGAGQPLPLVSPPFSVPVQNGAQPPSKIIQLTPVPVSTPSGLVPPLSPATLPGPTSQPQKVLLPSSTRITYVQSAGGHAL 1924
Cdd:PHA03247  2701 PPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPP 2780

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1925 PLGTSPASSQAGTVTSYGPTSSvalgftslGPSGPAFVQPLLSAGQAPLLAPGqvGVSPVPSPQLPPACAAPGGPVITAF 2004
Cdd:PHA03247  2781 RRLTRPAVASLSESRESLPSPW--------DPADPPAAVLAPAAALPPAASPA--GPLPPPTSAQPTAPPPPPGPPPPSL 2850

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 2005 -YSGSPAPTSSAPLAQPSQAPPSlvyTVATSTTPPAATIlpkgppapatatpapTSPFPSATgsmTYSLVAPKAQRPSPK 2083
Cdd:PHA03247  2851 pLGGSVAPGGDVRRRPPSRSPAA---KPAAPARPPVRRL---------------ARPAVSRS---TESFALPPDQPERPP 2909

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 2084 APQkvkaaIASIPVGSFEAGASGRPGPAPRQPLEPGPVREP---TAPESELEGQPTPPAPPPLPETWTPTARSSPPLPPP 2160
Cdd:PHA03247  2910 QPQ-----APPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPttdPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAP 2984

                          410       420
                   ....*....|....*....|....
gi 2462564004 2161 AEErTSAKGPETMASKFPSSSSDW 2184
Cdd:PHA03247  2985 SRE-APASSTPPLTGHSLSRVSSW 3007
NHP6B COG5648
Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics];
1080-1224 1.65e-06

Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics];


Pssm-ID: 227935 [Multi-domain]  Cd Length: 211  Bit Score: 51.40  E-value: 1.65e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1080 TQSLSALPKERDSSSEKDGRSPnkrekdhiRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYH 1159
Cdd:COG5648     50 TKPRKKTKSKRLVRKKKDPNGP--------KRPLSAYFLYSAENRDEIRKENPKLTFGEVGKLLSEKWKELTDEEKEPYY 121

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1160 DLAFQVKEAHFKA-HPDwkwcnkDRKKSSSEAKPTSLGLAGGHKETRERSMSETG----TAAAPGVSSEL 1224
Cdd:COG5648    122 KEANSDRERYQREkEEY------NKKLPNKAPIGPFIENEPKIRPKVEGPSPDKAlveeTKIISKAWSEL 185
PTZ00199 PTZ00199
high mobility group protein; Provisional
 1092-1166 2.01e-06

high mobility group protein; Provisional


Pssm-ID: 185511 [Multi-domain]  Cd Length: 94  Bit Score: 48.31  E-value: 2.01e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462564004 1092 SSSEKDGRSPNKREKDHI--RRPMNAFMIFSKRHRALVHQRHPN--QDNRTVSKILGEWWYALGPKEKQKYHDLAFQVK 1166
Cdd:PTZ00199     4 KQGKVLVRKNKRKKKDPNapKRALSAYMFFAKEKRAEIIAENPElaKDVAAVGKMVGEAWNKLSEEEKAPYEKKAQEDK 82
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
1836-2045 2.32e-05

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 49.75  E-value: 2.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1836 AAPSMSVRGGGAGQPLPLVSPPFSVPVQNGAQPPSKIIQLTPVPVSTPSGLVPPLSPATLPGPTSQPQKVLLPSSTRITY 1915
Cdd:COG3469     14 GASATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATSTS 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1916 VQSAGghALPLGTSPASSQAGTVTSYGPTSSVALGFTSLGPSGPAFVQPLLSAGQAPLLAPGQVGVSPVPSPQLPPACAA 1995
Cdd:COG3469     94 ATLVA--TSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTT 171

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1996 PGGPVITAFYSGSPAPTSSAPLAQPSQAPPslvytvaTSTTPPAATILPK 2045
Cdd:COG3469    172 TTSASTTPSATTTATATTASGATTPSATTT-------ATTTGPPTPGLPK 214
dnaA PRK14086
chromosomal replication initiator protein DnaA;
871-1046 3.88e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 45.97  E-value: 3.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004  871 VPPAAPTAVAQPMPAFGLASSPFQPVAFHPSPAALLPVLVPSSY----TSHPAPKKEVIMGRPGTvWtnvePRSVAVFPW 946
Cdd:PRK14086    93 GEPAPPPPHARRTSEPELPRPGRRPYEGYGGPRADDRPPGLPRQdqlpTARPAYPAYQQRPEPGA-W----PRAADDYGW 167

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004  947 HSlvPFLAPSQPDPSVQPSEAQQPASH---PVASNQSKEPAESAAVAHERP----PGGTGSADPERPPGA-----TCPES 1014
Cdd:PRK14086   168 QQ--QRLGFPPRAPYASPASYAPEQERdrePYDAGRPEYDQRRRDYDHPRPdwdrPRRDRTDRPEPPPGAghvhrGGPGP 245

                          170       180       190
                   ....*....|....*....|....*....|..
gi 2462564004 1015 PGPGPPHPLGVVESGKGPPPTTEEEASGPPGE 1046
Cdd:PRK14086   246 PERDDAPVVPIRPSAPGPLAAQPAPAPGPGEP 277
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 743-1105 5.80e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.55  E-value: 5.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004  743 DSLDSGVDSVSHTPTPSTPAGFRAVSPAVPFSRSRQPSPLLLLPPPAGLTSDPGPSVRRVPAVQRDSPVIVRNPDVPLPS 822
Cdd:PHA03307    12 EAAAEGGEFFPRPPATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWS 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004  823 KFPGEVGTAGEVRAGGPGRGCRETPVPPGVASGKPGLPPPLPAPVPITVPPAAPTAVAQPMPAFGLASSPFQPVAFHPSP 902
Cdd:PHA03307    92 LSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQ 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004  903 AALLPVLVPSSYTSHPAPKKEVIMGRPGTVWTNVEPRsvavfPWHSLVPFLAPSQPDPSVQPSEAQQPASHPVASNQSKE 982
Cdd:PHA03307   172 AALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPR-----RSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSG 246

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004  983 PAESAAVAHERPPGGTGSADPERPPGATCPESPGPGPPHPLGVVESGKGPPPTTEEEASGPPGEPRLDSETESDHDDAFL 1062
Cdd:PHA03307   247 CGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSS 326

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 2462564004 1063 SIMSPEIQLPLPPGKRRTQSLSALPKERDSSSEKDGRSPNKRE 1105
Cdd:PHA03307   327 SSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRP 369
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1787-2202 4.30e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.45  E-value: 4.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1787 AATAPTPGIPILQSVPSA-PPPKAQSVSPVQAPPPGgsaqlLPGKVLVPLAAPSMSVRGGGAGQPLPLVSPpfSVPVQNG 1865
Cdd:pfam03154  180 AASPPSPPPPGTTQAATAgPTPSAPSVPPQGSPATS-----QPPNQTQSTAAPHTLIQQTPTLHPQRLPSP--HPPLQPM 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1866 AQP-PSKIIQLTPVPVSTPSGLVPPLSPATLPGPTSQPQKVllPSSTRITYVQSAGGHALPLGTSPASSQAGTVTSYGPT 1944
Cdd:pfam03154  253 TQPpPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPV--PPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPS 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1945 SSvalgftSLGPSGPAFVQPLLSAGQA--PLLAPGQVGVSPVPSPQLPPACAAPGGPVITAFYSGSPAPTSSAPLAQ-PS 2021
Cdd:pfam03154  331 QS------QLQSQQPPREQPLPPAPLSmpHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPPALKPLSSlST 404

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 2022 QAPPSlvytvatsTTPPAATILPKGPPapatatpaptspfpsatgsmtysLVAPKAQRPSPKAPQKVKAAIASIPvgsfe 2101
Cdd:pfam03154  405 HHPPS--------AHPPPLQLMPQSQQ-----------------------LPPPPAQPPVLTQSQSLPPPAASHP----- 448

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 2102 agasgrpgpaPRQPLEPGPVREPTAPESELEGQPTPPAPPPLPETWTPTARSSPPLPPPAEERTSAKGPETMASKFPSSS 2181
Cdd:pfam03154  449 ----------PTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQ 518

                          410       420
                   ....*....|....*....|.
gi 2462564004 2182 SDWRVPGQGLENRGEPPTPPS 2202
Cdd:pfam03154  519 IKEEALDEAEEPESPPPPPRS 539
 
Name Accession Description Interval E-value
HMG-box_CIC-like cd21990
high mobility group (HMG)-box found in protein capicua (CIC) and similar proteins; CIC is a ...
 1108-1185 2.23e-59

high mobility group (HMG)-box found in protein capicua (CIC) and similar proteins; CIC is a transcriptional repressor which plays a role in the development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, CIC is involved in brain development.


Pssm-ID: 438806 [Multi-domain]  Cd Length: 78  Bit Score: 198.45  E-value: 2.23e-59
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462564004 1108 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKK 1185
Cdd:cd21990      1 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPEEKQKYHDLAFQVKEAHFKAHPDWKWCSKDRKK 78
HMG-box_HBP2 cd21989
high mobility group (HMG)-box found in HMG box-containing protein 2 (HBP2) and similar ...
 1110-1178 4.48e-34

high mobility group (HMG)-box found in HMG box-containing protein 2 (HBP2) and similar proteins; HBP2, also called HMG box transcription factor BBX, or Bobby sox homolog, is a transcription factor that is necessary for cell cycle progression from the G1 to S phase.


Pssm-ID: 438805 [Multi-domain]  Cd Length: 69  Bit Score: 125.98  E-value: 4.48e-34
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462564004 1110 RRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKW 1178
Cdd:cd21989      1 RRPMNAFLLFCKRHRSLVRERHPRLDNRGITKILGDWWAVLDPDEKQKYTDLAKQYKEAFMKANPNFKW 69
DUF4819 pfam16090
Domain of unknown function (DUF4819); This presumed domain is functionally uncharacterized. ...
 252-346 1.32e-24

Domain of unknown function (DUF4819); This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is typically between 82 and 99 amino acids in length.


Pssm-ID: 465014  Cd Length: 84  Bit Score: 99.68  E-value: 1.32e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004  252 DVVLDATPPPGALVVGTAVCTCV----EPGVAAYREGVVVEVATKPAAYKVRLSPGPSSqpglpgslpqppqplhrepEE 327
Cdd:pfam16090    1 DVILDASPSLSDVAVGTRVCVRLdpglEGGENVYREGVVVEVNNKPVRYVVKVSGGDEA-------------------KG 61

                           90
                   ....*....|....*....
gi 2462564004  328 AVWVARSSLRLLRPPWEPE 346
Cdd:pfam16090   62 GVWVKRADLRLLRPPWWDE 80
HMG-box_SOX cd22004
high mobility group (HMG)-box found in sex-determining region Y (SRY)-box (SOX) family ...
 1108-1181 2.75e-22

high mobility group (HMG)-box found in sex-determining region Y (SRY)-box (SOX) family transcription factors; The SOX gene family of transcription factors are characterized by the evolutionarily conserved SRY-type HMG box, which is a DNA binding domain that binds the minor groove of DNA on a common consensus site, (A/T)(A/T)CAA(A/T)G but with different levels of efficiency. Members include SRY and its homologs identified in mammals that can be subdivided into 8 groups (A, B1, B2, C, D, E, F, G, H). They are involved in embryonic development, regulating processes such as cell differentiation, maintenance of stemness, sex determination, and development of the central nervous, haematopoietic and other organ systems. The SOX gene family has a crucial role in carcinogenesis and cancer progression.


Pssm-ID: 438820 [Multi-domain]  Cd Length: 75  Bit Score: 92.61  E-value: 2.75e-22
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462564004 1108 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNK 1181
Cdd:cd22004      1 HIKRPMNAFMVWSQQERKKIAKQNPKLHNSEISKILGKEWKKLTEEEKRPYVEEAERLREEHKKEYPDYKYRPR 74
HMG-box_ROX1-like cd01389
high mobility group (HMG)-box found in Saccharomyces cerevisiae repressor ROX1 and similar ...
 1109-1177 1.91e-21

high mobility group (HMG)-box found in Saccharomyces cerevisiae repressor ROX1 and similar proteins; This family includes class I members of the HMG-box superfamily of DNA-binding proteins, including Saccharomyces cerevisiae repressor ROX1, Schizosaccharomyces pombe mating-type M-specific polypeptide Mc (mat-Mc), Schizosaccharomyces pombe transcription factor ste11, Podospora anserina MAT+ sexual cell fertilization-promoting factor (FPR1), Podospora anserina sporulation minus regulator 2 (SMR2) and Candida albicans repressor of filamentous growth 1 (RFG1). These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. ROX1, also called heme-dependent repression factor, or hypoxic function repressor, is a transcription factor that represses the expression of HEM13, COX5B, ANB1, CYC7 or AAC3. It binds to the DNA sequence 5'-RRRTAACAAGAG-3'. mat-Mc belongs to the mating type protein family, which contains sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. mat-Mc is a positive regulator of MFM genes and is required for conjugation and efficient meiosis. Its HMG box recognizes the DNA sequence 5'-AACAAAG-3'. Ste11 is a key transcription factor for sexual development. It activates the transcription of the matp, matm, mei2, mfm, ste6 and rgs1 genes. It binds specifically to a DNA fragment carrying a 10-base motif 5'-TTCTTTGTTY-3'. FPR1 controls fertilization, probably by determining the mating type. SMR2 is a transcription factor that is required for post-fertilization events. It is required for the developmental events that occur in the female organ after fertilization. RFG1 is a transcription regulator that functions in both the positive and negative regulation of filamentous growth, depending upon environmental conditions.


Pssm-ID: 438791 [Multi-domain]  Cd Length: 72  Bit Score: 89.95  E-value: 1.91e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462564004 1109 IRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWK 1177
Cdd:cd01389      1 IPRPPNAFILFRKEKHKQLRAQNPGLTNSEISKIIGKMWKNLSEEEKEPYKELAEEEKEEHKLKYPDYK 69
HMG-box_SoxH_SOX30 cd22033
high mobility group (HMG)-box found in sex determining region Y (SRY)-box 30 (SOX30) and ...
 1108-1179 9.60e-20

high mobility group (HMG)-box found in sex determining region Y (SRY)-box 30 (SOX30) and similar proteins; SOX-30 is a crucial transcription factor that controls the transition from a late meiotic to a post-meiotic gene expression program and subsequent round spermatid development. It specially prevents Wnt-signaling to suppress metastasis. SOX-30 binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif. SOX-30 is the only member of the group H of SRY-related high-mobility group (HMG) box (Sox) transcription factors.


Pssm-ID: 438842 [Multi-domain]  Cd Length: 75  Bit Score: 85.16  E-value: 9.60e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462564004 1108 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWC 1179
Cdd:cd22033      1 HIKRPMNAFMVWARIHRPALAKANPNANNADISVQLGEEWNKLTEEQKKPYYDEAQKLKEQHRKEHPGWVYQ 72
HMG smart00398
high mobility group;
1108-1177 9.62e-19

high mobility group;


Pssm-ID: 197700 [Multi-domain]  Cd Length: 70  Bit Score: 82.36  E-value: 9.62e-19
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004  1108 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWK 1177
Cdd:smart00398    1 KPKRPMSAFMLFSQENRAKIKAENPDLSNAEISKKLGERWKLLSEEEKAPYEEKAKKDKERYEEEMPEYK 70
HMG-box_HBP1 cd21988
high mobility group (HMG)-box found in HMG box-containing protein 1 (HBP1) and similar ...
 1110-1177 1.95e-18

high mobility group (HMG)-box found in HMG box-containing protein 1 (HBP1) and similar proteins; HBP1, also called HMG box transcription factor 1, or high mobility group box transcription factor 1, is a transcriptional repressor that binds to the promoter region of target genes. It plays a role in the regulation of the cell cycle and the Wnt pathway. HBP1 binds preferentially to the sequence 5'-TTCATTCATTCA-3'.


Pssm-ID: 438804 [Multi-domain]  Cd Length: 69  Bit Score: 81.35  E-value: 1.95e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462564004 1110 RRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPD-WK 1177
Cdd:cd21988      1 KRPMNAFMLFAKKYRVEYTQMHPGKDNRAISVILGDRWKKMKNEERRVYTLEAKALAEEHKRLHPDcWK 69
HMG-box_SoxA_SoxB_SoxG cd22028
high mobility group (HMG)-box found in group A, group B and group G of SRY-related ...
 1108-1185 2.65e-18

high mobility group (HMG)-box found in group A, group B and group G of SRY-related high-mobility group (HMG) box (Sox) transcription factors; This subfamily includes SoxA, SoxB, and SoxG proteins. SRY is the only member of group A SRY-related high-mobility group (HMG) box (Sox) transcription factors. SRY, also called testis-determining factor, is a transcriptional regulator that controls a genetic switch in male development. It promotes DNA bending and is also involved in pre-mRNA splicing. The SRY HMG box recognizes DNA by partial intercalation in the minor groove. It binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SoxB transcription factors play critical roles in the regulation of neurogenesis. They can be divided into two main subgroups, SoxB1 (Sox-1/Sox-2/Sox-3) and SoxB2 (SOX-14/SOX-21). SoxB1 proteins suppress neurogenesis by maintaining neural cells in an undifferentiated state. SoxB2 proteins may have the opposite activity and promote neuronal differentiation. SOX-5 is the only member of group G Sox transcription factors. It is also called SOX-12, SOX-20, SOX-26, or SOX-27. SOX-5 is a crucial transcription factor involved in the regulation of embryonic development and in cell fate determination. It binds to the 5'-AACAAT-3' sequence. SOX-15 can be a tumor suppressor in multiple cancer types.


Pssm-ID: 438837 [Multi-domain]  Cd Length: 76  Bit Score: 81.25  E-value: 2.65e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462564004 1108 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWcnKDRKK 1185
Cdd:cd22028      1 RVKRPMNAFMVWSREQRRKIAQENPKMHNSEISKRLGAEWKQLSEDEKRPFIDEAKRLRAQHMKEHPDYKY--RPRRK 76
HMG_box pfam00505
HMG (high mobility group) box;
1109-1176 4.54e-17

HMG (high mobility group) box;


Pssm-ID: 459837 [Multi-domain]  Cd Length: 68  Bit Score: 77.65  E-value: 4.54e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462564004 1109 IRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDW 1176
Cdd:pfam00505    1 PKRPMSAFFLFSKEQRAKLKAENPGLKNAEISKILGEKWKALSEEEKKPYEEKAEKEKARYEKEHPEY 68
HMG-box_EGL13-like cd22042
high mobility group (HMG)-box found in Caenorhabditis elegans protein egg laying defective 13 ...
 1108-1178 1.06e-16

high mobility group (HMG)-box found in Caenorhabditis elegans protein egg laying defective 13 (EGL-13) and similar proteins; EGL-13 may act as a transcription factor that is required for uterine cell fate decisions in Caenorhabditis elegans. It controls genes required for the specification and differentiation of O(2) and CO(2)-sensing neurons and for maintaining URX sensory neuronal cell fate.


Pssm-ID: 438848 [Multi-domain]  Cd Length: 78  Bit Score: 76.86  E-value: 1.06e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462564004 1108 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKW 1178
Cdd:cd22042      2 HIKRPMNAFMVWAKDERRKILKACPDMHNSNISKILGAKWKAMSNAEKQPYYEEQSRLSKLHMEKHPDYRY 72
HMG-box_SF cd00084
high mobility group (HMG)-box domain superfamily; The High Mobility Group (HMG)-box is found ...
 1111-1169 2.76e-16

high mobility group (HMG)-box domain superfamily; The High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenetically distinct groups of Class I proteins bind DNA in a sequence specific fashion and contain a single HMG box. One group (SOX-TCF) includes transcription factors, TCF-1, -3, -4, and also SRY and LEF-1, which bind four-way DNA junctions and duplex DNA targets. The second group (MATA) includes fungal mating type gene products MC, MATA1 and Ste11. Class II and III proteins (HMGB-UBF) bind DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal proteins, HMG1 and HMG2, which bind to bent or distorted DNA such as four-way DNA junctions, synthetic DNA cruciforms, kinked cisplatin-modified DNA, DNA bulges, cross-overs in supercoiled DNA, and can cause looping of linear DNA. Class III members include nucleolar and mitochondrial transcription factors, UBF and mtTF1, which bind four-way DNA junctions.


Pssm-ID: 438789 [Multi-domain]  Cd Length: 59  Bit Score: 74.86  E-value: 2.76e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462564004 1111 RPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAH 1169
Cdd:cd00084      1 RPLSAYLLFSKEKRPKLKKENPDLSFTEISKLLGERWKELSEEEKQPYEEKAKEDKERY 59
HMG-box_SoxB cd01388
high mobility group (HMG)-box found in group B SRY-related high-mobility group (HMG) box (Sox) ...
 1107-1188 1.48e-15

high mobility group (HMG)-box found in group B SRY-related high-mobility group (HMG) box (Sox) transcription factors; SoxB transcription factors play critical roles in the regulation of neurogenesis. They can be divided into two main subgroups, SoxB1 (Sox-1/Sox-2/Sox-3) and SoxB2 (SOX-14/SOX-21). SoxB1 proteins suppress neurogenesis by maintaining neural cells in an undifferentiated state. SoxB2 proteins may have the opposite activity and promote neuronal differentiation. SOX-1 is involved in the regulation of embryonic development and cell fate determination. It also acts as a tumor suppressor that plays an anti-tumorigenicity role in different cells and its expression is inhibited in a variety of cancers. SOX-2 plays an important role in various phases of embryonic development, including cell fate and differentiation. Its overexpression and gene amplification may be associated with tumor aggression and metastasis in various cancer types, including breast, prostate, lung, ovarian and colon cancer. SOX-3 is required during the formation of the hypothalamic-pituitary axis. It plays a role in both normal neural development and carcinogenesis. SOX-14, also called SOX-28, acts as a negative regulator of transcription. It is mainly involved in the regulation of neural development. It can also promote proliferation and invasion capacity of cervical cancer cells by activating the Wnt/beta-catenin pathway. SOX-21, also called SOX-A, or SOX-25, promotes the progression of vertebrate neurogenesis.


Pssm-ID: 438790 [Multi-domain]  Cd Length: 80  Bit Score: 73.79  E-value: 1.48e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1107 DHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWcnKDRKKS 1186
Cdd:cd01388      1 DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSEAEKRPFIDEAKRLRALHMKEHPDYKY--RPRRKT 78


                   ..
gi 2462564004 1187 SS 1188
Cdd:cd01388     79 KT 80
HMG-box_SoxD cd22030
high mobility group (HMG)-box found in group D SRY-related high-mobility group (HMG) box (Sox) ...
 1108-1185 5.11e-15

high mobility group (HMG)-box found in group D SRY-related high-mobility group (HMG) box (Sox) transcription factors; SoxD transcription factors includes three members, Sox5, Sox6, and Sox13. They function as important transcriptional regulators of glial development in the central nervous system. SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function. This subfamily also contains SoxD transcription factor homolog EGL-13, which specifies distinct O2 and CO2 sensory neuron fates in Caenorhabditis elegans. SOX-5 plays important roles in various cancer types. It binds specifically to the DNA sequence 5'-AACAAT-3'. SOX-6 plays a key role in cell proliferation, differentiation, and cell fate determination, as well as neurogenesis and skeleton formation. It is a tumor suppressor and downregulated in various cancers. SOX-6 binds specifically to the DNA sequence 5'-AACAAT-3'. SOX-13, also called Islet cell antigen 12 (ICA12), or type 1 diabetes auto-antigen ICA12, modulates T cell specification and is an autoimmune antigen. It binds to the sequence 5'-AACAAT-3'.


Pssm-ID: 438839 [Multi-domain]  Cd Length: 77  Bit Score: 71.96  E-value: 5.11e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462564004 1108 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWcnKDRKK 1185
Cdd:cd22030      1 HIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKQHLEKYPDYKY--KPRPK 76
HMG-box_SoxE cd22031
high mobility group (HMG)-box found in group E SRY-related high-mobility group (HMG) box (Sox) ...
 1108-1178 9.64e-15

high mobility group (HMG)-box found in group E SRY-related high-mobility group (HMG) box (Sox) transcription factors; SoxE transcription factors includes three members: Sox8, Sox9, and Sox10. They function as important transcriptional regulators of neural differentiation and nervous system development. They regulate mammalian development directing sex determination, gliogenesis, pancreas specification and neural crest development. SOX-8 is specifically expressed by M cells in the intestinal epithelium. It acts as a transcription factor necessary for the maintenance of spermatogenesis. It may play a role in central nervous system, limb and facial development. SOX-9 is involved in cell differentiation, sex determination, and tumorigenesis. It plays a role in chondrocyte differentiation and skeletal development. SOX-10 plays a central role in the development of melanocytes and glial cells from neural crest precursors.


Pssm-ID: 438840 [Multi-domain]  Cd Length: 75  Bit Score: 71.27  E-value: 9.64e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462564004 1108 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKW 1178
Cdd:cd22031      1 HVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLSESEKRPFIEEAERLRVQHKKDHPDYKY 71
HMG-box_TCF7-like cd21996
high mobility group (HMG)-box found in the transcription factor 7 (TCF-7)-like family; The ...
 1108-1185 2.35e-14

high mobility group (HMG)-box found in the transcription factor 7 (TCF-7)-like family; The TCF7-like family includes TCF-7, TCF7-like 1 (TF7L1), lymphoid enhancer-binding factor 1 (LEF-1), and similar proteins. TCF-7, also called T-cell-specific transcription factor 1, or T-cell factor 1 (TCF-1), is a T lymphocyte-specific transcriptional activator involved in T-cell lymphocyte differentiation. It is necessary for the survival of CD4(+) CD8(+) immature thymocytes. It binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. TF7L1, also called HMG box transcription factor 3 (TCF-3), participates in the Wnt signaling pathway. It binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. TF7L2, also called HMG box transcription factor 4, or T-cell-specific transcription factor 4, or T-cell factor 4, or TCF-4, participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. It acts as a repressor in the absence of CTNNB1, and it activates transcription from promoters with several copies of the TCF motif 5'-CCTTTGATC-3' in the presence of CTNNB1. LEF-1, also called T cell-specific transcription factor 1-alpha (TCF1-alpha), is a transcription factor that binds DNA in a sequence-specific manner. It may participate in the Wnt signaling pathway. All family members contain one HMG-box domain.


Pssm-ID: 438812 [Multi-domain]  Cd Length: 85  Bit Score: 70.44  E-value: 2.35e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1108 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWK-----WCNKD 1182
Cdd:cd21996      1 HIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSardnyGKKKK 80


                   ...
gi 2462564004 1183 RKK 1185
Cdd:cd21996     81 RKR 83
HMG-box_SoxF cd22032
high mobility group (HMG)-box found in group F SRY-related high-mobility group (HMG) box (Sox) ...
 1108-1178 3.46e-14

high mobility group (HMG)-box found in group F SRY-related high-mobility group (HMG) box (Sox) transcription factors; SoxF transcription factors includes three members: Sox7, Sox17, and Sox18. They regulate endothelial cell fate as well as development and differentiation of the developing heart, blood cells, and lymphatic vessels.


Pssm-ID: 438841 [Multi-domain]  Cd Length: 76  Bit Score: 69.75  E-value: 3.46e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462564004 1108 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKW 1178
Cdd:cd22032      1 RIRRPMNAFMVWAKDERKRLADENPDLHNAELSKMLGKKWKSLSLAEKRPFVEEAERLRVQHMQDYPNYKY 71
HMG-box_SoxC cd22029
high mobility group (HMG)-box found in group C SRY-related high-mobility group (HMG) box (Sox) ...
 1108-1185 6.62e-14

high mobility group (HMG)-box found in group C SRY-related high-mobility group (HMG) box (Sox) transcription factors; SoxC transcription factors includes three members: SOX4, SOX11 and SOX12. They play key roles, often in redundancy, in multiple developmental pathways, including neurogenesis and skeletogenesis. SOX-4 is a transcriptional activator that promotes neuronal differentiation both in the adult and embryonic neural progenitors. It binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif. SOX-4 is abnormally expressed in various cancers. SOX-11 is a neural transcriptional factor involved in precursor survival, neuronal fate determination, migration and morphogenesis. SOX-12, also called SOX-22, is a transcription factor essential for embryonic development and cell fate determination. It binds to the sequence 5'-AACAAT-3'.


Pssm-ID: 438838 [Multi-domain]  Cd Length: 76  Bit Score: 68.62  E-value: 6.62e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462564004 1108 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWcnKDRKK 1185
Cdd:cd22029      1 HIKRPMNAFMVWSQIERRKIMEQQPDMHNAEISKRLGKRWKLLSDSEKIPFIEEAERLRLLHMQEYPDYKY--RPRKK 76
HMG-box_SoxF_SOX7 cd22046
high mobility group (HMG)-box found in sex determining region Y (SRY)-box 7 (SOX7) and similar ...
 1099-1185 1.71e-13

high mobility group (HMG)-box found in sex determining region Y (SRY)-box 7 (SOX7) and similar proteins; SOX-7 is an endothelial-associated transcription factor that acts as a tumor suppressor in a number of cancer types. It binds the DNA sequence 5'-AACAAT-3'. SOX-7 belongs to the group F of SRY-related high-mobility group (HMG) box (Sox) transcription factors.


Pssm-ID: 438849 [Multi-domain]  Cd Length: 88  Bit Score: 68.18  E-value: 1.71e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1099 RSP-NKREKDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWK 1177
Cdd:cd22046      1 RSPgEKGSEPRIRRPMNAFMVWAKDERKRLAVQNPDLHNAELSKMLGKSWKALTPSQKRPYVEEAERLRVQHMQDYPNYK 80


                   ....*...
gi 2462564004 1178 WCNKDRKK 1185
Cdd:cd22046     81 YRPRRKKQ 88
HMG-box_SoxF_SOX18 cd22048
high mobility group (HMG)-box found in sex determining region Y (SRY)-box 18 (SOX18) and ...
 1109-1185 1.94e-13

high mobility group (HMG)-box found in sex determining region Y (SRY)-box 18 (SOX18) and similar proteins; SOX-18 is a transcription factor involved in the development of cardiovascular and lymphatic vessels during embryonic development. It binds to the consensus sequence 5'-AACAAAG-3' and is able to trans-activate transcription via this site. SOX-18 belongs to the group F of SRY-related high-mobility group (HMG) box (Sox) transcription factors.


Pssm-ID: 438851 [Multi-domain]  Cd Length: 80  Bit Score: 67.79  E-value: 1.94e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462564004 1109 IRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKK 1185
Cdd:cd22048      4 IRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGQSWKSLSAAEKRPFVEEAERLRVQHLQDHPNYKYRPRRKKQ 80
HMG-box_SoxF_SOX17 cd22047
high mobility group (HMG)-box found in sex determining region Y (SRY)-box 17 (SOX17) and ...
 1109-1178 1.34e-12

high mobility group (HMG)-box found in sex determining region Y (SRY)-box 17 (SOX17) and similar proteins; SOX-17 is a developmental transcription regulator involved in endoderm formation, angiogenesis, and carcinogenesis. It acts as a tumor suppressor and modulates WNT signaling. SOX-17 binds target promoter DNA and bends the DNA. It binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. SOX-17 belongs to the group F of SRY-related high-mobility group (HMG) box (Sox) transcription factors.


Pssm-ID: 438850 [Multi-domain]  Cd Length: 81  Bit Score: 65.11  E-value: 1.34e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1109 IRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKW 1178
Cdd:cd22047      7 IRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALTLAEKRPFVEEAERLRVQHMQDHPNYKY 76
HMG-box_SoxG_SOX15 cd22035
high mobility group (HMG)-box found in sex determining region Y (SRY)-box 15 (SOX15) and ...
 1107-1186 2.78e-12

high mobility group (HMG)-box found in sex determining region Y (SRY)-box 15 (SOX15) and similar proteins; SOX-15, also called SOX-12, SOX-20, SOX-26, or SOX-27, is a crucial transcription factor involved in the regulation of embryonic development and in cell fate determination. It binds to the 5'-AACAAT-3' sequence. SOX-15 can be a tumor suppressor in multiple cancer types. SOX-5 is the only member of group G SRY-related high-mobility group (HMG) box (Sox) transcription factors.


Pssm-ID: 438844 [Multi-domain]  Cd Length: 84  Bit Score: 64.33  E-value: 2.78e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1107 DHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWcnKDRKKS 1186
Cdd:cd22035      6 EKVKRPMNAFMVWSSAQRRQMAQEHPKMHNSEISKRLGAAWKLLPEAEKRPFVEEAKRLRARHMRDYPDYKY--RPRRKG 83
HMG-box_SoxC_SOX12 cd22038
high mobility group (HMG)-box found in sex determining region Y (SRY)-box 12 (SOX12) and ...
 1103-1186 1.25e-10

high mobility group (HMG)-box found in sex determining region Y (SRY)-box 12 (SOX12) and similar proteins; SOX-12, also called SOX-22, is a transcription factor essential for embryonic development and cell fate determination. It binds to the sequence 5'-AACAAT-3'. SOX-12 belongs to the group C of SRY-related high-mobility group (HMG) box (Sox) transcription factors.


Pssm-ID: 438847 [Multi-domain]  Cd Length: 88  Bit Score: 60.08  E-value: 1.25e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1103 KREKDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWcnKD 1182
Cdd:cd22038      6 KTPSGHIKRPMNAFMVWSQIERRKIMEQWPDMHNAEISKRLGRRWKLLQDYEKIPFIKEAERLRLKHMADYPDYKY--RP 83


                   ....
gi 2462564004 1183 RKKS 1186
Cdd:cd22038     84 RKKS 87
HMG-box_SoxA_SRY cd22034
high mobility group (HMG)-box found in sex-determining region Y protein (SRY) and similar ...
 1106-1185 8.24e-10

high mobility group (HMG)-box found in sex-determining region Y protein (SRY) and similar proteins; SRY, also called testis-determining factor, is a transcriptional regulator that controls a genetic switch in male development. It promotes DNA bending and is also involved in pre-mRNA splicing. The SRY HMG box recognizes DNA by partial intercalation in the minor groove. It binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY is the only member of group A SRY-related high-mobility group (HMG) box (Sox) transcription factors.


Pssm-ID: 438843 [Multi-domain]  Cd Length: 85  Bit Score: 57.34  E-value: 8.24e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1106 KDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKK 1185
Cdd:cd22034      2 QDRVKRPMNAFIVWSRDQRRKMALENPRMRNSEISKQLGYQWKMLTEAEKWPFFQEAQKLQAMHREKYPNYKYRPRRKAK 81
HMG-box_NHP6-like cd01390
high mobility group (HMG)-box found in Saccharomyces cerevisiae non-histone chromosomal ...
 1096-1169 8.75e-10

high mobility group (HMG)-box found in Saccharomyces cerevisiae non-histone chromosomal proteins NHP6A, NHP6B and similar proteins; This subfamily includes Saccharomyces cerevisiae high-mobility-group proteins NHP6A and its closely related paralog NHP6B. NHP6A and NHP6B seem to be functionally redundant. They are DNA-binding proteins that induce severe bending of DNA and are required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. They augment the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex. They may also play essential roles in transcriptional initiation fidelity of some but not all tRNA genes.


Pssm-ID: 438792 [Multi-domain]  Cd Length: 81  Bit Score: 57.38  E-value: 8.75e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462564004 1096 KDGRSPNKREKDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAH 1169
Cdd:cd01390      1 KKKKGRKKKDPNAPKRGLSAYMFFSQDNREKVKEENPDATFGEVGKLLGEKWKELSEEEKAPYEEKAAKDKKRY 74
HMG-box_SoxC_SOX11 cd22037
high mobility group (HMG)-box found in sex determining region Y (SRY)-box 11 (SOX11) and ...
 1103-1188 1.72e-09

high mobility group (HMG)-box found in sex determining region Y (SRY)-box 11 (SOX11) and similar proteins; SOX-11 is a neural transcriptional factor involved in precursor survival, neuronal fate determination, migration and morphogenesis. SOX-11 belongs to group C SRY-related high-mobility group (HMG) box (Sox) transcription factors.


Pssm-ID: 438846 [Multi-domain]  Cd Length: 92  Bit Score: 57.03  E-value: 1.72e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1103 KREKDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKD 1182
Cdd:cd22037      6 KTATGHIKRPMNAFMVWSKIERRKIMEQSPDMHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHMADYPDYKYRPRK 85


                   ....*.
gi 2462564004 1183 RKKSSS 1188
Cdd:cd22037     86 KPKVDP 91
HMG-box_SoxC_SOX4 cd22036
high mobility group (HMG)-box found in sex determining region Y (SRY)-box 4 (SOX4) and similar ...
 1108-1185 1.84e-09

high mobility group (HMG)-box found in sex determining region Y (SRY)-box 4 (SOX4) and similar proteins; SOX-4 is a transcriptional activator that promotes neuronal differentiation both in the adult and embryonic neural progenitors. It binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif. SOX-4 is abnormally expressed in various cancers. SOX-4 belongs to group C SRY-related high-mobility group (HMG) box (Sox) transcription factors.


Pssm-ID: 438845 [Multi-domain]  Cd Length: 79  Bit Score: 56.29  E-value: 1.84e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462564004 1108 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWcnKDRKK 1185
Cdd:cd22036      2 HIKRPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDSDKIPFIREAERLRLKHMADYPDYKY--RPRKK 77
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1765-2184 9.64e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 61.49  E-value: 9.64e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1765 PAPTTSIRFTLPPGTSTngkvlaATAPTPGIPILQSVPSAPPPKAQSVSPVQAPPPGGSAQLLPGKVLVPLAAPSMSVRG 1844
Cdd:PHA03247  2627 PPPSPSPAANEPDPHPP------PTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLAD 2700

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1845 GGAGQPLPLVSPPFSVPVQNGAQPPSKIIQLTPVPVSTPSGLVPPLSPATLPGPTSQPQKVLLPSSTRITYVQSAGGHAL 1924
Cdd:PHA03247  2701 PPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPP 2780

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1925 PLGTSPASSQAGTVTSYGPTSSvalgftslGPSGPAFVQPLLSAGQAPLLAPGqvGVSPVPSPQLPPACAAPGGPVITAF 2004
Cdd:PHA03247  2781 RRLTRPAVASLSESRESLPSPW--------DPADPPAAVLAPAAALPPAASPA--GPLPPPTSAQPTAPPPPPGPPPPSL 2850

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 2005 -YSGSPAPTSSAPLAQPSQAPPSlvyTVATSTTPPAATIlpkgppapatatpapTSPFPSATgsmTYSLVAPKAQRPSPK 2083
Cdd:PHA03247  2851 pLGGSVAPGGDVRRRPPSRSPAA---KPAAPARPPVRRL---------------ARPAVSRS---TESFALPPDQPERPP 2909

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 2084 APQkvkaaIASIPVGSFEAGASGRPGPAPRQPLEPGPVREP---TAPESELEGQPTPPAPPPLPETWTPTARSSPPLPPP 2160
Cdd:PHA03247  2910 QPQ-----APPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPttdPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAP 2984

                          410       420
                   ....*....|....*....|....
gi 2462564004 2161 AEErTSAKGPETMASKFPSSSSDW 2184
Cdd:PHA03247  2985 SRE-APASSTPPLTGHSLSRVSSW 3007
HMG-box_SSRP1-like cd21994
high mobility group (HMG)-box found in structure-specific recognition protein 1 (SSRP1) and ...
 1111-1177 1.37e-08

high mobility group (HMG)-box found in structure-specific recognition protein 1 (SSRP1) and similar proteins; SSRP1, also called FACT complex subunit SSRP1, chromatin-specific transcription elongation factor 80 kDa subunit, facilitates chromatin transcription complex 80 kDa subunit (FACT 80 kDa subunit or FACTp80), facilitates chromatin transcription complex subunit SSRP1, recombination signal sequence recognition protein 1, or T160, is a factor that facilitates transcript elongation through nucleosomes. It is a component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication, and DNA repair.


Pssm-ID: 438810 [Multi-domain]  Cd Length: 67  Bit Score: 53.46  E-value: 1.37e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462564004 1111 RPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWK 1177
Cdd:cd21994      1 RPMSAYMLWLNENREKIKKENPGISVTEISKKAGEIWKELDEEDKEKWEQKAEKAKERYDKAMKEYK 67
HMG-box_HMG20 cd21980
high mobility group (HMG)-box found in the high mobility group protein 20 (HMG20) subfamily; ...
 1110-1167 1.80e-08

high mobility group (HMG)-box found in the high mobility group protein 20 (HMG20) subfamily; The HMG20 subfamily includes HMG20A and HMG20B. HMG20A, also called HMG box-containing protein 20A, HMG domain-containing protein 1, HMG domain-containing protein HMGX1, HMGXB1, or iBRAF, is a chromatin-associated protein involved in neuronal differentiation and maturation. It is required for SNAI1-mediated epithelial to mesenchymal transition. HMG20A acts as an inhibitor of HMG20B. HMG20B, also called SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related, SMARCE1-related protein (SMARCE1R), BRCA2-associated factor 35 (BRAF35), HMG box-containing protein 20B, HMG domain-containing protein 2, HMG domain-containing protein HMGX2, Sox-like transcriptional factor, or structural DNA-binding protein BRAF35, is a DNA binding factor that acts as a repressor of erythroid differentiation. It is required for correct progression through the G2 phase of the cell cycle and entry into mitosis. It is also required for RCOR1/CoREST mediated repression of neuronal specific gene promoters. HMG20B is a core subunit of the Lys-specific demethylase 1/REST co-repressor 1 (LSD1-CoREST) histone demethylase complex. Both HMG20A and HMG20B contain one HMG-box.


Pssm-ID: 438796 [Multi-domain]  Cd Length: 81  Bit Score: 53.32  E-value: 1.80e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462564004 1110 RRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKE 1167
Cdd:cd21980      3 KAPLTGYVRFLNERREKLRAENPDLSFPEITKILGAEWSSLSAEEKQKYLDEAEKDKE 60
HMG-box_ABF2_IXR1-like_rpt2 cd22012
second high mobility group (HMG)-box found in Saccharomyces cerevisiae mitochondrial ...
 1111-1160 8.54e-08

second high mobility group (HMG)-box found in Saccharomyces cerevisiae mitochondrial ARS-binding factor 2 (ABF2), intrastrand cross-link recognition protein (Ixr1) and similar proteins; ABF2 is a close relative of the nuclear, chromosomal high-mobility group protein HMG1 in yeast mitochondria. It specifically binds to the autonomously replicating sequence 1 (ARS1). It might play a positive role in gene expression and replication. Ixr1, also called structure-specific recognition protein (SSRP), is a homolog of the yeast mitochondrial regulator ABF2. It binds to platinated DNA and confers sensitivity to the anticancer drug cisplatin. Both ABF2 and Ixr1 contain two HMG-box domains. This model corresponds to the second one.


Pssm-ID: 438828 [Multi-domain]  Cd Length: 64  Bit Score: 51.13  E-value: 8.54e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1111 RPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHD 1160
Cdd:cd22012      4 RPASAYFLFAKEVRPKLKEENPNEKYTDITKLISEKWRSLDESEKEPYQE 53
HMG-box_AtHMGB6-like_rpt1 cd22006
first high mobility group (HMG)-box found in Arabidopsis thaliana high mobility group B ...
 1110-1171 1.45e-07

first high mobility group (HMG)-box found in Arabidopsis thaliana high mobility group B protein 6 (HMGB6) and similar proteins; HMGB6, also called nucleosome/chromatin assembly factor group D 06 (or D 6), WRKY transcription factor 53 (WRKY53), or WRKY DNA-binding protein 53, is a master regulator of age-induced leaf senescence. It acts in a complex transcription factor signaling network regulating senescence specific gene expression; hydrogen peroxide might be involved in signal transduction. The subfamily also includes Arabidopsis thaliana HMGB13 (also known as nucleosome/chromatin assembly factor group D 13). Both HMGB6 and HMGB13 contain three HMG-box domains. This model corresponds to the first one.


Pssm-ID: 438822 [Multi-domain]  Cd Length: 68  Bit Score: 50.53  E-value: 1.45e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462564004 1110 RRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFK 1171
Cdd:cd22006      1 KKPKTAYFLWCKDQREEVKKENPNADFSEVSKILGAKWKNLSEEEKKPYEEKYKEEKEKYLK 62
HMG-box_HMGB_rpt2 cd21979
second high mobility group (HMG)-box found in the high mobility group protein B (HMGB) family; ...
 1110-1171 6.70e-07

second high mobility group (HMG)-box found in the high mobility group protein B (HMGB) family; HMGB proteins are chromatin-associated nuclear proteins that act as architectural factors in nucleoprotein structures, which regulate DNA-dependent processes including transcription. In mammals, four family members are present: HMGB1, HMGB2, HMGB3 and HMGB4. They regulate the expression of a wide range of genes through architectural remodeling of the chromatin structure. HMGB1, also called high mobility group protein 1 (HMG-1), is a prototypical alarmin or damage-associated molecular pattern (DAMP) molecule when released from cells. It plays important roles in the regulation of a wide range of processes, including transcription, replication, DNA repair, and nucleosome formation, in the nucleus. It also plays multiple roles in regulating inflammation and responses to cell and tissue stress. HMGB2, also called high mobility group protein 2 (HMG-2), has been implicated in numerous cellular processes, including proliferation, differentiation, apoptosis, and tumor growth. It acts as a chromatin-associated nonhistone protein involved in transcriptional regulation and nucleic-acid-mediated innate immune responses in mammalian. It binds DNA to stabilize nucleosomes and promote transcription. HMGB3, also called high mobility group protein 2a (HMG-2a), or high mobility group protein 4 (HMG-4), is an X-linked member of HMGB family and functions as a universal sentinel for nucleic acid-mediated innate immune responses. HMGB3 has been implicated in the regulation of cellular proliferation and differentiation, as well as inflammatory response. HMGB4 is expressed by neuronal cells and affects the expression of genes involved in neural differentiation. It is a factor that regulates chromatin and expression of neuronal differentiation markers. The family also includes high mobility group protein B1 pseudogene 1 (HMGB1P1) and nuclear auto-antigen Sp-100. HMGB1P1, also called putative high mobility group protein B1-like 1 (HMGB1L1), or putative high mobility group protein 1-like 1 (HMG-1L1), is an HMG-box containing protein that binds preferentially single-stranded DNA and unwinds double-stranded DNA. Sp-100, also called nuclear dot-associated Sp100 protein, or speckled 100 kDa. It is a tumor suppressor that is a major constituent of the promyelocytic leukemia (PML) bodies, a subnuclear organelle involved in many physiological processes including cell growth, differentiation and apoptosis. Through the regulation of ETS1, Sp-100 may play a role in angiogenesis, controlling endothelial cell motility and invasion. It may also play roles in the regulation of telomeres lengthening, TP53-mediated transcription, FAS-mediated apoptosis, etc. In addition, the family includes Drosophila melanogaster high mobility group protein DSP1 (dDSP1) and similar proteins. dDSP1, also called protein dorsal switch 1, is a Drosophila HMG1 protein that binds preferentially single-stranded DNA and unwinds double-stranded DNA. It converts Dorsal and nuclear factor (NF)-kappa B from transcriptional activators to repressors. Members of the HMGB family contain two HMG-box domains. This model corresponds to the second one.


Pssm-ID: 438795 [Multi-domain]  Cd Length: 71  Bit Score: 48.56  E-value: 6.70e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462564004 1110 RRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFK 1171
Cdd:cd21979      4 KRPPSAFFLFCSEHRPKIKGEHPGLSIGDVAKKLGEMWNNTSAKDKQPYEKKAAKLKEKYEK 65
HMG-box_AtHMGB6-like_rpt3 cd22008
third high mobility group (HMG)-box found in Arabidopsis thaliana high mobility group B ...
 1101-1172 7.29e-07

third high mobility group (HMG)-box found in Arabidopsis thaliana high mobility group B protein 6 (HMGB6) and similar proteins; HMGB6, also called nucleosome/chromatin assembly factor group D 06 (or D 6), WRKY transcription factor 53 (WRKY53), or WRKY DNA-binding protein 53, is a master regulator of age-induced leaf senescence. It acts in a complex transcription factor signaling network regulating senescence specific gene expression; hydrogen peroxide might be involved in signal transduction. The subfamily also includes Arabidopsis thaliana HMGB13 (also known as nucleosome/chromatin assembly factor group D 13). Both HMGB6 and HMGB13 contain three HMG-box domains. This model corresponds to the third one.


Pssm-ID: 438824 [Multi-domain]  Cd Length: 78  Bit Score: 48.79  E-value: 7.29e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462564004 1101 PNKREKdhirrPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKA 1172
Cdd:cd22008      7 PNKPKK-----PASSYLLFGKEYRKKLQEERPGANNATVTALISLKWKELGEEEKQVYNDKAAVLMEKYKKE 73
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1569-2039 7.32e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.33  E-value: 7.32e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1569 PAAPLSRPAATmvTNVVRPVSSTPVPIASKPFPTSGRAEASPNDTAGartemgtgsRVPGGSPlgvslvySDKKSAAATS 1648
Cdd:PHA03247  2554 PLPPAAPPAAP--DRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARP---------RAPVDDR-------GDPRGPAPPS 2615

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1649 PAPHLVAGPLLGTVGKAPATvtNLLVGTPGYGAPAPPAVQFIAQGAPGGGTTAGSGAGAGSGPNGPvPLGILQPGALGKA 1728
Cdd:PHA03247  2616 PLPPDTHAPDPPPPSPSPAA--NEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSP-PQRPRRRAARPTV 2692

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1729 GGITQVQYILPTLPqqlqvapapAPAPGTKAAAPSGPAP--TTSIRFTLPPGTSTngkvlAATAPTPGIPILQSVPSAPP 1806
Cdd:PHA03247  2693 GSLTSLADPPPPPP---------TPEPAPHALVSATPLPpgPAAARQASPALPAA-----PAPPAVPAGPATPGGPARPA 2758

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1807 PKAQSVSPVQAPPPGGSAQLLPGKVLVPlAAPSMSVRGGGAGQPLPLVSPPFSVPVQNGAQPPSKiiqlTPVPVSTPSGL 1886
Cdd:PHA03247  2759 RPPTTAGPPAPAPPAAPAAGPPRRLTRP-AVASLSESRESLPSPWDPADPPAAVLAPAAALPPAA----SPAGPLPPPTS 2833

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1887 VPPLSPATLPGPtsqpqkvlLPSSTRITYVQSAGGHALPLGTSPASSQAGTVTSYGPTSSVALgfTSLGPSGPAFVQPLL 1966
Cdd:PHA03247  2834 AQPTAPPPPPGP--------PPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLAR--PAVSRSTESFALPPD 2903

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1967 S-------AGQAPLLAPGQVGVSPVPSPQLPPACAAPGGPVITAFYSGSPAPTSSAPLAQPSQAPPSLVYTVATSTTPPA 2039
Cdd:PHA03247  2904 QperppqpQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA 2983
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1742-2200 8.02e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.94  E-value: 8.02e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1742 PQQLQVAPAPAPAPGTKAAAPSGPAPTtsiRFTLPPGTSTNGKVLAATAPTPGipilQSVPSAPPPKAQSVSPVQAPPPG 1821
Cdd:PHA03247  2633 PAANEPDPHPPPTVPPPERPRDDPAPG---RVSRPRRARRLGRAAQASSPPQR----PRRRAARPTVGSLTSLADPPPPP 2705

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1822 GSAQLLPGKVLVPLAAPSMSVRGGGAGQPLPLVSPPFSVPvQNGAQPPSKIIQLTPVPVSTPSGLVPPLSPATLPGPTSQ 1901
Cdd:PHA03247  2706 PTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVP-AGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLT 2784

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1902 PQKVllpsstrityvqSAGGHALPLGTSPASSQAGTVTSYGPTSSVALGFTSLGPSGPafvqPLLSAGQAPLLAPGqvgv 1981
Cdd:PHA03247  2785 RPAV------------ASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPP----PTSAQPTAPPPPPG---- 2844

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1982 sPVPSPQLPPACAAPGGPVITAFYSGSPAPTSSAPLAQPSQ--APPSLVYTVATSTTPPAATILPKGPPAPATATPAPTS 2059
Cdd:PHA03247  2845 -PPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRrlARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQP 2923

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 2060 PFPSATGSMTYSLVAPKAQRPSPKAPQKVKAAIASIPVGSFEAGASGRPGPAPRQPLEPGPVREPTAPESelegQPTPPA 2139
Cdd:PHA03247  2924 PPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASST----PPLTGH 2999

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462564004 2140 PPPLPETWTPT-ARSSPPLPPPAEERTSAKGPETMASKFPSSSSDWRVPGQGLE----NRGEPPTP 2200
Cdd:PHA03247  3000 SLSRVSSWASSlALHEETDPPPVSLKQTLWPPDDTEDSDADSLFDSDSERSDLEaldpLPPEPHDP 3065
HMG-box_ABF2-like_rpt1 cd22010
first high mobility group (HMG)-box found in Saccharomyces cerevisiae mitochondrial ...
 1110-1176 1.30e-06

first high mobility group (HMG)-box found in Saccharomyces cerevisiae mitochondrial ARS-binding factor 2 (ABF2) and similar proteins; ABF2 is a close relative of the nuclear, chromosomal high-mobility group protein HMG1 in yeast mitochondria. It specifically binds to the autonomously replicating sequence 1 (ARS1). It might play a positive role in gene expression and replication. ABF2 contains two HMG-box domains. This model corresponds to the first one.


Pssm-ID: 438826 [Multi-domain]  Cd Length: 68  Bit Score: 47.92  E-value: 1.30e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462564004 1110 RRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDW 1176
Cdd:cd22010      2 KRPLSAYFLYFQEHRSDFVKENPDAKMTEISKIGGDKWKNLSADDKKKYEDDFQRELSEYQKAKAEF 68
NHP6B COG5648
Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics];
1080-1224 1.65e-06

Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics];


Pssm-ID: 227935 [Multi-domain]  Cd Length: 211  Bit Score: 51.40  E-value: 1.65e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1080 TQSLSALPKERDSSSEKDGRSPnkrekdhiRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYH 1159
Cdd:COG5648     50 TKPRKKTKSKRLVRKKKDPNGP--------KRPLSAYFLYSAENRDEIRKENPKLTFGEVGKLLSEKWKELTDEEKEPYY 121

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1160 DLAFQVKEAHFKA-HPDwkwcnkDRKKSSSEAKPTSLGLAGGHKETRERSMSETG----TAAAPGVSSEL 1224
Cdd:COG5648    122 KEANSDRERYQREkEEY------NKKLPNKAPIGPFIENEPKIRPKVEGPSPDKAlveeTKIISKAWSEL 185
PTZ00199 PTZ00199
high mobility group protein; Provisional
 1092-1166 2.01e-06

high mobility group protein; Provisional


Pssm-ID: 185511 [Multi-domain]  Cd Length: 94  Bit Score: 48.31  E-value: 2.01e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462564004 1092 SSSEKDGRSPNKREKDHI--RRPMNAFMIFSKRHRALVHQRHPN--QDNRTVSKILGEWWYALGPKEKQKYHDLAFQVK 1166
Cdd:PTZ00199     4 KQGKVLVRKNKRKKKDPNapKRALSAYMFFAKEKRAEIIAENPElaKDVAAVGKMVGEAWNKLSEEEKAPYEKKAQEDK 82
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 1787-2174 3.72e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 52.68  E-value: 3.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1787 AATAPTPGIPILQSVPSAPPPKAQSvsPVQAPPPGGSAqllPGKVLVPLAAPSMSVRGGGAGQPLPLVSPPFSVPVQNGA 1866
Cdd:PRK07764   406 PAAAPAPAAAAPAAAAAPAPAAAPQ--PAPAPAPAPAP---PSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAP 480

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1867 QPPSKIIQLTPVPVSTPSGLVPPLSPATLPGPTSQPQKVL--LPSSTRIT------YVQSAG--GHALPLG-TSPAS--- 1932
Cdd:PRK07764   481 APAPPAAPAPAAAPAAPAAPAAPAGADDAATLRERWPEILaaVPKRSRKTwaillpEATVLGvrGDTLVLGfSTGGLarr 560

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1933 -SQAGTVTSY------------GPTSSVALGFTSLGPSGPAFVQPLLSAGQAPllAPGQVGVSPVPSPQLPPACAAPGGP 1999
Cdd:PRK07764   561 fASPGNAEVLvtalaeelggdwQVEAVVGPAPGAAGGEGPPAPASSGPPEEAA--RPAAPAAPAAPAAPAPAGAAAAPAE 638

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 2000 VITAFYSGSPAPTSSAPlAQPSQAPPSLVYTVATSTTPPAATilpkgppaPATATPAPTSPFPSATGSMTYSLVAPKAQR 2079
Cdd:PRK07764   639 ASAAPAPGVAAPEHHPK-HVAVPDASDGGDGWPAKAGGAAPA--------APPPAPAPAAPAAPAGAAPAQPAPAPAATP 709

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 2080 PSPKAPQKvkaaiASIPVGSFEAGASGRPGPAPRQPLEPGPVREPTAPEseLEGQPTPPAPPPLPETWTPTARSSPPLPP 2159
Cdd:PRK07764   710 PAGQADDP-----AAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAG--APAQPPPPPAPAPAAAPAAAPPPSPPSEE 782

                          410
                   ....*....|....*
gi 2462564004 2160 PAEERTSAKGPETMA 2174
Cdd:PRK07764   783 EEMAEDDAPSMDDED 797
HMG_box_2 pfam09011
HMG-box domain; This short 71 residue domain is an HMG-box domain. HMG-box domains mediate ...
 1101-1176 1.00e-05

HMG-box domain; This short 71 residue domain is an HMG-box domain. HMG-box domains mediate re-modelling of chromatin-structure. Mammalian HMG-box proteins are of two types: those that are non-sequence-specific DNA-binding proteins with two HMG-box domains and a long highly acidic C-tail; and a diverse group of sequence-specific transcription factor-proteins with either a single HMG-box or up to six copies, and no acidic C-tail.


Pssm-ID: 430369 [Multi-domain]  Cd Length: 72  Bit Score: 45.47  E-value: 1.00e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462564004 1101 PNKRekdhiRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDW 1176
Cdd:pfam09011    1 PNKP-----KRARNAYAFFVQEMIPEHKRQNPVIGFAEVSKLCSERWKNLSEEEKEKYEEMAKEDKNRYDREMGTY 71
HMG-box_UBF1_rpt4 cd22001
fourth high mobility group (HMG)-box found in upstream-binding factor 1 (UBF1) and similar ...
 1107-1167 1.29e-05

fourth high mobility group (HMG)-box found in upstream-binding factor 1 (UBF1) and similar proteins; UBF1, also called UBTF, nucleolar transcription factor 1, or auto-antigen NOR-90, is a nucleolar transcription factor that recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. UBF1 contains six HMG-box domains. This model corresponds to the fourth one.


Pssm-ID: 438817 [Multi-domain]  Cd Length: 66  Bit Score: 44.98  E-value: 1.29e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462564004 1107 DHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKE 1167
Cdd:cd22001      1 EKPKRPISAMFIYSKEKRSKLKKKHPELSEQELTRLLAKKYNELPDKKKAKYKKKEALAKA 61
HMG-box_AtHMGB6-like_rpt2 cd22007
second high mobility group (HMG)-box found in Arabidopsis thaliana high mobility group B ...
 1110-1172 1.35e-05

second high mobility group (HMG)-box found in Arabidopsis thaliana high mobility group B protein 6 (HMGB6) and similar proteins; HMGB6, also called nucleosome/chromatin assembly factor group D 06 (or D 6), WRKY transcription factor 53 (WRKY53), or WRKY DNA-binding protein 53, is a master regulator of age-induced leaf senescence. It acts in a complex transcription factor signaling network regulating senescence specific gene expression; hydrogen peroxide might be involved in signal transduction. The subfamily also includes Arabidopsis thaliana HMGB13 (also known as nucleosome/chromatin assembly factor group D 13). Both HMGB6 and HMGB13 contain three HMG-box domains. This model corresponds to the second one.


Pssm-ID: 438823 [Multi-domain]  Cd Length: 68  Bit Score: 44.94  E-value: 1.35e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462564004 1110 RRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKA 1172
Cdd:cd22007      2 KRPQSAYFLYANDRRAALKEENKNVKITEIAKMLGAEWKNLSDAKKKPYEEKAKKLKEAYLQE 64
HMG-box_NHP10-like cd22016
high mobility group (HMG)-box found in Saccharomyces cerevisiae non-histone protein 10 (NHP10) ...
 1095-1167 1.93e-05

high mobility group (HMG)-box found in Saccharomyces cerevisiae non-histone protein 10 (NHP10) and similar proteins; NHP10, also called high mobility group protein 2, is probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex.


Pssm-ID: 438832 [Multi-domain]  Cd Length: 79  Bit Score: 45.02  E-value: 1.93e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462564004 1095 EKDGRSPnkrekdhiRRPMNAFMIFSKRHRALVHQR----HPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKE 1167
Cdd:cd22016      2 EKDPNAP--------KRPANAFFLFCQEQREKVREEykeeHQEIDHHDLTKALAQAWRNLDAEDKKPYYELYEKDKE 70
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
1836-2045 2.32e-05

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 49.75  E-value: 2.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1836 AAPSMSVRGGGAGQPLPLVSPPFSVPVQNGAQPPSKIIQLTPVPVSTPSGLVPPLSPATLPGPTSQPQKVLLPSSTRITY 1915
Cdd:COG3469     14 GASATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATSTS 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1916 VQSAGghALPLGTSPASSQAGTVTSYGPTSSVALGFTSLGPSGPAFVQPLLSAGQAPLLAPGQVGVSPVPSPQLPPACAA 1995
Cdd:COG3469     94 ATLVA--TSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTT 171

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1996 PGGPVITAFYSGSPAPTSSAPLAQPSQAPPslvytvaTSTTPPAATILPK 2045
Cdd:COG3469    172 TTSASTTPSATTTATATTASGATTPSATTT-------ATTTGPPTPGLPK 214
HMG-box_PMS1 cd21985
high mobility group (HMG)-box found in PMS1 protein homolog 1 (PMS1) and similar proteins; ...
 1109-1169 3.83e-05

high mobility group (HMG)-box found in PMS1 protein homolog 1 (PMS1) and similar proteins; PMS1, also called DNA mismatch repair protein PMS1, is probably involved in the repair of mismatches in DNA.


Pssm-ID: 438801 [Multi-domain]  Cd Length: 73  Bit Score: 43.69  E-value: 3.83e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462564004 1109 IRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAH 1169
Cdd:cd21985      2 IRKPMSASALFEQETRPQFLAENPKASLQDITLKIEERWKNLSEEEKKKYEEKAAKDLERY 62
HMG-box_AtHMGB1-like cd22005
high mobility group (HMG)-box found in Arabidopsis thaliana high mobility group B protein 1 ...
 1111-1166 4.66e-05

high mobility group (HMG)-box found in Arabidopsis thaliana high mobility group B protein 1 (HMGB1) and similar proteins; This subfamily contains a group of Arabidopsis thaliana HMGB family proteins, including HMGB1, 2, 3, 4, 5, 7, 12 and 14. They bind preferentially to double-stranded DNA. HMGB1 modulates general plant growth and stress tolerance and confers sensitivity to salt and genotoxic (methyl methanesulfonate, MMS) stresses. HMGB2 and HMGB5 confer sensitivity to salt and drought stresses. HMGB7 is required for karyogamy during female gametophyte development, when the two polar nuclei fuse to form the diploid central cell nucleus. Members of this subfamily contain only one HMG-box domain.


Pssm-ID: 438821 [Multi-domain]  Cd Length: 60  Bit Score: 43.07  E-value: 4.66e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462564004 1111 RPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVK 1166
Cdd:cd22005      2 RPPTAFFLFLADFRKTYKKKNPDKSVKAVGKAAGEKWKSMSDEEKAPYVEKAEKEK 57
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1777-2195 6.51e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 6.51e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1777 PGTSTNGKVLAATAPTPGIPILQSVPSAPPPKA---------QSVSPVQAPPPGGSAQLLPgkvlvPLAAPSMSVRGGGA 1847
Cdd:PHA03247  2496 PDPGGGGPPDPDAPPAPSRLAPAILPDEPVGEPvhprmltwiRGLEELASDDAGDPPPPLP-----PAAPPAAPDRSVPP 2570

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1848 GQPLPLVSPPfsvPVQNGAQPPSKIIQLT--PVPVSTPSGLVPPLSPATLPGPTSQPQKVllPSSTRITYVQSAGGHALP 1925
Cdd:PHA03247  2571 PRPAPRPSEP---AVTSRARRPDAPPQSArpRAPVDDRGDPRGPAPPSPLPPDTHAPDPP--PPSPSPAANEPDPHPPPT 2645

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1926 LGTSPASSQAGTVTSYGPTSSVALGFTSLGPSGPafvqpllSAGQAPLLAPGQVGvsPVPSPQLPPACAAPGGPVITAFY 2005
Cdd:PHA03247  2646 VPPPERPRDDPAPGRVSRPRRARRLGRAAQASSP-------PQRPRRRAARPTVG--SLTSLADPPPPPPTPEPAPHALV 2716

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 2006 SGSPAPTSSAPLAQPSQAPPslvytvATSTTPPAATilpkgppapATATPAPTSPFPSATGSMTYSLVAPKAQRPSPKAP 2085
Cdd:PHA03247  2717 SATPLPPGPAAARQASPALP------AAPAPPAVPA---------GPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR 2781

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 2086 QKVKAAIASipvgsfeAGASGRPGPAPRQPLEPGPVREPTAPeselegqptppappplpeTWTPTARSSPPLPPPAEERT 2165
Cdd:PHA03247  2782 RLTRPAVAS-------LSESRESLPSPWDPADPPAAVLAPAA------------------ALPPAASPAGPLPPPTSAQP 2836

                          410       420       430
                   ....*....|....*....|....*....|
gi 2462564004 2166 SAKGPETMASKFPSSSSDWRVPGQGLENRG 2195
Cdd:PHA03247  2837 TAPPPPPGPPPPSLPLGGSVAPGGDVRRRP 2866
HMG-box_HMGB_rpt1 cd21978
first high mobility group (HMG)-box found in the high mobility group protein B (HMGB) family; ...
 1110-1167 1.15e-04

first high mobility group (HMG)-box found in the high mobility group protein B (HMGB) family; HMGB proteins are chromatin-associated nuclear proteins that act as architectural factors in nucleoprotein structures, which regulate DNA-dependent processes including transcription. In mammals, four family members are present: HMGB1, HMGB2, HMGB3 and HMGB4. They regulate the expression of a wide range of genes through architectural remodeling of the chromatin structure. HMGB1, also called high mobility group protein 1 (HMG-1), is a prototypical alarmin or damage-associated molecular pattern (DAMP) molecule when released from cells. It plays important roles in the regulation of a wide range of processes, including transcription, replication, DNA repair, and nucleosome formation, in the nucleus. It also plays multiple roles in regulating inflammation and responses to cell and tissue stress. HMGB2, also called high mobility group protein 2 (HMG-2), has been implicated in numerous cellular processes, including proliferation, differentiation, apoptosis, and tumor growth. It acts as a chromatin-associated nonhistone protein involved in transcriptional regulation and nucleic-acid-mediated innate immune responses in mammalian cells. It binds DNA to stabilize nucleosomes and promote transcription. HMGB3, also called high mobility group protein 2a (HMG-2a), or high mobility group protein 4 (HMG-4), is an X-linked member of the HMGB family that functions as a universal sentinel for nucleic acid-mediated innate immune responses. HMGB3 has been implicated in the regulation of cellular proliferation and differentiation, as well as inflammatory responses. HMGB4 is expressed by neuronal cells and affects the expression of genes involved in neural differentiation. It is a factor that regulates chromatin and expression of neuronal differentiation markers. This family also includes high mobility group protein B1 pseudogene 1 (HMGB1P1) and nuclear auto-antigen Sp-100. HMGB1P1, also called putative high mobility group protein B1-like 1 (HMGB1L1), or putative high mobility group protein 1-like 1 (HMG-1L1), is an HMG-box containing protein that binds preferentially single-stranded DNA and unwinds double-stranded DNA. Sp-100, also called nuclear dot-associated Sp100 protein, or speckled 100 kDa, is a tumor suppressor that is a major constituent of promyelocytic leukemia (PML) bodies, a subnuclear organelle involved in many physiological processes including cell growth, differentiation and apoptosis. Through the regulation of ETS1, Sp-100 may play a role in angiogenesis, controlling endothelial cell motility and invasion. It may also play roles in the regulation of telomere lengthening, TP53-mediated transcription, FAS-mediated apoptosis, etc. In addition, the family includes Drosophila melanogaster high mobility group protein DSP1 (dDSP1) and similar proteins. dDSP1, also called protein dorsal switch 1, binds preferentially to single-stranded DNA and unwinds double-stranded DNA. It converts Dorsal and nuclear factor (NF)-kappa B from transcriptional activators to repressors. Members of the HMGB family contain two HMG-box domains. This model corresponds to the first one.


Pssm-ID: 438794 [Multi-domain]  Cd Length: 69  Bit Score: 42.29  E-value: 1.15e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1110 RRPMNAFMIFSKRHRALVHQRHPNQ--DNRTVSKILGEWWYALGPKEKQKYHDLAFQVKE 1167
Cdd:cd21978      3 RGKMSSYAFFVQTCREEHKKKHPNEsvNFSEFSKKCSERWKTMSAKEKKKFEDMAKKDKA 62
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1765-2162 2.26e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.70  E-value: 2.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1765 PAPTTSIRFTLPPGTSTNGKVLAATAPTPGIPilqSVPSAPPPKAQSVSPVQAPPPGGSAQLLPGKVLVPLAAPSMsvrg 1844
Cdd:PHA03307    80 PANESRSTPTWSLSTLAPASPAREGSPTPPGP---SSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASP---- 152

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1845 ggAGQPLPLVSPPFSVPVQNGAQPPSKIIQLTPVPVSTPSGLVPPLSPATLPGPTSQPqkvllPSSTRITYVQSAGGHAL 1924
Cdd:PHA03307   153 --PAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPR-----RSSPISASASSPAPAPG 225

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1925 PLGTSPASSQAGTVTSYGPTSSvalgftslgPSGPAFVQPLLSAGQAPLLAPGQVGVSPVPSPQLPPACAAPGGPVITaf 2004
Cdd:PHA03307   226 RSAADDAGASSSDSSSSESSGC---------GWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRER-- 294

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 2005 ysgSPAPTSSAPLAQPSQAPPSLVYTVATSTTPPAATILPKGPPAPATATPAPTSPFPSATGSMTyslvapkaqrPSPKA 2084
Cdd:PHA03307   295 ---SPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRP----------PPPAD 361

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462564004 2085 PQKVKAAIASIPVGSFEAGASGRPGPAPRQPLEPGPVREPTAPESeLEGQPTPPAPPPLPETWTPTARSSPPLPPPAE 2162
Cdd:PHA03307   362 PSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR-FPAGRPRPSPLDAGAASGAFYARYPLLTPSGE 438
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
1875-2088 2.79e-04

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 46.28  E-value: 2.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1875 LTPVPVSTPSGLVPPLSPATLPGPTSQPQKVLLPSSTriTYVQSAGGHALPLGTSPASSQAGTVTSYGPTSSVALGFTSL 1954
Cdd:COG3469      2 SSVSTAASPTAGGASATAVTLLGAAATAASVTLTAAT--ATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTT 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1955 GP---SGPAFVQPLLSAGQAPLLAPGQVGVSPVPSPQLPPACAAPGGPVITAFYSGSPAPTSSAPLAQPSQAPPSLVYTV 2031
Cdd:COG3469     80 ATataAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETA 159

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462564004 2032 ATSTTPPAATILPKGPPAPATATPAPTSPFPSATGSMTYSLVAPKAQRPSPKAPQKV 2088
Cdd:COG3469    160 TGGTTTTSTTTTTTSASTTPSATTTATATTASGATTPSATTTATTTGPPTPGLPKHV 216
HMG-box_BHMG1 cd21977
high mobility group (HMG)-box found in basic helix-loop-helix and HMG box domain-containing ...
 1113-1169 3.11e-04

high mobility group (HMG)-box found in basic helix-loop-helix and HMG box domain-containing protein 1 (BHMG1) and similar proteins; BHMG1 is an uncharacterized HMG-box containing protein that contains a degenerate basic motif not likely to bind DNA.


Pssm-ID: 438793 [Multi-domain]  Cd Length: 66  Bit Score: 41.15  E-value: 3.11e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462564004 1113 MNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAH 1169
Cdd:cd21977      5 VNGFIMFCRLNRKNYIDKHPGLASTELTKELGQLWRELSAEEKKPYCVRARELSQLH 61
dnaA PRK14086
chromosomal replication initiator protein DnaA;
871-1046 3.88e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 45.97  E-value: 3.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004  871 VPPAAPTAVAQPMPAFGLASSPFQPVAFHPSPAALLPVLVPSSY----TSHPAPKKEVIMGRPGTvWtnvePRSVAVFPW 946
Cdd:PRK14086    93 GEPAPPPPHARRTSEPELPRPGRRPYEGYGGPRADDRPPGLPRQdqlpTARPAYPAYQQRPEPGA-W----PRAADDYGW 167

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004  947 HSlvPFLAPSQPDPSVQPSEAQQPASH---PVASNQSKEPAESAAVAHERP----PGGTGSADPERPPGA-----TCPES 1014
Cdd:PRK14086   168 QQ--QRLGFPPRAPYASPASYAPEQERdrePYDAGRPEYDQRRRDYDHPRPdwdrPRRDRTDRPEPPPGAghvhrGGPGP 245

                          170       180       190
                   ....*....|....*....|....*....|..
gi 2462564004 1015 PGPGPPHPLGVVESGKGPPPTTEEEASGPPGE 1046
Cdd:PRK14086   246 PERDDAPVVPIRPSAPGPLAAQPAPAPGPGEP 277
HMG-box_SMARCE1 cd21983
high mobility group (HMG)-box found in SWI/SNF-related matrix-associated actin-dependent ...
 1111-1160 5.40e-04

high mobility group (HMG)-box found in SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1) and similar proteins; SMARCE1, also called BRG1-associated factor 57 (BAF57), is a ubiquitously expressed protein involved in transcriptional activation and repression of select genes by chromatin remodeling. It is a component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. SMARCE1 has a single HMG domain that displays non-specific DNA-binding characteristics. It also contains a kinesin-like coiled-coil (KLCC) domain.


Pssm-ID: 438799 [Multi-domain]  Cd Length: 73  Bit Score: 40.74  E-value: 5.40e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1111 RPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHD 1160
Cdd:cd21983      7 KPLMPYMRYSRKVWDQVKASNPDLKLWEIGKIIGQMWRELSDEEKQEYIE 56
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 743-1105 5.80e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.55  E-value: 5.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004  743 DSLDSGVDSVSHTPTPSTPAGFRAVSPAVPFSRSRQPSPLLLLPPPAGLTSDPGPSVRRVPAVQRDSPVIVRNPDVPLPS 822
Cdd:PHA03307    12 EAAAEGGEFFPRPPATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWS 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004  823 KFPGEVGTAGEVRAGGPGRGCRETPVPPGVASGKPGLPPPLPAPVPITVPPAAPTAVAQPMPAFGLASSPFQPVAFHPSP 902
Cdd:PHA03307    92 LSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQ 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004  903 AALLPVLVPSSYTSHPAPKKEVIMGRPGTVWTNVEPRsvavfPWHSLVPFLAPSQPDPSVQPSEAQQPASHPVASNQSKE 982
Cdd:PHA03307   172 AALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPR-----RSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSG 246

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004  983 PAESAAVAHERPPGGTGSADPERPPGATCPESPGPGPPHPLGVVESGKGPPPTTEEEASGPPGEPRLDSETESDHDDAFL 1062
Cdd:PHA03307   247 CGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSS 326

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 2462564004 1063 SIMSPEIQLPLPPGKRRTQSLSALPKERDSSSEKDGRSPNKRE 1105
Cdd:PHA03307   327 SSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRP 369
HMG-box_PB1 cd21984
high mobility group (HMG)-box found in protein polybromo-1 (PB1) and similar proteins; PB1, ...
 1110-1167 6.04e-04

high mobility group (HMG)-box found in protein polybromo-1 (PB1) and similar proteins; PB1, also called BRG1-associated factor 180 (BAF180), or polybromo-1D, is a subunit of the PBAF (polybromo/Brg1-associated factor) chromatin-remodeling complex required for kinetochore localization during mitosis and the transcription of estrogen-responsive genes. It is involved in transcriptional activation and repression of select genes by chromatin remodeling. It acts as a negative regulator of cell proliferation.


Pssm-ID: 438800 [Multi-domain]  Cd Length: 60  Bit Score: 39.92  E-value: 6.04e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462564004 1110 RRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKE 1167
Cdd:cd21984      1 KRNPSGYILFSSEVRKSIKAENPDYSFGEISRLVGTEWRNLPAEKKAEYEERAQKQAE 58
HMG-box_AtSSRP1 cd22013
high mobility group (HMG)-box found in Arabidopsis thaliana FACT complex subunit SSRP1 and ...
 1103-1177 1.61e-03

high mobility group (HMG)-box found in Arabidopsis thaliana FACT complex subunit SSRP1 and similar proteins; SSRP1, also called facilitates chromatin transcription complex subunit SSRP1, high mobility group B protein 8, nucleosome/chromatin assembly factor group D 08 (or D 8), protein NUCLEAR FUSION DEFECTIVE 8, or recombination signal sequence recognition protein 1, is a component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication, and DNA repair. SSRP1 may bind specifically to double-stranded DNA. It is required for karyogamy during female gametophyte development, when the two polar nuclei fuse to form the diploid central cell nucleus. SSRP1 contains only one HMG-box domain.


Pssm-ID: 438829 [Multi-domain]  Cd Length: 80  Bit Score: 39.46  E-value: 1.61e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462564004 1103 KREKD--HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWK 1177
Cdd:cd22013      1 KKKKDpnAPKRALSGFMFFSLMERENLKKEKPGISFGEVGKVLGEKWKNMSADDKAPYEAKAQVDKERYKKEMSGYK 77
HMG-box_NSD2 cd21991
high mobility group (HMG)-box found in nuclear SET domain-containing protein 2 (NSD2) and ...
 1109-1158 1.65e-03

high mobility group (HMG)-box found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2, also called multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1), acts as a histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness.


Pssm-ID: 438807 [Multi-domain]  Cd Length: 62  Bit Score: 38.83  E-value: 1.65e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1109 IRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKY 1158
Cdd:cd21991      2 KKVKKGQFEVFCQKHREEVAQEHPDLSEEEIEEYLKKQWNNMSEKQRARY 51
HMG-box_HMG20B cd22018
high mobility group (HMG)-box found in high mobility group protein 20B (HMG20B) and similar ...
 1110-1171 2.25e-03

high mobility group (HMG)-box found in high mobility group protein 20B (HMG20B) and similar proteins; HMG20B, also called SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related, SMARCE1-related protein (SMARCE1R), BRCA2-associated factor 35 (BRAF35), HMG box-containing protein 20B, HMG domain-containing protein 2 (HMGXB2), HMG domain-containing protein HMGX2, Sox-like transcriptional factor, or structural DNA-binding protein BRAF35, is a DNA binding factor that acts as a repressor of erythroid differentiation. It is required for correct progression through the G2 phase of the cell cycle and entry into mitosis. It is also required for RCOR1/CoREST mediated repression of neuronal specific gene promoters. HMG20B is a core subunit of the Lys-specific demethylase 1/REST co-repressor 1 (LSD1-CoREST) histone demethylase complex.


Pssm-ID: 438834 [Multi-domain]  Cd Length: 85  Bit Score: 39.19  E-value: 2.25e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462564004 1110 RRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFK 1171
Cdd:cd22018      3 KAPVTGYVRFLNERREQIRTQHPDLPFPEITKMLGAEWSKLQPHEKQRYLDEAERDKQQYMK 64
HMG-box_HMGXB4 cd21982
high mobility group (HMG)-box found in HMG domain-containing protein 4 (HMGXB4) and similar ...
 1110-1156 2.72e-03

high mobility group (HMG)-box found in HMG domain-containing protein 4 (HMGXB4) and similar proteins; HMGXB4, also called HMG box-containing protein 4, high mobility group protein 2-like 1 (HMG2L1), or protein HMGBCG, is a non-histone chromosomal protein that negatively regulates Wnt/beta-catenin signaling during development. It plays a role in the hematopoietic system.


Pssm-ID: 438798 [Multi-domain]  Cd Length: 61  Bit Score: 38.41  E-value: 2.72e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2462564004 1110 RRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQ 1156
Cdd:cd21982      2 KKNMSAYQVFCKEYRVSIVAEHPGIDFGELSKKLAEVWKQLPEKDKL 48
HMG-box_CMB1-like cd22014
high mobility group (HMG)-box found in Schizosaccharomyces pombe mismatch-binding protein cmb1 ...
 1111-1172 3.29e-03

high mobility group (HMG)-box found in Schizosaccharomyces pombe mismatch-binding protein cmb1 and similar proteins; Cmb1 binds to cytosines in base mismatches and opposite chemically altered guanines. It contains only one HMG-box domain.


Pssm-ID: 438830 [Multi-domain]  Cd Length: 62  Bit Score: 38.12  E-value: 3.29e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462564004 1111 RPMNAFMIFSKRHRALVHQRHPNQDNrtvSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKA 1172
Cdd:cd22014      3 RPPSPFLLFMEEFRRNEDNGKNLVEL---SRIAAEAWKNMSEDEKQPYIDRAKELLEEYKKQ 61
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1955-2195 3.38e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.94  E-value: 3.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1955 GPSGPAfvqpllSAGQAPLLAPGQVGVSP---VPSPQLPPACAAPGGPVITAFYS--GSPAPTSSAPLAQPSQAPPSLVY 2029
Cdd:PRK12323   370 GGAGPA------TAAAAPVAQPAPAAAAPaaaAPAPAAPPAAPAAAPAAAAAARAvaAAPARRSPAPEALAAARQASARG 443

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 2030 TVATSTTPPAATILPKGPPAPATATPAPTSPFPSATGSMTYSLVAPKAQRPSPKAPQKVKAAIASIPVGSFEAG-----A 2104
Cdd:PRK12323   444 PGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAApagwvA 523

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 2105 SGRPGPAPRQPLEPGPVREPTAPESELEgqptppappplpetwtPTARSSPPLPPPAEERTSAKGPETMaskfpsSSSDW 2184
Cdd:PRK12323   524 ESIPDPATADPDDAFETLAPAPAAAPAP----------------RAAAATEPVVAPRPPRASASGLPDM------FDGDW 581

                          250
                   ....*....|.
gi 2462564004 2185 RVPGQGLENRG 2195
Cdd:PRK12323   582 PALAARLPVRG 592
HMG-box_UBF1_rpt1-like cd21998
first high mobility group (HMG)-box found in upstream-binding factor 1 (UBF1) and similar ...
 1107-1175 3.40e-03

first high mobility group (HMG)-box found in upstream-binding factor 1 (UBF1) and similar proteins; UBF1, also called UBTF, nucleolar transcription factor 1, or auto-antigen NOR-90, is a nucleolar transcription factor that recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. UBF1 contains six HMG-box domains. This model corresponds to the first one. This model also includes the first HMG-box domain of upstream-binding factor 1-like protein 1 (UBTFL1), which contains two HMG-box domains.


Pssm-ID: 438814 [Multi-domain]  Cd Length: 77  Bit Score: 38.46  E-value: 3.40e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462564004 1107 DHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHD------LAFQVKEAHFKA-HPD 1175
Cdd:cd21998      2 DFPKKPLTPYFRFFMEKRAKYAKKHPEMSNLELTKILSKKYKELPEKKKQKYIQdyekekEEYEQKMARFREeHPD 77
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1787-2202 4.30e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.45  E-value: 4.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1787 AATAPTPGIPILQSVPSA-PPPKAQSVSPVQAPPPGgsaqlLPGKVLVPLAAPSMSVRGGGAGQPLPLVSPpfSVPVQNG 1865
Cdd:pfam03154  180 AASPPSPPPPGTTQAATAgPTPSAPSVPPQGSPATS-----QPPNQTQSTAAPHTLIQQTPTLHPQRLPSP--HPPLQPM 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1866 AQP-PSKIIQLTPVPVSTPSGLVPPLSPATLPGPTSQPQKVllPSSTRITYVQSAGGHALPLGTSPASSQAGTVTSYGPT 1944
Cdd:pfam03154  253 TQPpPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPV--PPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPS 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1945 SSvalgftSLGPSGPAFVQPLLSAGQA--PLLAPGQVGVSPVPSPQLPPACAAPGGPVITAFYSGSPAPTSSAPLAQ-PS 2021
Cdd:pfam03154  331 QS------QLQSQQPPREQPLPPAPLSmpHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPPALKPLSSlST 404

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 2022 QAPPSlvytvatsTTPPAATILPKGPPapatatpaptspfpsatgsmtysLVAPKAQRPSPKAPQKVKAAIASIPvgsfe 2101
Cdd:pfam03154  405 HHPPS--------AHPPPLQLMPQSQQ-----------------------LPPPPAQPPVLTQSQSLPPPAASHP----- 448

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 2102 agasgrpgpaPRQPLEPGPVREPTAPESELEGQPTPPAPPPLPETWTPTARSSPPLPPPAEERTSAKGPETMASKFPSSS 2181
Cdd:pfam03154  449 ----------PTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQ 518

                          410       420
                   ....*....|....*....|.
gi 2462564004 2182 SDWRVPGQGLENRGEPPTPPS 2202
Cdd:pfam03154  519 IKEEALDEAEEPESPPPPPRS 539
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 1906-2024 4.88e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 42.36  E-value: 4.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1906 LLPSSTRITYVQSAGGHALPLGTS----PASSQAGTVTSYGPTSSVALG-FTSLGPSGPAFVQPLLSAGQAPLL------ 1974
Cdd:PRK14959   361 MLPRLMPVESLRPSGGGASAPSGSaaegPASGGAATIPTPGTQGPQGTApAAGMTPSSAAPATPAPSAAPSPRVpwddap 440

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462564004 1975 -APGQVGVSPVPSPQLPPACAAPGGPVITAFYSGSPaPTSSAPLAQPSQAP 2024
Cdd:PRK14959   441 pAPPRSGIPPRPAPRMPEASPVPGAPDSVASASDAP-PTLGDPSDTAEHTP 490
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1963-2169 5.32e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.14  E-value: 5.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1963 QPLLSAGQAPllapgqVGVSPVPSPQLPPACAAPGGPVITAFYSGSPAPTSSAPLAQPsqAPPSLVYTVATSTTPPAATI 2042
Cdd:PRK07003   359 EPAVTGGGAP------GGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAAL--APKAAAAAAATRAEAPPAAP 430

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 2043 LPKGPPAPATATPAPTSPFPSATGSMtyslVAPKAQRPSPKAPQKVKAAIASIPVGSFEAGASGRPGP--APRQPLEPGP 2120
Cdd:PRK07003   431 APPATADRGDDAADGDAPVPAKANAR----ASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPraAAPSAATPAA 506

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 2462564004 2121 VREPTAPESELEGQPTPPAPPplpetwtPTARSSPPLPPPAEERTSAKG 2169
Cdd:PRK07003   507 VPDARAPAAASREDAPAAAAP-------PAPEARPPTPAAAAPAARAGG 548
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 1910-2178 7.57e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 41.48  E-value: 7.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1910 STRITYVQSAGGHALPLGTSPASSQAGTV------TSYGPTSSVALGFTSLGPSGPAFVQP-----LLSAGQAPLLAPGQ 1978
Cdd:pfam17823   98 SEPATREGAADGAASRALAAAASSSPSSAaqslpaAIAALPSEAFSAPRAAACRANASAAPraaiaAASAPHAASPAPRT 177

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1979 VGVSPVPSPQLPPACAAPGGPVITAFYSGSPA-PTSSAPLAQPSQAPPSLVYTVATSTTPPAATILPKGPPAPATATPAP 2057
Cdd:pfam17823  178 AASSTTAASSTTAASSAPTTAASSAPATLTPArGISTAATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLA 257

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 2058 TSPFPSATGSMTYSLVAPKAQRPSP--KAPQKVKAAIASIPVGSFEAG-------------ASGRPGPAPRQplepgPVR 2122
Cdd:pfam17823  258 AAAGTVASAAGTINMGDPHARRLSPakHMPSDTMARNPAAPMGAQAQGpiiqvstdqpvhnTAGEPTPSPSN-----TTL 332

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462564004 2123 EPTAPESeLEGQPTPPAPPPLPETWTPTARSSPPLPPPAEERTSAKGPETMASKFP 2178
Cdd:pfam17823  333 EPNTPKS-VASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPEVEATSPTTQPSPLL 387
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1739-2125 8.81e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.68  E-value: 8.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1739 PTLPQQLQVAPAPAPAPGTKAAAPSGPAPTT----SIRFTLPPGT--STNGKVLAATAPTPGIPILQSVPSAPPPKaqsV 1812
Cdd:pfam03154  185 SPPPPGTTQAATAGPTPSAPSVPPQGSPATSqppnQTQSTAAPHTliQQTPTLHPQRLPSPHPPLQPMTQPPPPSQ---V 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1813 SPVQAPPPGGSAQLLPGKVLVPLAAPSMSVRGGGAGQPLPLVSPPFSVPV--QNGAQPPSKIIQLTPVPVSTPSGLVPPL 1890
Cdd:pfam03154  262 SPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPgpSPAAPGQSQQRIHTPPSQSQLQSQQPPR 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1891 SPATLPGPTSQPQkVLLPSSTRITYVQSAGGHALPLGTSPASSqagtvtsygptssvaLGFTSLGPSGPAfVQPL--LSA 1968
Cdd:pfam03154  342 EQPLPPAPLSMPH-IKPPPTTPIPQLPNPQSHKHPPHLSGPSP---------------FQMNSNLPPPPA-LKPLssLST 404

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564004 1969 GQAPLLAPGQVGVSPvPSPQLPPACAAPggPVITAFYSgSPAPTSSAPlaqpsqaPPSLVYTVATSTTPPAATILPKGPP 2048
Cdd:pfam03154  405 HHPPSAHPPPLQLMP-QSQQLPPPPAQP--PVLTQSQS-LPPPAASHP-------PTSGLHQVPSQSPFPQHPFVPGGPP 473

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462564004 2049 APATATPAPTSPFPSATGSMTYSLVAPKAQRPSPKAPQKVKAAIASIPVGSFEAGASGRPGPAPRQPL-EPGPVREPT 2125
Cdd:pfam03154  474 PITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSpEPTVVNTPS 551
HMG-box_TOX-like cd21995
high mobility group (HMG)-box found in the TOX high mobility group box family; The TOX family ...
 1110-1172 9.74e-03

high mobility group (HMG)-box found in the TOX high mobility group box family; The TOX family includes four members: TOX, TOX2, TOX3 and TOX4. TOX, also called thymus high mobility group box protein TOX, is a transcriptional regulator with a major role in neural stem cell commitment and corticogenesis as well as in lymphoid cell development and lymphoid tissue organogenesis. It binds to GC-rich DNA sequences in the proximity of transcription start sites and may alter chromatin structure, modifying access of transcription factors to DNA. TOX2, also called granulosa cell HMG box protein 1 (GCX-1), is a putative transcriptional activator involved in the hypothalamic-pituitary-gonadal system. TOX3, also called CAG trinucleotide repeat-containing gene F9 protein (CAGF9), or trinucleotide repeat-containing gene 9 protein (TNRC9), is a transcriptional coactivator of the p300/CBP-mediated transcription complex. It activates transactivation through cAMP response element (CRE) sites. It protects against cell death by inducing anti-apoptotic and repressing pro-apoptotic transcripts. TOX4, also called epidermal Langerhans cell protein LCP1, is a component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. All family members contain one HMG-box domain.


Pssm-ID: 438811 [Multi-domain]  Cd Length: 70  Bit Score: 37.07  E-value: 9.74e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462564004 1110 RRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKA 1172
Cdd:cd21995      1 QKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLDEEQKQVYKKKTEAAKKEYLKA 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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