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Conserved domains on  [gi|2462558237|ref|XP_054173510|]
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nuclear speckle splicing regulatory protein 1 isoform X2 [Homo sapiens]

Protein Classification

nuclear speckle splicing regulatory protein 1 family protein( domain architecture ID 10560920)

nuclear speckle splicing regulatory protein 1 (NSRP1) family protein is a DUF2040 domain-containing protein similar to Schizosaccharomyces pombe NSRP1 homolog, also called coiled-coil domain-containing protein 55 homolog

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NRP1_C pfam20427
Nuclear speckle splicing regulatory protein 1, RS-like domain; This domain found at the ...
 323-500 1.46e-50

Nuclear speckle splicing regulatory protein 1, RS-like domain; This domain found at the C-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55). This is the RS-like domain, that resembles the arginine/serine-rich (RS) domain in other SR proteins, interacts with two SR proteins and with target mRNA, being essential for NRP1 activity. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation.


:

Pssm-ID: 466576 [Multi-domain]  Cd Length: 174  Bit Score: 172.33  E-value: 1.46e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558237 323 SEERGHSTRHHTKGSRtSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRE 402
Cdd:pfam20427   2 SEERGHGTKHHTKSSK-SRGHEKREDQHQKRQSRDQESYYTDHDHRKEKDSHRHREASHRDSHWKRHEQEDKLRGRDQRE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558237 403 RSDRVWKREKdrekYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQD 482
Cdd:pfam20427  81 RNDREWKREK----YSSREQERDRQRNDHDRHSEKGEKEEKSKEKEEHMKGRKERYENSDKYRDREKQEVSVQSSERNRD 156

                         170
                  ....*....|....*...
gi 2462558237 483 RKESSPNSRAKDKFLDQE 500
Cdd:pfam20427 157 RKESSPNSRAKDEFLDQE 174
NSRP1_N pfam09745
Nuclear speckle splicing regulatory protein 1, N-terminal; This domain is found at the ...
 88-207 2.15e-33

Nuclear speckle splicing regulatory protein 1, N-terminal; This domain is found at the N-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55) and contains a coiled-coil domain that plays a critical role in NRP1 alternative splicing activity and self-oligomerization. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation.


:

Pssm-ID: 462876 [Multi-domain]  Cd Length: 121  Bit Score: 123.40  E-value: 2.15e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558237  88 TKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLG-KDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGE 166
Cdd:pfam09745   1 AKKEAEKALEEDPSVFDYDEVYDSMKAAKEEKKAAKKAErKERKPKYIENLLKAAERRKRERERAEERKLQKEREAEGDE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2462558237 167 FDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQ 207
Cdd:pfam09745  81 FADKEKFVTSAYKKKLEELRKLEEEEKRREELEEKKDVTKG 121
 
Name Accession Description Interval E-value
NRP1_C pfam20427
Nuclear speckle splicing regulatory protein 1, RS-like domain; This domain found at the ...
 323-500 1.46e-50

Nuclear speckle splicing regulatory protein 1, RS-like domain; This domain found at the C-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55). This is the RS-like domain, that resembles the arginine/serine-rich (RS) domain in other SR proteins, interacts with two SR proteins and with target mRNA, being essential for NRP1 activity. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation.


Pssm-ID: 466576 [Multi-domain]  Cd Length: 174  Bit Score: 172.33  E-value: 1.46e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558237 323 SEERGHSTRHHTKGSRtSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRE 402
Cdd:pfam20427   2 SEERGHGTKHHTKSSK-SRGHEKREDQHQKRQSRDQESYYTDHDHRKEKDSHRHREASHRDSHWKRHEQEDKLRGRDQRE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558237 403 RSDRVWKREKdrekYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQD 482
Cdd:pfam20427  81 RNDREWKREK----YSSREQERDRQRNDHDRHSEKGEKEEKSKEKEEHMKGRKERYENSDKYRDREKQEVSVQSSERNRD 156

                         170
                  ....*....|....*...
gi 2462558237 483 RKESSPNSRAKDKFLDQE 500
Cdd:pfam20427 157 RKESSPNSRAKDEFLDQE 174
NSRP1_N pfam09745
Nuclear speckle splicing regulatory protein 1, N-terminal; This domain is found at the ...
 88-207 2.15e-33

Nuclear speckle splicing regulatory protein 1, N-terminal; This domain is found at the N-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55) and contains a coiled-coil domain that plays a critical role in NRP1 alternative splicing activity and self-oligomerization. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation.


Pssm-ID: 462876 [Multi-domain]  Cd Length: 121  Bit Score: 123.40  E-value: 2.15e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558237  88 TKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLG-KDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGE 166
Cdd:pfam09745   1 AKKEAEKALEEDPSVFDYDEVYDSMKAAKEEKKAAKKAErKERKPKYIENLLKAAERRKRERERAEERKLQKEREAEGDE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2462558237 167 FDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQ 207
Cdd:pfam09745  81 FADKEKFVTSAYKKKLEELRKLEEEEKRREELEEKKDVTKG 121
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 320-482 8.52e-07

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 51.83  E-value: 8.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558237 320 RSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDShwKRHEQEDKPRARD 399
Cdd:PRK12678  133 RGEAARRGAARKAGEGGEQPATEARADAAERTEEEERDERRRRGDREDRQAEAERGERGRREERG--RDGDDRDRRDRRE 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558237 400 QRERSDRvwKREKDREKYSQREQERDRQQNDQNRpSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSER 479
Cdd:PRK12678  211 QGDRREE--RGRRDGGDRRGRRRRRDRRDARGDD-NREDRGDRDGDDGEGRGGRRGRRFRDRDRRGRRGGDGGNEREPEL 287


                  ...
gi 2462558237 480 NQD 482
Cdd:PRK12678  288 RED 290
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 340-431 1.25e-04

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 44.91  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558237 340 SRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREashRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQ 419
Cdd:TIGR01622   2 YRDRERERLRDSSSAGDRDRRRDKGRERSRDRSRDRERS---RSRRRDRHRDRDYYRGRERRSRSRRPNRRYRPREKRRR 78

                          90
                  ....*....|..
gi 2462558237 420 REQERDRQQNDQ 431
Cdd:TIGR01622  79 RGDSYRRRRDDR 90
 
Name Accession Description Interval E-value
NRP1_C pfam20427
Nuclear speckle splicing regulatory protein 1, RS-like domain; This domain found at the ...
 323-500 1.46e-50

Nuclear speckle splicing regulatory protein 1, RS-like domain; This domain found at the C-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55). This is the RS-like domain, that resembles the arginine/serine-rich (RS) domain in other SR proteins, interacts with two SR proteins and with target mRNA, being essential for NRP1 activity. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation.


Pssm-ID: 466576 [Multi-domain]  Cd Length: 174  Bit Score: 172.33  E-value: 1.46e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558237 323 SEERGHSTRHHTKGSRtSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRE 402
Cdd:pfam20427   2 SEERGHGTKHHTKSSK-SRGHEKREDQHQKRQSRDQESYYTDHDHRKEKDSHRHREASHRDSHWKRHEQEDKLRGRDQRE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558237 403 RSDRVWKREKdrekYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQD 482
Cdd:pfam20427  81 RNDREWKREK----YSSREQERDRQRNDHDRHSEKGEKEEKSKEKEEHMKGRKERYENSDKYRDREKQEVSVQSSERNRD 156

                         170
                  ....*....|....*...
gi 2462558237 483 RKESSPNSRAKDKFLDQE 500
Cdd:pfam20427 157 RKESSPNSRAKDEFLDQE 174
NSRP1_N pfam09745
Nuclear speckle splicing regulatory protein 1, N-terminal; This domain is found at the ...
 88-207 2.15e-33

Nuclear speckle splicing regulatory protein 1, N-terminal; This domain is found at the N-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55) and contains a coiled-coil domain that plays a critical role in NRP1 alternative splicing activity and self-oligomerization. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation.


Pssm-ID: 462876 [Multi-domain]  Cd Length: 121  Bit Score: 123.40  E-value: 2.15e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558237  88 TKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLG-KDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGE 166
Cdd:pfam09745   1 AKKEAEKALEEDPSVFDYDEVYDSMKAAKEEKKAAKKAErKERKPKYIENLLKAAERRKRERERAEERKLQKEREAEGDE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2462558237 167 FDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQ 207
Cdd:pfam09745  81 FADKEKFVTSAYKKKLEELRKLEEEEKRREELEEKKDVTKG 121
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 320-482 8.52e-07

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 51.83  E-value: 8.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558237 320 RSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDShwKRHEQEDKPRARD 399
Cdd:PRK12678  133 RGEAARRGAARKAGEGGEQPATEARADAAERTEEEERDERRRRGDREDRQAEAERGERGRREERG--RDGDDRDRRDRRE 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558237 400 QRERSDRvwKREKDREKYSQREQERDRQQNDQNRpSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSER 479
Cdd:PRK12678  211 QGDRREE--RGRRDGGDRRGRRRRRDRRDARGDD-NREDRGDRDGDDGEGRGGRRGRRFRDRDRRGRRGGDGGNEREPEL 287


                  ...
gi 2462558237 480 NQD 482
Cdd:PRK12678  288 RED 290
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 340-431 1.25e-04

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 44.91  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558237 340 SRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREashRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQ 419
Cdd:TIGR01622   2 YRDRERERLRDSSSAGDRDRRRDKGRERSRDRSRDRERS---RSRRRDRHRDRDYYRGRERRSRSRRPNRRYRPREKRRR 78

                          90
                  ....*....|..
gi 2462558237 420 REQERDRQQNDQ 431
Cdd:TIGR01622  79 RGDSYRRRRDDR 90
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 276-434 1.91e-04

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 44.51  E-value: 1.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558237 276 ADSDFDAKSSADDEIEETRVNCRREkviETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQS 355
Cdd:PRK12678  137 ARRGAARKAGEGGEQPATEARADAA---ERTEEEERDERRRRGDREDRQAEAERGERGRREERGRDGDDRDRRDRREQGD 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558237 356 RDQENHYTDRDYRKERDSHRHREASHRDshwkRHEQEDKPRARDQRE-RSDRVWKREKDREkysqREQERDRQQNDQNRP 434
Cdd:PRK12678  214 RREERGRRDGGDRRGRRRRRDRRDARGD----DNREDRGDRDGDDGEgRGGRRGRRFRDRD----RRGRRGGDGGNEREP 285
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 368-481 1.10e-03

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 41.83  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558237 368 RKERDSHRHREashRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAK 447
Cdd:TIGR01622   2 YRDRERERLRD---SSSAGDRDRRRDKGRERSRDRSRDRERSRSRRRDRHRDRDYYRGRERRSRSRRPNRRYRPREKRRR 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2462558237 448 EEHM--KVRKERYENNDKYRDREKREVGVQSSERNQ 481
Cdd:TIGR01622  79 RGDSyrRRRDDRRSRREKPRARDGTPEPLTEDERDR 114
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 319-515 1.19e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 41.81  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558237 319 SRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDShrhREASHRDSHWKRHEQEDKPRAR 398
Cdd:PRK12678   79 RAARAAAAARQAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAPEAAQARERRER---GEAARRGAARKAGEGGEQPATE 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558237 399 DQRERSDRvwKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYR--DREKREVGVQS 476
Cdd:PRK12678  156 ARADAAER--TEEEERDERRRRGDREDRQAEAERGERGRREERGRDGDDRDRRDRREQGDRREERGRrdGGDRRGRRRRR 233

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2462558237 477 SERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERN 515
Cdd:PRK12678  234 DRRDARGDDNREDRGDRDGDDGEGRGGRRGRRFRDRDRR 272
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 382-513 1.43e-03

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 41.44  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558237 382 RDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRqqndqnrpsekgekeekskakeehmkvRKERyenn 461
Cdd:TIGR01622   3 RDRERERLRDSSSAGDRDRRRDKGRERSRDRSRDRERSRSRRRDR---------------------------HRDR---- 51

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462558237 462 DKYRDREKREVGVQSSERNQDRKESS--PNSRAKDKFLDQERSNKMRNMAKDKE 513
Cdd:TIGR01622  52 DYYRGRERRSRSRRPNRRYRPREKRRrrGDSYRRRRDDRRSRREKPRARDGTPE 105
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 307-416 1.70e-03

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 41.03  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558237 307 ENDFKHHRSQNHSRSPSEERgHSTRHHTKGSRTSRGHEKRE------DQHQQKQSRDQENHYTDRDYRKERDSHRHREAS 380
Cdd:TIGR01642   4 EPDREREKSRGRDRDRSSER-PRRRSRDRSRFRDRHRRSRErsyredSRPRDRRRYDSRSPRSLRYSSVRRSRDRPRRRS 82

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2462558237 381 HRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREK 416
Cdd:TIGR01642  83 RSVRSIEQHRRRLRDRSPSNQWRKDDKKRSLWDIKP 118
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 386-495 2.93e-03

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 40.26  E-value: 2.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558237 386 WKRHEQEdKPRARDQRERSDRVWKREKDREkysqREQERDRQQNDQNRPSEKGEKEEKSKAKEehmKVRKERYENNDKYR 465
Cdd:TIGR01642   4 EPDRERE-KSRGRDRDRSSERPRRRSRDRS----RFRDRHRRSRERSYREDSRPRDRRRYDSR---SPRSLRYSSVRRSR 75

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2462558237 466 DREKRE---VGVQSSERNQDRKESSPNSRAKDK 495
Cdd:TIGR01642  76 DRPRRRsrsVRSIEQHRRRLRDRSPSNQWRKDD 108
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 265-433 3.45e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 40.27  E-value: 3.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558237 265 QTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGhe 344
Cdd:PRK12678  114 AAAEAASAPEAAQARERRERGEAARRGAARKAGEGGEQPATEARADAAERTEEEERDERRRRGDREDRQAEAERGERG-- 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558237 345 KREDQHQQKQSRDQENhytDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVW-KREKDREKYSQREQE 423
Cdd:PRK12678  192 RREERGRDGDDRDRRD---RREQGDRREERGRRDGGDRRGRRRRRDRRDARGDDNREDRGDRDGdDGEGRGGRRGRRFRD 268

                         170
                  ....*....|
gi 2462558237 424 RDRqqNDQNR 433
Cdd:PRK12678  269 RDR--RGRRG 276
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 388-519 7.05e-03

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 39.13  E-value: 7.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558237 388 RHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDqnrpsekgekeekskakeehmkvRKERYENNDKYRDR 467
Cdd:TIGR01622   1 RYRDRERERLRDSSSAGDRDRRRDKGRERSRDRSRDRERSRSR-----------------------RRDRHRDRDYYRGR 57

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462558237 468 EKRevgvqssernqdRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKP 519
Cdd:TIGR01622  58 ERR------------SRSRRPNRRYRPREKRRRRGDSYRRRRDDRRSRREKP 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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