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Conserved domains on  [gi|2462556547|ref|XP_054172712|]
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MIF4G domain-containing protein isoform X7 [Homo sapiens]

Protein Classification

MIF4G domain-containing protein( domain architecture ID 4130)

Middle domain of eukaryotic initiation factor 4G (eIF4G) similar to human death-associated protein 5 (DAP5/p97), a homolog of the eukaryotic initiation factor 4G (eIF4G) that promotes the IRES-driven translation of multiple cellular mRNAs

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIF4G super family cl02652
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 75-220 3.85e-05

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


The actual alignment was detected with superfamily member smart00543:

Pssm-ID: 413423  Cd Length: 200  Bit Score: 43.50  E-value: 3.85e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462556547   75 LEKVANVIVDHSLQDCVFSKEAGRMCYAIIQAeskqagQSVFRRGLLNRLQQEYQAR-EQLRARSLQGWVCYVTFICNIF 153
Cdd:smart00543  34 RKYILELIFEKAVEEPNFIPAYARLCALLNAK------NPDFGSLLLERLQEEFEKGlESEEESDKQRRLGLVRFLGELY 107

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462556547  154 DYLRVNNMPMMALvnpVYDCLFRLAQPDSLSKEEEVDCLVLQLHRVGEQLEKMNG-QRMDELFVLIRD 220
Cdd:smart00543 108 NFQVLTSKIILEL---LKELLNDLTKLDPPRSDFSVECLLSLLPTCGKDLEREKSpKLLDEILERLQD 172
 
Name Accession Description Interval E-value
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 75-220 3.85e-05

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 43.50  E-value: 3.85e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462556547   75 LEKVANVIVDHSLQDCVFSKEAGRMCYAIIQAeskqagQSVFRRGLLNRLQQEYQAR-EQLRARSLQGWVCYVTFICNIF 153
Cdd:smart00543  34 RKYILELIFEKAVEEPNFIPAYARLCALLNAK------NPDFGSLLLERLQEEFEKGlESEEESDKQRRLGLVRFLGELY 107

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462556547  154 DYLRVNNMPMMALvnpVYDCLFRLAQPDSLSKEEEVDCLVLQLHRVGEQLEKMNG-QRMDELFVLIRD 220
Cdd:smart00543 108 NFQVLTSKIILEL---LKELLNDLTKLDPPRSDFSVECLLSLLPTCGKDLEREKSpKLLDEILERLQD 172
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 113-220 4.68e-04

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 40.42  E-value: 4.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462556547 113 QSVFRRGLLNRLQQEYQ---AREQLRARSLQGWVCYVTFICNIFDYLRVNNmpmmalvNPVYDCLFRL----AQPDSLSK 185
Cdd:pfam02854  67 PTDFGIHLLNRLQEEFEkrfELEENEQGNRRRRLGLVRFLGELYKFGLLTE-------KILFECLKELlsslTKEDLKRD 139

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2462556547 186 EEEVDCLVLQLHRVGEQLEKMNG-QRMDELFVLIRD 220
Cdd:pfam02854 140 LFNLECLLTLLTTIGKLLENEKLpKLMDQFLDEIQK 175
 
Name Accession Description Interval E-value
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 75-220 3.85e-05

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 43.50  E-value: 3.85e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462556547   75 LEKVANVIVDHSLQDCVFSKEAGRMCYAIIQAeskqagQSVFRRGLLNRLQQEYQAR-EQLRARSLQGWVCYVTFICNIF 153
Cdd:smart00543  34 RKYILELIFEKAVEEPNFIPAYARLCALLNAK------NPDFGSLLLERLQEEFEKGlESEEESDKQRRLGLVRFLGELY 107

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462556547  154 DYLRVNNMPMMALvnpVYDCLFRLAQPDSLSKEEEVDCLVLQLHRVGEQLEKMNG-QRMDELFVLIRD 220
Cdd:smart00543 108 NFQVLTSKIILEL---LKELLNDLTKLDPPRSDFSVECLLSLLPTCGKDLEREKSpKLLDEILERLQD 172
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 113-220 4.68e-04

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 40.42  E-value: 4.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462556547 113 QSVFRRGLLNRLQQEYQ---AREQLRARSLQGWVCYVTFICNIFDYLRVNNmpmmalvNPVYDCLFRL----AQPDSLSK 185
Cdd:pfam02854  67 PTDFGIHLLNRLQEEFEkrfELEENEQGNRRRRLGLVRFLGELYKFGLLTE-------KILFECLKELlsslTKEDLKRD 139

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2462556547 186 EEEVDCLVLQLHRVGEQLEKMNG-QRMDELFVLIRD 220
Cdd:pfam02854 140 LFNLECLLTLLTTIGKLLENEKLpKLMDQFLDEIQK 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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