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Conserved domains on  [gi|2462553030|ref|XP_054171001|]
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seizure protein 6 homolog isoform X1 [Homo sapiens]

Protein Classification

CUB domain-containing protein; beta-2-glycoprotein 1( domain architecture ID 13042673)

CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein| beta-2-glycoprotein 1 is a heavily glycosylated plasma membrane-adhesion protein, which plays a role in blood coagulation and removal of apoptotic bodies

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 416-526 6.55e-25

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 100.56  E-value: 6.55e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  416 CGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDD----DRLIIRNGDNVEApPVYDSYEVE 491
Cdd:cd00041      1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPncsyDYLEIYDGPSTSS-PLLGRFCGS 79

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2462553030  492 YLPIEgLLSSGKHFFVELSTDSSGAAAGMALRYEA 526
Cdd:cd00041     80 TLPPP-IISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 593-702 3.00e-21

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 89.78  E-value: 3.00e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  593 CSGEITDSA-GVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPG-----DVLTFYDGDDLTARVLGQYSGPR 666
Cdd:cd00041      1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPSTSSPLLGRFCGST 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2462553030  667 SHFKLFTSMADVTIQFQSDPGTSvlgyQQGFVIHFF 702
Cdd:cd00041     81 LPPPIISSGNSLTVRFRSDSSVT----GRGFKATYS 112
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 710-766 1.54e-14

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 69.03  E-value: 1.54e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462553030  710 CPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSCQ 766
Cdd:cd00033      1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 710-895 6.86e-14

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 73.15  E-value: 6.86e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  710 CPELPEIPNGWKSPSQPELvhGTVVTYQCYPGYQVVGSSVLMCQW----DLTWSEDLPSCQRVtSCHDPGDVEHSRRLIS 785
Cdd:PHA02927    86 CPSPRDIDNGQLDIGGVDF--GSSITYSCNSGYQLIGESKSYCELgstgSMVWNPEAPICESV-KCQSPPSISNGRHNGY 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  786 SPKFPVGATVQYICDQGFVLTGSSILTChdrqaGSPKWSDrAPKClleQLKPCHGLSAPENGARSPEKQLHPAGATIHFS 865
Cdd:PHA02927   163 EDFYTDGSVVTYSCNSGYSLIGNSGVLC-----SGGEWSD-PPTC---QIVKCPHPTISNGYLSSGFKRSYSYNDNVDFK 233

                          170       180       190
                   ....*....|....*....|....*....|
gi 2462553030  866 CAPGYVLKGQASIKCVPGHPshWSDPPPIC 895
Cdd:PHA02927   234 CKYGYKLSGSSSSTCSPGNT--WQPELPKC 261
Sushi pfam00084
Sushi repeat (SCR repeat);
532-589 1.44e-10

Sushi repeat (SCR repeat);


:

Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 57.51  E-value: 1.44e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462553030  532 CYEPF-VKYGNFSSSAPTYPVGTTVEFSCDPGYTLeQGSIIIECVDphDPQWNETEPAC 589
Cdd:pfam00084    1 CPPPPdIPNGKVSATKNEYNYGASVSYECDPGYRL-VGSPTITCQE--DGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 357-413 2.42e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 45.53  E-value: 2.42e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462553030  357 CHFPRRPAYGDVTV--TSLHPGGSARFHCATGYQLKGARHLTCLNATQpfWDSKEPVCI 413
Cdd:cd00033      1 CPPPPVPENGTVTGskGSYSYGSTVTYSCNEGYTLVGSSTITCTENGG--WSPPPPTCE 57
PHA03379 super family cl33730
EBNA-3A; Provisional
 31-188 1.66e-05

EBNA-3A; Provisional


The actual alignment was detected with superfamily member PHA03379:

Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 48.90  E-value: 1.66e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030   31 QAPGIEETDGELTAAPTPEQPErgVHFVTTAPTLKLLNHHPLLEEFLQEG----LEKGDEElrPALPFQPDPpapfTPSP 106
Cdd:PHA03379   426 EVPQSLETATSHGSAQVPEPPP--VHDLEPGPLHDQHSMAPCPVAQLPPGplqdLEPGDQL--PGVVQDGRP----ACAP 497

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  107 LPRLANQDSRPVFTSPT--PAMAAVPTQPQSKEGPWSPESESPMLRITAPLPPGPSMAvptlGPGEIASTTPPSRAWTPT 184
Cdd:PHA03379   498 VPAPAGPIVRPWEASLSqvPGVAFAPVMPQPMPVEPVPVPTVALERPVCPAPPLIAMQ----GPGETSGIVRVRERWRPA 573


                   ....
gi 2462553030  185 QEGP 188
Cdd:PHA03379   574 PWTP 577
CUB super family cl00049
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 244-352 2.69e-05

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


The actual alignment was detected with superfamily member cd00041:

Pssm-ID: 412131 [Multi-domain]  Cd Length: 113  Bit Score: 44.33  E-value: 2.69e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  244 CSWNFSGP-EGSLDSPtDLSSPTDVGLDCFFYISVYPGYGVEIKVQNISLREGET-----VTVEGLGGPDPLPLANQSFL 317
Cdd:cd00041      1 CGGTLTAStSGTISSP-NYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNcsydyLEIYDGPSTSSPLLGRFCGS 79

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2462553030  318 LRGQVIRSPTHQAALRFQSLPPPAGPGtFHFHYQA 352
Cdd:cd00041     80 TLPPPIISSGNSLTVRFRSDSSVTGRG-FKATYSA 113
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 416-526 6.55e-25

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 100.56  E-value: 6.55e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  416 CGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDD----DRLIIRNGDNVEApPVYDSYEVE 491
Cdd:cd00041      1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPncsyDYLEIYDGPSTSS-PLLGRFCGS 79

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2462553030  492 YLPIEgLLSSGKHFFVELSTDSSGAAAGMALRYEA 526
Cdd:cd00041     80 TLPPP-IISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 593-702 3.00e-21

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 89.78  E-value: 3.00e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  593 CSGEITDSA-GVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPG-----DVLTFYDGDDLTARVLGQYSGPR 666
Cdd:cd00041      1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPSTSSPLLGRFCGST 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2462553030  667 SHFKLFTSMADVTIQFQSDPGTSvlgyQQGFVIHFF 702
Cdd:cd00041     81 LPPPIISSGNSLTVRFRSDSSVT----GRGFKATYS 112
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 426-524 3.12e-19

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 83.59  E-value: 3.12e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030   426 GRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDD----DRLIIRNGDNVEApPVYDSYEVEYLPIEGLLSS 501
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDnceyDYVEIYDGPSASS-PLLGRFCGSEAPPPVISSS 79

                            90       100
                    ....*....|....*....|...
gi 2462553030   502 GKHFFVELSTDSSGAAAGMALRY 524
Cdd:smart00042   80 SNSLTLTFVSDSSVQKRGFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 602-701 6.73e-18

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 80.13  E-value: 6.73e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030   602 GVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPG-----DVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMA 676
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSdnceyDYVEIYDGPSASSPLLGRFCGSEAPPPVISSSS 80

                            90       100
                    ....*....|....*....|....*.
gi 2462553030   677 D-VTIQFQSDPGTSVlgyqQGFVIHF 701
Cdd:smart00042   81 NsLTLTFVSDSSVQK----RGFSARY 102
CUB pfam00431
CUB domain;
416-524 1.05e-16

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 76.95  E-value: 1.05e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  416 CGGVIRNATtGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDD----DRLIIRNGDNvEAPPVYDSYEVE 491
Cdd:pfam00431    1 CGGVLTDSS-GSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDecgyDYVEIRDGPS-ASSPLLGRFCGS 78

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2462553030  492 YLPiEGLLSSGKHFFVELSTDSSGAAAGMALRY 524
Cdd:pfam00431   79 GIP-EDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB pfam00431
CUB domain;
593-701 1.09e-14

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 71.17  E-value: 1.09e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  593 CSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIML-----DIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRS 667
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLtfqdfELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2462553030  668 HFKLFTSMADVTIQFQSDPGTSvlgyQQGFVIHF 701
Cdd:pfam00431   81 PEDIVSSSNQMTIKFVSDASVQ----KRGFKATY 110
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 710-766 1.54e-14

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 69.03  E-value: 1.54e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462553030  710 CPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSCQ 766
Cdd:cd00033      1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 710-765 2.25e-14

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 68.32  E-value: 2.25e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462553030   710 CPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSC 765
Cdd:smart00032    1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 710-895 6.86e-14

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 73.15  E-value: 6.86e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  710 CPELPEIPNGWKSPSQPELvhGTVVTYQCYPGYQVVGSSVLMCQW----DLTWSEDLPSCQRVtSCHDPGDVEHSRRLIS 785
Cdd:PHA02927    86 CPSPRDIDNGQLDIGGVDF--GSSITYSCNSGYQLIGESKSYCELgstgSMVWNPEAPICESV-KCQSPPSISNGRHNGY 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  786 SPKFPVGATVQYICDQGFVLTGSSILTChdrqaGSPKWSDrAPKClleQLKPCHGLSAPENGARSPEKQLHPAGATIHFS 865
Cdd:PHA02927   163 EDFYTDGSVVTYSCNSGYSLIGNSGVLC-----SGGEWSD-PPTC---QIVKCPHPTISNGYLSSGFKRSYSYNDNVDFK 233

                          170       180       190
                   ....*....|....*....|....*....|
gi 2462553030  866 CAPGYVLKGQASIKCVPGHPshWSDPPPIC 895
Cdd:PHA02927   234 CKYGYKLSGSSSSTCSPGNT--WQPELPKC 261
Sushi pfam00084
Sushi repeat (SCR repeat);
710-765 3.25e-12

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 62.13  E-value: 3.25e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462553030  710 CPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSC 765
Cdd:pfam00084    1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 838-896 1.75e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 60.17  E-value: 1.75e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462553030  838 CHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGhpSHWSDPPPICR 896
Cdd:cd00033      1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTEN--GGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 771-830 5.42e-11

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 58.69  E-value: 5.42e-11
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030   771 CHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLTGSSILTCHDrqagSPKWSDRAPKC 830
Cdd:smart00032    1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLE----NGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
532-589 1.44e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 57.51  E-value: 1.44e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462553030  532 CYEPF-VKYGNFSSSAPTYPVGTTVEFSCDPGYTLeQGSIIIECVDphDPQWNETEPAC 589
Cdd:pfam00084    1 CPPPPdIPNGKVSATKNEYNYGASVSYECDPGYRL-VGSPTITCQE--DGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 535-590 3.24e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 53.62  E-value: 3.24e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462553030  535 PFVKYGNFSSSAPTYPVGTTVEFSCDPGYTLeQGSIIIECVDphDPQWNETEPACR 590
Cdd:cd00033      5 PVPENGTVTGSKGSYSYGSTVTYSCNEGYTL-VGSSTITCTE--NGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 535-589 1.12e-08

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 52.14  E-value: 1.12e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 2462553030   535 PFVKYGNFSSSAPTYPVGTTVEFSCDPGYTLeQGSIIIECVDphDPQWNETEPAC 589
Cdd:smart00032    5 PDIENGTVTSSSGTYSYGDTVTYSCDPGYTL-IGSSTITCLE--NGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
771-830 3.93e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 47.88  E-value: 3.93e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  771 CHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLTGSSILTCHDrqagSPKWSDRAPKC 830
Cdd:pfam00084    1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQE----DGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 357-413 2.42e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 45.53  E-value: 2.42e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462553030  357 CHFPRRPAYGDVTV--TSLHPGGSARFHCATGYQLKGARHLTCLNATQpfWDSKEPVCI 413
Cdd:cd00033      1 CPPPPVPENGTVTGskGSYSYGSTVTYSCNEGYTLVGSSTITCTENGG--WSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 357-412 3.21e-06

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 45.21  E-value: 3.21e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462553030   357 CHFPRRPAYGDVTVTS--LHPGGSARFHCATGYQLKGARHLTCLNATQpfWDSKEPVC 412
Cdd:smart00032    1 CPPPPDIENGTVTSSSgtYSYGDTVTYSCDPGYTLIGSSTITCLENGT--WSPPPPTC 56
PHA03379 PHA03379
EBNA-3A; Provisional
 31-188 1.66e-05

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 48.90  E-value: 1.66e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030   31 QAPGIEETDGELTAAPTPEQPErgVHFVTTAPTLKLLNHHPLLEEFLQEG----LEKGDEElrPALPFQPDPpapfTPSP 106
Cdd:PHA03379   426 EVPQSLETATSHGSAQVPEPPP--VHDLEPGPLHDQHSMAPCPVAQLPPGplqdLEPGDQL--PGVVQDGRP----ACAP 497

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  107 LPRLANQDSRPVFTSPT--PAMAAVPTQPQSKEGPWSPESESPMLRITAPLPPGPSMAvptlGPGEIASTTPPSRAWTPT 184
Cdd:PHA03379   498 VPAPAGPIVRPWEASLSqvPGVAFAPVMPQPMPVEPVPVPTVALERPVCPAPPLIAMQ----GPGETSGIVRVRERWRPA 573


                   ....
gi 2462553030  185 QEGP 188
Cdd:PHA03379   574 PWTP 577
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 244-352 2.69e-05

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 44.33  E-value: 2.69e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  244 CSWNFSGP-EGSLDSPtDLSSPTDVGLDCFFYISVYPGYGVEIKVQNISLREGET-----VTVEGLGGPDPLPLANQSFL 317
Cdd:cd00041      1 CGGTLTAStSGTISSP-NYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNcsydyLEIYDGPSTSSPLLGRFCGS 79

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2462553030  318 LRGQVIRSPTHQAALRFQSLPPPAGPGtFHFHYQA 352
Cdd:cd00041     80 TLPPPIISSGNSLTVRFRSDSSVTGRG-FKATYSA 113
Sushi pfam00084
Sushi repeat (SCR repeat);
357-412 1.16e-04

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 40.95  E-value: 1.16e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462553030  357 CHFPRRPAYGDVTVT--SLHPGGSARFHCATGYQLKGARHLTCLnaTQPFWDSKEPVC 412
Cdd:pfam00084    1 CPPPPDIPNGKVSATknEYNYGASVSYECDPGYRLVGSPTITCQ--EDGTWSPPFPEC 56
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 100-184 3.51e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 44.91  E-value: 3.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  100 APFTPSPLPRLANQDSR---------------PVFTSPTPAM------AAVPT----QPQSKEGPWSPESESPMLRITAP 154
Cdd:pfam05109  486 SPVTPSPSPRDNGTESKapdmtsptsavttptPNATSPTPAVttptpnATSPTlgktSPTSAVTTPTPNATSPTPAVTTP 565

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2462553030  155 LppgPSMAVPTLGPGEIAS--TTPPSRAWTPT 184
Cdd:pfam05109  566 T---PNATIPTLGKTSPTSavTTPTPNATSPT 594
PHA02831 PHA02831
EEV host range protein; Provisional
 704-765 8.00e-04

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 42.67  E-value: 8.00e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462553030  704 VPRNDTCP----ELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSC 765
Cdd:PHA02831   130 VPKYPVCKlircKYPALQNGFLNVFEKKFYYGDIVNFKCKKGFILLGSSVSTCDINSIWYPGIPKC 195
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 416-526 6.55e-25

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 100.56  E-value: 6.55e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  416 CGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDD----DRLIIRNGDNVEApPVYDSYEVE 491
Cdd:cd00041      1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPncsyDYLEIYDGPSTSS-PLLGRFCGS 79

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2462553030  492 YLPIEgLLSSGKHFFVELSTDSSGAAAGMALRYEA 526
Cdd:cd00041     80 TLPPP-IISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 593-702 3.00e-21

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 89.78  E-value: 3.00e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  593 CSGEITDSA-GVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPG-----DVLTFYDGDDLTARVLGQYSGPR 666
Cdd:cd00041      1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPSTSSPLLGRFCGST 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2462553030  667 SHFKLFTSMADVTIQFQSDPGTSvlgyQQGFVIHFF 702
Cdd:cd00041     81 LPPPIISSGNSLTVRFRSDSSVT----GRGFKATYS 112
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 426-524 3.12e-19

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 83.59  E-value: 3.12e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030   426 GRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDD----DRLIIRNGDNVEApPVYDSYEVEYLPIEGLLSS 501
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDnceyDYVEIYDGPSASS-PLLGRFCGSEAPPPVISSS 79

                            90       100
                    ....*....|....*....|...
gi 2462553030   502 GKHFFVELSTDSSGAAAGMALRY 524
Cdd:smart00042   80 SNSLTLTFVSDSSVQKRGFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 602-701 6.73e-18

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 80.13  E-value: 6.73e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030   602 GVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPG-----DVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMA 676
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSdnceyDYVEIYDGPSASSPLLGRFCGSEAPPPVISSSS 80

                            90       100
                    ....*....|....*....|....*.
gi 2462553030   677 D-VTIQFQSDPGTSVlgyqQGFVIHF 701
Cdd:smart00042   81 NsLTLTFVSDSSVQK----RGFSARY 102
CUB pfam00431
CUB domain;
416-524 1.05e-16

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 76.95  E-value: 1.05e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  416 CGGVIRNATtGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDD----DRLIIRNGDNvEAPPVYDSYEVE 491
Cdd:pfam00431    1 CGGVLTDSS-GSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDecgyDYVEIRDGPS-ASSPLLGRFCGS 78

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2462553030  492 YLPiEGLLSSGKHFFVELSTDSSGAAAGMALRY 524
Cdd:pfam00431   79 GIP-EDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB pfam00431
CUB domain;
593-701 1.09e-14

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 71.17  E-value: 1.09e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  593 CSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIML-----DIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRS 667
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLtfqdfELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2462553030  668 HFKLFTSMADVTIQFQSDPGTSvlgyQQGFVIHF 701
Cdd:pfam00431   81 PEDIVSSSNQMTIKFVSDASVQ----KRGFKATY 110
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 710-766 1.54e-14

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 69.03  E-value: 1.54e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462553030  710 CPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSCQ 766
Cdd:cd00033      1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 710-765 2.25e-14

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 68.32  E-value: 2.25e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462553030   710 CPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSC 765
Cdd:smart00032    1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 710-895 6.86e-14

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 73.15  E-value: 6.86e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  710 CPELPEIPNGWKSPSQPELvhGTVVTYQCYPGYQVVGSSVLMCQW----DLTWSEDLPSCQRVtSCHDPGDVEHSRRLIS 785
Cdd:PHA02927    86 CPSPRDIDNGQLDIGGVDF--GSSITYSCNSGYQLIGESKSYCELgstgSMVWNPEAPICESV-KCQSPPSISNGRHNGY 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  786 SPKFPVGATVQYICDQGFVLTGSSILTChdrqaGSPKWSDrAPKClleQLKPCHGLSAPENGARSPEKQLHPAGATIHFS 865
Cdd:PHA02927   163 EDFYTDGSVVTYSCNSGYSLIGNSGVLC-----SGGEWSD-PPTC---QIVKCPHPTISNGYLSSGFKRSYSYNDNVDFK 233

                          170       180       190
                   ....*....|....*....|....*....|
gi 2462553030  866 CAPGYVLKGQASIKCVPGHPshWSDPPPIC 895
Cdd:PHA02927   234 CKYGYKLSGSSSSTCSPGNT--WQPELPKC 261
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 731-892 3.64e-13

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 70.84  E-value: 3.64e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  731 GTVVTYQCYPGY--QVVGSSVLMCQ---WDLtwsedLPSCQRvTSCHDPGDVEHSRRLISSPKFpvGATVQYICDQGFVL 805
Cdd:PHA02927    47 GDTIEYLCLPGYrkQKMGPIYAKCTgtgWTL-----FNQCIK-RRCPSPRDIDNGQLDIGGVDF--GSSITYSCNSGYQL 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  806 TGSSILTCHDRQAGSPKWSDRAPKCllEQLKpCHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGhp 885
Cdd:PHA02927   119 IGESKSYCELGSTGSMVWNPEAPIC--ESVK-CQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLIGNSGVLCSGG-- 193


                   ....*..
gi 2462553030  886 sHWSDPP 892
Cdd:PHA02927   194 -EWSDPP 199
Sushi pfam00084
Sushi repeat (SCR repeat);
710-765 3.25e-12

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 62.13  E-value: 3.25e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462553030  710 CPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSC 765
Cdd:pfam00084    1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 838-896 1.75e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 60.17  E-value: 1.75e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462553030  838 CHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGhpSHWSDPPPICR 896
Cdd:cd00033      1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTEN--GGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 771-830 5.42e-11

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 58.69  E-value: 5.42e-11
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030   771 CHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLTGSSILTCHDrqagSPKWSDRAPKC 830
Cdd:smart00032    1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLE----NGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 771-830 8.52e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 58.24  E-value: 8.52e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  771 CHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLTGSSILTCHDrqagSPKWSDRAPKC 830
Cdd:cd00033      1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTE----NGGWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
532-589 1.44e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 57.51  E-value: 1.44e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462553030  532 CYEPF-VKYGNFSSSAPTYPVGTTVEFSCDPGYTLeQGSIIIECVDphDPQWNETEPAC 589
Cdd:pfam00084    1 CPPPPdIPNGKVSATKNEYNYGASVSYECDPGYRL-VGSPTITCQE--DGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 838-895 4.15e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.38  E-value: 4.15e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462553030   838 CHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGhpSHWSDPPPIC 895
Cdd:smart00032    1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLEN--GTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 535-590 3.24e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 53.62  E-value: 3.24e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462553030  535 PFVKYGNFSSSAPTYPVGTTVEFSCDPGYTLeQGSIIIECVDphDPQWNETEPACR 590
Cdd:cd00033      5 PVPENGTVTGSKGSYSYGSTVTYSCNEGYTL-VGSSTITCTE--NGGWSPPPPTCE 57
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 710-831 5.71e-09

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 58.13  E-value: 5.71e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  710 CPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDlTWSeDLPSCQrVTSCHDPGDVEHSRRLISSPKF 789
Cdd:PHA02927   148 CQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLIGNSGVLCSGG-EWS-DPPTCQ-IVKCPHPTISNGYLSSGFKRSY 224

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 2462553030  790 PVGATVQYICDQGFVLTGSSILTChdrqagSP--KWSDRAPKCL 831
Cdd:PHA02927   225 SYNDNVDFKCKYGYKLSGSSSSTC------SPgnTWQPELPKCV 262
PHA02639 PHA02639
EEV host range protein; Provisional
 771-896 8.25e-09

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 58.14  E-value: 8.25e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  771 CHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLTGSSILTChDRQAGSPKWSDRAPKCLleqLKPCHGLSAPENGARS 850
Cdd:PHA02639    22 CDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTC-IKDKNNAIWSNKAPFCM---LKECNDPPSIINGKIY 97

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462553030  851 PEKQLHPAGATIHFSC----APGYVLKGQASIKCVpgHPSHWSDPPPICR 896
Cdd:PHA02639    98 NKREMYKVGDEIYYVCnehkGVQYSLVGNEKITCI--QDKSWKPDPPICK 145
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 535-589 1.12e-08

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 52.14  E-value: 1.12e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 2462553030   535 PFVKYGNFSSSAPTYPVGTTVEFSCDPGYTLeQGSIIIECVDphDPQWNETEPAC 589
Cdd:smart00032    5 PDIENGTVTSSSGTYSYGDTVTYSCDPGYTL-IGSSTITCLE--NGTWSPPPPTC 56
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 709-831 1.44e-08

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 57.79  E-value: 1.44e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  709 TCPELP----EIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDlTWSEdLPSCQRvtSCHDPgdvEHSRRLI 784
Cdd:PHA02954   124 TCPNAEcqplQLEHGSCQPVKEKYSFGEHITINCDVGYEVIGASYISCTAN-SWNV-IPSCQQ--KCDIP---SLSNGLI 196

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 2462553030  785 SSPKFPVGATVQYICDQGFVLTGSSILTCHDrqagsPKWSDRAPKCL 831
Cdd:PHA02954   197 SGSTFSIGGVIHLSCKSGFTLTGSPSSTCID-----GKWNPVLPICV 238
Sushi pfam00084
Sushi repeat (SCR repeat);
771-830 3.93e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 47.88  E-value: 3.93e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  771 CHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLTGSSILTCHDrqagSPKWSDRAPKC 830
Cdd:pfam00084    1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQE----DGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 357-413 2.42e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 45.53  E-value: 2.42e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462553030  357 CHFPRRPAYGDVTV--TSLHPGGSARFHCATGYQLKGARHLTCLNATQpfWDSKEPVCI 413
Cdd:cd00033      1 CPPPPVPENGTVTGskGSYSYGSTVTYSCNEGYTLVGSSTITCTENGG--WSPPPPTCE 57
PHA02639 PHA02639
EEV host range protein; Provisional
 710-895 2.95e-06

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 50.43  E-value: 2.95e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  710 CPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWD---LTWSEDLPSCQrVTSCHDPGDVEHSRRLISS 786
Cdd:PHA02639    22 CDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCIKDknnAIWSNKAPFCM-LKECNDPPSIINGKIYNKR 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  787 PKFPVGATVQYICDQ----GFVLTGSSILTCHDRQAgspkWSDRAPKCLLEQLKpchgLSAPENGARS--PEKQLHPAGA 860
Cdd:PHA02639   101 EMYKVGDEIYYVCNEhkgvQYSLVGNEKITCIQDKS----WKPDPPICKMINCR----FPALQNGYINgiPSNKKFYYKT 172

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 2462553030  861 TIHFSCAPGYVLKGQASIKCvpGHPSHWSDPPPIC 895
Cdd:PHA02639   173 RVGFSCKSGFDLVGEKYSTC--NINATWFPSIPTC 205
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 357-412 3.21e-06

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 45.21  E-value: 3.21e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462553030   357 CHFPRRPAYGDVTVTS--LHPGGSARFHCATGYQLKGARHLTCLNATQpfWDSKEPVC 412
Cdd:smart00032    1 CPPPPDIENGTVTSSSgtYSYGDTVTYSCDPGYTLIGSSTITCLENGT--WSPPPPTC 56
PHA03379 PHA03379
EBNA-3A; Provisional
 31-188 1.66e-05

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 48.90  E-value: 1.66e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030   31 QAPGIEETDGELTAAPTPEQPErgVHFVTTAPTLKLLNHHPLLEEFLQEG----LEKGDEElrPALPFQPDPpapfTPSP 106
Cdd:PHA03379   426 EVPQSLETATSHGSAQVPEPPP--VHDLEPGPLHDQHSMAPCPVAQLPPGplqdLEPGDQL--PGVVQDGRP----ACAP 497

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  107 LPRLANQDSRPVFTSPT--PAMAAVPTQPQSKEGPWSPESESPMLRITAPLPPGPSMAvptlGPGEIASTTPPSRAWTPT 184
Cdd:PHA03379   498 VPAPAGPIVRPWEASLSqvPGVAFAPVMPQPMPVEPVPVPTVALERPVCPAPPLIAMQ----GPGETSGIVRVRERWRPA 573


                   ....
gi 2462553030  185 QEGP 188
Cdd:PHA03379   574 PWTP 577
PHA02831 PHA02831
EEV host range protein; Provisional
 710-831 2.00e-05

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 47.68  E-value: 2.00e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  710 CPELPEIPNGWKSPSQPELVHGTVVTYQC----YPGYQVVGSSVLMCqWDLTWSEDLPSCqRVTSCHDPGdVEHSRRLIS 785
Cdd:PHA02831    78 CKDPVTILNGYIKNKKDQYSFGDSVTYACkvnkLEKYSIVGNETVKC-INKQWVPKYPVC-KLIRCKYPA-LQNGFLNVF 154

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2462553030  786 SPKFPVGATVQYICDQGFVLTGSSILTCHDRQAgspkWSDRAPKCL 831
Cdd:PHA02831   155 EKKFYYGDIVNFKCKKGFILLGSSVSTCDINSI----WYPGIPKCV 196
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 244-352 2.69e-05

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 44.33  E-value: 2.69e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  244 CSWNFSGP-EGSLDSPtDLSSPTDVGLDCFFYISVYPGYGVEIKVQNISLREGET-----VTVEGLGGPDPLPLANQSFL 317
Cdd:cd00041      1 CGGTLTAStSGTISSP-NYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNcsydyLEIYDGPSTSSPLLGRFCGS 79

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2462553030  318 LRGQVIRSPTHQAALRFQSLPPPAGPGtFHFHYQA 352
Cdd:cd00041     80 TLPPPIISSGNSLTVRFRSDSSVTGRG-FKATYSA 113
Sushi pfam00084
Sushi repeat (SCR repeat);
838-895 3.74e-05

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 42.10  E-value: 3.74e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462553030  838 CHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGhpSHWSDPPPIC 895
Cdd:pfam00084    1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQED--GTWSPPFPEC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 708-830 5.48e-05

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 45.70  E-value: 5.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  708 DTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPG-----YQVVGSSVLMCQWDLTWSEDLPSCQrVTSCHDPG-DVEHSR 781
Cdd:PHA02817    22 NKCCYPPSIKNGYIYNKKTEYNIGSNVTFFCGNNtrgvrYTLVGEKNIICEKDGKWNKEFPVCK-IIRCRFPAlQNGFVN 100

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2462553030  782 RLISSPKFPVGATVQYICDQGFVLTGSSILTCHDRQAgspkWSDRAPKC 830
Cdd:PHA02817   101 GIPDSKKFYYESEVSFSCKPGFVLIGTKYSVCGINSS----WIPKVPIC 145
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
89-222 9.13e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.41  E-value: 9.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030   89 RPALPFQPDPPAPFTPSPLPRLANQDSRPVFTSPTPAMAAVPTQPQSKEGPWSPESESPMLRITAPLPPGPSMAVPTLGP 168
Cdd:PRK12323   393 AAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPV 472

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462553030  169 GEIASTTPPSRA-----------WTPTQEGPGDMGRPWVAEVVSQGAGIGIQGTITSSTASGDDE 222
Cdd:PRK12323   473 AAAAAAAPARAApaaapapadddPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDA 537
Sushi pfam00084
Sushi repeat (SCR repeat);
357-412 1.16e-04

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 40.95  E-value: 1.16e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462553030  357 CHFPRRPAYGDVTVT--SLHPGGSARFHCATGYQLKGARHLTCLnaTQPFWDSKEPVC 412
Cdd:pfam00084    1 CPPPPDIPNGKVSATknEYNYGASVSYECDPGYRLVGSPTITCQ--EDGTWSPPFPEC 56
PHA03247 PHA03247
large tegument protein UL36; Provisional
 90-188 1.30e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 1.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030   90 PALPFQPDPPAPFTPSPLPRLANQDSRPVFTS--PTPAMAAVPTQPQSKEGPWSPESESPMLRITAPLPPGPS---MAVP 164
Cdd:PHA03247  2733 PALPAAPAPPAVPAGPATPGGPARPARPPTTAgpPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPAdppAAVL 2812

                           90       100
                   ....*....|....*....|....
gi 2462553030  165 TLGPGEIASTTPPSRAWTPTQEGP 188
Cdd:PHA03247  2813 APAAALPPAASPAGPLPPPTSAQP 2836
PHA03247 PHA03247
large tegument protein UL36; Provisional
 25-194 2.49e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 2.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030   25 PTVGKGQAPGIEETDGELTAAPTPEQPErgvhfvTTAPTLKLLNHHPLLEEflqegLEKGDEELRPALPFQPDPPAPFTP 104
Cdd:PHA03247  2593 PQSARPRAPVDDRGDPRGPAPPSPLPPD------THAPDPPPPSPSPAANE-----PDPHPPPTVPPPERPRDDPAPGRV 2661

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  105 SPlPRLANQDSRPVFTSPTP----------AMAAVPTQPQSKEGPWSPESESPMLRITAPLPPGPSMAVPTLGPGEIAST 174
Cdd:PHA03247  2662 SR-PRRARRLGRAAQASSPPqrprrraarpTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPA 2740

                          170       180
                   ....*....|....*....|
gi 2462553030  175 TPPSRAWTPTQEGPGDMGRP 194
Cdd:PHA03247  2741 PPAVPAGPATPGGPARPARP 2760
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 100-184 3.51e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 44.91  E-value: 3.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  100 APFTPSPLPRLANQDSR---------------PVFTSPTPAM------AAVPT----QPQSKEGPWSPESESPMLRITAP 154
Cdd:pfam05109  486 SPVTPSPSPRDNGTESKapdmtsptsavttptPNATSPTPAVttptpnATSPTlgktSPTSAVTTPTPNATSPTPAVTTP 565

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2462553030  155 LppgPSMAVPTLGPGEIAS--TTPPSRAWTPT 184
Cdd:pfam05109  566 T---PNATIPTLGKTSPTSavTTPTPNATSPT 594
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 24-179 3.64e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.78  E-value: 3.64e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030   24 APTVGKGQAPGIEETDGELTAAPTPEQPERGVHFVTTAPTLKLLNHHPLLEEFLQEGLEKGDEELRPALPFQPDPPAPFT 103
Cdd:PHA03307    54 TVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPD 133

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462553030  104 PSPLPRLANQDSRPVFTSPTPAMAAVPTQPQSKEGPWSPESESPMLRITAPLPPGPSMAVPTLGPGEIASTTPPSR 179
Cdd:PHA03307   134 LSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRR 209
PHA02831 PHA02831
EEV host range protein; Provisional
 736-959 3.75e-04

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 43.44  E-value: 3.75e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  736 YQCYPGYQVVgssVLMCQwDLTWSEDlPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICD----QGFVLTGSSIL 811
Cdd:PHA02831    48 YKCNNNFDKV---FVTCN-NGSWSTK-NMCIGKRNCKDPVTILNGYIKNKKDQYSFGDSVTYACKvnklEKYSIVGNETV 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  812 TCHDRQagspkWSDRAPKCLLEQLKpchgLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCvpGHPSHWSDP 891
Cdd:PHA02831   123 KCINKQ-----WVPKYPVCKLIRCK----YPALQNGFLNVFEKKFYYGDIVNFKCKKGFILLGSSVSTC--DINSIWYPG 191

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462553030  892 PPICRAASLDGFYNSRSL--DVAKAPAASST---LDAAHIAAAIFLPLVAMVLLVGGVYFYFSRRRENMKSPS 959
Cdd:PHA02831   192 IPKCVKDKVHNEIQPNYLfdDLDEDFNNSTTnynMQQNIITIIILLSIICFIFVLGLIALFLSCNKSTLKPSI 264
PHA03247 PHA03247
large tegument protein UL36; Provisional
 90-199 6.51e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 6.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030   90 PALPFQPDPPAPFTPSPLPRLANQDSRPVFTSpTPAMAAVPTQPQSKEGPWSPESESPMLRITAPLPPGPSMAVPTLGPG 169
Cdd:PHA03247  2553 PPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTS-RARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSP 2631

                           90       100       110
                   ....*....|....*....|....*....|
gi 2462553030  170 EIASTTPPSRAWTPTQEGPGDMGRPWVAEV 199
Cdd:PHA03247  2632 SPAANEPDPHPPPTVPPPERPRDDPAPGRV 2661
PHA02831 PHA02831
EEV host range protein; Provisional
 704-765 8.00e-04

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 42.67  E-value: 8.00e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462553030  704 VPRNDTCP----ELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSC 765
Cdd:PHA02831   130 VPKYPVCKlircKYPALQNGFLNVFEKKFYYGDIVNFKCKKGFILLGSSVSTCDINSIWYPGIPKC 195
PHA02639 PHA02639
EEV host range protein; Provisional
 710-831 2.68e-03

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 41.19  E-value: 2.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  710 CPELPEIPNGWKSPSQPELVHGTVVTYQC--YPG--YQVVGSSVLMCQWDLTWSEDLPSCQRVtSCHDPG-DVEHSRRLI 784
Cdd:PHA02639    85 CNDPPSIINGKIYNKREMYKVGDEIYYVCneHKGvqYSLVGNEKITCIQDKSWKPDPPICKMI-NCRFPAlQNGYINGIP 163

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 2462553030  785 SSPKFPVGATVQYICDQGFVLTGSSILTCHDrqagSPKWSDRAPKCL 831
Cdd:PHA02639   164 SNKKFYYKTRVGFSCKSGFDLVGEKYSTCNI----NATWFPSIPTCV 206
PHA03247 PHA03247
large tegument protein UL36; Provisional
 89-183 4.41e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 4.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030   89 RPALP--------FQPDPPAPFTPSPLPRlANQDSRPVFTSP------TPAMAAVPTQPQSKEGPWSPESESPmlRITAP 154
Cdd:PHA03247  2685 RRAARptvgsltsLADPPPPPPTPEPAPH-ALVSATPLPPGPaaarqaSPALPAAPAPPAVPAGPATPGGPAR--PARPP 2761

                           90       100
                   ....*....|....*....|....*....
gi 2462553030  155 LPPGPSMAVPTLGPgeiaSTTPPSRAWTP 183
Cdd:PHA03247  2762 TTAGPPAPAPPAAP----AAGPPRRLTRP 2786
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 88-187 5.49e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 40.56  E-value: 5.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030   88 LRPALPFQPDPPAPFTPSPLprlanQDSRPVFTSPTPAMAAVPTQPQSKEGPWSPESESPmlRITAPLPPGPSMAVPTLG 167
Cdd:PRK14950   360 LVPVPAPQPAKPTAAAPSPV-----RPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPP--RPVAPPVPHTPESAPKLT 432

                           90       100
                   ....*....|....*....|.
gi 2462553030  168 PGEI-ASTTPPSRAWTPTQEG 187
Cdd:PRK14950   433 RAAIpVDEKPKYTPPAPPKEE 453
PHA02817 PHA02817
EEV Host range protein; Provisional
 764-895 5.53e-03

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 39.54  E-value: 5.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  764 SCQRVTSCHDPgDVEHSRRLISSPKFPVGATVQYICDQG-----FVLTGSSILTCHDrqagSPKWSDRAPKClleQLKPC 838
Cdd:PHA02817    18 LCDLNKCCYPP-SIKNGYIYNKKTEYNIGSNVTFFCGNNtrgvrYTLVGEKNIICEK----DGKWNKEFPVC---KIIRC 89

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462553030  839 HgLSAPENGARS--PEKQLHPAGATIHFSCAPGYVLKGQASIKCvpGHPSHWSDPPPIC 895
Cdd:PHA02817    90 R-FPALQNGFVNgiPDSKKFYYESEVSFSCKPGFVLIGTKYSVC--GINSSWIPKVPIC 145
MCPVI pfam02993
Minor capsid protein VI; This minor capsid protein may act as a link between the external ...
 71-147 5.95e-03

Minor capsid protein VI; This minor capsid protein may act as a link between the external capsid and the internal DNA-protein core. The C-terminal 11 residues may function as a protease cofactor leading to enzyme activation.


Pssm-ID: 367287  Cd Length: 225  Bit Score: 39.60  E-value: 5.95e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462553030   71 PLLEEFLQEGLekgdeelRPALPFQPDPPAPFTPS--PLPRLANQDSRPVFTSPTPAMAAVPTQPQSKEGPWSPESESP 147
Cdd:pfam02993  128 PSYEEAVKQGE-------PTTRPIAPMATGVLTPVtlDLPPPVDEVQPPVLSSPSAVVVTRPSRASLRRAASGPRRKRP 199
PHA03247 PHA03247
large tegument protein UL36; Provisional
 44-183 7.43e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 7.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030   44 AAPTPEQPERGVHFVTTAPTLKLLNHHPLLEEflqegLEKGDEELRPALPFQPDPPAPFTPSPLPRLANQDSRPVFTSPT 123
Cdd:PHA03247  2676 ASSPPQRPRRRAARPTVGSLTSLADPPPPPPT-----PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAT 2750

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030  124 PAMAAVPTQPQSKEGPWSPesESPMLRITAPLPPGPSMAVPTLGPGEIASTTPPSRAWTP 183
Cdd:PHA03247  2751 PGGPARPARPPTTAGPPAP--APPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPP 2808
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 79-212 8.56e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 8.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030   79 EGLEKGDEELRPALPFQPDPPAPFTPSPLPRLANQDSRPVFTSPTPAMAAVPTQPQSKEGPWSPESESPMLRITAPLPPG 158
Cdd:PRK07764   379 ERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPP 458

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462553030  159 PSMAVPTLGPGEIASTTPPSRAWTPTQEGPGDMGRPWVAEVVSQGAGIGIQGTI 212
Cdd:PRK07764   459 AAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATL 512
PHA03247 PHA03247
large tegument protein UL36; Provisional
 89-197 8.80e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 8.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030   89 RPALPFQPDPPAPFTPSPLPRLANQDSRPVFTSPTPAMAAVPTQPQskegpwspesespmlrITAPLPPGPSMAVPTLGP 168
Cdd:PHA03247   377 RASLPTRKRRSARHAATPFARGPGGDDQTRPAAPVPASVPTPAPTP----------------VPASAPPPPATPLPSAEP 440

                           90       100
                   ....*....|....*....|....*....
gi 2462553030  169 GEIASTTPPSRAWTPTQEGPGDMGRPWVA 197
Cdd:PHA03247   441 GSDDGPAPPPERQPPAPATEPAPDDPDDA 469
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 93-188 9.03e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 9.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553030   93 PFQPDPPAPFTPSPLPRLANQDSRP-VFTSPTPAMAAVPTQPQSKEGPWSPESESPML---RITAPLPPGPSMAVPTLGP 168
Cdd:pfam03154  180 AASPPSPPPPGTTQAATAGPTPSAPsVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLhpqRLPSPHPPLQPMTQPPPPS 259

                           90       100
                   ....*....|....*....|
gi 2462553030  169 GEIASTTPPSRAWTPTQEGP 188
Cdd:pfam03154  260 QVSPQPLPQPSLHGQMPPMP 279
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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