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Conserved domains on  [gi|2462551388|ref|XP_054170200|]
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contactin-associated protein-like 4 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 54-176 4.71e-32

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


:

Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 120.92  E-value: 4.71e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551388  54 HGPGFARLNRrdgAGGWSPLVSNKYQWLQIDLGERMEVTAVATQG--GYGSSNWVTSYLLMFSDSGWNWKQYRQEDSIWG 131
Cdd:cd00057    24 WEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGrkGGGSSEWVTSYKVQYSLDGETWTTYKDKGEEKV 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2462551388 132 FSGNANADSVVYYRLQPSIKARFLRFIPLEWNpkGRIGMRIEVFG 176
Cdd:cd00057   101 FTGNSDGSTPVTNDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 212-341 7.94e-29

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 111.36  E-value: 7.94e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551388 212 FKTMQSDGILLHREGPNGDHITLQLRRARLFLLINSGeaklpsTSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEH 291
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLG------SGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462551388 292 RHHFHARGEFNL-MNLDYEISFGGIPAPGKSVSFP-HRNFHGCLENLYYNGV 341
Cdd:pfam02210  75 TVVSSLPPGESLlLNLNGPLYLGGLPPLLLLPALPvRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 398-524 9.85e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 96.72  E-value: 9.85e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551388 398 FRTWNKAGLLLFSElQLISGGILLFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDGQMA-SA 476
Cdd:pfam02210   1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVvSS 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462551388 477 APLLGPEQIYSGGTYYFGGCPDKSfGSKCKSPLGGFQGCMRLISISGK 524
Cdd:pfam02210  80 LPPGESLLLNLNGPLYLGGLPPLL-LLPALPVRAGFVGCIRDVRVNGE 126
GGGWT_bact super family cl49103
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 593-627 9.09e-08

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


The actual alignment was detected with superfamily member NF040941:

Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 48.71  E-value: 9.09e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2462551388 593 SCEAYKHRGNT--SGFYYIDSDGSGPLEPFLLYCNMT 627
Cdd:NF040941    1 SCWEILQAGPSapSGVYWIDPDGMGGLAPFQVYCDMT 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 553-584 3.63e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.83  E-value: 3.63e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2462551388 553 CLPNYCEHGGECSQSWSTFHCNCTnTGYRGAT 584
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 54-176 4.71e-32

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 120.92  E-value: 4.71e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551388  54 HGPGFARLNRrdgAGGWSPLVSNKYQWLQIDLGERMEVTAVATQG--GYGSSNWVTSYLLMFSDSGWNWKQYRQEDSIWG 131
Cdd:cd00057    24 WEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGrkGGGSSEWVTSYKVQYSLDGETWTTYKDKGEEKV 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2462551388 132 FSGNANADSVVYYRLQPSIKARFLRFIPLEWNpkGRIGMRIEVFG 176
Cdd:cd00057   101 FTGNSDGSTPVTNDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 54-174 2.98e-29

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 112.54  E-value: 2.98e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551388  54 HGPGFARLNRrDGAGGWSPLVSNKYQWLQIDLGERMEVTAVATQGGY-GSSNWVTSYLLMFSDSGWNWKQYRQEdsiwGF 132
Cdd:pfam00754  11 EGPAAAALDG-DPNTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQdGSNGYVTSYKIEYSLDGENWTTVKDE----KI 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2462551388 133 SGNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIGMRIEV 174
Cdd:pfam00754  86 PGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGNGIALRAEL 127
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 212-341 7.94e-29

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 111.36  E-value: 7.94e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551388 212 FKTMQSDGILLHREGPNGDHITLQLRRARLFLLINSGeaklpsTSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEH 291
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLG------SGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462551388 292 RHHFHARGEFNL-MNLDYEISFGGIPAPGKSVSFP-HRNFHGCLENLYYNGV 341
Cdd:pfam02210  75 TVVSSLPPGESLlLNLNGPLYLGGLPPLLLLPALPvRAGFVGCIRDVRVNGE 126
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 55-177 6.53e-26

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 103.36  E-value: 6.53e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551388   55 GPGFARLNRrDGAGGWSPLVSNKYQWLQIDLGERMEVTAVATQGGYGSSNWVTSYlLMFSDSGWNWKQYRQEDSIwGFSG 134
Cdd:smart00231  22 AAKIARLNG-GSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNGDWVTYK-LEYSDDGVNWTTYKDGNSK-VFPG 98

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2462551388  135 NANADSVVYYRLQPSIKARFLRFIPLEWNpkGRIGMRIEVFGC 177
Cdd:smart00231  99 NSDAGTVVLNDFPPPIVARYVRILPTGWN--GNIILRVELLGC 139
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 398-524 9.85e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 96.72  E-value: 9.85e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551388 398 FRTWNKAGLLLFSElQLISGGILLFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDGQMA-SA 476
Cdd:pfam02210   1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVvSS 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462551388 477 APLLGPEQIYSGGTYYFGGCPDKSfGSKCKSPLGGFQGCMRLISISGK 524
Cdd:pfam02210  80 LPPGESLLLNLNGPLYLGGLPPLL-LLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 194-339 4.14e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 95.95  E-value: 4.14e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551388 194 YRFDQKSLSPIKDIISLKFKTMQSDGILLHREG-PNGDHITLQLRRARLFLLINSGEAKLPststlvnLTLGSLLDDQHW 272
Cdd:cd00110    10 VRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSqNGGDFLALELEDGRLVLRYDLGSGSLV-------LSSKTPLNDGQW 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462551388 273 HSVLIQRLGKQVNFTVDEHRH-HFHARGEFNLMNLDYEISFGGIPAPGKSVSFPHRN-FHGCLENLYYN 339
Cdd:cd00110    83 HSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPgFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 371-521 1.36e-22

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 94.41  E-value: 1.36e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551388 371 PVTFlSSRSYLALPDFSGEE-EVSATFQFRTWNKAGLLLFSELQLISGGILLFLSDGKLKSNlYQPGKLPSDITAGVELN 449
Cdd:cd00110     1 GVSF-SGSSYVRLPTLPAPRtRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLR-YDLGSGSLVLSSKTPLN 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462551388 450 DGQWHSVSLSAKKNHLSVAVDG-QMASAAPLLGPEQIYSGGTYYFGGCPDKSfGSKCKSPLGGFQGCMRLISI 521
Cdd:cd00110    79 DGQWHSVSVERNGRSVTLSVDGeRVVESGSPGGSALLNLDGPLYLGGLPEDL-KSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
208-341 1.99e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 93.17  E-value: 1.99e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551388  208 ISLKFKTMQSDGILLHREGPNG-DHITLQLRRARLFLLIN--SGEAKLPSTSTLVNltlgslldDQHWHSVLIQRLGKQV 284
Cdd:smart00282   2 ISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLVLRYDlgSGPARLTSDPTPLN--------DGQWHRVAVERNGRSV 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462551388  285 NFTVDEHRH-HFHARGEFNLMNLDYEISFGGIPAPGKSVSFP-HRNFHGCLENLYYNGV 341
Cdd:smart00282  74 TLSVDGGNRvSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPvTPGFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
393-524 3.11e-20

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 87.01  E-value: 3.11e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551388  393 SATFQFRTWNKAGLLLFSELQLISGGILLFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDGQ 472
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462551388  473 MASAAPLLGPEQIY-SGGTYYFGGCPDkSFGSKCKSPLGGFQGCMRLISISGK 524
Cdd:smart00282  81 NRVSGESPGGLTILnLDGPLYLGGLPE-DLKLPPLPVTPGFRGCIRNLKVNGK 132
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 593-627 9.09e-08

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 48.71  E-value: 9.09e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2462551388 593 SCEAYKHRGNT--SGFYYIDSDGSGPLEPFLLYCNMT 627
Cdd:NF040941    1 SCWEILQAGPSapSGVYWIDPDGMGGLAPFQVYCDMT 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 553-584 3.63e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.83  E-value: 3.63e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2462551388 553 CLPNYCEHGGECSQSWSTFHCNCTnTGYRGAT 584
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 551-585 8.52e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 8.52e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2462551388 551 DRCL-PNYCEHGGECSQSWSTFHCNCTNtGYRGATC 585
Cdd:cd00054     3 DECAsGNPCQNGGTCVNTVGSYRCSCPP-GYTGRNC 37
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 54-176 4.71e-32

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 120.92  E-value: 4.71e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551388  54 HGPGFARLNRrdgAGGWSPLVSNKYQWLQIDLGERMEVTAVATQG--GYGSSNWVTSYLLMFSDSGWNWKQYRQEDSIWG 131
Cdd:cd00057    24 WEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGrkGGGSSEWVTSYKVQYSLDGETWTTYKDKGEEKV 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2462551388 132 FSGNANADSVVYYRLQPSIKARFLRFIPLEWNpkGRIGMRIEVFG 176
Cdd:cd00057   101 FTGNSDGSTPVTNDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 54-174 2.98e-29

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 112.54  E-value: 2.98e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551388  54 HGPGFARLNRrDGAGGWSPLVSNKYQWLQIDLGERMEVTAVATQGGY-GSSNWVTSYLLMFSDSGWNWKQYRQEdsiwGF 132
Cdd:pfam00754  11 EGPAAAALDG-DPNTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQdGSNGYVTSYKIEYSLDGENWTTVKDE----KI 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2462551388 133 SGNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIGMRIEV 174
Cdd:pfam00754  86 PGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGNGIALRAEL 127
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 212-341 7.94e-29

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 111.36  E-value: 7.94e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551388 212 FKTMQSDGILLHREGPNGDHITLQLRRARLFLLINSGeaklpsTSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEH 291
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLG------SGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462551388 292 RHHFHARGEFNL-MNLDYEISFGGIPAPGKSVSFP-HRNFHGCLENLYYNGV 341
Cdd:pfam02210  75 TVVSSLPPGESLlLNLNGPLYLGGLPPLLLLPALPvRAGFVGCIRDVRVNGE 126
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 55-177 6.53e-26

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 103.36  E-value: 6.53e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551388   55 GPGFARLNRrDGAGGWSPLVSNKYQWLQIDLGERMEVTAVATQGGYGSSNWVTSYlLMFSDSGWNWKQYRQEDSIwGFSG 134
Cdd:smart00231  22 AAKIARLNG-GSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNGDWVTYK-LEYSDDGVNWTTYKDGNSK-VFPG 98

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2462551388  135 NANADSVVYYRLQPSIKARFLRFIPLEWNpkGRIGMRIEVFGC 177
Cdd:smart00231  99 NSDAGTVVLNDFPPPIVARYVRILPTGWN--GNIILRVELLGC 139
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 398-524 9.85e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 96.72  E-value: 9.85e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551388 398 FRTWNKAGLLLFSElQLISGGILLFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDGQMA-SA 476
Cdd:pfam02210   1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVvSS 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462551388 477 APLLGPEQIYSGGTYYFGGCPDKSfGSKCKSPLGGFQGCMRLISISGK 524
Cdd:pfam02210  80 LPPGESLLLNLNGPLYLGGLPPLL-LLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 194-339 4.14e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 95.95  E-value: 4.14e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551388 194 YRFDQKSLSPIKDIISLKFKTMQSDGILLHREG-PNGDHITLQLRRARLFLLINSGEAKLPststlvnLTLGSLLDDQHW 272
Cdd:cd00110    10 VRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSqNGGDFLALELEDGRLVLRYDLGSGSLV-------LSSKTPLNDGQW 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462551388 273 HSVLIQRLGKQVNFTVDEHRH-HFHARGEFNLMNLDYEISFGGIPAPGKSVSFPHRN-FHGCLENLYYN 339
Cdd:cd00110    83 HSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPgFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 371-521 1.36e-22

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 94.41  E-value: 1.36e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551388 371 PVTFlSSRSYLALPDFSGEE-EVSATFQFRTWNKAGLLLFSELQLISGGILLFLSDGKLKSNlYQPGKLPSDITAGVELN 449
Cdd:cd00110     1 GVSF-SGSSYVRLPTLPAPRtRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLR-YDLGSGSLVLSSKTPLN 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462551388 450 DGQWHSVSLSAKKNHLSVAVDG-QMASAAPLLGPEQIYSGGTYYFGGCPDKSfGSKCKSPLGGFQGCMRLISI 521
Cdd:cd00110    79 DGQWHSVSVERNGRSVTLSVDGeRVVESGSPGGSALLNLDGPLYLGGLPEDL-KSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
208-341 1.99e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 93.17  E-value: 1.99e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551388  208 ISLKFKTMQSDGILLHREGPNG-DHITLQLRRARLFLLIN--SGEAKLPSTSTLVNltlgslldDQHWHSVLIQRLGKQV 284
Cdd:smart00282   2 ISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLVLRYDlgSGPARLTSDPTPLN--------DGQWHRVAVERNGRSV 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462551388  285 NFTVDEHRH-HFHARGEFNLMNLDYEISFGGIPAPGKSVSFP-HRNFHGCLENLYYNGV 341
Cdd:smart00282  74 TLSVDGGNRvSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPvTPGFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
393-524 3.11e-20

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 87.01  E-value: 3.11e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551388  393 SATFQFRTWNKAGLLLFSELQLISGGILLFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDGQ 472
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462551388  473 MASAAPLLGPEQIY-SGGTYYFGGCPDkSFGSKCKSPLGGFQGCMRLISISGK 524
Cdd:smart00282  81 NRVSGESPGGLTILnLDGPLYLGGLPE-DLKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
398-527 1.26e-17

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 79.28  E-value: 1.26e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551388 398 FRTWNKAGLLLFSELQLISGGILLFLSDGKLKSnLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDG-QMASA 476
Cdd:pfam00054   1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEV-SYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGeARPTG 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462551388 477 APLLGPEQIYS-GGTYYFGGCPDKSFGSKCKSPLGGFQGCMRLISISGKVVD 527
Cdd:pfam00054  80 ESPLGATTDLDvDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
212-341 2.24e-10

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 58.87  E-value: 2.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551388 212 FKTMQSDGILLHREGPN-GDHITLQLRRARLFLLINSGeaklpstSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVD- 289
Cdd:pfam00054   1 FRTTEPSGLLLYNGTQTeRDFLALELRDGRLEVSYDLG-------SGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDg 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462551388 290 EHRHHfharGEFNL-----MNLDYEISFGGIPAPGKSVS-FPHR-NFHGCLENLYYNGV 341
Cdd:pfam00054  74 EARPT----GESPLgattdLDVDGPLYVGGLPSLGVKKRrLAISpSFDGCIRDVIVNGK 128
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 593-627 9.09e-08

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 48.71  E-value: 9.09e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2462551388 593 SCEAYKHRGNT--SGFYYIDSDGSGPLEPFLLYCNMT 627
Cdd:NF040941    1 SCWEILQAGPSapSGVYWIDPDGMGGLAPFQVYCDMT 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 553-584 3.63e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.83  E-value: 3.63e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2462551388 553 CLPNYCEHGGECSQSWSTFHCNCTnTGYRGAT 584
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 416-495 4.58e-04

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 40.83  E-value: 4.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551388 416 SGGILLFL-SDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQIYSGGTYYFG 494
Cdd:pfam13385  43 GGGYSLGLdGDGRLRFAVNGGNGGWDTVTSGASVPLGQWTHVAVTYDGGTLRLYVNGVLVGSSTLTGGPPPGTGGPLYIG 122


                  .
gi 2462551388 495 G 495
Cdd:pfam13385 123 R 123
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 551-585 8.52e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 8.52e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2462551388 551 DRCL-PNYCEHGGECSQSWSTFHCNCTNtGYRGATC 585
Cdd:cd00054     3 DECAsGNPCQNGGTCVNTVGSYRCSCPP-GYTGRNC 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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