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Conserved domains on  [gi|2437432499|ref|XP_053093827|]
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transforming growth factor-beta receptor-associated protein 1 [Pangasianodon hypophthalmus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Vps39_2 super family cl11034
Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein ...
 727-833 1.84e-17

Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. This domain is involved in localization and in mediating the interactions of Vps39 with Vps11.


The actual alignment was detected with superfamily member pfam10367:

Pssm-ID: 402126  Cd Length: 109  Bit Score: 78.45  E-value: 1.84e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2437432499 727 VDLLNQNAVAFNLLRVLEVLPGSWSLQLVMRFLCESLRATTHDRRMRGLEKSLARMDNLRQRHAWMEATQGMVRMDRSQV 806
Cdd:pfam10367   1 LDLLNKHAERIDPAQVLQLLPDEIPLQDLSSFLERALRNSSEAKREAQVVKNLSKAENLQVEEELLKLRSRKVRVTEESV 80

                          90       100
                  ....*....|....*....|....*..
gi 2437432499 807 CHSCQRQFIGPEFLRRSTGELLHTHCY 833
Cdd:pfam10367  81 CAVCHKRLGESVFVVYPNGVVVHYGCF 107
Vps39_1 super family cl11033
Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein ...
 443-545 1.99e-09

Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. The precise function of this domain has not been characterized.


The actual alignment was detected with superfamily member pfam10366:

Pssm-ID: 371008  Cd Length: 108  Bit Score: 55.71  E-value: 1.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2437432499 443 IDTTLLKVYLrlgYYDN--LNQLVSSRNDCVLDVCVPDLEQYKRFFTIGLLYQSHGQHFNAIQTWVWMVDESvDSSEPNV 520
Cdd:pfam10366   1 IDTTLLKCYL---YTNPslVGPLLRIENACDLEDVEEWLKKHKKYSELIDLYYGKGLHREALQLLTELADET-TGDETDS 76

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2437432499 521 LLH-----IVKTLSRLKEKSI--IMKFIDWAL 545
Cdd:pfam10366  77 TLKgpketIIQYLQKLGPSDLdlILEYSDWVL 108
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 565-692 1.15e-05

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


:

Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 45.71  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2437432499 565 NTFEPQEVLSIL--TNYPVALVSYLEFLVNEQQSQMEKHHTLLANTYATqilhtdremqnndthmEEMRQKLQQFLWQSS 642
Cdd:pfam00637   6 DPIDVSRVVKLFekAGLLEELISYLESALKEDSRENPALQTALIELYAK----------------YDDPEELEEFLKKNN 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2437432499 643 IYDADAVYAKIQSSALHVEKAILLGRVGEHRKALRLLVDEERDEKAAEVY 692
Cdd:pfam00637  70 NYDLEKVAKLCEKADLYEEAVILYKKIGNWKEAISLLKKLGDYKDAIEYA 119
 
Name Accession Description Interval E-value
Vps39_2 pfam10367
Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein ...
 727-833 1.84e-17

Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. This domain is involved in localization and in mediating the interactions of Vps39 with Vps11.


Pssm-ID: 402126  Cd Length: 109  Bit Score: 78.45  E-value: 1.84e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2437432499 727 VDLLNQNAVAFNLLRVLEVLPGSWSLQLVMRFLCESLRATTHDRRMRGLEKSLARMDNLRQRHAWMEATQGMVRMDRSQV 806
Cdd:pfam10367   1 LDLLNKHAERIDPAQVLQLLPDEIPLQDLSSFLERALRNSSEAKREAQVVKNLSKAENLQVEEELLKLRSRKVRVTEESV 80

                          90       100
                  ....*....|....*....|....*..
gi 2437432499 807 CHSCQRQFIGPEFLRRSTGELLHTHCY 833
Cdd:pfam10367  81 CAVCHKRLGESVFVVYPNGVVVHYGCF 107
Vps39_1 pfam10366
Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein ...
 443-545 1.99e-09

Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. The precise function of this domain has not been characterized.


Pssm-ID: 371008  Cd Length: 108  Bit Score: 55.71  E-value: 1.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2437432499 443 IDTTLLKVYLrlgYYDN--LNQLVSSRNDCVLDVCVPDLEQYKRFFTIGLLYQSHGQHFNAIQTWVWMVDESvDSSEPNV 520
Cdd:pfam10366   1 IDTTLLKCYL---YTNPslVGPLLRIENACDLEDVEEWLKKHKKYSELIDLYYGKGLHREALQLLTELADET-TGDETDS 76

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2437432499 521 LLH-----IVKTLSRLKEKSI--IMKFIDWAL 545
Cdd:pfam10366  77 TLKgpketIIQYLQKLGPSDLdlILEYSDWVL 108
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 565-692 1.15e-05

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 45.71  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2437432499 565 NTFEPQEVLSIL--TNYPVALVSYLEFLVNEQQSQMEKHHTLLANTYATqilhtdremqnndthmEEMRQKLQQFLWQSS 642
Cdd:pfam00637   6 DPIDVSRVVKLFekAGLLEELISYLESALKEDSRENPALQTALIELYAK----------------YDDPEELEEFLKKNN 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2437432499 643 IYDADAVYAKIQSSALHVEKAILLGRVGEHRKALRLLVDEERDEKAAEVY 692
Cdd:pfam00637  70 NYDLEKVAKLCEKADLYEEAVILYKKIGNWKEAISLLKKLGDYKDAIEYA 119
 
Name Accession Description Interval E-value
Vps39_2 pfam10367
Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein ...
 727-833 1.84e-17

Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. This domain is involved in localization and in mediating the interactions of Vps39 with Vps11.


Pssm-ID: 402126  Cd Length: 109  Bit Score: 78.45  E-value: 1.84e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2437432499 727 VDLLNQNAVAFNLLRVLEVLPGSWSLQLVMRFLCESLRATTHDRRMRGLEKSLARMDNLRQRHAWMEATQGMVRMDRSQV 806
Cdd:pfam10367   1 LDLLNKHAERIDPAQVLQLLPDEIPLQDLSSFLERALRNSSEAKREAQVVKNLSKAENLQVEEELLKLRSRKVRVTEESV 80

                          90       100
                  ....*....|....*....|....*..
gi 2437432499 807 CHSCQRQFIGPEFLRRSTGELLHTHCY 833
Cdd:pfam10367  81 CAVCHKRLGESVFVVYPNGVVVHYGCF 107
Vps39_1 pfam10366
Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein ...
 443-545 1.99e-09

Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. The precise function of this domain has not been characterized.


Pssm-ID: 371008  Cd Length: 108  Bit Score: 55.71  E-value: 1.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2437432499 443 IDTTLLKVYLrlgYYDN--LNQLVSSRNDCVLDVCVPDLEQYKRFFTIGLLYQSHGQHFNAIQTWVWMVDESvDSSEPNV 520
Cdd:pfam10366   1 IDTTLLKCYL---YTNPslVGPLLRIENACDLEDVEEWLKKHKKYSELIDLYYGKGLHREALQLLTELADET-TGDETDS 76

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2437432499 521 LLH-----IVKTLSRLKEKSI--IMKFIDWAL 545
Cdd:pfam10366  77 TLKgpketIIQYLQKLGPSDLdlILEYSDWVL 108
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 565-692 1.15e-05

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 45.71  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2437432499 565 NTFEPQEVLSIL--TNYPVALVSYLEFLVNEQQSQMEKHHTLLANTYATqilhtdremqnndthmEEMRQKLQQFLWQSS 642
Cdd:pfam00637   6 DPIDVSRVVKLFekAGLLEELISYLESALKEDSRENPALQTALIELYAK----------------YDDPEELEEFLKKNN 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2437432499 643 IYDADAVYAKIQSSALHVEKAILLGRVGEHRKALRLLVDEERDEKAAEVY 692
Cdd:pfam00637  70 NYDLEKVAKLCEKADLYEEAVILYKKIGNWKEAISLLKKLGDYKDAIEYA 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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