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Conserved domains on  [gi|2312341303|ref|XP_050816851|]
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U3 small nucleolar RNA-interacting protein 2 isoform X2 [Gopherus flavomarginatus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
133-401 9.26e-52

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 180.11  E-value: 9.26e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 133 DTAAIRVLRGHQLPITCLVISPDDKYIFSAAKDCSIIKWDVESGKKLHVIPGgkkgteaqhigHTAHVLSMAISSDGKYL 212
Cdd:COG2319   151 TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG-----------HTGAVRSVAFSPDGKLL 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 213 ATGDRNKLIMIWEAVTCKHLYKFTGHRDTVTGLSFQKGTHQLYSASHDRSVKVWNVAENAYVETLFGHQDAITGL----D 288
Cdd:COG2319   220 ASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVafspD 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 289 SLSreccVTSGGRDGTVRVWKIPEESQL-VFYGHQGSIDCVQLI-NEEHMVSGADDGSVALWGLSKKKPLATVRqAHSNf 366
Cdd:COG2319   300 GKL----LASGSDDGTVRLWDLATGKLLrTLTGHTGAVRSVAFSpDGKTLASGSDDGTVRLWDLATGELLRTLT-GHTG- 373

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2312341303 367 gaqgleqpyWISSVATLLNSDVVATGSHSSSVRLW 401
Cdd:COG2319   374 ---------AVTSVAFSPDGRTLASGSADGTVRLW 399
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
133-401 9.26e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 180.11  E-value: 9.26e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 133 DTAAIRVLRGHQLPITCLVISPDDKYIFSAAKDCSIIKWDVESGKKLHVIPGgkkgteaqhigHTAHVLSMAISSDGKYL 212
Cdd:COG2319   151 TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG-----------HTGAVRSVAFSPDGKLL 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 213 ATGDRNKLIMIWEAVTCKHLYKFTGHRDTVTGLSFQKGTHQLYSASHDRSVKVWNVAENAYVETLFGHQDAITGL----D 288
Cdd:COG2319   220 ASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVafspD 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 289 SLSreccVTSGGRDGTVRVWKIPEESQL-VFYGHQGSIDCVQLI-NEEHMVSGADDGSVALWGLSKKKPLATVRqAHSNf 366
Cdd:COG2319   300 GKL----LASGSDDGTVRLWDLATGKLLrTLTGHTGAVRSVAFSpDGKTLASGSDDGTVRLWDLATGELLRTLT-GHTG- 373

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2312341303 367 gaqgleqpyWISSVATLLNSDVVATGSHSSSVRLW 401
Cdd:COG2319   374 ---------AVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 137-437 5.07e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 174.83  E-value: 5.07e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 137 IRVLRGHQLPITCLVISPDDKYIFSAAKDCSIIKWDVESGKKLHVIpggkkgteaqhIGHTAHVLSMAISSDGKYLATGD 216
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-----------KGHTGPVRDVAASADGTYLASGS 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 217 RNKLIMIWEAVTCKHLYKFTGHRDTVTGLSFQKGTHQLYSASHDRSVKVWNVAENAYVETLFGHQDAITGLDSLSRECCV 296
Cdd:cd00200    71 SDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 297 TSGGRDGTVRVWKIPEES-QLVFYGHQGSIDCVQLI-NEEHMVSGADDGSVALWGLSKKKPLATVRqAHSNfgaqgleqp 374
Cdd:cd00200   151 ASSSQDGTIKLWDLRTGKcVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCLGTLR-GHEN--------- 220

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2312341303 375 yWISSVATLLNSDVVATGSHSSSVRLWKcgegFRRLEPLFDIPL-IGFVNSLKFSNAGDFLVVG 437
Cdd:cd00200   221 -GVNSVAFSPDGYLLASGSEDGTIRVWD----LRTGECVQTLSGhTNSVTSLAWSPDGKRLASG 279
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 200-401 1.25e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.40  E-value: 1.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 200 VLSMAISSDGKYLATGDRNKLIMIWEavtCKHLYKFT----------GHRDTVTGL---SFQKGthQLYSASHDRSVKVW 266
Cdd:PLN00181  486 VCAIGFDRDGEFFATAGVNKKIKIFE---CESIIKDGrdihypvvelASRSKLSGIcwnSYIKS--QVASSNFEGVVQVW 560

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 267 NVAENAYVETLFGHQDAITGLD-SLSRECCVTSGGRDGTVRVWKIPEESQLVFYGHQGSIDCVQLINE--EHMVSGADDG 343
Cdd:PLN00181  561 DVARSQLVTEMKEHEKRVWSIDySSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSEsgRSLAFGSADH 640

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2312341303 344 SVALWGLSKKK-PLATVRQAHSNFgaqgleqpywisSVATLLNSDVVATGSHSSSVRLW 401
Cdd:PLN00181  641 KVYYYDLRNPKlPLCTMIGHSKTV------------SYVRFVDSSTLVSSSTDNTLKLW 687
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 137-172 6.30e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 6.30e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2312341303  137 IRVLRGHQLPITCLVISPDDKYIFSAAKDCSIIKWD 172
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
137-172 1.35e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.35e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2312341303 137 IRVLRGHQLPITCLVISPDDKYIFSAAKDCSIIKWD 172
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
133-401 9.26e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 180.11  E-value: 9.26e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 133 DTAAIRVLRGHQLPITCLVISPDDKYIFSAAKDCSIIKWDVESGKKLHVIPGgkkgteaqhigHTAHVLSMAISSDGKYL 212
Cdd:COG2319   151 TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG-----------HTGAVRSVAFSPDGKLL 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 213 ATGDRNKLIMIWEAVTCKHLYKFTGHRDTVTGLSFQKGTHQLYSASHDRSVKVWNVAENAYVETLFGHQDAITGL----D 288
Cdd:COG2319   220 ASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVafspD 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 289 SLSreccVTSGGRDGTVRVWKIPEESQL-VFYGHQGSIDCVQLI-NEEHMVSGADDGSVALWGLSKKKPLATVRqAHSNf 366
Cdd:COG2319   300 GKL----LASGSDDGTVRLWDLATGKLLrTLTGHTGAVRSVAFSpDGKTLASGSDDGTVRLWDLATGELLRTLT-GHTG- 373

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2312341303 367 gaqgleqpyWISSVATLLNSDVVATGSHSSSVRLW 401
Cdd:COG2319   374 ---------AVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 137-437 5.07e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 174.83  E-value: 5.07e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 137 IRVLRGHQLPITCLVISPDDKYIFSAAKDCSIIKWDVESGKKLHVIpggkkgteaqhIGHTAHVLSMAISSDGKYLATGD 216
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-----------KGHTGPVRDVAASADGTYLASGS 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 217 RNKLIMIWEAVTCKHLYKFTGHRDTVTGLSFQKGTHQLYSASHDRSVKVWNVAENAYVETLFGHQDAITGLDSLSRECCV 296
Cdd:cd00200    71 SDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 297 TSGGRDGTVRVWKIPEES-QLVFYGHQGSIDCVQLI-NEEHMVSGADDGSVALWGLSKKKPLATVRqAHSNfgaqgleqp 374
Cdd:cd00200   151 ASSSQDGTIKLWDLRTGKcVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCLGTLR-GHEN--------- 220

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2312341303 375 yWISSVATLLNSDVVATGSHSSSVRLWKcgegFRRLEPLFDIPL-IGFVNSLKFSNAGDFLVVG 437
Cdd:cd00200   221 -GVNSVAFSPDGYLLASGSEDGTIRVWD----LRTGECVQTLSGhTNSVTSLAWSPDGKRLASG 279
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 137-402 6.45e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 174.45  E-value: 6.45e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 137 IRVLRGHQLPITCLVISPDDKYIFSAAKDCSIIKWDVESGKKLHVIpggkkgteaqhIGHTAHVLSMAISSDGKYLATGD 216
Cdd:cd00200    44 LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL-----------TGHTSYVSSVAFSPDGRILSSSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 217 RNKLIMIWEAVTCKHLYKFTGHRDTVTGLSFQKGTHQLYSASHDRSVKVWNVAENAYVETLFGHQDAITGLDSLSRECCV 296
Cdd:cd00200   113 RDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKL 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 297 TSGGRDGTVRVWKIPEESQL-VFYGHQGSIDCVQLI-NEEHMVSGADDGSVALWGLSKKKPLATVrQAHSNfgaqgleqp 374
Cdd:cd00200   193 LSSSSDGTIKLWDLSTGKCLgTLRGHENGVNSVAFSpDGYLLASGSEDGTIRVWDLRTGECVQTL-SGHTN--------- 262

                         250       260
                  ....*....|....*....|....*...
gi 2312341303 375 yWISSVATLLNSDVVATGSHSSSVRLWK 402
Cdd:cd00200   263 -SVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
130-437 1.20e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 177.41  E-value: 1.20e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 130 QPPDTAAIRVLRGHQLPITCLVISPDDKYIFSAAKDCSIIKWDVESGKKLHVIPGgkkgteaqhigHTAHVLSMAISSDG 209
Cdd:COG2319   106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG-----------HSGAVTSVAFSPDG 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 210 KYLATGDRNKLIMIWEAVTCKHLYKFTGHRDTVTGLSFQKGTHQLYSASHDRSVKVWNVAENAYVETLFGHQDAITGLdS 289
Cdd:COG2319   175 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV-A 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 290 LSREC-CVTSGGRDGTVRVWKIPEESQLVFY-GHQGSIDCVQLI-NEEHMVSGADDGSVALWGLSKKKPLATVrQAHSNf 366
Cdd:COG2319   254 FSPDGrLLASGSADGTVRLWDLATGELLRTLtGHSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTG- 331

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2312341303 367 gaqgleqpyWISSVATLLNSDVVATGSHSSSVRLWKCgEGFRRLEPLFDIPliGFVNSLKFSNAGDFLVVG 437
Cdd:COG2319   332 ---------AVRSVAFSPDGKTLASGSDDGTVRLWDL-ATGELLRTLTGHT--GAVTSVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
137-351 1.76e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 152.76  E-value: 1.76e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 137 IRVLRGHQLPITCLVISPDDKYIFSAAKDCSIIKWDVESGKKLHVIPGgkkgteaqhigHTAHVLSMAISSDGKYLATGD 216
Cdd:COG2319   197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTG-----------HSGSVRSVAFSPDGRLLASGS 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 217 RNKLIMIWEAVTCKHLYKFTGHRDTVTGLSFQKGTHQLYSASHDRSVKVWNVAENAYVETLFGHQDAITGLDSLSRECCV 296
Cdd:COG2319   266 ADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTL 345

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2312341303 297 TSGGRDGTVRVWKIPEESQL-VFYGHQGSIDCVQLI-NEEHMVSGADDGSVALWGLS 351
Cdd:COG2319   346 ASGSDDGTVRLWDLATGELLrTLTGHTGAVTSVAFSpDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
121-467 3.19e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.12  E-value: 3.19e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 121 LQRLIAKDLQPPDTAAIRVLRGHQLPITCLVISPDDKYIFSAAKDCSIIKWDVESGKKLHVIPGgkkgteaqhigHTAHV 200
Cdd:COG2319    13 SADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLG-----------HTAAV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 201 LSMAISSDGKYLATGDRNKLIMIWEAVTCKHLYKFTGHRDTVTGLSFQKGTHQLYSASHDRSVKVWNVAENAYVETLFGH 280
Cdd:COG2319    82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 281 QDAITGL----DSLSreccVTSGGRDGTVRVWKIPEESQL-VFYGHQGSIDCVQLI-NEEHMVSGADDGSVALWGLSKKK 354
Cdd:COG2319   162 SGAVTSVafspDGKL----LASGSDDGTVRLWDLATGKLLrTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGK 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 355 PLATVRqAHSNfgaqgleqpyWISSVATLLNSDVVATGSHSSSVRLWKCGEGfrRLEPLFDIPLiGFVNSLKFSNAGDFL 434
Cdd:COG2319   238 LLRTLT-GHSG----------SVRSVAFSPDGRLLASGSADGTVRLWDLATG--ELLRTLTGHS-GGVNSVAFSPDGKLL 303

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 2312341303 435 VVGvGQEHRLgRWWRIKEAK------------NSICIIPLQRTVA 467
Cdd:COG2319   304 ASG-SDDGTV-RLWDLATGKllrtltghtgavRSVAFSPDGKTLA 346
WD40 COG2319
WD40 repeat [General function prediction only];
204-437 3.22e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.42  E-value: 3.22e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 204 AISSDGKYLATGDRNKLIMIWEAVTCKHLYKFTGHRDTVTGLSFQKGTHQLYSASHDRSVKVWNVAENAYVETLFGHQDA 283
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 284 ITGLDSLSRECCVTSGGRDGTVRVWKIPEESQL-VFYGHQGSIDCVQL-INEEHMVSGADDGSVALWGLSKKKPLATVRq 361
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLrTLTGHTGAVRSVAFsPDGKTLASGSADGTVRLWDLATGKLLRTLT- 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2312341303 362 AHSNfgaqgleqpyWISSVATLLNSDVVATGSHSSSVRLWKCGEGfRRLEPLfdIPLIGFVNSLKFSNAGDFLVVG 437
Cdd:COG2319   160 GHSG----------AVTSVAFSPDGKLLASGSDDGTVRLWDLATG-KLLRTL--TGHTGAVRSVAFSPDGKLLASG 222
WD40 COG2319
WD40 repeat [General function prediction only];
137-228 3.22e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.26  E-value: 3.22e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 137 IRVLRGHQLPITCLVISPDDKYIFSAAKDCSIIKWDVESGKKLHVIPGgkkgteaqhigHTAHVLSMAISSDGKYLATGD 216
Cdd:COG2319   323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG-----------HTGAVTSVAFSPDGRTLASGS 391

                          90
                  ....*....|..
gi 2312341303 217 RNKLIMIWEAVT 228
Cdd:COG2319   392 ADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 200-401 1.25e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.40  E-value: 1.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 200 VLSMAISSDGKYLATGDRNKLIMIWEavtCKHLYKFT----------GHRDTVTGL---SFQKGthQLYSASHDRSVKVW 266
Cdd:PLN00181  486 VCAIGFDRDGEFFATAGVNKKIKIFE---CESIIKDGrdihypvvelASRSKLSGIcwnSYIKS--QVASSNFEGVVQVW 560

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 267 NVAENAYVETLFGHQDAITGLD-SLSRECCVTSGGRDGTVRVWKIPEESQLVFYGHQGSIDCVQLINE--EHMVSGADDG 343
Cdd:PLN00181  561 DVARSQLVTEMKEHEKRVWSIDySSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSEsgRSLAFGSADH 640

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2312341303 344 SVALWGLSKKK-PLATVRQAHSNFgaqgleqpywisSVATLLNSDVVATGSHSSSVRLW 401
Cdd:PLN00181  641 KVYYYDLRNPKlPLCTMIGHSKTV------------SYVRFVDSSTLVSSSTDNTLKLW 687
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 137-172 6.30e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 6.30e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2312341303  137 IRVLRGHQLPITCLVISPDDKYIFSAAKDCSIIKWD 172
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
137-172 1.35e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.35e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2312341303 137 IRVLRGHQLPITCLVISPDDKYIFSAAKDCSIIKWD 172
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 228-267 1.95e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 1.95e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2312341303  228 TCKHLYKFTGHRDTVTGLSFQKGTHQLYSASHDRSVKVWN 267
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
230-267 4.78e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 4.78e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2312341303 230 KHLYKFTGHRDTVTGLSFQKGTHQLYSASHDRSVKVWN 267
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 192-347 2.06e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 46.60  E-value: 2.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 192 QHIGHTAHVLS-MAISSDGKYLATGDRNKLIMIWEAVTCKHLYKFTghRDTVTglsfqkgthqlysashDRSVKVWNVAE 270
Cdd:pfam20426 118 QSIRQHKDVVScVAVTSDGSILATGSYDTTVMVWEVLRGRSSEKRS--RNTQT----------------EFPRKDHVIAE 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 271 NAYvETLFGHQDAITGLDSLSRECCVTSGGRDGT-----------VRVWKIPEESQL-----------VFYGHQ------ 322
Cdd:pfam20426 180 TPF-HILCGHDDIITCLYVSVELDIVISGSKDGTcifhtlregryVRSIRHPSGCPLsklvasrhgriVLYADDdlslhl 258

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2312341303 323 --------------GSIDCVQLIN-EEHMVSGADDGSVAL 347
Cdd:pfam20426 259 ysingkhiassesnGRLNCIELSScGEFLVCAGDQGQIVV 298
PTZ00421 PTZ00421
coronin; Provisional
 208-307 3.67e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.04  E-value: 3.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2312341303 208 DGKYLATGDRNKLIMIW-------EAVTCKHLYKFTGHRDTVTGLSFQKGTHQ-LYSASHDRSVKVWNVAENAYVETLFG 279
Cdd:PTZ00421   87 DPQKLFTASEDGTIMGWgipeeglTQNISDPIVHLQGHTKKVGIVSFHPSAMNvLASAGADMVVNVWDVERGKAVEVIKC 166

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2312341303 280 HQDAITGLD-----SLsreCCVTSggRDGTVRV 307
Cdd:PTZ00421  167 HSDQITSLEwnldgSL---LCTTS--KDKKLNI 194
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 195-225 4.78e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 4.78e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2312341303  195 GHTAHVLSMAISSDGKYLATGDRNKLIMIWE 225
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
195-225 7.55e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 7.55e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2312341303 195 GHTAHVLSMAISSDGKYLATGDRNKLIMIWE 225
Cdd:pfam00400   9 GHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
274-308 1.10e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.10e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2312341303 274 VETLFGHQDAITGLDSLSRECCVTSGGRDGTVRVW 308
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 274-309 1.40e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.40e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2312341303  274 VETLFGHQDAITGLDSLSRECCVTSGGRDGTVRVWK 309
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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