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Conserved domains on  [gi|2257803397|ref|XP_048588498|]
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A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X1 [Nematostella vectensis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 236-441 4.04e-98

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


:

Pssm-ID: 239801  Cd Length: 207  Bit Score: 314.95  E-value: 4.04e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  236 YVETMVTADKSMVDAFpSKAELQSFIITIMGMVARIYRDKTIGNSINIVLVKIIILEIDLPELEITSNAASSLRSFCKWQ 315
Cdd:cd04273      2 YVETLVVADSKMVEFH-HGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLLISGNAQKSLKSFCRWQ 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  316 TKMNKPSDEEPGHFDTAILLTRTDICRAAGKCDTLGLAELGTVCNPSRSCSIVEVTGLSSAFTIAHELAHVFNVPHDGDH 395
Cdd:cd04273     81 KKLNPPNDSDPEHHDHAILLTRQDICRSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGDG 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 2257803397  396 NMCDEKSGNYNLMAPSLSFNTKPWMWSTCSRDAIRLFFDLGYGKCL 441
Cdd:cd04273    161 NSCGPEGKDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGDGNCL 206
GON pfam08685
GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain ...
 2607-2806 2.22e-91

GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.


:

Pssm-ID: 462559  Cd Length: 200  Bit Score: 295.29  E-value: 2.22e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397 2607 PRTCREIQLTSGLQADGEHVLQVQGKLLKIYCHGMTTDDPKEYISLKTGSKDNFAEVYTKKLLDPNQCPSNGKHVDSCAC 2686
Cdd:pfam08685    1 PRSCKEIQSRSGVRKDGEYTLNVRGRNVRIYCHGMNTSSPKEYLTLPSGPQENYSEVYGYRLKNPNECPFNGSRRDDCAC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397 2687 ySQDYID-SGSSYFTKLRIDIVKMKIIPDDFQFASTRGLKPPPYATAGDCYSRKRCPQGRFSINLEGTGIELSPDVRWRS 2765
Cdd:pfam08685   81 -RQDYPAnAGTTTFSKVRLDLTSLRIITNDFTFARTIRGKPVPFGTAGDCYSAAKCPQGRFSINLTGTGLRVSPDTKWVS 159

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 2257803397 2766 TGRSFTQLIYRYPEGKRVIAKCGGRCGTCSPATGIGLQVLV 2806
Cdd:pfam08685  160 QGNYAVSKIHRSQDGTKVRGRCGGYCGKCTPSPGTGLLLDV 200
ADAMTS_spacer1 super family cl20316
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 702-818 1.48e-25

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


The actual alignment was detected with superfamily member pfam05986:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 103.43  E-value: 1.48e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  702 KHKGTY-RKIAYGYNPVYKIPAGSTNVVIIEygSRDADNFLALKQVGptARYLINGGSVVSLGERTYQIEGASIYYSGSD 780
Cdd:pfam05986    1 TVSGSFtEGRAKGYVTFVTIPAGATHIHIVN--RKPSFTHLAVKNVQ--GKYILNGKGSISLNPTYPSLLGTVLEYRRSL 76

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2257803397  781 KAEEMIKITGKTQEDLLLEVLSV-GKLTPPNVHYSLNVP 818
Cdd:pfam05986   77 PALEELHAPGPTQEDLEIQVLRQyGKGTNPGITYEYFIP 115
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 43-178 1.43e-24

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


:

Pssm-ID: 460254  Cd Length: 128  Bit Score: 101.24  E-value: 1.43e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397   43 VTPVRVNETGdafpssqQFLSYSSSVRDSGPLYYNLTVYGRtlrlrllrDH-------SGFVSPGLVVEHVFSAGHKL-P 114
Cdd:pfam01562    3 VIPVRLDPSR-------RRRSLASESTYLDTLSYRLAAFGK--------KFhlhltpnRLLLAPGFTVTYYLDGGTGVeS 67

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2257803397  115 LDSGLAHCFYTGSIQGDSLSSAILSVCHGLRGTFFTGGQEYFIEPREQERLVSRQHPrriHIVY 178
Cdd:pfam01562   68 PPVQTDHCYYQGHVEGHPDSSVALSTCSGLRGFIRTENEEYLIEPLEKYSREEGGHP---HVVY 128
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 458-527 1.44e-23

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


:

Pssm-ID: 465496  Cd Length: 68  Bit Score: 96.26  E-value: 1.44e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  458 PGEKYSANDQCQLIFGSQSRLCPFLFEDPCMRLWCVKnlGKRRGCQTHHMPWADGTPCGNHKWCIRGKCV 527
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTFCPNGDEDVCSKLWCSN--PGGSTCTTKNLPAADGTPCGNKKWCLNGKCV 68
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 999-1051 4.79e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.86  E-value: 4.79e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397  999 WRAADWEQCSASCGSGMQSRVVQC--SVGSVIHPDSACPRAAKPTGTQRCNQQPC 1051
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1359-1406 1.34e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.00  E-value: 1.34e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1359 WNAGDWGQCSLTCGGGVQTRRIDCSSSL-------TKCDHRKKPVESRRCNTEAC 1406
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggsivpdSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1175-1228 2.17e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 58.23  E-value: 2.17e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1175 WKHGAWGLCSKSCGKGVQSRIVKCA-YENWKIAKDSQCDPFKRPPEQRECELQKC 1228
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1861-1908 3.57e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.46  E-value: 3.57e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1861 WEAGRWSICSVTCGDGVQTRDVTCST-------RDDRCNAKSMPQRQRKCNLGAC 1908
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkgggsivPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1510-1557 1.11e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 56.31  E-value: 1.11e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1510 WNAGQWSQCSVTCGRGNIRRLVECVP-------AGSNCEARYRPSDSRPCLMQPC 1557
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkgggsivPDSECSAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 539-591 1.52e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 55.67  E-value: 1.52e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2257803397   539 WGNWAAFGACSRTCGGGIQFAKRECNNPEPENGGLYCQGARKRFRSCNSEECP 591
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1961-2008 2.01e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 55.54  E-value: 2.01e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1961 WLSQEWGECSVSCGGGTKTRAVTCSP-------SPDACGALRKPPSSMRCNGQRC 2008
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkgggsivPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1760-1808 2.14e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 55.54  E-value: 2.14e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1760 WTAGPWRKCSVSCGEGVQRRLVQCQS------QHRKHCDRRTRPSDVRRCSAGTC 1808
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkgggsiVPDSECSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 super family cl41950
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 596-700 2.45e-09

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


The actual alignment was detected with superfamily member pfam19236:

Pssm-ID: 437068  Cd Length: 115  Bit Score: 57.41  E-value: 2.45e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  596 DFRALQCAQLNNKPVRIS-GVAKTVNWLPKYQGVREEDRCKLYCQVESKRIHFKMSDKVIDGTPC------QQFSSDVCV 668
Cdd:pfam19236    4 EFMSQQCARTDGQPLRSSpGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCmpsgprEDGTLSLCV 83

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2257803397  669 DGKCISAGCDRIVGSQAKYDVCRVCNGDNTTC 700
Cdd:pfam19236   84 LGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1560-1607 4.86e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.38  E-value: 4.86e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1560 WNVGAWSQCSVSCGRGQRRRNVYCLPEGGN-------CDLRVKPSEIQPCAKKAC 1607
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsivpdseCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2438-2491 4.86e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.38  E-value: 4.86e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 2438 WRTTSWTKCSRTCGFGSKSRYVTCVDKQGQ-PVPKSNCDGRPKPHAYLPCFEVKC 2491
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1811-1858 6.21e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.00  E-value: 6.21e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1811 WVPGSWSECSVTCGEGTRKRTVDC-------NSGEKNCDMRSRPIERERCNMGGC 1858
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqkgggsIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1118-1172 6.65e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.00  E-value: 6.65e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2257803397 1118 WKAGPWSQCSQSCGdQGRRMRRVTCADSRG-VAVAERLCDAPNRPATYERCNVKPC 1172
Cdd:pfam19030    1 WVAGPWGECSVTCG-GGVQTRLVQCVQKGGgSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1660-1707 9.37e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 53.61  E-value: 9.37e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1660 WKSGPWEKCSKTCGVGFQARSVYC------TASSVDKCD-EKKPSSRRQCNIRPC 1707
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqkgggSIVPDSECSaQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2262-2314 1.64e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.84  E-value: 1.64e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 2262 WIIGNWSQCSRTCGIGITSREVQCI--LGNNSLPYASCDSNSRPVIRRVCQLIEC 2314
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2551-2605 2.05e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.46  E-value: 2.05e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2257803397 2551 WRVGSWSECSVTCGTGQMKRAVRCLNARNELM-PDAHCRqPALKPDEARPCTMPPC 2605
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIvPDSECS-AQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2495-2545 2.47e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.46  E-value: 2.47e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2257803397 2495 WKVGDWSECSRTCGdGGYQIRPVTC-----EGVPGVDECNKRNKPPIWRPCHLGPC 2545
Cdd:pfam19030    1 WVAGPWGECSVTCG-GGVQTRLVQCvqkggGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2011-2058 4.36e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 51.68  E-value: 4.36e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 2011 WTVGPWEECSVTCGVGLQSRPVRCDTQRKP-------CDPDNKPDSTQQCNRSAC 2058
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsivpdseCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2210-2253 4.67e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 51.68  E-value: 4.67e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2257803397 2210 WQTGTWSQCSVTCGKGTQVRTVTCSDKDT------SACDLRTKPQSSTVC 2253
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgsivpdSECSAQKKPPETQSC 50
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1911-1958 7.18e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.91  E-value: 7.18e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1911 WRVGPWEKCSVTCGEGVVRRVVTCSAGGNR-------CQDDTKPEVVKLCELPDC 1958
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsivpdseCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1054-1106 7.25e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.91  E-value: 7.25e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1054 WETRNWSGCSVSCGVGEKTRSVTCR--YNGTSISPTRCDRALRPSLTERCTQPPC 1106
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2061-2108 1.60e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.14  E-value: 1.60e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 2061 WAAGPWEQCSVTCGAGVKRRTVTC--TSDNIT-----CNESQKPPHVARCEKGEC 2108
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqKGGGSIvpdseCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1460-1507 1.62e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.14  E-value: 1.62e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1460 WTVGKWSECSRTCGGGISARTVTCS-------SRDQPCYRMSKPPTTRICNSQDC 1507
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqkgggsiVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1710-1752 1.72e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.14  E-value: 1.72e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2257803397 1710 WISEQWSQCSVSCGRGVQSRAVKCST-------DELECDAETKPNSRQPC 1752
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkgggsivPDSECSAQKKPPETQSC 50
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1311-1356 2.42e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 49.76  E-value: 2.42e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1311 WIMGSWSECSVTCGFGYKRREVYCSR---------NNCDTARKPTQLLKCELPVC 1356
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkgggsivpdSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2377-2429 2.42e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 49.76  E-value: 2.42e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 2377 WETGAWSECSKSCGDGVKTRELRC--LYNIEYANEENCEESTRPIAELPCRKQAC 2429
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1410-1457 4.32e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 48.99  E-value: 4.32e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1410 WREGPWSKCSVTCGEGIQLHTVVC------STGNQSQCK-KPKPSEARKCQLPAC 1457
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqkgggSIVPDSECSaQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1610-1657 6.98e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 48.22  E-value: 6.98e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1610 WTVGRWSECSVTCGSGKASRQVLC-------EPAGSQCDNATRPASVRVCALGEC 1657
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqkgggsIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2320-2372 9.55e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 47.83  E-value: 9.55e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2257803397 2320 WRAGNWGECSSRCSSGIKTRRTWCTASNGTQIQ-DKYCSQPRRPRDQRECNRHR 2372
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVpDSECSAQKKPPETQSCNLKP 54
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2161-2207 1.47e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 47.45  E-value: 1.47e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 2161 WSVGQWSSCSVTCGVGRRLRSVVCSIHG--------KCDKQRQPSSSTLCNMGPC 2207
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggsivpdsECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1258-1308 2.81e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 46.68  E-value: 2.81e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1258 WRTSAWGACSVTCGKGIRRRPVTCTR--NGRT--SNACVQDSRPADTEVCTNAAC 1308
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkgGGSIvpDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 944-992 3.85e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 46.29  E-value: 3.85e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2257803397  944 WVYTRWSQCSRTCGSGIKTRRANCVDHKGDFL-PDADCRPSDRLLLQQVC 992
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIvPDSECSAQKKPPETQSC 50
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2111-2158 5.40e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 42.83  E-value: 5.40e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 2111 WTAGAWSECSSTCGSGVRTRFVSCKPRDGT-------CNPEDKPDAYKECDVMEC 2158
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsivpdseCSAQKKPPETQSCNLKPC 55
 
Name Accession Description Interval E-value
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 236-441 4.04e-98

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 314.95  E-value: 4.04e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  236 YVETMVTADKSMVDAFpSKAELQSFIITIMGMVARIYRDKTIGNSINIVLVKIIILEIDLPELEITSNAASSLRSFCKWQ 315
Cdd:cd04273      2 YVETLVVADSKMVEFH-HGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLLISGNAQKSLKSFCRWQ 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  316 TKMNKPSDEEPGHFDTAILLTRTDICRAAGKCDTLGLAELGTVCNPSRSCSIVEVTGLSSAFTIAHELAHVFNVPHDGDH 395
Cdd:cd04273     81 KKLNPPNDSDPEHHDHAILLTRQDICRSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGDG 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 2257803397  396 NMCDEKSGNYNLMAPSLSFNTKPWMWSTCSRDAIRLFFDLGYGKCL 441
Cdd:cd04273    161 NSCGPEGKDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGDGNCL 206
GON pfam08685
GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain ...
 2607-2806 2.22e-91

GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.


Pssm-ID: 462559  Cd Length: 200  Bit Score: 295.29  E-value: 2.22e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397 2607 PRTCREIQLTSGLQADGEHVLQVQGKLLKIYCHGMTTDDPKEYISLKTGSKDNFAEVYTKKLLDPNQCPSNGKHVDSCAC 2686
Cdd:pfam08685    1 PRSCKEIQSRSGVRKDGEYTLNVRGRNVRIYCHGMNTSSPKEYLTLPSGPQENYSEVYGYRLKNPNECPFNGSRRDDCAC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397 2687 ySQDYID-SGSSYFTKLRIDIVKMKIIPDDFQFASTRGLKPPPYATAGDCYSRKRCPQGRFSINLEGTGIELSPDVRWRS 2765
Cdd:pfam08685   81 -RQDYPAnAGTTTFSKVRLDLTSLRIITNDFTFARTIRGKPVPFGTAGDCYSAAKCPQGRFSINLTGTGLRVSPDTKWVS 159

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 2257803397 2766 TGRSFTQLIYRYPEGKRVIAKCGGRCGTCSPATGIGLQVLV 2806
Cdd:pfam08685  160 QGNYAVSKIHRSQDGTKVRGRCGGYCGKCTPSPGTGLLLDV 200
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 702-818 1.48e-25

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 103.43  E-value: 1.48e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  702 KHKGTY-RKIAYGYNPVYKIPAGSTNVVIIEygSRDADNFLALKQVGptARYLINGGSVVSLGERTYQIEGASIYYSGSD 780
Cdd:pfam05986    1 TVSGSFtEGRAKGYVTFVTIPAGATHIHIVN--RKPSFTHLAVKNVQ--GKYILNGKGSISLNPTYPSLLGTVLEYRRSL 76

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2257803397  781 KAEEMIKITGKTQEDLLLEVLSV-GKLTPPNVHYSLNVP 818
Cdd:pfam05986   77 PALEELHAPGPTQEDLEIQVLRQyGKGTNPGITYEYFIP 115
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 43-178 1.43e-24

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


Pssm-ID: 460254  Cd Length: 128  Bit Score: 101.24  E-value: 1.43e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397   43 VTPVRVNETGdafpssqQFLSYSSSVRDSGPLYYNLTVYGRtlrlrllrDH-------SGFVSPGLVVEHVFSAGHKL-P 114
Cdd:pfam01562    3 VIPVRLDPSR-------RRRSLASESTYLDTLSYRLAAFGK--------KFhlhltpnRLLLAPGFTVTYYLDGGTGVeS 67

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2257803397  115 LDSGLAHCFYTGSIQGDSLSSAILSVCHGLRGTFFTGGQEYFIEPREQERLVSRQHPrriHIVY 178
Cdd:pfam01562   68 PPVQTDHCYYQGHVEGHPDSSVALSTCSGLRGFIRTENEEYLIEPLEKYSREEGGHP---HVVY 128
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 458-527 1.44e-23

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 96.26  E-value: 1.44e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  458 PGEKYSANDQCQLIFGSQSRLCPFLFEDPCMRLWCVKnlGKRRGCQTHHMPWADGTPCGNHKWCIRGKCV 527
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTFCPNGDEDVCSKLWCSN--PGGSTCTTKNLPAADGTPCGNKKWCLNGKCV 68
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 236-445 1.79e-23

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 100.45  E-value: 1.79e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  236 YVETMVTADKSMVDAF-PSKAELQSFIITIMGMVARIYRDKtignSINIVLVKiiiLEI--DLPELEITSNAASSLRSFC 312
Cdd:pfam01421    2 YIELFIVVDKQLFQKMgSDTTVVRQRVFQVVNLVNSIYKEL----NIRVVLVG---LEIwtDEDKIDVSGDANDTLRNFL 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  313 KWQTKMNKpsdeEPGHFDTAILLTRTDIcraagKCDTLGLAELGTVCNPSRSCSIVE---VTGLSSAFTIAHELAHVFNV 389
Cdd:pfam01421   75 KWRQEYLK----KRKPHDVAQLLSGVEF-----GGTTVGAAYVGGMCSLEYSGGVNEdhsKNLESFAVTMAHELGHNLGM 145

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2257803397  390 PHDGDHNMCDEKSGNYNLMAPSLSFnTKPWMWSTCSRDAIRLFFDLGYGKCLEDKP 445
Cdd:pfam01421  146 QHDDFNGGCKCPPGGGCIMNPSAGS-SFPRKFSNCSQEDFEQFLTKQKGACLFNKP 200
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 999-1051 4.79e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.86  E-value: 4.79e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397  999 WRAADWEQCSASCGSGMQSRVVQC--SVGSVIHPDSACPRAAKPTGTQRCNQQPC 1051
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1359-1406 1.34e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.00  E-value: 1.34e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1359 WNAGDWGQCSLTCGGGVQTRRIDCSSSL-------TKCDHRKKPVESRRCNTEAC 1406
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggsivpdSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1175-1228 2.17e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 58.23  E-value: 2.17e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1175 WKHGAWGLCSKSCGKGVQSRIVKCA-YENWKIAKDSQCDPFKRPPEQRECELQKC 1228
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1861-1908 3.57e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.46  E-value: 3.57e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1861 WEAGRWSICSVTCGDGVQTRDVTCST-------RDDRCNAKSMPQRQRKCNLGAC 1908
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkgggsivPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1510-1557 1.11e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 56.31  E-value: 1.11e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1510 WNAGQWSQCSVTCGRGNIRRLVECVP-------AGSNCEARYRPSDSRPCLMQPC 1557
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkgggsivPDSECSAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 539-591 1.52e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 55.67  E-value: 1.52e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2257803397   539 WGNWAAFGACSRTCGGGIQFAKRECNNPEPENGGLYCQGARKRFRSCNSEECP 591
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1961-2008 2.01e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 55.54  E-value: 2.01e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1961 WLSQEWGECSVSCGGGTKTRAVTCSP-------SPDACGALRKPPSSMRCNGQRC 2008
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkgggsivPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1760-1808 2.14e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 55.54  E-value: 2.14e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1760 WTAGPWRKCSVSCGEGVQRRLVQCQS------QHRKHCDRRTRPSDVRRCSAGTC 1808
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkgggsiVPDSECSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 596-700 2.45e-09

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 57.41  E-value: 2.45e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  596 DFRALQCAQLNNKPVRIS-GVAKTVNWLPKYQGVREEDRCKLYCQVESKRIHFKMSDKVIDGTPC------QQFSSDVCV 668
Cdd:pfam19236    4 EFMSQQCARTDGQPLRSSpGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCmpsgprEDGTLSLCV 83

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2257803397  669 DGKCISAGCDRIVGSQAKYDVCRVCNGDNTTC 700
Cdd:pfam19236   84 LGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1560-1607 4.86e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.38  E-value: 4.86e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1560 WNVGAWSQCSVSCGRGQRRRNVYCLPEGGN-------CDLRVKPSEIQPCAKKAC 1607
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsivpdseCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2438-2491 4.86e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.38  E-value: 4.86e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 2438 WRTTSWTKCSRTCGFGSKSRYVTCVDKQGQ-PVPKSNCDGRPKPHAYLPCFEVKC 2491
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1811-1858 6.21e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.00  E-value: 6.21e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1811 WVPGSWSECSVTCGEGTRKRTVDC-------NSGEKNCDMRSRPIERERCNMGGC 1858
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqkgggsIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1118-1172 6.65e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.00  E-value: 6.65e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2257803397 1118 WKAGPWSQCSQSCGdQGRRMRRVTCADSRG-VAVAERLCDAPNRPATYERCNVKPC 1172
Cdd:pfam19030    1 WVAGPWGECSVTCG-GGVQTRLVQCVQKGGgSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1660-1707 9.37e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 53.61  E-value: 9.37e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1660 WKSGPWEKCSKTCGVGFQARSVYC------TASSVDKCD-EKKPSSRRQCNIRPC 1707
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqkgggSIVPDSECSaQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2262-2314 1.64e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.84  E-value: 1.64e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 2262 WIIGNWSQCSRTCGIGITSREVQCI--LGNNSLPYASCDSNSRPVIRRVCQLIEC 2314
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2551-2605 2.05e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.46  E-value: 2.05e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2257803397 2551 WRVGSWSECSVTCGTGQMKRAVRCLNARNELM-PDAHCRqPALKPDEARPCTMPPC 2605
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIvPDSECS-AQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2495-2545 2.47e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.46  E-value: 2.47e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2257803397 2495 WKVGDWSECSRTCGdGGYQIRPVTC-----EGVPGVDECNKRNKPPIWRPCHLGPC 2545
Cdd:pfam19030    1 WVAGPWGECSVTCG-GGVQTRLVQCvqkggGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2011-2058 4.36e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 51.68  E-value: 4.36e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 2011 WTVGPWEECSVTCGVGLQSRPVRCDTQRKP-------CDPDNKPDSTQQCNRSAC 2058
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsivpdseCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2210-2253 4.67e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 51.68  E-value: 4.67e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2257803397 2210 WQTGTWSQCSVTCGKGTQVRTVTCSDKDT------SACDLRTKPQSSTVC 2253
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgsivpdSECSAQKKPPETQSC 50
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1911-1958 7.18e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.91  E-value: 7.18e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1911 WRVGPWEKCSVTCGEGVVRRVVTCSAGGNR-------CQDDTKPEVVKLCELPDC 1958
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsivpdseCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1054-1106 7.25e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.91  E-value: 7.25e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1054 WETRNWSGCSVSCGVGEKTRSVTCR--YNGTSISPTRCDRALRPSLTERCTQPPC 1106
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2061-2108 1.60e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.14  E-value: 1.60e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 2061 WAAGPWEQCSVTCGAGVKRRTVTC--TSDNIT-----CNESQKPPHVARCEKGEC 2108
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqKGGGSIvpdseCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1460-1507 1.62e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.14  E-value: 1.62e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1460 WTVGKWSECSRTCGGGISARTVTCS-------SRDQPCYRMSKPPTTRICNSQDC 1507
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqkgggsiVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1710-1752 1.72e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.14  E-value: 1.72e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2257803397 1710 WISEQWSQCSVSCGRGVQSRAVKCST-------DELECDAETKPNSRQPC 1752
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkgggsivPDSECSAQKKPPETQSC 50
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1311-1356 2.42e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 49.76  E-value: 2.42e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1311 WIMGSWSECSVTCGFGYKRREVYCSR---------NNCDTARKPTQLLKCELPVC 1356
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkgggsivpdSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2377-2429 2.42e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 49.76  E-value: 2.42e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 2377 WETGAWSECSKSCGDGVKTRELRC--LYNIEYANEENCEESTRPIAELPCRKQAC 2429
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1410-1457 4.32e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 48.99  E-value: 4.32e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1410 WREGPWSKCSVTCGEGIQLHTVVC------STGNQSQCK-KPKPSEARKCQLPAC 1457
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqkgggSIVPDSECSaQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1610-1657 6.98e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 48.22  E-value: 6.98e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1610 WTVGRWSECSVTCGSGKASRQVLC-------EPAGSQCDNATRPASVRVCALGEC 1657
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqkgggsIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2320-2372 9.55e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 47.83  E-value: 9.55e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2257803397 2320 WRAGNWGECSSRCSSGIKTRRTWCTASNGTQIQ-DKYCSQPRRPRDQRECNRHR 2372
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVpDSECSAQKKPPETQSCNLKP 54
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2161-2207 1.47e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 47.45  E-value: 1.47e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 2161 WSVGQWSSCSVTCGVGRRLRSVVCSIHG--------KCDKQRQPSSSTLCNMGPC 2207
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggsivpdsECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1258-1308 2.81e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 46.68  E-value: 2.81e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1258 WRTSAWGACSVTCGKGIRRRPVTCTR--NGRT--SNACVQDSRPADTEVCTNAAC 1308
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkgGGSIvpDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 944-992 3.85e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 46.29  E-value: 3.85e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2257803397  944 WVYTRWSQCSRTCGSGIKTRRANCVDHKGDFL-PDADCRPSDRLLLQQVC 992
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIvPDSECSAQKKPPETQSC 50
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1810-1859 8.62e-06

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 45.27  E-value: 8.62e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2257803397  1810 VWVPGSWSECSVTCGEGTRKRTVDCNSGEKNCDMRS---RPIERERCNMGGCP 1859
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPctgEDVETRACNEQPCP 53
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 2124-2207 3.97e-05

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 49.19  E-value: 3.97e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397 2124 GSGVRTRF----VSCKPRDGTCNPED-----------KPDAYKECDVME----CPTWSvgQWSSCSVTCGVGRRLRSVVc 2184
Cdd:PTZ00441   187 GQGINHQFnrllAGCRPREGKCKFYSdadweeaknliKPFIAKVCTEVErtasCGPWD--EWTPCSVTCGKGTHSRSRP- 263

                           90       100
                   ....*....|....*....|...
gi 2257803397 2185 SIHGKCDKQRQPSsstlCNMGPC 2207
Cdd:PTZ00441   264 ILHEGCTTHMVEE----CEEEEC 282
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2111-2158 5.40e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 42.83  E-value: 5.40e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 2111 WTAGAWSECSSTCGSGVRTRFVSCKPRDGT-------CNPEDKPDAYKECDVMEC 2158
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsivpdseCSAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1003-1052 7.56e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.57  E-value: 7.56e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 2257803397  1003 DWEQCSASCGSGMQSRVVQCSVGSVIHPDSACPRAAKPtgTQRCNQQPCP 1052
Cdd:smart00209    6 EWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVE--TRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1362-1407 9.02e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.19  E-value: 9.02e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 2257803397  1362 GDWGQCSLTCGGGVQTRRIDCSSSLTKCDHRKKP---VESRRCNTEACP 1407
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTgedVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 2377-2430 1.26e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.80  E-value: 1.26e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2257803397  2377 WETGAWSECSKSCGDGVKTRELRCLYNIEYANEENCEESTRPIAelPCRKQACP 2430
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETR--ACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1460-1508 3.65e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 40.65  E-value: 3.65e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2257803397  1460 WTVGKWSECSRTCGGGISARTVTCSSRDQPCYRMSKP---PTTRICNSQDCP 1508
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTgedVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 2554-2605 7.05e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.88  E-value: 7.05e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2257803397  2554 GSWSECSVTCGTGQMKRAVRCLNArNELMPDAHCRQPALkpdEARPCTMPPC 2605
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSP-PPQNGGGPCTGEDV---ETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1258-1309 9.28e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.49  E-value: 9.28e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2257803397  1258 WRTSAWGACSVTCGKGIRRRPVTCTRNGRTSNACVQDSRPADTEVCTNAACP 1309
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 1807-1851 1.22e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 44.18  E-value: 1.22e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2257803397 1807 TCPVWVPgsWSECSVTCGEGTRKRTVD-----CNSG-EKNCDMRSRPIERE 1851
Cdd:PTZ00441   239 SCGPWDE--WTPCSVTCGKGTHSRSRPilhegCTTHmVEECEEEECPVEPE 287
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1563-1608 1.35e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.11  E-value: 1.35e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 2257803397  1563 GAWSQCSVSCGRGQRRRNVYCL---PEGGNCDLRVKPSEIQPCAKKACP 1608
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCsppPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1413-1458 1.60e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.72  E-value: 1.60e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 2257803397  1413 GPWSKCSVTCGEGIQLHTVVCSTGNQSQCKKPKP---SEARKCQLPACP 1458
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTgedVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 2262-2314 1.68e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.72  E-value: 1.68e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2257803397  2262 WIIGNWSQCSRTCGIGITSREVQCILGNNSLPYASCDSNSRpvIRRVCQLIEC 2314
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDV--ETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 2210-2235 1.94e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.72  E-value: 1.94e-03
                            10        20
                    ....*....|....*....|....*.
gi 2257803397  2210 WQTGTWSQCSVTCGKGTQVRTVTCSD 2235
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCS 27
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1965-2009 2.21e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.34  E-value: 2.21e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 2257803397  1965 EWGECSVSCGGGTKTRAVTCSPSPDACGALRKPPSSMR---CNGQRCP 2009
Cdd:smart00209    6 EWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVEtraCNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 2011-2059 2.30e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.34  E-value: 2.30e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2257803397  2011 WTVGPWEECSVTCGVGLQSRPVRCDTQRKPCDPDNKPDS---TQQCNRSACP 2059
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEdveTRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 2114-2159 2.64e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.34  E-value: 2.64e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 2257803397  2114 GAWSECSSTCGSGVRTRFVSCKPRDGTCNPEDKPDAYKE---CDVMECP 2159
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVEtraCNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1663-1708 4.27e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.57  E-value: 4.27e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 2257803397  1663 GPWEKCSKTCGVGFQARSVYCTASSVDKCDEKKPSSRRQ---CNIRPCP 1708
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVEtraCNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1172-1229 4.31e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.57  E-value: 4.31e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 2257803397  1172 CTSWkhGAWGLCSKSCGKGVQSRIVKCaYENWKIAKDSQCDPFKrpPEQRECELQKCE 1229
Cdd:smart00209    1 WSEW--SEWSPCSVTCGGGVQTRTRSC-CSPPPQNGGGPCTGED--VETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 2064-2109 4.67e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.57  E-value: 4.67e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 2257803397  2064 GPWEQCSVTCGAGVKRRTVTCTSDNITCNESQKPPH---VARCEKGECP 2109
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEdveTRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1861-1909 5.41e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.18  E-value: 5.41e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2257803397  1861 WEAGRWSICSVTCGDGVQTRDVTCSTRDDRCNAKS---MPQRQRKCNLGACP 1909
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPctgEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1054-1107 6.27e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.18  E-value: 6.27e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2257803397  1054 WETRNWSGCSVSCGVGEKTRSVTCRYNGTSISPTRCDRALRpsLTERCTQPPCP 1107
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDV--ETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 944-985 6.79e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.18  E-value: 6.79e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2257803397   944 WVYTRWSQCSRTCGSGIKTRRANCVDHKGDFlPDADCRPSDR 985
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQN-GGGPCTGEDV 42
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1311-1357 7.42e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.80  E-value: 7.42e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2257803397  1311 WIMGSWSECSVTCGFGYKRREVYCSRNN-------CDTARKPTQllKCELPVCP 1357
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPpqngggpCTGEDVETR--ACNEQPCP 53
 
Name Accession Description Interval E-value
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 236-441 4.04e-98

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 314.95  E-value: 4.04e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  236 YVETMVTADKSMVDAFpSKAELQSFIITIMGMVARIYRDKTIGNSINIVLVKIIILEIDLPELEITSNAASSLRSFCKWQ 315
Cdd:cd04273      2 YVETLVVADSKMVEFH-HGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLLISGNAQKSLKSFCRWQ 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  316 TKMNKPSDEEPGHFDTAILLTRTDICRAAGKCDTLGLAELGTVCNPSRSCSIVEVTGLSSAFTIAHELAHVFNVPHDGDH 395
Cdd:cd04273     81 KKLNPPNDSDPEHHDHAILLTRQDICRSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGDG 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 2257803397  396 NMCDEKSGNYNLMAPSLSFNTKPWMWSTCSRDAIRLFFDLGYGKCL 441
Cdd:cd04273    161 NSCGPEGKDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGDGNCL 206
GON pfam08685
GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain ...
 2607-2806 2.22e-91

GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.


Pssm-ID: 462559  Cd Length: 200  Bit Score: 295.29  E-value: 2.22e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397 2607 PRTCREIQLTSGLQADGEHVLQVQGKLLKIYCHGMTTDDPKEYISLKTGSKDNFAEVYTKKLLDPNQCPSNGKHVDSCAC 2686
Cdd:pfam08685    1 PRSCKEIQSRSGVRKDGEYTLNVRGRNVRIYCHGMNTSSPKEYLTLPSGPQENYSEVYGYRLKNPNECPFNGSRRDDCAC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397 2687 ySQDYID-SGSSYFTKLRIDIVKMKIIPDDFQFASTRGLKPPPYATAGDCYSRKRCPQGRFSINLEGTGIELSPDVRWRS 2765
Cdd:pfam08685   81 -RQDYPAnAGTTTFSKVRLDLTSLRIITNDFTFARTIRGKPVPFGTAGDCYSAAKCPQGRFSINLTGTGLRVSPDTKWVS 159

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 2257803397 2766 TGRSFTQLIYRYPEGKRVIAKCGGRCGTCSPATGIGLQVLV 2806
Cdd:pfam08685  160 QGNYAVSKIHRSQDGTKVRGRCGGYCGKCTPSPGTGLLLDV 200
ZnMc_ADAM_like cd04267
Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ...
 236-434 1.06e-41

Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ADAM family of metalloproteases contains proteolytic domains from snake venoms, proteases from the mammalian reproductive tract, and the tumor necrosis factor alpha convertase, TACE. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239795  Cd Length: 192  Bit Score: 152.57  E-value: 1.06e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  236 YVETMVTADKSMVDAFPSKAE-LQSFIITIMGMVARIYRDKTIGNSINIVLVKIIILEIDLPELEITSNAASSLRSFCKW 314
Cdd:cd04267      2 EIELVVVADHRMVSYFNSDENiLQAYITELINIANSIYRSTNLRLGIRISLEGLQILKGEQFAPPIDSDASNTLNSFSFW 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  315 QTkmnkpsdEEPGHFDTAILLTRTDIcraaGKCDTLGLAELGTVCNPSRSCSIVEVTG--LSSAFTIAHELAHVFNVPHD 392
Cdd:cd04267     82 RA-------EGPIRHDNAVLLTAQDF----IEGDILGLAYVGSMCNPYSSVGVVEDTGftLLTALTMAHELGHNLGAEHD 150

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 2257803397  393 GDHNMCDEKSGNYN-LMAPSLSFnTKPWMWSTCSRDAIRLFFD 434
Cdd:cd04267    151 GGDELAFECDGGGNyIMAPVDSG-LNSYRFSQCSIGSIREFLD 192
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 702-818 1.48e-25

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 103.43  E-value: 1.48e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  702 KHKGTY-RKIAYGYNPVYKIPAGSTNVVIIEygSRDADNFLALKQVGptARYLINGGSVVSLGERTYQIEGASIYYSGSD 780
Cdd:pfam05986    1 TVSGSFtEGRAKGYVTFVTIPAGATHIHIVN--RKPSFTHLAVKNVQ--GKYILNGKGSISLNPTYPSLLGTVLEYRRSL 76

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2257803397  781 KAEEMIKITGKTQEDLLLEVLSV-GKLTPPNVHYSLNVP 818
Cdd:pfam05986   77 PALEELHAPGPTQEDLEIQVLRQyGKGTNPGITYEYFIP 115
ZnMc_adamalysin_II_like cd04269
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom ...
 236-441 7.50e-25

Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239797 [Multi-domain]  Cd Length: 194  Bit Score: 104.23  E-value: 7.50e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  236 YVETMVTADKSMVDAFPSKAEL-QSFIITIMGMVARIYRdktignSINIVLVkIIILEI----DLpeLEITSNAASSLRS 310
Cdd:cd04269      2 YVELVVVVDNSLYKKYGSNLSKvRQRVIEIVNIVDSIYR------PLNIRVV-LVGLEIwtdkDK--ISVSGDAGETLNR 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  311 FCKW-QTKMNKPSdeepgHFDTAILLTRTDICRaagkcDTLGLAELGTVCNPSRSCSIVEVTG---LSSAFTIAHELAHV 386
Cdd:cd04269     73 FLDWkRSNLLPRK-----PHDNAQLLTGRDFDG-----NTVGLAYVGGMCSPKYSGGVVQDHSrnlLLFAVTMAHELGHN 142

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397  387 FNVPHDGDHNMCDEKSGnynLMAPSLSFNTKpwMWSTCSRDAIRLFFDLGYGKCL 441
Cdd:cd04269    143 LGMEHDDGGCTCGRSTC---IMAPSPSSLTD--AFSNCSYEDYQKFLSRGGGQCL 192
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 43-178 1.43e-24

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


Pssm-ID: 460254  Cd Length: 128  Bit Score: 101.24  E-value: 1.43e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397   43 VTPVRVNETGdafpssqQFLSYSSSVRDSGPLYYNLTVYGRtlrlrllrDH-------SGFVSPGLVVEHVFSAGHKL-P 114
Cdd:pfam01562    3 VIPVRLDPSR-------RRRSLASESTYLDTLSYRLAAFGK--------KFhlhltpnRLLLAPGFTVTYYLDGGTGVeS 67

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2257803397  115 LDSGLAHCFYTGSIQGDSLSSAILSVCHGLRGTFFTGGQEYFIEPREQERLVSRQHPrriHIVY 178
Cdd:pfam01562   68 PPVQTDHCYYQGHVEGHPDSSVALSTCSGLRGFIRTENEEYLIEPLEKYSREEGGHP---HVVY 128
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 458-527 1.44e-23

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 96.26  E-value: 1.44e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  458 PGEKYSANDQCQLIFGSQSRLCPFLFEDPCMRLWCVKnlGKRRGCQTHHMPWADGTPCGNHKWCIRGKCV 527
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTFCPNGDEDVCSKLWCSN--PGGSTCTTKNLPAADGTPCGNKKWCLNGKCV 68
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 236-445 1.79e-23

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 100.45  E-value: 1.79e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  236 YVETMVTADKSMVDAF-PSKAELQSFIITIMGMVARIYRDKtignSINIVLVKiiiLEI--DLPELEITSNAASSLRSFC 312
Cdd:pfam01421    2 YIELFIVVDKQLFQKMgSDTTVVRQRVFQVVNLVNSIYKEL----NIRVVLVG---LEIwtDEDKIDVSGDANDTLRNFL 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  313 KWQTKMNKpsdeEPGHFDTAILLTRTDIcraagKCDTLGLAELGTVCNPSRSCSIVE---VTGLSSAFTIAHELAHVFNV 389
Cdd:pfam01421   75 KWRQEYLK----KRKPHDVAQLLSGVEF-----GGTTVGAAYVGGMCSLEYSGGVNEdhsKNLESFAVTMAHELGHNLGM 145

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2257803397  390 PHDGDHNMCDEKSGNYNLMAPSLSFnTKPWMWSTCSRDAIRLFFDLGYGKCLEDKP 445
Cdd:pfam01421  146 QHDDFNGGCKCPPGGGCIMNPSAGS-SFPRKFSNCSQEDFEQFLTKQKGACLFNKP 200
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 320-432 1.48e-18

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 85.27  E-value: 1.48e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  320 KPSDEEPGHFDTAILLTRTDIcraagKCDTLGLAELGTVCNPSRSCSIVEVTGLSS---AFTIAHELAHVFNVPHDGDHN 396
Cdd:cd00203     43 VLVGVEIDKADIAILVTRQDF-----DGGTGGWAYLGRVCDSLRGVGVLQDNQSGTkegAQTIAHELGHALGFYHDHDRK 117

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2257803397  397 MCDEKS-----------GNYNLMAPSLSFNTKP--WMWSTCSRDAIRLF 432
Cdd:cd00203    118 DRDDYPtiddtlnaeddDYYSVMSYTKGSFSDGqrKDFSQCDIDQINKL 166
ZnMc_salivary_gland_MPs cd04272
Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary ...
 236-442 1.32e-14

Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.


Pssm-ID: 239800  Cd Length: 220  Bit Score: 75.47  E-value: 1.32e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  236 YVETMVTADKSMVDAFPSKAELQSFIITIMGMVARIYRDkTIGNSINIVLVKIIILEIDLPELEI------TSNAASSLR 309
Cdd:cd04272      2 YPELFVVVDYDHQSEFFSNEQLIRYLAVMVNAANLRYRD-LKSPRIRLLLVGITISKDPDFEPYIhpinygYIDAAETLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  310 SFCKWQTKMNkpsdeEPGHFDTAILLTRTDICRAA-GKCDT--LGLAELGTVCNpSRSCSIVEVTGLS--SAFTIAHELA 384
Cdd:cd04272     81 NFNEYVKKKR-----DYFNPDVVFLVTGLDMSTYSgGSLQTgtGGYAYVGGACT-ENRVAMGEDTPGSyyGVYTMTHELA 154

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  385 HVFNVPHDGD-----------HNMCDEKSGnYnLMapSLSFN-TKPWMWSTCSRDAIRLFFDLGYGKCLE 442
Cdd:cd04272    155 HLLGAPHDGSpppswvkghpgSLDCPWDDG-Y-IM--SYVVNgERQYRFSQCSQRQIRNVFRRLGASCLH 220
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 999-1051 4.79e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.86  E-value: 4.79e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397  999 WRAADWEQCSASCGSGMQSRVVQC--SVGSVIHPDSACPRAAKPTGTQRCNQQPC 1051
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1359-1406 1.34e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.00  E-value: 1.34e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1359 WNAGDWGQCSLTCGGGVQTRRIDCSSSL-------TKCDHRKKPVESRRCNTEAC 1406
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggsivpdSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1175-1228 2.17e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 58.23  E-value: 2.17e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1175 WKHGAWGLCSKSCGKGVQSRIVKCA-YENWKIAKDSQCDPFKRPPEQRECELQKC 1228
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1861-1908 3.57e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.46  E-value: 3.57e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1861 WEAGRWSICSVTCGDGVQTRDVTCST-------RDDRCNAKSMPQRQRKCNLGAC 1908
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkgggsivPDSECSAQKKPPETQSCNLKPC 55
Reprolysin_5 pfam13688
Metallo-peptidase family M12;
240-415 3.58e-10

Metallo-peptidase family M12;


Pssm-ID: 372673  Cd Length: 191  Bit Score: 61.67  E-value: 3.58e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  240 MVTADKSMVDAFPSKAeLQSFIITIMGMVARIYRDKTignSINIVLVKIIILEIDLPELEI---TSNAASSLRSFCKWQT 316
Cdd:pfam13688    8 LVAADCSYVAAFGGDA-AQANIINMVNTASNVYERDF---NISLGLVNLTISDSTCPYTPPacsTGDSSDRLSEFQDFSA 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  317 KMNKPSDeepghfDTAILLTRTDicraagkCDTLGLAELGTVCNPSRSCSIVE--------VTGLSSAFTIAHELAHVFN 388
Cdd:pfam13688   84 WRGTQND------DLAYLFLMTN-------CSGGGLAWLGQLCNSGSAGSVSTrvsgnnvvVSTATEWQVFAHEIGHNFG 150

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 2257803397  389 VPHDGD----------HNMCDEKSGNYnLMAPSLSFN 415
Cdd:pfam13688  151 AVHDCDsstssqccppSNSTCPAGGRY-IMNPSSSPN 186
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1510-1557 1.11e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 56.31  E-value: 1.11e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1510 WNAGQWSQCSVTCGRGNIRRLVECVP-------AGSNCEARYRPSDSRPCLMQPC 1557
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkgggsivPDSECSAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 539-591 1.52e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 55.67  E-value: 1.52e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2257803397   539 WGNWAAFGACSRTCGGGIQFAKRECNNPEPENGGLYCQGARKRFRSCNSEECP 591
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1961-2008 2.01e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 55.54  E-value: 2.01e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1961 WLSQEWGECSVSCGGGTKTRAVTCSP-------SPDACGALRKPPSSMRCNGQRC 2008
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkgggsivPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1760-1808 2.14e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 55.54  E-value: 2.14e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1760 WTAGPWRKCSVSCGEGVQRRLVQCQS------QHRKHCDRRTRPSDVRRCSAGTC 1808
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkgggsiVPDSECSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 596-700 2.45e-09

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 57.41  E-value: 2.45e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  596 DFRALQCAQLNNKPVRIS-GVAKTVNWLPKYQGVREEDRCKLYCQVESKRIHFKMSDKVIDGTPC------QQFSSDVCV 668
Cdd:pfam19236    4 EFMSQQCARTDGQPLRSSpGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCmpsgprEDGTLSLCV 83

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2257803397  669 DGKCISAGCDRIVGSQAKYDVCRVCNGDNTTC 700
Cdd:pfam19236   84 LGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1560-1607 4.86e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.38  E-value: 4.86e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1560 WNVGAWSQCSVSCGRGQRRRNVYCLPEGGN-------CDLRVKPSEIQPCAKKAC 1607
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsivpdseCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2438-2491 4.86e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.38  E-value: 4.86e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 2438 WRTTSWTKCSRTCGFGSKSRYVTCVDKQGQ-PVPKSNCDGRPKPHAYLPCFEVKC 2491
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1811-1858 6.21e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.00  E-value: 6.21e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1811 WVPGSWSECSVTCGEGTRKRTVDC-------NSGEKNCDMRSRPIERERCNMGGC 1858
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqkgggsIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1118-1172 6.65e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.00  E-value: 6.65e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2257803397 1118 WKAGPWSQCSQSCGdQGRRMRRVTCADSRG-VAVAERLCDAPNRPATYERCNVKPC 1172
Cdd:pfam19030    1 WVAGPWGECSVTCG-GGVQTRLVQCVQKGGgSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1660-1707 9.37e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 53.61  E-value: 9.37e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1660 WKSGPWEKCSKTCGVGFQARSVYC------TASSVDKCD-EKKPSSRRQCNIRPC 1707
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqkgggSIVPDSECSaQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2262-2314 1.64e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.84  E-value: 1.64e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 2262 WIIGNWSQCSRTCGIGITSREVQCI--LGNNSLPYASCDSNSRPVIRRVCQLIEC 2314
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2551-2605 2.05e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.46  E-value: 2.05e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2257803397 2551 WRVGSWSECSVTCGTGQMKRAVRCLNARNELM-PDAHCRqPALKPDEARPCTMPPC 2605
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIvPDSECS-AQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2495-2545 2.47e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.46  E-value: 2.47e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2257803397 2495 WKVGDWSECSRTCGdGGYQIRPVTC-----EGVPGVDECNKRNKPPIWRPCHLGPC 2545
Cdd:pfam19030    1 WVAGPWGECSVTCG-GGVQTRLVQCvqkggGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2011-2058 4.36e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 51.68  E-value: 4.36e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 2011 WTVGPWEECSVTCGVGLQSRPVRCDTQRKP-------CDPDNKPDSTQQCNRSAC 2058
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsivpdseCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2210-2253 4.67e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 51.68  E-value: 4.67e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2257803397 2210 WQTGTWSQCSVTCGKGTQVRTVTCSDKDT------SACDLRTKPQSSTVC 2253
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgsivpdSECSAQKKPPETQSC 50
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1911-1958 7.18e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.91  E-value: 7.18e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1911 WRVGPWEKCSVTCGEGVVRRVVTCSAGGNR-------CQDDTKPEVVKLCELPDC 1958
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsivpdseCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1054-1106 7.25e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.91  E-value: 7.25e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1054 WETRNWSGCSVSCGVGEKTRSVTCR--YNGTSISPTRCDRALRPSLTERCTQPPC 1106
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2061-2108 1.60e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.14  E-value: 1.60e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 2061 WAAGPWEQCSVTCGAGVKRRTVTC--TSDNIT-----CNESQKPPHVARCEKGEC 2108
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqKGGGSIvpdseCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1460-1507 1.62e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.14  E-value: 1.62e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1460 WTVGKWSECSRTCGGGISARTVTCS-------SRDQPCYRMSKPPTTRICNSQDC 1507
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqkgggsiVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1710-1752 1.72e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.14  E-value: 1.72e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2257803397 1710 WISEQWSQCSVSCGRGVQSRAVKCST-------DELECDAETKPNSRQPC 1752
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkgggsivPDSECSAQKKPPETQSC 50
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1311-1356 2.42e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 49.76  E-value: 2.42e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1311 WIMGSWSECSVTCGFGYKRREVYCSR---------NNCDTARKPTQLLKCELPVC 1356
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkgggsivpdSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2377-2429 2.42e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 49.76  E-value: 2.42e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 2377 WETGAWSECSKSCGDGVKTRELRC--LYNIEYANEENCEESTRPIAELPCRKQAC 2429
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1410-1457 4.32e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 48.99  E-value: 4.32e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1410 WREGPWSKCSVTCGEGIQLHTVVC------STGNQSQCK-KPKPSEARKCQLPAC 1457
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqkgggSIVPDSECSaQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1610-1657 6.98e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 48.22  E-value: 6.98e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1610 WTVGRWSECSVTCGSGKASRQVLC-------EPAGSQCDNATRPASVRVCALGEC 1657
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqkgggsIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2320-2372 9.55e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 47.83  E-value: 9.55e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2257803397 2320 WRAGNWGECSSRCSSGIKTRRTWCTASNGTQIQ-DKYCSQPRRPRDQRECNRHR 2372
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVpDSECSAQKKPPETQSCNLKP 54
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2161-2207 1.47e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 47.45  E-value: 1.47e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 2161 WSVGQWSSCSVTCGVGRRLRSVVCSIHG--------KCDKQRQPSSSTLCNMGPC 2207
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggsivpdsECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1258-1308 2.81e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 46.68  E-value: 2.81e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 1258 WRTSAWGACSVTCGKGIRRRPVTCTR--NGRT--SNACVQDSRPADTEVCTNAAC 1308
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkgGGSIvpDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 944-992 3.85e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 46.29  E-value: 3.85e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2257803397  944 WVYTRWSQCSRTCGSGIKTRRANCVDHKGDFL-PDADCRPSDRLLLQQVC 992
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIvPDSECSAQKKPPETQSC 50
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1810-1859 8.62e-06

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 45.27  E-value: 8.62e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2257803397  1810 VWVPGSWSECSVTCGEGTRKRTVDCNSGEKNCDMRS---RPIERERCNMGGCP 1859
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPctgEDVETRACNEQPCP 53
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 2124-2207 3.97e-05

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 49.19  E-value: 3.97e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397 2124 GSGVRTRF----VSCKPRDGTCNPED-----------KPDAYKECDVME----CPTWSvgQWSSCSVTCGVGRRLRSVVc 2184
Cdd:PTZ00441   187 GQGINHQFnrllAGCRPREGKCKFYSdadweeaknliKPFIAKVCTEVErtasCGPWD--EWTPCSVTCGKGTHSRSRP- 263

                           90       100
                   ....*....|....*....|...
gi 2257803397 2185 SIHGKCDKQRQPSsstlCNMGPC 2207
Cdd:PTZ00441   264 ILHEGCTTHMVEE----CEEEEC 282
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 2111-2158 5.40e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 42.83  E-value: 5.40e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2257803397 2111 WTAGAWSECSSTCGSGVRTRFVSCKPRDGT-------CNPEDKPDAYKECDVMEC 2158
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsivpdseCSAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1003-1052 7.56e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.57  E-value: 7.56e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 2257803397  1003 DWEQCSASCGSGMQSRVVQCSVGSVIHPDSACPRAAKPtgTQRCNQQPCP 1052
Cdd:smart00209    6 EWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVE--TRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1362-1407 9.02e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.19  E-value: 9.02e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 2257803397  1362 GDWGQCSLTCGGGVQTRRIDCSSSLTKCDHRKKP---VESRRCNTEACP 1407
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTgedVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 2377-2430 1.26e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.80  E-value: 1.26e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2257803397  2377 WETGAWSECSKSCGDGVKTRELRCLYNIEYANEENCEESTRPIAelPCRKQACP 2430
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETR--ACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1460-1508 3.65e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 40.65  E-value: 3.65e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2257803397  1460 WTVGKWSECSRTCGGGISARTVTCSSRDQPCYRMSKP---PTTRICNSQDCP 1508
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTgedVETRACNEQPCP 53
Reprolysin_3 pfam13582
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 280-392 6.21e-04

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 463926 [Multi-domain]  Cd Length: 122  Bit Score: 41.97  E-value: 6.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  280 SINIVLVKIIILeiDLPELEITSNAAS-SLRSFCKWQtkmnkpsDEEPGH--FDTAILLTRTDicraagKCDTLGLAELG 356
Cdd:pfam13582   19 GIRLQLAAIIIT--TSADTPYTSSDALeILDELQEVN-------DTRIGQygYDLGHLFTGRD------GGGGGGIAYVG 83

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2257803397  357 TVCNPSRSCSIVE---VTGLSSAFTIAHELAHVFNVPHD 392
Cdd:pfam13582   84 GVCNSGSKFGVNSgsgPVGDTGADTFAHEIGHNFGLNHT 122
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 2554-2605 7.05e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.88  E-value: 7.05e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2257803397  2554 GSWSECSVTCGTGQMKRAVRCLNArNELMPDAHCRQPALkpdEARPCTMPPC 2605
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSP-PPQNGGGPCTGEDV---ETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1258-1309 9.28e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.49  E-value: 9.28e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2257803397  1258 WRTSAWGACSVTCGKGIRRRPVTCTRNGRTSNACVQDSRPADTEVCTNAACP 1309
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
ZnMc_TACE_like cd04270
Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha ...
 349-430 1.16e-03

Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.


Pssm-ID: 239798 [Multi-domain]  Cd Length: 244  Bit Score: 43.13  E-value: 1.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257803397  349 TLGLAELGT--------VCNPSRSCSIVEV----TGLSSAF-------------TIAHELAHVFNVPHDGDHNMC---DE 400
Cdd:cd04270    116 TLGLAYVGSprdnsaggICEKAYYYSNGKKkylnTGLTTTVnygkrvptkesdlVTAHELGHNFGSPHDPDIAECapgES 195

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2257803397  401 KSGNYnLMAPSLSFNTKP--WMWSTCSRDAIR 430
Cdd:cd04270    196 QGGNY-IMYARATSGDKEnnKKFSPCSKKSIS 226
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 1807-1851 1.22e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 44.18  E-value: 1.22e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2257803397 1807 TCPVWVPgsWSECSVTCGEGTRKRTVD-----CNSG-EKNCDMRSRPIERE 1851
Cdd:PTZ00441   239 SCGPWDE--WTPCSVTCGKGTHSRSRPilhegCTTHmVEECEEEECPVEPE 287
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1563-1608 1.35e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.11  E-value: 1.35e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 2257803397  1563 GAWSQCSVSCGRGQRRRNVYCL---PEGGNCDLRVKPSEIQPCAKKACP 1608
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCsppPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1413-1458 1.60e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.72  E-value: 1.60e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 2257803397  1413 GPWSKCSVTCGEGIQLHTVVCSTGNQSQCKKPKP---SEARKCQLPACP 1458
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTgedVETRACNEQPCP 53
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 2554-2605 1.64e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 38.80  E-value: 1.64e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2257803397 2554 GSWSECSVTCGTGQMKRavrclnARNELMPDAHCRQPALKPDEARPCTMPPC 2605
Cdd:pfam19028    7 SEWSECSVTCGGGVQTR------TRTVIVEPQNGGRPCPELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 2262-2314 1.68e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.72  E-value: 1.68e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2257803397  2262 WIIGNWSQCSRTCGIGITSREVQCILGNNSLPYASCDSNSRpvIRRVCQLIEC 2314
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDV--ETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 2210-2235 1.94e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.72  E-value: 1.94e-03
                            10        20
                    ....*....|....*....|....*.
gi 2257803397  2210 WQTGTWSQCSVTCGKGTQVRTVTCSD 2235
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCS 27
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1965-2009 2.21e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.34  E-value: 2.21e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 2257803397  1965 EWGECSVSCGGGTKTRAVTCSPSPDACGALRKPPSSMR---CNGQRCP 2009
Cdd:smart00209    6 EWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVEtraCNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 2011-2059 2.30e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.34  E-value: 2.30e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2257803397  2011 WTVGPWEECSVTCGVGLQSRPVRCDTQRKPCDPDNKPDS---TQQCNRSACP 2059
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEdveTRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 2114-2159 2.64e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.34  E-value: 2.64e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 2257803397  2114 GAWSECSSTCGSGVRTRFVSCKPRDGTCNPEDKPDAYKE---CDVMECP 2159
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVEtraCNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
1260-1308 3.53e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 37.78  E-value: 3.53e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2257803397 1260 TSAWGACSVTCGKGIRRRPVTCTRNGRTSNACVQDSRPadTEVCTNAAC 1308
Cdd:pfam00090    3 WSPWSPCSVTCGKGIQVRQRTCKSPFPGGEPCTGDDIE--TQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1663-1708 4.27e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.57  E-value: 4.27e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 2257803397  1663 GPWEKCSKTCGVGFQARSVYCTASSVDKCDEKKPSSRRQ---CNIRPCP 1708
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVEtraCNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1172-1229 4.31e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.57  E-value: 4.31e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 2257803397  1172 CTSWkhGAWGLCSKSCGKGVQSRIVKCaYENWKIAKDSQCDPFKrpPEQRECELQKCE 1229
Cdd:smart00209    1 WSEW--SEWSPCSVTCGGGVQTRTRSC-CSPPPQNGGGPCTGED--VETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
2212-2233 4.34e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 37.40  E-value: 4.34e-03
                           10        20
                   ....*....|....*....|..
gi 2257803397 2212 TGTWSQCSVTCGKGTQVRTVTC 2233
Cdd:pfam00090    3 WSPWSPCSVTCGKGIQVRQRTC 24
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 2064-2109 4.67e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.57  E-value: 4.67e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 2257803397  2064 GPWEQCSVTCGAGVKRRTVTCTSDNITCNESQKPPH---VARCEKGECP 2109
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEdveTRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1861-1909 5.41e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.18  E-value: 5.41e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2257803397  1861 WEAGRWSICSVTCGDGVQTRDVTCSTRDDRCNAKS---MPQRQRKCNLGACP 1909
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPctgEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1054-1107 6.27e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.18  E-value: 6.27e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2257803397  1054 WETRNWSGCSVSCGVGEKTRSVTCRYNGTSISPTRCDRALRpsLTERCTQPPCP 1107
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDV--ETRACNEQPCP 53
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1413-1457 6.66e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 36.87  E-value: 6.66e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2257803397 1413 GPWSKCSVTCGEGIQLHT---VVCSTGNQSQCkkPKPSEARKCQLPAC 1457
Cdd:pfam19028    7 SEWSECSVTCGGGVQTRTrtvIVEPQNGGRPC--PELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 944-985 6.79e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.18  E-value: 6.79e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2257803397   944 WVYTRWSQCSRTCGSGIKTRRANCVDHKGDFlPDADCRPSDR 985
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQN-GGGPCTGEDV 42
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1311-1357 7.42e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.80  E-value: 7.42e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2257803397  1311 WIMGSWSECSVTCGFGYKRREVYCSRNN-------CDTARKPTQllKCELPVCP 1357
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPpqngggpCTGEDVETR--ACNEQPCP 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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