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Conserved domains on  [gi|2217349097|ref|XP_047305631|]
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protein phosphatase Mn(2+)-dependent 1K isoform X6 [Homo sapiens]

Protein Classification

PP2C family serine/threonine-protein phosphatase( domain architecture ID 303)

PP2C family protein-serine/threonine phosphatase catalyzes the dephosphorylation of phosphoserine and phosphothreonine residues of specific protein substrates

CATH:  3.60.40.10
EC:  3.1.3.16
Gene Ontology:  GO:0004722
PubMed:  8819174|2549856
SCOP:  3000909

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PP2Cc super family cl00120
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
 95-180 4.62e-16

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


The actual alignment was detected with superfamily member cd00143:

Pssm-ID: 469621 [Multi-domain]  Cd Length: 254  Bit Score: 73.51  E-value: 4.62e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217349097  95 VGCASQIGKRKENEDRF--DFAQLTDEVLYFAVYDGHGGPAAADFCHTHMEKCIMDLLPK-----EKNLETLLTLAFLEI 167
Cdd:cd00143     3 AGVSDKGGDRKTNEDAVviKPNLNNEDGGLFGVFDGHGGHAAGEFASKLLVEELLEELEEtltlsEEDIEEALRKAFLRA 82

                          90
                  ....*....|...
gi 2217349097 168 DKAFSSHARLSAD 180
Cdd:cd00143    83 DEEILEEAQDEPD 95
 
Name Accession Description Interval E-value
PP2Cc cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
 95-180 4.62e-16

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 238083 [Multi-domain]  Cd Length: 254  Bit Score: 73.51  E-value: 4.62e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217349097  95 VGCASQIGKRKENEDRF--DFAQLTDEVLYFAVYDGHGGPAAADFCHTHMEKCIMDLLPK-----EKNLETLLTLAFLEI 167
Cdd:cd00143     3 AGVSDKGGDRKTNEDAVviKPNLNNEDGGLFGVFDGHGGHAAGEFASKLLVEELLEELEEtltlsEEDIEEALRKAFLRA 82

                          90
                  ....*....|...
gi 2217349097 168 DKAFSSHARLSAD 180
Cdd:cd00143    83 DEEILEEAQDEPD 95
PP2Cc smart00332
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
 95-175 1.00e-14

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 214625 [Multi-domain]  Cd Length: 252  Bit Score: 70.10  E-value: 1.00e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217349097   95 VGCASQIGKRKENEDRF-DFAQLTDEVLYFAVYDGHGGPAAADFCHTHMEKCIMDLLPKEK----NLETLLTLAFLEIDK 169
Cdd:smart00332  11 YGLSSMQGVRKPMEDAHvITPDLSDSGGFFGVFDGHGGSEAAKFLSKNLPEILAEELIKEKdeleDVEEALRKAFLSTDE 90


                   ....*.
gi 2217349097  170 AFSSHA 175
Cdd:smart00332  91 EILEEL 96
PLN03145 PLN03145
Protein phosphatase 2c; Provisional
 96-179 7.83e-07

Protein phosphatase 2c; Provisional


Pssm-ID: 215603 [Multi-domain]  Cd Length: 365  Bit Score: 48.37  E-value: 7.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217349097  96 GCASQIGKRKENEDRF--------DFAQLTDEV---LYFAVYDGHGGPAAADFCHTHMEKCIMDLLPKEKNLETLLTLAF 164
Cdd:PLN03145   68 GAWADIGSRSSMEDVYicvdnfmsDFGLKNSEDgpsAFYGVFDGHGGKHAADFACYHLPRFIVEDEDFPREIEKVVSSAF 147

                          90
                  ....*....|....*
gi 2217349097 165 LEIDKAFSSHARLSA 179
Cdd:PLN03145  148 LQTDTAFAEACSLDA 162
PP2C pfam00481
Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine ...
 95-177 5.28e-05

Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.


Pssm-ID: 395385  Cd Length: 252  Bit Score: 42.32  E-value: 5.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217349097  95 VGCASQiGKRKENEDR----FDFAQLTDEVL--YFAVYDGHGGPAAADFCHTHMEKCI--MDLLPKEKNLETLLTLAFLE 166
Cdd:pfam00481   4 GGPRMQ-GWRKSMEDAhidlPNLNSSSGKDSwsFFAVFDGHGGSEAAKYCGKHLHTILalRRSFLEGEKLEDALRKSFLE 82

                          90
                  ....*....|..
gi 2217349097 167 -IDKAFSSHARL 177
Cdd:pfam00481  83 dTDEVLRSAEKE 94
PTC1 COG0631
Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];
94-136 3.07e-04

Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];


Pssm-ID: 440396 [Multi-domain]  Cd Length: 247  Bit Score: 40.19  E-value: 3.07e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2217349097  94 NVGCASQIGK-RKENEDRFDFAQLTDEVLyFAVYDGHGGPAAAD 136
Cdd:COG0631     2 EVAAASDVGRvRENNEDAFLVALDPGGGL-FVVADGMGGHAAGE 44
 
Name Accession Description Interval E-value
PP2Cc cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
 95-180 4.62e-16

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 238083 [Multi-domain]  Cd Length: 254  Bit Score: 73.51  E-value: 4.62e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217349097  95 VGCASQIGKRKENEDRF--DFAQLTDEVLYFAVYDGHGGPAAADFCHTHMEKCIMDLLPK-----EKNLETLLTLAFLEI 167
Cdd:cd00143     3 AGVSDKGGDRKTNEDAVviKPNLNNEDGGLFGVFDGHGGHAAGEFASKLLVEELLEELEEtltlsEEDIEEALRKAFLRA 82

                          90
                  ....*....|...
gi 2217349097 168 DKAFSSHARLSAD 180
Cdd:cd00143    83 DEEILEEAQDEPD 95
PP2Cc smart00332
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
 95-175 1.00e-14

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 214625 [Multi-domain]  Cd Length: 252  Bit Score: 70.10  E-value: 1.00e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217349097   95 VGCASQIGKRKENEDRF-DFAQLTDEVLYFAVYDGHGGPAAADFCHTHMEKCIMDLLPKEK----NLETLLTLAFLEIDK 169
Cdd:smart00332  11 YGLSSMQGVRKPMEDAHvITPDLSDSGGFFGVFDGHGGSEAAKFLSKNLPEILAEELIKEKdeleDVEEALRKAFLSTDE 90


                   ....*.
gi 2217349097  170 AFSSHA 175
Cdd:smart00332  91 EILEEL 96
PLN03145 PLN03145
Protein phosphatase 2c; Provisional
 96-179 7.83e-07

Protein phosphatase 2c; Provisional


Pssm-ID: 215603 [Multi-domain]  Cd Length: 365  Bit Score: 48.37  E-value: 7.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217349097  96 GCASQIGKRKENEDRF--------DFAQLTDEV---LYFAVYDGHGGPAAADFCHTHMEKCIMDLLPKEKNLETLLTLAF 164
Cdd:PLN03145   68 GAWADIGSRSSMEDVYicvdnfmsDFGLKNSEDgpsAFYGVFDGHGGKHAADFACYHLPRFIVEDEDFPREIEKVVSSAF 147

                          90
                  ....*....|....*
gi 2217349097 165 LEIDKAFSSHARLSA 179
Cdd:PLN03145  148 LQTDTAFAEACSLDA 162
PP2C pfam00481
Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine ...
 95-177 5.28e-05

Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.


Pssm-ID: 395385  Cd Length: 252  Bit Score: 42.32  E-value: 5.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217349097  95 VGCASQiGKRKENEDR----FDFAQLTDEVL--YFAVYDGHGGPAAADFCHTHMEKCI--MDLLPKEKNLETLLTLAFLE 166
Cdd:pfam00481   4 GGPRMQ-GWRKSMEDAhidlPNLNSSSGKDSwsFFAVFDGHGGSEAAKYCGKHLHTILalRRSFLEGEKLEDALRKSFLE 82

                          90
                  ....*....|..
gi 2217349097 167 -IDKAFSSHARL 177
Cdd:pfam00481  83 dTDEVLRSAEKE 94
PTZ00224 PTZ00224
protein phosphatase 2C; Provisional
 94-171 2.46e-04

protein phosphatase 2C; Provisional


Pssm-ID: 240318 [Multi-domain]  Cd Length: 381  Bit Score: 40.91  E-value: 2.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217349097  94 NVGCASQIGKRKENEDRfDFAQLTDEVLYFAVYDGHGGpaaaDFCHTHMEKCIMDLLPKEK---NLETLLTLAfLEIDKA 170
Cdd:PTZ00224   23 RCASACVNGYRESMEDA-HLLYLTDDWGFFGVFDGHVN----DECSQYLARAWPQALEKEPepmTDERMEELC-LEIDEE 96


                  .
gi 2217349097 171 F 171
Cdd:PTZ00224   97 W 97
PTC1 COG0631
Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];
94-136 3.07e-04

Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];


Pssm-ID: 440396 [Multi-domain]  Cd Length: 247  Bit Score: 40.19  E-value: 3.07e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2217349097  94 NVGCASQIGK-RKENEDRFDFAQLTDEVLyFAVYDGHGGPAAAD 136
Cdd:COG0631     2 EVAAASDVGRvRENNEDAFLVALDPGGGL-FVVADGMGGHAAGE 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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