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Conserved domains on  [gi|2217264598|ref|XP_047303927|]
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tetratricopeptide repeat protein 24 isoform X5 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 19590209)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 157-393 1.24e-14

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 74.38  E-value: 1.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 157 WAKMGACYQALGQPELAAHCLQEASQAYAQERQLRAaalalgaaagcMLKSGRHRVGEVVQVLEKSRRLAERSTERrllG 236
Cdd:COG2956    11 WYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHL-----------ALGNLYRRRGEYDRAIRIHQKLLERDPDR---A 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 237 HLYNDLGLGYSQLQLFPLAVEAFLQALPLcwvPGEQATVLRNLGMAHNALGNYQEAREFHQKAADLHGSVGQRWEQgrsf 316
Cdd:COG2956    77 EALLELAQDYLKAGLLDRAEELLEKLLEL---DPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCE---- 149

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217264598 317 gsLAFALSQLGDHKAARDNYLHALQAARDSGDmkgqwqACEGLGAAAARLGQYDQALKYYKEALAQCQEPDSVRERL 393
Cdd:COG2956   150 --LAELYLEQGDYDEAIEALEKALKLDPDCAR------ALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRL 218
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 29-182 1.53e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 63.86  E-value: 1.53e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598  29 WLRQEASIQALTRAGHGALQAGQNHEALNNFQRAFLLASKAPQTRdtpvlqacaFNLGAAYVETGDPARGLELLLRAHpe 108
Cdd:COG3914    71 AAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEAL---------FNLGNLLLALGRLEEALAALRRAL-- 139

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217264598 109 ekAQGRRHGDQCFNVALAYHALGELPQALAWYHRALghyQPQGDQGEAWAKMGACYQALGQPELAAHCLQEASQ 182
Cdd:COG3914   140 --ALNPDFAEAYLNLGEALRRLGRLEEAIAALRRAL---ELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALE 208
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 157-393 1.24e-14

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 74.38  E-value: 1.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 157 WAKMGACYQALGQPELAAHCLQEASQAYAQERQLRAaalalgaaagcMLKSGRHRVGEVVQVLEKSRRLAERSTERrllG 236
Cdd:COG2956    11 WYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHL-----------ALGNLYRRRGEYDRAIRIHQKLLERDPDR---A 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 237 HLYNDLGLGYSQLQLFPLAVEAFLQALPLcwvPGEQATVLRNLGMAHNALGNYQEAREFHQKAADLHGSVGQRWEQgrsf 316
Cdd:COG2956    77 EALLELAQDYLKAGLLDRAEELLEKLLEL---DPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCE---- 149

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217264598 317 gsLAFALSQLGDHKAARDNYLHALQAARDSGDmkgqwqACEGLGAAAARLGQYDQALKYYKEALAQCQEPDSVRERL 393
Cdd:COG2956   150 --LAELYLEQGDYDEAIEALEKALKLDPDCAR------ALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRL 218
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 29-182 1.53e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 63.86  E-value: 1.53e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598  29 WLRQEASIQALTRAGHGALQAGQNHEALNNFQRAFLLASKAPQTRdtpvlqacaFNLGAAYVETGDPARGLELLLRAHpe 108
Cdd:COG3914    71 AAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEAL---------FNLGNLLLALGRLEEALAALRRAL-- 139

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217264598 109 ekAQGRRHGDQCFNVALAYHALGELPQALAWYHRALghyQPQGDQGEAWAKMGACYQALGQPELAAHCLQEASQ 182
Cdd:COG3914   140 --ALNPDFAEAYLNLGEALRRLGRLEEAIAALRRAL---ELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALE 208
TPR_12 pfam13424
Tetratricopeptide repeat;
271-345 3.81e-09

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 53.55  E-value: 3.81e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217264598 271 EQATVLRNLGMAHNALGNYQEAREFHQKAADLHGSV--GQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQAARD 345
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLlgPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
TPR_12 pfam13424
Tetratricopeptide repeat;
122-186 4.98e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.91  E-value: 4.98e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 122 NVALAYHALGELPQALAWYHRALGHYQPQGD-----QGEAWAKMGACYQALGQPELAAHCLQEASQAYAQ 186
Cdd:pfam13424   8 NLAAVLRRLGRYDEALELLEKALEIARRLLGpdhplTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 353-385 8.05e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 37.04  E-value: 8.05e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2217264598  353 WQACEGLGAAAARLGQYDQALKYYKEALAQCQE 385
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPN 33
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 54-136 2.30e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.84  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598  54 EALNNFQRAFLLASKAPQTRDTpvlqacafnLGAAYVETGDPARGLELLLRAhpeeKAQGRRHGDQCFNVALAYHALGEL 133
Cdd:TIGR02917 821 RALEYAERALKLAPNIPAILDT---------LGWLLVEKGEADRALPLLRKA----VNIAPEAAAIRYHLALALLATGRK 887


                  ...
gi 2217264598 134 PQA 136
Cdd:TIGR02917 888 AEA 890
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 157-393 1.24e-14

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 74.38  E-value: 1.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 157 WAKMGACYQALGQPELAAHCLQEASQAYAQERQLRAaalalgaaagcMLKSGRHRVGEVVQVLEKSRRLAERSTERrllG 236
Cdd:COG2956    11 WYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHL-----------ALGNLYRRRGEYDRAIRIHQKLLERDPDR---A 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 237 HLYNDLGLGYSQLQLFPLAVEAFLQALPLcwvPGEQATVLRNLGMAHNALGNYQEAREFHQKAADLHGSVGQRWEQgrsf 316
Cdd:COG2956    77 EALLELAQDYLKAGLLDRAEELLEKLLEL---DPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCE---- 149

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217264598 317 gsLAFALSQLGDHKAARDNYLHALQAARDSGDmkgqwqACEGLGAAAARLGQYDQALKYYKEALAQCQEPDSVRERL 393
Cdd:COG2956   150 --LAELYLEQGDYDEAIEALEKALKLDPDCAR------ALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRL 218
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
121-399 1.50e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 73.50  E-value: 1.50e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 121 FNVALAYHALGELPQALAWYHRALGHYQpqgDQGEAWAKMGACYQALGQPELAAHCLQEAsqayaqerqlraaalalgaa 200
Cdd:COG0457    12 NNLGLAYRRLGRYEEAIEDYEKALELDP---DDAEALYNLGLAYLRLGRYEEALADYEQA-------------------- 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 201 agcmlksgrhrvgevvqvLEKSRRLAErsterrllghLYNDLGLGYSQLQLFPLAVEAFLQALPLcwvPGEQATVLRNLG 280
Cdd:COG0457    69 ------------------LELDPDDAE----------ALNNLGLALQALGRYEEALEDYDKALEL---DPDDAEALYNLG 117

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 281 MAHNALGNYQEAREFHQKAADLHGSVGQRWEqgrsfgSLAFALSQLGDHKAARDNYLHALQAARDsgDMKGQWQACEGLG 360
Cdd:COG0457   118 LALLELGRYDEAIEAYERALELDPDDADALY------NLGIALEKLGRYEEALELLEKLEAAALA--ALLAAALGEAALA 189

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2217264598 361 AAAARLGQYDQALKYYKEALAQCQEPDSVRERLVAKLAD 399
Cdd:COG0457   190 LAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALA 228
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 42-382 9.55e-14

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 71.68  E-value: 9.55e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598  42 AGHGALQAGQNHEALNNFQRAFLLASKA----PQTRDTpvlqacAFNLGAAYVETGDPARGLELLLRAHpeekAQGRRHG 117
Cdd:COG2956     7 AALGWYFKGLNYLLNGQPDKAIDLLEEAleldPETVEA------HLALGNLYRRRGEYDRAIRIHQKLL----ERDPDRA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 118 DQCFNVALAYHALGELPQALAWYHRALghyQPQGDQGEAWAKMGACYQALGQPELAAHCLQEASQAYAQErqlraaalal 197
Cdd:COG2956    77 EALLELAQDYLKAGLLDRAEELLEKLL---ELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPEN---------- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 198 gaaagcmlksgrhrvgevvqvleksrrlaersterrllGHLYNDLGLGYSQLQLFPLAVEAFLQAL---PLCwvpgeqAT 274
Cdd:COG2956   144 --------------------------------------AHAYCELAELYLEQGDYDEAIEALEKALkldPDC------AR 179

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 275 VLRNLGMAHNALGNYQEAREFHQKAADLHGsvgqrwEQGRSFGSLAFALSQLGDHKAARDNYLHALQAARDSGDMkgqwq 354
Cdd:COG2956   180 ALLLLAELYLEQGDYEEAIAALERALEQDP------DYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLL----- 248

                         330       340
                  ....*....|....*....|....*...
gi 2217264598 355 acEGLGAAAARLGQYDQALKYYKEALAQ 382
Cdd:COG2956   249 --LALADLLERKEGLEAALALLERQLRR 274
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
83-373 6.94e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.49  E-value: 6.94e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598  83 FNLGAAYVETGDPARGLELLLRAHpeekAQGRRHGDQCFNVALAYHALGELPQALAWYHRALgHYQPqgDQGEAWAKMGA 162
Cdd:COG0457    12 NNLGLAYRRLGRYEEAIEDYEKAL----ELDPDDAEALYNLGLAYLRLGRYEEALADYEQAL-ELDP--DDAEALNNLGL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 163 CYQALGQPELAAHCLQEAsqayaqerqlraaalalgaaagcmlksgrhrvgevvqvLEKSRRLAErsterrllghLYNDL 242
Cdd:COG0457    85 ALQALGRYEEALEDYDKA--------------------------------------LELDPDDAE----------ALYNL 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 243 GLGYSQLQLFPLAVEAFLQALPLCWvpgEQATVLRNLGMAHNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFA 322
Cdd:COG0457   117 GLALLELGRYDEAIEAYERALELDP---DDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAA 193

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2217264598 323 LSQLGDHKAARDNYLHALQAARDSGDMKGQWQACEGLGAAAARLGQYDQAL 373
Cdd:COG0457   194 EVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALALYQYR 244
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
152-407 9.11e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.49  E-value: 9.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 152 DQGEAWAKMGACYQALGQPELAAHCLQEAsqayaqerqlraaalalgaaagcmlksgrhrvgevvqvLEKSRRLAErste 231
Cdd:COG0457     6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKA--------------------------------------LELDPDDAE---- 43

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 232 rrllghLYNDLGLGYSQLQLFPLAVEAFLQALPLCwvpGEQATVLRNLGMAHNALGNYQEAREFHQKAADLHGsvgqrwE 311
Cdd:COG0457    44 ------ALYNLGLAYLRLGRYEEALADYEQALELD---PDDAEALNNLGLALQALGRYEEALEDYDKALELDP------D 108

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 312 QGRSFGSLAFALSQLGDHKAARDNYLHALQAARDSGDmkgqwqACEGLGAAAARLGQYdqalkyyKEALAQCQEPDSVRE 391
Cdd:COG0457   109 DAEALYNLGLALLELGRYDEAIEAYERALELDPDDAD------ALYNLGIALEKLGRY-------EEALELLEKLEAAAL 175

                         250
                  ....*....|....*.
gi 2217264598 392 RLVAKLADTVRTRLAQ 407
Cdd:COG0457   176 AALLAAALGEAALALA 191
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 121-387 2.04e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 67.83  E-value: 2.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 121 FNVALAYHALGELPQALAWYHRALghyQPQGDQGEAWAKMGACYQALGQPELAAHCLQEASQAYAQERQLRAAALAlgaa 200
Cdd:COG2956    12 YFKGLNYLLNGQPDKAIDLLEEAL---ELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQ---- 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 201 agCMLKSGRHRvgEVVQVLEKSRRLAERSTE-RRLLGHLYNDLGLgysqlqlFPLAVEAFLQALPLCwvpGEQATVLRNL 279
Cdd:COG2956    85 --DYLKAGLLD--RAEELLEKLLELDPDDAEaLRLLAEIYEQEGD-------WEKAIEVLERLLKLG---PENAHAYCEL 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 280 GMAHNALGNYQEAREFHQKAADLHgsvgqrWEQGRSFGSLAFALSQLGDHKAARDNYLHALQAARDSGdmkgqwQACEGL 359
Cdd:COG2956   151 AELYLEQGDYDEAIEALEKALKLD------PDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYL------PALPRL 218

                         250       260
                  ....*....|....*....|....*...
gi 2217264598 360 GAAAARLGQYDQALKYYKEALAQCQEPD 387
Cdd:COG2956   219 AELYEKLGDPEEALELLRKALELDPSDD 246
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 155-437 8.05e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 65.01  E-value: 8.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 155 EAWAKMGACYQALGQPELAAHCLQEASQAYAQERQLRAAALALGAaagcmLKSGRHRVGEVVQVLEKSRRLAERSTERRL 234
Cdd:COG3914     2 AAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALL-----LLAALAEAAAAALLALAAGEAAAAAAALLL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 235 LGHLYNDLGLGYSQLQLFPLAVEAFLQALPLCwvpGEQATVLRNLGMAHNALGNYQEAREFHQKAADLHGsvgqrwEQGR 314
Cdd:COG3914    77 LAALLELAALLLQALGRYEEALALYRRALALN---PDNAEALFNLGNLLLALGRLEEALAALRRALALNP------DFAE 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 315 SFGSLAFALSQLGDHKAARDNYLHALQAARDsgdmkgQWQACEGLGAAAARLGQYDQALKYYKEALAQCQEPDSVRERLV 394
Cdd:COG3914   148 AYLNLGEALRRLGRLEEAIAALRRALELDPD------NAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLL 221

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2217264598 395 AKLADTVRTRLAQVGLVQTHTLTSAPGRLQAPGGASQAEGTPA 437
Cdd:COG3914   222 FALRQACDWEVYDRFEELLAALARGPSELSPFALLYLPDDDPA 264
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 29-182 1.53e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 63.86  E-value: 1.53e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598  29 WLRQEASIQALTRAGHGALQAGQNHEALNNFQRAFLLASKAPQTRdtpvlqacaFNLGAAYVETGDPARGLELLLRAHpe 108
Cdd:COG3914    71 AAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEAL---------FNLGNLLLALGRLEEALAALRRAL-- 139

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217264598 109 ekAQGRRHGDQCFNVALAYHALGELPQALAWYHRALghyQPQGDQGEAWAKMGACYQALGQPELAAHCLQEASQ 182
Cdd:COG3914   140 --ALNPDFAEAYLNLGEALRRLGRLEEAIAALRRAL---ELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALE 208
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 37-328 1.82e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 63.86  E-value: 1.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598  37 QALTRAGHGALQAGQNHEALNNFQRAFLLASKAPQTRDTPVLQACAFNLGAAYvetgDPARGLELLLRAHPEEKAQGRRH 116
Cdd:COG3914     2 AAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEA----AAAALLALAAGEAAAAAAALLLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 117 GDQCFNVALAYHALGELPQALAWYHRALGHyqpQGDQGEAWAKMGACYQALGQPELAAHCLQEAsqayaqerqlraaala 196
Cdd:COG3914    78 AALLELAALLLQALGRYEEALALYRRALAL---NPDNAEALFNLGNLLLALGRLEEALAALRRA---------------- 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 197 lgaaagcmlksgrhrvgevvqvLEKSRRLAErsterrllghLYNDLGLGYSQLQLFPLAVEAFLQALPLcwVPgEQATVL 276
Cdd:COG3914   139 ----------------------LALNPDFAE----------AYLNLGEALRRLGRLEEAIAALRRALEL--DP-DNAEAL 183

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217264598 277 RNLGMAHNALGNYQEAREFHQKAADLHGsvgqrwEQGRSFGSLAFALSQLGD 328
Cdd:COG3914   184 NNLGNALQDLGRLEEAIAAYRRALELDP------DNADAHSNLLFALRQACD 229
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 271-399 1.05e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 56.55  E-value: 1.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 271 EQATVLRNLGMAHNALGNYQEAREFHQKAADLHGSVGQRWeqgrsfGSLAFALSQLGDHKAARDNYLHALqaARDSGDMK 350
Cdd:COG4235    15 NDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADAL------LDLAEALLAAGDTEEAEELLERAL--ALDPDNPE 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2217264598 351 GQWQacegLGAAAARLGQYDQALKYYKEALAQcQEPDSVRERLVAKLAD 399
Cdd:COG4235    87 ALYL----LGLAAFQQGDYAEAIAAWQKLLAL-LPADAPARLLEASIAE 130
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
37-180 1.23e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.86  E-value: 1.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598  37 QALTRAGHGALQAGQNHEALNNFQRAFLLASKAPQTRdtpvlqacaFNLGAAYVETGDPARGLELLLRAHpeekAQGRRH 116
Cdd:COG0457     9 EAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEAL---------YNLGLAYLRLGRYEEALADYEQAL----ELDPDD 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217264598 117 GDQCFNVALAYHALGELPQALAWYHRALGHyqpQGDQGEAWAKMGACYQALGQPELAAHCLQEA 180
Cdd:COG0457    76 AEALNNLGLALQALGRYEEALEDYDKALEL---DPDDAEALYNLGLALLELGRYDEAIEAYERA 136
TPR_12 pfam13424
Tetratricopeptide repeat;
271-345 3.81e-09

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 53.55  E-value: 3.81e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217264598 271 EQATVLRNLGMAHNALGNYQEAREFHQKAADLHGSV--GQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQAARD 345
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLlgPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
238-381 1.08e-08

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 55.69  E-value: 1.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 238 LYNDLGLGYSQLQLFPLAVEAFLQALPLCwvPgEQATVLRNLGMAHNALGNYQEAREFHQKAADLhgsvgqRWEQGRSFG 317
Cdd:COG4785    75 LYYERGVAYDSLGDYDLAIADFDQALELD--P-DLAEAYNNRGLAYLLLGDYDAALEDFDRALEL------DPDYAYAYL 145

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217264598 318 SLAFALSQLGDHKAARDNYLHALQAARDSGDMKGQWQACEG-LGAAAAR-------------LGQYDQALKYYKEALA 381
Cdd:COG4785   146 NRGIALYYLGRYELAIADLEKALELDPNDPERALWLYLAERkLDPEKALallledwatayllQGDTEEARELFKLALA 223
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 35-190 9.40e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 53.58  E-value: 9.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598  35 SIQALTRAGHGALQAGQNHEALNNFQRAFLLASKAPQTRdtpvlqacaFNLGAAYVETGDPARGLELLLRAHPEEKAQGR 114
Cdd:COG2956   109 DAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAY---------CELAELYLEQGDYDEAIEALEKALKLDPDCAR 179

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217264598 115 RHgdqcFNVALAYHALGELPQALAWYHRALghyQPQGDQGEAWAKMGACYQALGQPELAAHCLQEASQAYAQERQL 190
Cdd:COG2956   180 AL----LLLAELYLEQGDYEEAIAALERAL---EQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLL 248
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 270-393 2.47e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 50.19  E-value: 2.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 270 GEQATVLRNLGMAHNALGNYQEAREFHQKAADLHGsvgqrwEQGRSFGSLAFALSQLGDHKAARDNYLHALQAARDSgdm 349
Cdd:COG4783     1 AACAEALYALAQALLLAGDYDEAEALLEKALELDP------DNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDE--- 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2217264598 350 kgqWQACEGLGAAAARLGQYDQALKYYKEALAQCQEPDSVRERL 393
Cdd:COG4783    72 ---PEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRL 112
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 222-381 4.04e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 49.96  E-value: 4.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 222 SRRLAERSTERRLLGHLYNDLGLGYSQLQLFPLAVEAFLQALPLCWVPGEQATVLRNLGMAHNALGNYQEAREFHQKAAD 301
Cdd:COG5010     3 ALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 302 LHGsvgqrwEQGRSFGSLAFALSQLGDHKAARDNYLHALQAARDSgdmkgqWQACEGLGAAAARLGQYDQALKYYKEALA 381
Cdd:COG5010    83 LDP------NNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDN------PNAYSNLAALLLSLGQDDEAKAALQRALG 150
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 33-187 2.17e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.49  E-value: 2.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598  33 EASIQALTRAGHGALQAGQNHEALNNFQRAFLLASKAPQTRdtpvlqacaFNLGAAYVETGDPARGLELLLRAHpeekAQ 112
Cdd:COG4783     1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAF---------ALLGEILLQLGDLDEAIVLLHEAL----EL 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217264598 113 GRRHGDQCFNVALAYHALGELPQALAWYHRALGHYQpqgDQGEAWAKMGACYQALGQPELAAHCLQEASQAYAQE 187
Cdd:COG4783    68 DPDEPEARLNLGLALLKAGDYDEALALLEKALKLDP---EHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
282-381 2.80e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 45.93  E-value: 2.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 282 AHNALGNYQEAREFHQKAADLHgsvgqrWEQGRSFGSLAFALSQLGDHKAARDnYLHALQAARDSgdmkgqWQACEGLGA 361
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELD------PDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNN------AEALLNLAE 67

                          90       100
                  ....*....|....*....|
gi 2217264598 362 AAARLGQYDQALKYYKEALA 381
Cdd:COG3063    68 LLLELGDYDEALAYLERALE 87
TPR_12 pfam13424
Tetratricopeptide repeat;
319-385 2.82e-06

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 45.46  E-value: 2.82e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217264598 319 LAFALSQLGDHKAARDNYLHALQAARDSGDMKGQWQAC--EGLGAAAARLGQYDQALKYYKEALAQCQE 385
Cdd:pfam13424   9 LAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATtlLNLGRLYLELGRYEEALELLERALALAEK 77
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 239-382 9.01e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 45.57  E-value: 9.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 239 YNDLGLGYSQLQLFPLAVEAFLQALPLCwvpGEQATVLRNLGMAHNALGNYQEAREFHQKAADLHGsvgqrwEQGRSFGS 318
Cdd:COG4783     7 LYALAQALLLAGDYDEAEALLEKALELD---PDNPEAFALLGEILLQLGDLDEAIVLLHEALELDP------DEPEARLN 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217264598 319 LAFALSQLGDHKAARDNYLHALQAARDSGDmkgqwqACEGLGAAAARLGQYDQALKYYKEALAQ 382
Cdd:COG4783    78 LGLALLKAGDYDEALALLEKALKLDPEHPE------AYLRLARAYRALGRPDEAIAALEKALEL 135
COG3899 COG3899
Predicted ATPase [General function prediction only];
36-449 9.24e-06

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 48.70  E-value: 9.24e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598   36 IQALTRAGHGALQAGQNHEALNNFQRAFLLASKAPQTRDTPVLQAcafNLGAAYVETGDPARGLELLLRAHPEEKAQG-- 113
Cdd:COG3899    705 ARLLLRAARRALARGAYAEALRYLERALELLPPDPEEEYRLALLL---ELAEALYLAGRFEEAEALLERALAARALAAla 781

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598  114 -RRHGDqCFNVALAYH-----ALGELPQALAWYHRALGHYQPQGD---QGEAWAKMGACYQALGQPELAAHCLQEASQAY 184
Cdd:COG3899    782 aLRHGN-PPASARAYAnlgllLLGDYEEAYEFGELALALAERLGDrrlEARALFNLGFILHWLGPLREALELLREALEAG 860

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598  185 AQERQLRAAALALGAAAGCMLKSGRHRVGEVVQVLEKSRRLAERSTERRLLGHLYNDLGLGYSQLQLFPLAVEAFLQALP 264
Cdd:COG3899    861 LETGDAALALLALAAAAAAAAAAAALAAAAAAAARLLAAAAAALAAAAAAAALAAAELARLAAAAAAAAALALAAAAAAA 940

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598  265 LCWVPGEQATVLRNLGMAHNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQAAR 344
Cdd:COG3899    941 AAAALAAAAAAAALAAALALAAAAAAAAAAALAAAAAAAAAAAAAAAAAALEAAAAALLALLAAAAAAAAAAAALAAALL 1020

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598  345 DSGDMKGQWQACEGLGAAAARLGQYDQALKYYKEALAQCQEPDSVRERLVAKLADTVRTRLAQVGLVQTHTLTSAPGRLQ 424
Cdd:COG3899   1021 AAALAALAAAAAAAALLAAAAALALLAALAAAAAAAAAAAALAAAAALLAAAAAAAAAAAAAAAAAALAAALAAAALAAA 1100

                          410       420
                   ....*....|....*....|....*
gi 2217264598  425 APGGASQAEGTPAKAGSSTAGVQHR 449
Cdd:COG3899   1101 AAAALALAAALAALALAAALAALAL 1125
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 118-303 1.89e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 44.80  E-value: 1.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 118 DQCFNVALAYHALGELPQALAWYHRALghyQPQGDQGEAWAKMGACYQALGQPELAAHCLQEASQAYAQERQlraaalal 197
Cdd:COG4783     5 EALYALAQALLLAGDYDEAEALLEKAL---ELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPE-------- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 198 gaaagcmlksgrhrvgevvqvleksrrlaersterrllghLYNDLGLGYSQLQLFPLAVEAFLQALPLCwvpGEQATVLR 277
Cdd:COG4783    74 ----------------------------------------ARLNLGLALLKAGDYDEALALLEKALKLD---PEHPEAYL 110

                         170       180
                  ....*....|....*....|....*.
gi 2217264598 278 NLGMAHNALGNYQEAREFHQKAADLH 303
Cdd:COG4783   111 RLARAYRALGRPDEAIAALEKALELD 136
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
246-345 2.38e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 43.24  E-value: 2.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 246 YSQLQLFPLAVEAFLQALPLcwVPgEQATVLRNLGMAHNALGNYQEAREFhQKAADLHGsvgqrwEQGRSFGSLAFALSQ 325
Cdd:COG3063     2 YLKLGDLEEAEEYYEKALEL--DP-DNADALNNLGLLLLEQGRYDEAIAL-EKALKLDP------NNAEALLNLAELLLE 71

                          90       100
                  ....*....|....*....|
gi 2217264598 326 LGDHKAARDNYLHALQAARD 345
Cdd:COG3063    72 LGDYDEALAYLERALELDPS 91
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 88-184 8.12e-05

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 42.29  E-value: 8.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598  88 AYVETGDP---ARGLELLLRAHPEEKAQGRRHgdqcFNVALAYHALGELPQALAWYHRALGHYqPQGDQ-GEAWAKMGAC 163
Cdd:COG1729     2 ALLKAGDYdeaIAAFKAFLKRYPNSPLAPDAL----YWLGEAYYALGDYDEAAEAFEKLLKRY-PDSPKaPDALLKLGLS 76

                          90       100
                  ....*....|....*....|.
gi 2217264598 164 YQALGQPELAAHCLQEASQAY 184
Cdd:COG1729    77 YLELGDYDKARATLEELIKKY 97
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 142-303 8.39e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 43.03  E-value: 8.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 142 RALGHYQPQGDQGEAWAKMGACYQALGQPELAAHCLQEASQAYAQERQLRAAALALGAAAGCMLKSGRHRvgEVVQVLEK 221
Cdd:COG5010     2 RALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFE--ESLALLEQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 222 SRRLAERSTErrllghLYNDLGLGYSQLQLFPLAVEAFLQALPLCwvpGEQATVLRNLGMAHNALGNYQEAREFHQKAAD 301
Cdd:COG5010    80 ALQLDPNNPE------LYYNLALLYSRSGDKDEAKEYYEKALALS---PDNPNAYSNLAALLLSLGQDDEAKAALQRALG 150


                  ..
gi 2217264598 302 LH 303
Cdd:COG5010   151 TS 152
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 219-343 1.44e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 42.64  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 219 LEKSRRLAERSTERRLLGHLYNDLGLGYSQLQLFPLAVEAFLQALPLCwvpGEQATVLRNLGMAHNALGNYQEAREFHQK 298
Cdd:COG5010    37 TKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLD---PNNPELYYNLALLYSRSGDKDEAKEYYEK 113

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2217264598 299 AADLHGSVGQRWEqgrsfgSLAFALSQLGDHKAARDNYLHALQAA 343
Cdd:COG5010   114 ALALSPDNPNAYS------NLAALLLSLGQDDEAKAALQRALGTS 152
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 31-184 4.29e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.41  E-value: 4.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598  31 RQEASIQALTRAGHGALQAGQNHEALNNFQRAFLLASKAPQTRdtpvlqacaFNLGAAYVETGDPARGLELLLRAhpeeK 110
Cdd:COG2956   139 LGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARAL---------LLLAELYLEQGDYEEAIAALERA----L 205

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217264598 111 AQGRRHGDQCFNVALAYHALGELPQALAWYHRALGHYqPQGDQGEAWAKMgacYQALGQPELAAHCLQEASQAY 184
Cdd:COG2956   206 EQDPDYLPALPRLAELYEKLGDPEEALELLRKALELD-PSDDLLLALADL---LERKEGLEAALALLERQLRRH 275
TPR_12 pfam13424
Tetratricopeptide repeat;
122-186 4.98e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.91  E-value: 4.98e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 122 NVALAYHALGELPQALAWYHRALGHYQPQGD-----QGEAWAKMGACYQALGQPELAAHCLQEASQAYAQ 186
Cdd:pfam13424   8 NLAAVLRRLGRYDEALELLEKALEIARRLLGpdhplTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 353-385 8.05e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 37.04  E-value: 8.05e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2217264598  353 WQACEGLGAAAARLGQYDQALKYYKEALAQCQE 385
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPN 33
TPR_1 pfam00515
Tetratricopeptide repeat;
354-380 9.04e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 37.02  E-value: 9.04e-04
                          10        20
                  ....*....|....*....|....*..
gi 2217264598 354 QACEGLGAAAARLGQYDQALKYYKEAL 380
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKAL 28
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
47-179 9.64e-04

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 41.02  E-value: 9.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598  47 LQAGQNHEALNNFQRAFllasKAPQTRDTPVLqacaFNLGAAYVETGDPARGLELL---LRAHPEekaqgRRHGDQCFNV 123
Cdd:COG4700   100 LELGRYDEAIELYEEAL----TGIFADDPHIL----LGLAQALFELGRYAEALETLeklIAKNPD-----FKSSDAHLLY 166

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217264598 124 ALAYHALGELPQALAWYHRALGHYqpqgDQGEAWAKMGACYQALGQPELAAHCLQE 179
Cdd:COG4700   167 ARALEALGDLEAAEAELEALARRY----SGPEARYRYAKFLARQGRTAEAKELLEE 218
TPR_10 pfam13374
Tetratricopeptide repeat;
273-303 1.20e-03

Tetratricopeptide repeat;


Pssm-ID: 463861 [Multi-domain]  Cd Length: 42  Bit Score: 36.71  E-value: 1.20e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2217264598 273 ATVLRNLGMAHNALGNYQEAREFHQKAADLH 303
Cdd:pfam13374   2 ASSLNNLANALRAQGRYDEAEELLEEALAIR 32
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
35-205 1.23e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.76  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598  35 SIQALTRAGHGALQAGQNHEALNNFQRAFLLASKAPQTRdtpvlqacaFNLGAAYVETGDPARGLELLLRAHpeekAQGR 114
Cdd:COG0457    75 DAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEAL---------YNLGLALLELGRYDEAIEAYERAL----ELDP 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 115 RHGDQCFNVALAYHALGELPQALAWYHRALGHYQPQGDQGEAWAKMGACYQALGQPELAAHCLQEASQAYAQERQLRAAA 194
Cdd:COG0457   142 DDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAE 221

                         170
                  ....*....|.
gi 2217264598 195 LALGAAAGCML 205
Cdd:COG0457   222 LLLLALALLLA 232
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 319-408 1.40e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 38.82  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 319 LAFALSQLGDHKAARDNYLHALQAARDSGDMKgqwQACEGLGAAAARLGQYDQALKYYKEALAQCqePDSvrerlvaKLA 398
Cdd:COG1729    36 LGEAYYALGDYDEAAEAFEKLLKRYPDSPKAP---DALLKLGLSYLELGDYDKARATLEELIKKY--PDS-------EAA 103

                          90
                  ....*....|
gi 2217264598 399 DTVRTRLAQV 408
Cdd:COG1729   104 KEARARLARL 113
COG3899 COG3899
Predicted ATPase [General function prediction only];
260-464 1.49e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 41.77  E-value: 1.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598  260 LQALPLCWVPGEQATVLRNLGMAHNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALS-----QLGDHKAARD 334
Cdd:COG3899    732 LELLPPDPEEEYRLALLLELAEALYLAGRFEEAEALLERALAARALAALAALRHGNPPASARAYAnlgllLLGDYEEAYE 811

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598  335 NYLHALQAARDSGDMKGQWQACEGLGAAAARLGQYDQALKYYKEALAQCQEPDSVRERLVAKLADTVRTRLAQVGLVQTH 414
Cdd:COG3899    812 FGELALALAERLGDRRLEARALFNLGFILHWLGPLREALELLREALEAGLETGDAALALLALAAAAAAAAAAAALAAAAA 891

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 2217264598  415 TLTSAPGRLQAPGGASQAEGTPAKAGSSTAGVQHRSSSGWEDEEFEEGHQ 464
Cdd:COG3899    892 AAARLLAAAAAALAAAAAAAALAAAELARLAAAAAAAAALALAAAAAAAA 941
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 273-302 1.57e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.27  E-value: 1.57e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2217264598  273 ATVLRNLGMAHNALGNYQEAREFHQKAADL 302
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALEL 30
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 260-407 1.60e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 39.56  E-value: 1.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598 260 LQALPLCWVPGEQATVLRNLGMAHNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHA 339
Cdd:COG5010     1 ARALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217264598 340 LQAARDSgdmkgqWQACEGLGAAAARLGQYDQALKYYKEALAQCQEPDSVRERLVAKLADTVRTRLAQ 407
Cdd:COG5010    81 LQLDPNN------PELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAK 142
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 46-144 1.91e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 39.17  E-value: 1.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598  46 ALQAGQNHEALNNFQRAFLLASKAPQTRdtpvlqacaFNLGAAYVETGDPARGLELLLRAHPEEKAQGRRHgdqcFNVAL 125
Cdd:COG5010    64 YNKLGDFEESLALLEQALQLDPNNPELY---------YNLALLYSRSGDKDEAKEYYEKALALSPDNPNAY----SNLAA 130

                          90
                  ....*....|....*....
gi 2217264598 126 AYHALGELPQALAWYHRAL 144
Cdd:COG5010   131 LLLSLGQDDEAKAALQRAL 149
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 353-381 2.30e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 35.96  E-value: 2.30e-03
                          10        20
                  ....*....|....*....|....*....
gi 2217264598 353 WQACEGLGAAAARLGQYDQALKYYKEALA 381
Cdd:pfam07719   1 AEALYNLGLAYYKLGDYEEALEAYEKALE 29
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 54-136 2.30e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.84  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598  54 EALNNFQRAFLLASKAPQTRDTpvlqacafnLGAAYVETGDPARGLELLLRAhpeeKAQGRRHGDQCFNVALAYHALGEL 133
Cdd:TIGR02917 821 RALEYAERALKLAPNIPAILDT---------LGWLLVEKGEADRALPLLRKA----VNIAPEAAAIRYHLALALLATGRK 887


                  ...
gi 2217264598 134 PQA 136
Cdd:TIGR02917 888 AEA 890
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
46-144 2.31e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.46  E-value: 2.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598  46 ALQAGQNHEALNNFQRAFLLASKAPQTRdtpvlqacaFNLGAAYVETGDP--ARGLELLLRAHPEekaqgrrHGDQCFNV 123
Cdd:COG3063     2 YLKLGDLEEAEEYYEKALELDPDNADAL---------NNLGLLLLEQGRYdeAIALEKALKLDPN-------NAEALLNL 65

                          90       100
                  ....*....|....*....|.
gi 2217264598 124 ALAYHALGELPQALAWYHRAL 144
Cdd:COG3063    66 AELLLELGDYDEALAYLERAL 86
TPR_1 pfam00515
Tetratricopeptide repeat;
273-302 5.42e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 34.70  E-value: 5.42e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 2217264598 273 ATVLRNLGMAHNALGNYQEAREFHQKAADL 302
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALEL 30
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
88-189 9.15e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 35.92  E-value: 9.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264598  88 AYVETGDPARGLELLLRAHpeekAQGRRHGDQCFNVALAYHALGELPQALAwYHRALGHYQpqgDQGEAWAKMGACYQAL 167
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKAL----ELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDP---NNAEALLNLAELLLEL 72

                          90       100
                  ....*....|....*....|..
gi 2217264598 168 GQPELAAHCLQEASQAYAQERQ 189
Cdd:COG3063    73 GDYDEALAYLERALELDPSALR 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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