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Conserved domains on  [gi|2217341339|ref|XP_047303191|]
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cohesin subunit SA-1 isoform X3 [Homo sapiens]

Protein Classification

STAG domain-containing protein( domain architecture ID 1916762)

STAG domain-containing protein may be a subunit of a cohesin complex - a protein complex required for sister chromatid cohesion in eukaryotes

Gene Ontology:  GO:0051301|GO:0007062

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IRR1 super family cl44256
Cohesin [Cell division and chromosome partitioning];
26-172 9.35e-14

Cohesin [Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5537:

Pssm-ID: 227824 [Multi-domain]  Cd Length: 740  Bit Score: 75.70  E-value: 9.35e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341339   26 EAERNKMIGKRANERLELLlqkrkelqenqdeIENMMNSIFKGIFVHRYRDAIAEIRAICIEEIGVWMKMYSDAFLNDSY 105
Cdd:COG5537    249 SEKKSRMNELALYDLNPSL-------------IRDEIKDICDSVFVSRYIDVDDVIRVLCSMSLRDWIGLVPDYFRKILG 315

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217341339  106 LKYVGWTLHDRQGEVRLKCLKALQSLYTNRELFPKLELFTNRFKDRIVSMTLDKEYDVAVEAIRLVT 172
Cdd:COG5537    316 LRYNGWSLSDNHEGVRLLVSKILLFLCSRIPHTDAIRRFVERFKDRILEFLRTDSDCVRICSIKSLC 382
STAG super family cl44568
STAG domain; STAG domain proteins are subunits of cohesin complex - a protein complex required ...
 1-47 2.56e-09

STAG domain; STAG domain proteins are subunits of cohesin complex - a protein complex required for sister chromatid cohesion in eukaryotes. The STAG domain is present in Schizosaccharomyces pombe mitotic cohesin Psc3, and the meiosis specific cohesin Rec11. Many organizms express a meiosis-specific STAG protein, for example, mice and humans have a meiosis specific variant called STAG3, although budding yeast does not have a meiosis specific version.


The actual alignment was detected with superfamily member pfam08514:

Pssm-ID: 462502  Cd Length: 113  Bit Score: 55.64  E-value: 2.56e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2217341339    1 MKLMTALVNVALNLSIHQDNTQRQYEAERNKmiGKRANERLELLLQK 47
Cdd:pfam08514   69 LALMTALCDVAAELSKSLETTQRQLEAEKKK--KRANKERLESLEKK 113
 
Name Accession Description Interval E-value
IRR1 COG5537
Cohesin [Cell division and chromosome partitioning];
26-172 9.35e-14

Cohesin [Cell division and chromosome partitioning];


Pssm-ID: 227824 [Multi-domain]  Cd Length: 740  Bit Score: 75.70  E-value: 9.35e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341339   26 EAERNKMIGKRANERLELLlqkrkelqenqdeIENMMNSIFKGIFVHRYRDAIAEIRAICIEEIGVWMKMYSDAFLNDSY 105
Cdd:COG5537    249 SEKKSRMNELALYDLNPSL-------------IRDEIKDICDSVFVSRYIDVDDVIRVLCSMSLRDWIGLVPDYFRKILG 315

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217341339  106 LKYVGWTLHDRQGEVRLKCLKALQSLYTNRELFPKLELFTNRFKDRIVSMTLDKEYDVAVEAIRLVT 172
Cdd:COG5537    316 LRYNGWSLSDNHEGVRLLVSKILLFLCSRIPHTDAIRRFVERFKDRILEFLRTDSDCVRICSIKSLC 382
STAG pfam08514
STAG domain; STAG domain proteins are subunits of cohesin complex - a protein complex required ...
 1-47 2.56e-09

STAG domain; STAG domain proteins are subunits of cohesin complex - a protein complex required for sister chromatid cohesion in eukaryotes. The STAG domain is present in Schizosaccharomyces pombe mitotic cohesin Psc3, and the meiosis specific cohesin Rec11. Many organizms express a meiosis-specific STAG protein, for example, mice and humans have a meiosis specific variant called STAG3, although budding yeast does not have a meiosis specific version.


Pssm-ID: 462502  Cd Length: 113  Bit Score: 55.64  E-value: 2.56e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2217341339    1 MKLMTALVNVALNLSIHQDNTQRQYEAERNKmiGKRANERLELLLQK 47
Cdd:pfam08514   69 LALMTALCDVAAELSKSLETTQRQLEAEKKK--KRANKERLESLEKK 113
 
Name Accession Description Interval E-value
IRR1 COG5537
Cohesin [Cell division and chromosome partitioning];
26-172 9.35e-14

Cohesin [Cell division and chromosome partitioning];


Pssm-ID: 227824 [Multi-domain]  Cd Length: 740  Bit Score: 75.70  E-value: 9.35e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341339   26 EAERNKMIGKRANERLELLlqkrkelqenqdeIENMMNSIFKGIFVHRYRDAIAEIRAICIEEIGVWMKMYSDAFLNDSY 105
Cdd:COG5537    249 SEKKSRMNELALYDLNPSL-------------IRDEIKDICDSVFVSRYIDVDDVIRVLCSMSLRDWIGLVPDYFRKILG 315

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217341339  106 LKYVGWTLHDRQGEVRLKCLKALQSLYTNRELFPKLELFTNRFKDRIVSMTLDKEYDVAVEAIRLVT 172
Cdd:COG5537    316 LRYNGWSLSDNHEGVRLLVSKILLFLCSRIPHTDAIRRFVERFKDRILEFLRTDSDCVRICSIKSLC 382
STAG pfam08514
STAG domain; STAG domain proteins are subunits of cohesin complex - a protein complex required ...
 1-47 2.56e-09

STAG domain; STAG domain proteins are subunits of cohesin complex - a protein complex required for sister chromatid cohesion in eukaryotes. The STAG domain is present in Schizosaccharomyces pombe mitotic cohesin Psc3, and the meiosis specific cohesin Rec11. Many organizms express a meiosis-specific STAG protein, for example, mice and humans have a meiosis specific variant called STAG3, although budding yeast does not have a meiosis specific version.


Pssm-ID: 462502  Cd Length: 113  Bit Score: 55.64  E-value: 2.56e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2217341339    1 MKLMTALVNVALNLSIHQDNTQRQYEAERNKmiGKRANERLELLLQK 47
Cdd:pfam08514   69 LALMTALCDVAAELSKSLETTQRQLEAEKKK--KRANKERLESLEKK 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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