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Conserved domains on  [gi|2217341287|ref|XP_047303122|]
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activated CDC42 kinase 1 isoform X24 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UBA_ACK1 cd14274
UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins; ACK1, also called ...
 486-529 6.05e-23

UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins; ACK1, also called tyrosine kinase non-receptor protein 2, is an intracellular non-receptor tyrosine kinase that specifically interacts with Cdc42 and act as Cdc42 effectors. It forms a signaling complex with Cdc42, p130(Cas), and Crk, and mediates Cdc42-dependent cell migration and signaling to p130(Cas). Ack1 also stimulates prostate tumorigenesis in part by inhibiting the proapoptotic tumor suppressor WW domain containing oxidoreductase (Wwox). Moreover, ACK1 associates directly with the heavy chain of clathrin and further participates in trafficking, underlying an ability to increase receptor-mediated transferrin uptake. It may functions as a regulator of the guanine nucleotide exchange factor Dbl that can activate Rho family proteins. ACK1 consists of an N-terminal tyrosine kinase catalytic domain followed by an SH3 domain, a Cdc42/Rac interactive binding (CRIB) domain, a proline-rich region, and a C-terminal ubiquitin-association (UBA) domain. The proline-rich region of ACK1 is responsible for the binding to the adaptor proteins Nck, Grb2, sorting nexin protein 9 (SH3PX1), and Hck.


:

Pssm-ID: 270460  Cd Length: 45  Bit Score: 91.44  E-value: 6.05e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2217341287 486 KIQMLQAMVHGVTTEECQAALQCHGWSVQRAAQYLKVEQLFGLG 529
Cdd:cd14274     2 SITQVQEAVHGVTLEECQAALQNHGWNVQRAVQYLKVEQLFCLG 45
Inhibitor_Mig-6 super family cl13070
EGFR receptor inhibitor Mig-6; When the kinase domain of EGFR binds to segment one of Mitogen ...
 299-365 7.05e-21

EGFR receptor inhibitor Mig-6; When the kinase domain of EGFR binds to segment one of Mitogen induced gene 6 (Mig-6), EGFR becomes inactive due to the conformation it adopts which is Src/CDK like. The binding of the two proteins prevents EGFR acting as a cyclin-like activator for other kinase domains.The structure of Mig-6(1) consists of alpha helices-G and -H with a polar surface and hydrophobic residues for interactions with EGFR. A critical step for the activation of EGFR is the formation of an asymmetric dimer involving the kinase domains of the protein. Since Mig-6 binds to the kinase domain it blocks this process and EGFR becomes inactive.


The actual alignment was detected with superfamily member pfam11555:

Pssm-ID: 463294 [Multi-domain]  Cd Length: 74  Bit Score: 86.59  E-value: 7.05e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217341287 299 SPPRVPPREPLSPQGSRTPSPLVPPGSSP-------LPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRA 365
Cdd:pfam11555   1 RPPQIPPRDPLSQPGSRTPSPMGLVVGSPqqpathsYSSYLSTSPGKLMPTTQSFASDPKYAAPKVIQAQGKDA 74
UBA_TNK1 cd14328
UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins; TNK1, also ...
 516-555 1.34e-17

UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins; TNK1, also called CD38 negative kinase 1, is a non-receptor protein tyrosine kinase (NRPTK) that has been implicated in the regulation of apoptosis, cell growth, nuclear factor-kappaB, and Ras. It associates with phospholipase C (PLC)-gamma1 and may play a role in phospholipid signal transduction. TNK1 contains an NH2-terminal kinase, a Src Homology 3 (SH3) domain, a proline-rich (PR) region, and a C-terminal ubiquitin-association (UBA) domain.


:

Pssm-ID: 270513  Cd Length: 40  Bit Score: 76.09  E-value: 1.34e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2217341287 516 AAQYLKVEQLFGLGLRPRGECHKVLEMFDWNLEQAGCHLL 555
Cdd:cd14328     1 AVRYLKVEQLFRLGLASREECEKALERTNWNLELASSLLL 40
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 100-366 7.44e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 7.44e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341287  100 EEPVVPALRPCAPSLAQLAMDACSLLDETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAqdeddfeICSINSTL 179
Cdd:PHA03247  2746 AGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA-------VLAPAAAL 2818

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341287  180 VGAGVPAGPSQGQTNYAFVPEQARPPPPLEdnlFLPPQGGGKPPSSAQTaeifqalqqecmrqlQAPAGSPAPSPSpggd 259
Cdd:PHA03247  2819 PPAASPAGPLPPPTSAQPTAPPPPPGPPPP---SLPLGGSVAPGGDVRR---------------RPPSRSPAAKPA---- 2876

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341287  260 dkpqvpprvpippRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPPREPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKT 339
Cdd:PHA03247  2877 -------------APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPL 2943

                          250       260
                   ....*....|....*....|....*..
gi 2217341287  340 MPTTqsfasDPKYATPQVIQAPGPRAG 366
Cdd:PHA03247  2944 APTT-----DPAGAGEPSGAVPQPWLG 2965
 
Name Accession Description Interval E-value
UBA_ACK1 cd14274
UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins; ACK1, also called ...
 486-529 6.05e-23

UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins; ACK1, also called tyrosine kinase non-receptor protein 2, is an intracellular non-receptor tyrosine kinase that specifically interacts with Cdc42 and act as Cdc42 effectors. It forms a signaling complex with Cdc42, p130(Cas), and Crk, and mediates Cdc42-dependent cell migration and signaling to p130(Cas). Ack1 also stimulates prostate tumorigenesis in part by inhibiting the proapoptotic tumor suppressor WW domain containing oxidoreductase (Wwox). Moreover, ACK1 associates directly with the heavy chain of clathrin and further participates in trafficking, underlying an ability to increase receptor-mediated transferrin uptake. It may functions as a regulator of the guanine nucleotide exchange factor Dbl that can activate Rho family proteins. ACK1 consists of an N-terminal tyrosine kinase catalytic domain followed by an SH3 domain, a Cdc42/Rac interactive binding (CRIB) domain, a proline-rich region, and a C-terminal ubiquitin-association (UBA) domain. The proline-rich region of ACK1 is responsible for the binding to the adaptor proteins Nck, Grb2, sorting nexin protein 9 (SH3PX1), and Hck.


Pssm-ID: 270460  Cd Length: 45  Bit Score: 91.44  E-value: 6.05e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2217341287 486 KIQMLQAMVHGVTTEECQAALQCHGWSVQRAAQYLKVEQLFGLG 529
Cdd:cd14274     2 SITQVQEAVHGVTLEECQAALQNHGWNVQRAVQYLKVEQLFCLG 45
Inhibitor_Mig-6 pfam11555
EGFR receptor inhibitor Mig-6; When the kinase domain of EGFR binds to segment one of Mitogen ...
 299-365 7.05e-21

EGFR receptor inhibitor Mig-6; When the kinase domain of EGFR binds to segment one of Mitogen induced gene 6 (Mig-6), EGFR becomes inactive due to the conformation it adopts which is Src/CDK like. The binding of the two proteins prevents EGFR acting as a cyclin-like activator for other kinase domains.The structure of Mig-6(1) consists of alpha helices-G and -H with a polar surface and hydrophobic residues for interactions with EGFR. A critical step for the activation of EGFR is the formation of an asymmetric dimer involving the kinase domains of the protein. Since Mig-6 binds to the kinase domain it blocks this process and EGFR becomes inactive.


Pssm-ID: 463294 [Multi-domain]  Cd Length: 74  Bit Score: 86.59  E-value: 7.05e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217341287 299 SPPRVPPREPLSPQGSRTPSPLVPPGSSP-------LPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRA 365
Cdd:pfam11555   1 RPPQIPPRDPLSQPGSRTPSPMGLVVGSPqqpathsYSSYLSTSPGKLMPTTQSFASDPKYAAPKVIQAQGKDA 74
UBA_TNK1 cd14328
UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins; TNK1, also ...
 516-555 1.34e-17

UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins; TNK1, also called CD38 negative kinase 1, is a non-receptor protein tyrosine kinase (NRPTK) that has been implicated in the regulation of apoptosis, cell growth, nuclear factor-kappaB, and Ras. It associates with phospholipase C (PLC)-gamma1 and may play a role in phospholipid signal transduction. TNK1 contains an NH2-terminal kinase, a Src Homology 3 (SH3) domain, a proline-rich (PR) region, and a C-terminal ubiquitin-association (UBA) domain.


Pssm-ID: 270513  Cd Length: 40  Bit Score: 76.09  E-value: 1.34e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2217341287 516 AAQYLKVEQLFGLGLRPRGECHKVLEMFDWNLEQAGCHLL 555
Cdd:cd14328     1 AVRYLKVEQLFRLGLASREECEKALERTNWNLELASSLLL 40
PHA03247 PHA03247
large tegument protein UL36; Provisional
 100-366 7.44e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 7.44e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341287  100 EEPVVPALRPCAPSLAQLAMDACSLLDETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAqdeddfeICSINSTL 179
Cdd:PHA03247  2746 AGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA-------VLAPAAAL 2818

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341287  180 VGAGVPAGPSQGQTNYAFVPEQARPPPPLEdnlFLPPQGGGKPPSSAQTaeifqalqqecmrqlQAPAGSPAPSPSpggd 259
Cdd:PHA03247  2819 PPAASPAGPLPPPTSAQPTAPPPPPGPPPP---SLPLGGSVAPGGDVRR---------------RPPSRSPAAKPA---- 2876

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341287  260 dkpqvpprvpippRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPPREPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKT 339
Cdd:PHA03247  2877 -------------APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPL 2943

                          250       260
                   ....*....|....*....|....*..
gi 2217341287  340 MPTTqsfasDPKYATPQVIQAPGPRAG 366
Cdd:PHA03247  2944 APTT-----DPAGAGEPSGAVPQPWLG 2965
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 245-355 3.37e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 40.43  E-value: 3.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341287 245 APAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPPREPLSPQGSRTPSPLVPpG 324
Cdd:PRK14959  380 APSGSAAEGPASGGAATIPTPGTQGPQGTAPAAGMTPSSAAPATPAPSAAPSPRVPWDDAPPAPPRSGIPPRPAPRMP-E 458

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2217341287 325 SSPLPPR-LSSSPGKTMPTTQSFASDPKYATP 355
Cdd:PRK14959  459 ASPVPGApDSVASASDAPPTLGDPSDTAEHTP 490
UBA smart00165
Ubiquitin associated domain; Present in Rad23, SNF1-like kinases. The newly-found UBA in p62 ...
 486-520 7.72e-03

Ubiquitin associated domain; Present in Rad23, SNF1-like kinases. The newly-found UBA in p62 is known to bind ubiquitin.


Pssm-ID: 197551 [Multi-domain]  Cd Length: 37  Bit Score: 34.38  E-value: 7.72e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2217341287  486 KIQMLQAMvhGVTTEECQAALQCHGWSVQRAAQYL 520
Cdd:smart00165   4 KIDQLLEM--GFSREEALKALRAANGNVERAAEYL 36
 
Name Accession Description Interval E-value
UBA_ACK1 cd14274
UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins; ACK1, also called ...
 486-529 6.05e-23

UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins; ACK1, also called tyrosine kinase non-receptor protein 2, is an intracellular non-receptor tyrosine kinase that specifically interacts with Cdc42 and act as Cdc42 effectors. It forms a signaling complex with Cdc42, p130(Cas), and Crk, and mediates Cdc42-dependent cell migration and signaling to p130(Cas). Ack1 also stimulates prostate tumorigenesis in part by inhibiting the proapoptotic tumor suppressor WW domain containing oxidoreductase (Wwox). Moreover, ACK1 associates directly with the heavy chain of clathrin and further participates in trafficking, underlying an ability to increase receptor-mediated transferrin uptake. It may functions as a regulator of the guanine nucleotide exchange factor Dbl that can activate Rho family proteins. ACK1 consists of an N-terminal tyrosine kinase catalytic domain followed by an SH3 domain, a Cdc42/Rac interactive binding (CRIB) domain, a proline-rich region, and a C-terminal ubiquitin-association (UBA) domain. The proline-rich region of ACK1 is responsible for the binding to the adaptor proteins Nck, Grb2, sorting nexin protein 9 (SH3PX1), and Hck.


Pssm-ID: 270460  Cd Length: 45  Bit Score: 91.44  E-value: 6.05e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2217341287 486 KIQMLQAMVHGVTTEECQAALQCHGWSVQRAAQYLKVEQLFGLG 529
Cdd:cd14274     2 SITQVQEAVHGVTLEECQAALQNHGWNVQRAVQYLKVEQLFCLG 45
Inhibitor_Mig-6 pfam11555
EGFR receptor inhibitor Mig-6; When the kinase domain of EGFR binds to segment one of Mitogen ...
 299-365 7.05e-21

EGFR receptor inhibitor Mig-6; When the kinase domain of EGFR binds to segment one of Mitogen induced gene 6 (Mig-6), EGFR becomes inactive due to the conformation it adopts which is Src/CDK like. The binding of the two proteins prevents EGFR acting as a cyclin-like activator for other kinase domains.The structure of Mig-6(1) consists of alpha helices-G and -H with a polar surface and hydrophobic residues for interactions with EGFR. A critical step for the activation of EGFR is the formation of an asymmetric dimer involving the kinase domains of the protein. Since Mig-6 binds to the kinase domain it blocks this process and EGFR becomes inactive.


Pssm-ID: 463294 [Multi-domain]  Cd Length: 74  Bit Score: 86.59  E-value: 7.05e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217341287 299 SPPRVPPREPLSPQGSRTPSPLVPPGSSP-------LPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRA 365
Cdd:pfam11555   1 RPPQIPPRDPLSQPGSRTPSPMGLVVGSPqqpathsYSSYLSTSPGKLMPTTQSFASDPKYAAPKVIQAQGKDA 74
UBA_TNK1 cd14328
UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins; TNK1, also ...
 516-555 1.34e-17

UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins; TNK1, also called CD38 negative kinase 1, is a non-receptor protein tyrosine kinase (NRPTK) that has been implicated in the regulation of apoptosis, cell growth, nuclear factor-kappaB, and Ras. It associates with phospholipase C (PLC)-gamma1 and may play a role in phospholipid signal transduction. TNK1 contains an NH2-terminal kinase, a Src Homology 3 (SH3) domain, a proline-rich (PR) region, and a C-terminal ubiquitin-association (UBA) domain.


Pssm-ID: 270513  Cd Length: 40  Bit Score: 76.09  E-value: 1.34e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2217341287 516 AAQYLKVEQLFGLGLRPRGECHKVLEMFDWNLEQAGCHLL 555
Cdd:cd14328     1 AVRYLKVEQLFRLGLASREECEKALERTNWNLELASSLLL 40
PHA03247 PHA03247
large tegument protein UL36; Provisional
 100-366 7.44e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 7.44e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341287  100 EEPVVPALRPCAPSLAQLAMDACSLLDETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAqdeddfeICSINSTL 179
Cdd:PHA03247  2746 AGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA-------VLAPAAAL 2818

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341287  180 VGAGVPAGPSQGQTNYAFVPEQARPPPPLEdnlFLPPQGGGKPPSSAQTaeifqalqqecmrqlQAPAGSPAPSPSpggd 259
Cdd:PHA03247  2819 PPAASPAGPLPPPTSAQPTAPPPPPGPPPP---SLPLGGSVAPGGDVRR---------------RPPSRSPAAKPA---- 2876

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341287  260 dkpqvpprvpippRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPPREPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKT 339
Cdd:PHA03247  2877 -------------APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPL 2943

                          250       260
                   ....*....|....*....|....*..
gi 2217341287  340 MPTTqsfasDPKYATPQVIQAPGPRAG 366
Cdd:PHA03247  2944 APTT-----DPAGAGEPSGAVPQPWLG 2965
PHA03247 PHA03247
large tegument protein UL36; Provisional
 74-446 1.09e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 1.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341287   74 AKPSARVPGTKASRGSGAEVTLIDFGEEPVVPALRPC---APSLAQLAMDACSLLDETPPQSPTRALPRPLHPTPV--VD 148
Cdd:PHA03247  2617 LPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRddpAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVgsLT 2696

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341287  149 WDARPLPPPPAYDDvaqdeddfeicsiNSTLVGAGVPAGPSQGQTNYAFVPEQARPPPPLEDNLFLPPQGGGKPPSSAQT 228
Cdd:PHA03247  2697 SLADPPPPPPTPEP-------------APHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTT 2763

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341287  229 AEIFQALQQecmrqlQAPAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPPREP 308
Cdd:PHA03247  2764 AGPPAPAPP------AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPT 2837

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341287  309 LSPQGSRTPSPLVPPGSS-----PLPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAGPcilpivrdgkkvssth 383
Cdd:PHA03247  2838 APPPPPGPPPPSLPLGGSvapggDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALP---------------- 2901

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217341287  384 yYLLPERPSYleryqrflREAQSPEEPTPLPVPLLLPPPSTPAPAAPTATVRPMPQAALDPKA 446
Cdd:PHA03247  2902 -PDQPERPPQ--------PQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEP 2955
PHA03247 PHA03247
large tegument protein UL36; Provisional
 104-446 6.39e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 6.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341287  104 VPALRPcAPSLAQLAMDACSLLDETPPQS--------PTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEICSI 175
Cdd:PHA03247  2568 VPPPRP-APRPSEPAVTSRARRPDAPPQSarprapvdDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTV 2646

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341287  176 NSTLVGAGVPAGP---------SQGQTNYAFVPEQARPPPPLED------NLFLPPQGGGKP---PSSAQTAEIFQALQQ 237
Cdd:PHA03247  2647 PPPERPRDDPAPGrvsrprrarRLGRAAQASSPPQRPRRRAARPtvgsltSLADPPPPPPTPepaPHALVSATPLPPGPA 2726

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341287  238 ECMRQLQAPAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPPREPL-SPQGSRT 316
Cdd:PHA03247  2727 AARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLpSPWDPAD 2806

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341287  317 PSPLVPPGSSPLPPrlSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAGPCIL--PIVRDGKKVSSTHYYLLPERPsyl 394
Cdd:PHA03247  2807 PPAAVLAPAAALPP--AASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggDVRRRPPSRSPAAKPAAPARP--- 2881

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2217341287  395 eRYQRFLREAQSPeeptpLPVPLLLPPPSTPAPAAPTATVRPMPQAALDPKA 446
Cdd:PHA03247  2882 -PVRRLARPAVSR-----STESFALPPDQPERPPQPQAPPPPQPQPQPPPPP 2927
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
180-376 1.71e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 1.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341287 180 VGAGVPAGPSQGQTNYAFVPEQARPPPPLEDNLFLPPQGGGKPPSSAQTAEIFQALQQECMRQLQAPAGSPAPSPSPGGD 259
Cdd:PRK12323  382 VAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAA 461

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341287 260 DKPQVPPRVPIPPRPTRPHVQLSPAP---PGEEETSQWPG-PASPPRVPPREP-LSPQGSRTPSPLVPPGSSPLPPRLSS 334
Cdd:PRK12323  462 ARPAAAGPRPVAAAAAAAPARAAPAAapaPADDDPPPWEElPPEFASPAPAQPdAAPAGWVAESIPDPATADPDDAFETL 541

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2217341287 335 SPGKtmptTQSFASDPKYATPQVIQAPGPRAGPCILPIVRDG 376
Cdd:PRK12323  542 APAP----AAAPAPRAAAATEPVVAPRPPRASASGLPDMFDG 579
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 245-355 3.37e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 40.43  E-value: 3.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341287 245 APAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPPREPLSPQGSRTPSPLVPpG 324
Cdd:PRK14959  380 APSGSAAEGPASGGAATIPTPGTQGPQGTAPAAGMTPSSAAPATPAPSAAPSPRVPWDDAPPAPPRSGIPPRPAPRMP-E 458

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2217341287 325 SSPLPPR-LSSSPGKTMPTTQSFASDPKYATP 355
Cdd:PRK14959  459 ASPVPGApDSVASASDAPPTLGDPSDTAEHTP 490
PHA03378 PHA03378
EBNA-3B; Provisional
 129-344 3.84e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.44  E-value: 3.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341287 129 PPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEICSINSTLVGAG-VPAGPSQGQTNyAFVPEQARP--- 204
Cdd:PHA03378  616 PETSAPRQWPMPLRPIPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGhIPYQPSPTGAN-TMLPIQWAPgtm 694

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341287 205 -PPPLEDNLFLPPQGGGKPPSSAQTAEIFQALQQECMRQLQAPAGSPAPSPSPGGddkpqvpprvpipprpTRPHVQLSP 283
Cdd:PHA03378  695 qPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAA----------------APGRARPPA 758

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217341287 284 APPGEEETSQWPGPASPPRVPPREPLSPQG--SRTPSPLVPPGSSPLPPRLS--SSPGKTMPTTQ 344
Cdd:PHA03378  759 AAPGRARPPAAAPGAPTPQPPPQAPPAPQQrpRGAPTPQPPPQAGPTSMQLMprAAPGQQGPTKQ 823
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 242-336 6.69e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 39.16  E-value: 6.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341287 242 QLQAPAGSPAPSPSPGGDDKPQVPPRVPipprptrphvqlsPAPPGEeetsqwPGPASP--PRVPPREPLSPQGSRTPSP 319
Cdd:PRK14954  372 ELVRNDGGVAPSPAGSPDVKKKAPEPDL-------------PQPDRH------PGPAKPeaPGARPAELPSPASAPTPEQ 432

                          90
                  ....*....|....*...
gi 2217341287 320 LVP-PGSSPLPPRLSSSP 336
Cdd:PRK14954  433 QPPvARSAPLPPSPQASA 450
UBA_VP13D cd14306
UBA domain found in vacuolar protein sorting-associated protein 13D (VP13D) and similar ...
 487-520 7.34e-03

UBA domain found in vacuolar protein sorting-associated protein 13D (VP13D) and similar proteins; VP13D is a chorea-acanthocytosis (CHAC)-similar protein encoded by gene VPS13D. it contains two putative domains, ubiquitin-associated (UBA) domain and lectin domain of ricin B chain profile (ricin-B-lectin), suggesting it may interact with, and be involved in the trafficking of, proteins modified with ubiquitin and/or carbohydrate molecules. Further investigation is required.


Pssm-ID: 270491  Cd Length: 36  Bit Score: 34.34  E-value: 7.34e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2217341287 487 IQMLQAMvhGVTTEECQAALQCHGWSVQRAAQYL 520
Cdd:cd14306     1 VAKLMEL--GFPEEDCIRALRACGGNVEEAANWL 32
PHA03247 PHA03247
large tegument protein UL36; Provisional
 153-367 7.54e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 7.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341287  153 PLPPPPAYDDVAQDEDDFEICSINSTLVGAGVPAGPSQGQTNYAFVPEQARPPPPLEDNLFLPPQGGGKPPSSAQTAeif 232
Cdd:PHA03247  2557 PAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSP--- 2633

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341287  233 qalqqecmRQLQAPAGSPAPSPSPGGDDKPQVPPRVPIPPRPTrphvQLSPAPPGEEETSQWPGPASPPRVPPREPLS-- 310
Cdd:PHA03247  2634 --------AANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRAR----RLGRAAQASSPPQRPRRRAARPTVGSLTSLAdp 2701

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217341287  311 PQGSRTPSPLVPPGSS--PLPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAGP 367
Cdd:PHA03247  2702 PPPPPTPEPAPHALVSatPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARP 2760
UBA smart00165
Ubiquitin associated domain; Present in Rad23, SNF1-like kinases. The newly-found UBA in p62 ...
 486-520 7.72e-03

Ubiquitin associated domain; Present in Rad23, SNF1-like kinases. The newly-found UBA in p62 is known to bind ubiquitin.


Pssm-ID: 197551 [Multi-domain]  Cd Length: 37  Bit Score: 34.38  E-value: 7.72e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2217341287  486 KIQMLQAMvhGVTTEECQAALQCHGWSVQRAAQYL 520
Cdd:smart00165   4 KIDQLLEM--GFSREEALKALRAANGNVERAAEYL 36
UBA_like_SF cd00194
UBA domain-like superfamily; The ubiquitin-associated (UBA) domain-like superfamily contains ...
 490-518 8.11e-03

UBA domain-like superfamily; The ubiquitin-associated (UBA) domain-like superfamily contains alpha-helical structural homology ubiquitin-binding domains, including UBA domains and coupling of ubiquitin conjugation to endoplasmic reticulum degradation (CUE) domains which share a common three-helical bundle architecture. UBA domains are commonly occurring sequence motifs found in proteins involved in ubiquitin-mediated proteolysis. They contribute to ubiquitin (Ub) binding or ubiquitin-like (UbL) domain binding. However, some kinds of UBA domains can only bind the UbL domain, but not the Ub domain. UBA domains are normally comprised of compact three-helix bundles which contain a conserved GF/Y-loop. They can bind polyubiquitin with high affinity. They also bind monoubiquitin and other proteins. Most UBA domain-containing proteins have one UBA domain, but some harbor two or three UBA domains. CUE domain containing proteins are characterized by an FP and a di-leucine-like sequence and bind to monoubiquitin with varying affinities. Some higher eukaryotic CUE domain proteins do not bind monoubiquitin efficiently, since they carry LP, rather than FP among CUE domains. This superfamily also includes many UBA-like domains found in AMP-activated protein kinase (AMPK) related kinases, the NXF family of mRNA nuclear export factors, elongation factor Ts (EF-Ts), nascent polypeptide-associated complex subunit alpha (NACA) and similar proteins. Although many UBA-like domains may have a conserved TG but not GF/Y-loop, they still show a high level of structural and sequence similarity with three-helical ubiquitin binding domains.


Pssm-ID: 270455  Cd Length: 28  Bit Score: 33.92  E-value: 8.11e-03
                          10        20
                  ....*....|....*....|....*....
gi 2217341287 490 LQAMVHGvTTEECQAALQCHGWSVQRAAQ 518
Cdd:cd00194     1 LVDITGA-SQEEAQQALEACGGNLNIAAN 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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