|
Name |
Accession |
Description |
Interval |
E-value |
| recomb_DMC1 |
TIGR02238 |
meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA ... |
24-274 |
5.88e-152 |
|
meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA repair and recombination proteins. It is eukaryotic only and most closely related to eukaryotic RAD51. It also resembles archaeal RadA (TIGR02236) and RadB (TIGR02237) and bacterial RecA (TIGR02012). It has been characterized for human as a recombinase active only in meiosis.
Pssm-ID: 131292 [Multi-domain] Cd Length: 313 Bit Score: 428.04 E-value: 5.88e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 24 IDLLQKHGINVADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVDKIKEAANKLIEPGFLTAFEYSEKRKMVFHITT 103
Cdd:TIGR02238 1 IDKLQAHGINAADIKKLKSAGICTVNGVIMTTRRALCKIKGLSEAKVDKIKEAASKIINPGFITAFEISQKRKKVLKITT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 104 GSQEFDKLLGGGIESMAITEAFGEFRTGKTQLSHTLC------------------------------------------- 140
Cdd:TIGR02238 81 GSQALDGILGGGIESMSITEVFGEFRCGKTQLSHTLCvtaqlpremgggngkvayidtegtfrpdriraiaerfgvdpda 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 141 ------------GEHQMELLDYVAAKFHEEagIFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYNVA 208
Cdd:TIGR02238 161 vldnilyaraytSEHQMELLDYLAAKFSEE--PFRLLIVDSIMALFRVDFSGRGELSERQQKLAQMLSRLNKISEEFNVA 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217338756 209 VFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDRLSEREQKASVK 274
Cdd:TIGR02238 239 VFVTNQVQADPGATMTFIADPKKPIGGHVLAHASTTRILLRKGRGEERVAKLYDSPDMPEAEASFQ 304
|
|
| PTZ00035 |
PTZ00035 |
Rad51 protein; Provisional |
15-262 |
1.13e-138 |
|
Rad51 protein; Provisional
Pssm-ID: 185407 [Multi-domain] Cd Length: 337 Bit Score: 395.14 E-value: 1.13e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 15 DEEESLFQDIDLLQKHGINVADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVDKIKEAANKLIEPGFLTAFEYSEK 94
Cdd:PTZ00035 14 EEEAEGFQEIEKLQSAGINAADIKKLKEAGICTVESVAYATKKDLCNIKGISEAKVEKIKEAASKLVPMGFISATEYLEA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 95 RKMVFHITTGSQEFDKLLGGGIESMAITEAFGEFRTGKTQLSHTLC---------------------------------- 140
Cdd:PTZ00035 94 RKNIIRITTGSTQLDKLLGGGIETGSITELFGEFRTGKTQLCHTLCvtcqlpieqgggegkvlyidtegtfrperivqia 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 141 ---------------------GEHQMELLDYVAAKFHEEAgiFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQ 199
Cdd:PTZ00035 174 erfgldpedvldniayaraynHEHQMQLLSQAAAKMAEER--FALLIVDSATALFRVDYSGRGELAERQQHLGKFLRALQ 251
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217338756 200 KISEEYNVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYD 262
Cdd:PTZ00035 252 KLADEFNVAVVITNQVMADVDGASMFVADPKKPIGGHIIAHASTTRLSLRKGRGEQRICKIYD 314
|
|
| DMC1 |
cd19514 |
homologous-pairing protein DMC1; DMC1 has a central role in homologous recombination in ... |
101-272 |
9.28e-119 |
|
homologous-pairing protein DMC1; DMC1 has a central role in homologous recombination in meiosis. It assembles at the sites of programmed DNA double-strand breaks and carries out a search for allelic DNA sequences located on homologous chromatids. It forms octameric rings.
Pssm-ID: 410922 [Multi-domain] Cd Length: 236 Bit Score: 340.87 E-value: 9.28e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 101 ITTGSQEFDKLLGGGIESMAITEAFGEFRTGKTQLSHTLC---------------------------------------- 140
Cdd:cd19514 1 ISTGSTELDKLLGGGIESMSITEVFGEFRTGKTQLSHTLCvtaqlpgsmgggggkvayidtegtfrpdrirpiaerfgvd 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 141 ---------------GEHQMELLDYVAAKFHEEAgIFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEY 205
Cdd:cd19514 81 hdavldnilyaraytSEHQMELLDYVAAKFHEEA-VFRLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEY 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217338756 206 NVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDRLSEREQKAS 272
Cdd:cd19514 160 NVAVFITNQVTADPGAAMTFQADPKKPIGGHILAHASTTRISLRKGRGEERIAKIYDSPDLPENEAT 226
|
|
| PLN03187 |
PLN03187 |
meiotic recombination protein DMC1 homolog; Provisional |
15-272 |
6.67e-117 |
|
meiotic recombination protein DMC1 homolog; Provisional
Pssm-ID: 215620 [Multi-domain] Cd Length: 344 Bit Score: 340.22 E-value: 6.67e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 15 DEEESLFQDIDLLQKHGINVADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVDKIKEAANKLIEPGFLTAFEYSEK 94
Cdd:PLN03187 22 DEEEDLFESIDKLISQGINAGDVKKLQDAGIYTCNGLMMHTKKNLTGIKGLSEAKVDKICEAAEKLLNQGFITGSDALLK 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 95 RKMVFHITTGSQEFDKLLGGGIESMAITEAFGEFRTGKTQLSHTLC---------------------------------- 140
Cdd:PLN03187 102 RKSVVRITTGSQALDELLGGGIETRCITEAFGEFRSGKTQLAHTLCvttqlptemgggngkvayidtegtfrpdrivpia 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 141 ---------------------GEHQMELLDYVAAKFHEEAgiFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQ 199
Cdd:PLN03187 182 erfgmdadavldniiyaraytYEHQYNLLLGLAAKMAEEP--FRLLIVDSVIALFRVDFTGRGELAERQQKLAQMLSRLT 259
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217338756 200 KISEEYNVAVFVTNQMTADPGAtMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDRLSEREQKAS 272
Cdd:PLN03187 260 KIAEEFNVAVYMTNQVIADPGG-GMFISDPKKPAGGHVLAHAATIRLMLRKGKGEQRVCKVFDAPNLPEAEAE 331
|
|
| recomb_RAD51 |
TIGR02239 |
DNA repair protein RAD51; This eukaryotic sequence family consists of RAD51, a protein ... |
24-281 |
4.95e-102 |
|
DNA repair protein RAD51; This eukaryotic sequence family consists of RAD51, a protein involved in DNA homologous recombination and repair. It is similar in sequence the exclusively meiotic recombinase DMC1 (TIGR02238), to archaeal families RadA (TIGR02236) and RadB (TIGR02237), and to bacterial RecA (TIGR02012).
Pssm-ID: 274048 [Multi-domain] Cd Length: 316 Bit Score: 301.64 E-value: 4.95e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 24 IDLLQKHGINVADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVDKIKEAANKLIEPGFLTAFEYSEKRKMVFHITT 103
Cdd:TIGR02239 1 IEKLEGNGITAADIKKLQEAGLHTVESVAYAPKKQLLEIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRQEVIQLTT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 104 GSQEFDKLLGGGIESMAITEAFGEFRTGKTQLSHTLC-----------GE------------------------------ 142
Cdd:TIGR02239 81 GSKELDKLLGGGIETGSITEIFGEFRTGKTQLCHTLAvtcqlpidqggGEgkalyidtegtfrperllaiaeryglnped 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 143 --------------HQMELLDYVAAKFHEEAgiFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYNVA 208
Cdd:TIGR02239 161 vldnvayarayntdHQLQLLQQAAAMMSESR--FALLIVDSATALYRTDFSGRGELSARQMHLARFLRSLQRLADEFGVA 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217338756 209 VFVTNQMTADP-GATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDR--LSEREQKASVKT--IKDPEE 281
Cdd:TIGR02239 239 VVITNQVVAQVdGAGSMFAGDPKKPIGGNIMAHASTTRLSLRKGRGEQRICKIYDSpcLPESEAMFAIYEdgIGDPKE 316
|
|
| PLN03186 |
PLN03186 |
DNA repair protein RAD51 homolog; Provisional |
1-275 |
1.31e-99 |
|
DNA repair protein RAD51 homolog; Provisional
Pssm-ID: 178728 [Multi-domain] Cd Length: 342 Bit Score: 296.26 E-value: 1.31e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 1 MKEDQVVAEEPGFQDEEESL-FQDIDLLQKHGINVADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVDKIKEAANK 79
Cdd:PLN03186 4 AVAAAAAQAMQEEEEEEAAHgPFPIEQLQASGIAALDIKKLKDAGIHTVESLAYAPKKDLLQIKGISEAKVEKILEAASK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 80 LIEPGFLTAFEYSEKRKMVFHITTGSQEFDKLLGGGIESMAITEAFGEFRTGKTQLSHTLC------------------- 140
Cdd:PLN03186 84 LVPLGFTTASQLHAQRQEIIQITTGSRELDKILEGGIETGSITEIYGEFRTGKTQLCHTLCvtcqlpldqgggegkamyi 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 141 ------------------------------------GEHQMELLDYVAAKFHEEAgiFKLLIIDSIMALFRVDFSGRGEL 184
Cdd:PLN03186 164 dtegtfrpqrliqiaerfglngadvlenvayaraynTDHQSELLLEAASMMAETR--FALMIVDSATALYRTEFSGRGEL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 185 AERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGAtMTFQADPK-KPIGGHILAHASTTRISLRKGRGELRIAKIYDR 263
Cdd:PLN03186 242 SARQMHLGKFLRSLQRLADEFGVAVVITNQVVAQVDG-SAFFAGPQlKPIGGNIMAHASTTRLALRKGRGENRICKVISS 320
|
330
....*....|....
gi 2217338756 264 --LSEREQKASVKT 275
Cdd:PLN03186 321 pcLPEAEARFSISS 334
|
|
| Rad51 |
pfam08423 |
Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ... |
84-268 |
6.67e-97 |
|
Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ATPase RecA protein.
Pssm-ID: 462471 [Multi-domain] Cd Length: 255 Bit Score: 286.12 E-value: 6.67e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 84 GFLTAFEYSEKRKMVFHITTGSQEFDKLLGGGIESMAITEAFGEFRTGKTQLSHTLC----------------------- 140
Cdd:pfam08423 2 GFTTATELHQRRSELIQITTGSKELDKLLGGGIETGSITEIFGEFRTGKTQLCHTLCvtcqlplemgggegkalyidteg 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 141 --------------------------------GEHQMELLDYVAAKFHEEAgiFKLLIIDSIMALFRVDFSGRGELAERQ 188
Cdd:pfam08423 82 tfrperlvaiaerygldpedvldnvayaraynSEHQMQLLQQAAAMMSESR--FALLIVDSATALYRTDFSGRGELAERQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 189 QKLAQMLSRLQKISEEYNVAVFVTNQMTADP-GATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDR--LS 265
Cdd:pfam08423 160 QHLAKFLRTLQRLADEFGVAVVITNQVVAQVdGAAGMFSGDPKKPIGGHIMAHASTTRLSLRKGRGEQRICKIYDSpcLP 239
|
...
gi 2217338756 266 ERE 268
Cdd:pfam08423 240 ESE 242
|
|
| Rad51_DMC1_archRadA |
cd01123 |
recombinase Rad51, DMC1, and archaeal RadA; This group of recombinases includes the eukaryotic ... |
101-262 |
1.14e-94 |
|
recombinase Rad51, DMC1, and archaeal RadA; This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal protein RadA. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a similar recombination reaction as RecA, using ATP-dependent DNA binding activity and a DNA-dependent ATPase. However, this reaction is less efficient and requires accessory proteins such as RAD55/57 .
Pssm-ID: 410868 [Multi-domain] Cd Length: 234 Bit Score: 279.80 E-value: 1.14e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 101 ITTGSQEFDKLLGGGIESMAITEAFGEFRTGKTQLSHTLC---------------------------------------- 140
Cdd:cd01123 1 ITTGSKELDKLLGGGIETGSITEMFGEFRTGKTQLCHTLAvtcqlpidrgggegkaiyidtegtfrperlraiaqrfgld 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 141 ---------------GEHQMELLDYVAAKFHEEagIFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEY 205
Cdd:cd01123 81 pddvldnvayarafnSDHQTQLLDQAAAMMVES--RFKLLIVDSATALYRTDYSGRGELSARQMHLAKFLRMLQRLADEF 158
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 2217338756 206 NVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYD 262
Cdd:cd01123 159 GVAVVVTNQVVAQVDGAMMFAADPKKPIGGNILAHASTTRLYLRKGRGETRICKIYD 215
|
|
| Rad51 |
cd19513 |
RAD51D recombinase; RAD51 recombinase plays an essential role in DNA repair by homologous ... |
101-268 |
2.47e-81 |
|
RAD51D recombinase; RAD51 recombinase plays an essential role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51 is recruited to the break site with the help of its paralogs, RAD51D, RAD51B, RAD51C, XRCC3, and XRCC2, where it forms long helical polymers which wrap around the ssDNA tail at the break which leads to pairing and strand invasion.
Pssm-ID: 410921 [Multi-domain] Cd Length: 235 Bit Score: 245.69 E-value: 2.47e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 101 ITTGSQEFDKLLGGGIESMAITEAFGEFRTGKTQLSHTLC-----------GE--------------------------- 142
Cdd:cd19513 1 ITTGSKELDKLLGGGIETGSITELFGEFRTGKTQLCHTLAvtcqlpidqggGEgkalyidtegtfrperllaiaerygln 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 143 -----------------HQMELLDYVAAKFHEEAgiFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEY 205
Cdd:cd19513 81 gedvldnvayarayntdHQMQLLIQASAMMAESR--YALLIVDSATALYRTDYSGRGELSARQMHLAKFLRMLQRLADEF 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217338756 206 NVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDR--LSERE 268
Cdd:cd19513 159 GVAVVITNQVVAQVDGAAMFAGDPKKPIGGNIMAHASTTRLYLRKGRGETRICKIYDSpcLPEAE 223
|
|
| radA |
PRK04301 |
DNA repair and recombination protein RadA; Validated |
23-279 |
2.13e-75 |
|
DNA repair and recombination protein RadA; Validated
Pssm-ID: 235273 [Multi-domain] Cd Length: 317 Bit Score: 233.62 E-value: 2.13e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 23 DIDLLQKHGINVADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVDKIKEAANKLIE-PGFLTAFEYSEKRKMVFHI 101
Cdd:PRK04301 5 EKDLEDLPGVGPATAEKLREAGYDTVEAIAVASPKELSEAAGIGESTAAKIIEAAREAADiGGFETALEVLERRKNVGKI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 102 TTGSQEFDKLLGGGIESMAITEAFGEFRTGKTQLSHTLC----------------------------------------- 140
Cdd:PRK04301 85 TTGSKELDELLGGGIETQSITEFYGEFGSGKTQICHQLAvnvqlpeekgglegkavyidtegtfrperieqmaealgldp 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 141 --------------GEHQMELLDYvAAKFHEEAGIFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYN 206
Cdd:PRK04301 165 devldnihvaraynSDHQMLLAEK-AEELIKEGENIKLVIVDSLTAHFRAEYVGRGNLAERQQKLNKHLHDLLRLADLYN 243
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217338756 207 VAVFVTNQMTADPGAtmtFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYD--RLSEREQKASVKT--IKDP 279
Cdd:PRK04301 244 AAVVVTNQVMARPDA---FFGDPTQPIGGHILGHTATFRIYLRKSKGNKRIARLVDspHLPEGEAVFRITEegIRDA 317
|
|
| recomb_radA |
TIGR02236 |
DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA ... |
31-262 |
4.78e-71 |
|
DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA protein, a homolog of bacterial RecA (TIGR02012), eukaryotic RAD51 (TIGR02239), and archaeal RadB (TIGR02237). This protein is involved in DNA repair and recombination. The member from Pyrococcus horikoshii contains an intein. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 131290 [Multi-domain] Cd Length: 310 Bit Score: 222.31 E-value: 4.78e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 31 GINVADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVDKIKEAANKLIEPG-FLTAFEYSEKRKMVFHITTGSQEFD 109
Cdd:TIGR02236 6 GVGPATAEKLREAGYDTFEAIAVASPKELSEIAGISEGTAAKIIQAARKAADLGgFETADDVLERRKTIGKITTGSKELD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 110 KLLGGGIESMAITEAFGEFRTGKTQLSHTLC------------------------------------------------- 140
Cdd:TIGR02236 86 ELLGGGIETQAITEVFGEFGSGKTQICHQLAvnvqlpeekgglggkavyidtentfrperimqmaeargldpdevlkniy 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 141 ------GEHQMELLDYVAAKFHEEAGIFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYNVAVFVTNQ 214
Cdd:TIGR02236 166 varaynSNHQMLLVEKAEDLIKELNNPVKLLIVDSLTSHFRAEYVGRGALAERQQKLNKHLHDLLRLADLYNAAVVVTNQ 245
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 2217338756 215 MTADPGAtmtFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYD 262
Cdd:TIGR02236 246 VMARPDA---FFGDPTRPIGGHILGHAATFRVYLRKGKGDKRIARLVD 290
|
|
| archRadA |
cd19515 |
archaeal recombinase Rad51/RadA; This group includes the archaeal protein RadA which is a ... |
101-268 |
2.83e-60 |
|
archaeal recombinase Rad51/RadA; This group includes the archaeal protein RadA which is a homolog of Rad51. RAD51 recombinase plays an essential role in DNA repair by homologous recombination (HR)
Pssm-ID: 410923 [Multi-domain] Cd Length: 233 Bit Score: 191.81 E-value: 2.83e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 101 ITTGSQEFDKLLGGGIESMAITEAFGEFRTGKTQLSHTLC---------------------------------------- 140
Cdd:cd19515 1 ISTGSKELDKLLGGGIETQAITEVFGEFGSGKTQLCHQLAvnvqlppeegglngkavyidtentfrperimqmakalgld 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 141 ---------------GEHQMELLDYVAAKFHEEAGIfKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEY 205
Cdd:cd19515 81 pdevldniyvaraynSNHQMLLVEKAEDLIKEGNNI-KLLIVDSLTSHFRAEYVGRGTLAERQQKLNKHLHDLHRLADLY 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217338756 206 NVAVFVTNQMTADPGAtmtFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYD--RLSERE 268
Cdd:cd19515 160 NIAVLVTNQVMAKPDA---FFGDPTQAIGGHILGHAATFRVYLRKGKGGKRIARLVDspHLPEGE 221
|
|
| radB |
PRK09361 |
DNA repair and recombination protein RadB; Provisional |
97-268 |
7.93e-24 |
|
DNA repair and recombination protein RadB; Provisional
Pssm-ID: 236482 [Multi-domain] Cd Length: 225 Bit Score: 96.85 E-value: 7.93e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 97 MVFHITTGSQEFDKLLGGGIESMAITEAFGEFRTGKTQLS---------------------------HTLCGEHQMELLD 149
Cdd:PRK09361 1 MDERLPTGCKMLDELLGGGFERGTITQIYGPPGSGKTNIClqlaveaakngkkviyidteglsperfKQIAGEDFEELLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 150 ----YVAAKFHEEAGI-----------FKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYNVAVFVTNQ 214
Cdd:PRK09361 81 niiiFEPSSFEEQSEAirkaeklakenVGLIVLDSATSLYRLELEDEEDNSKLNRELGRQLTHLLKLARKHDLAVVITNQ 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 2217338756 215 MTADPGATMTfqadpkKPIGGHILAHASTTRISLRKGRGELRIAKIYDRLSERE 268
Cdd:PRK09361 161 VYSDIDSDGL------RPLGGHTLEHWSKTILRLEKFRNGKRRATLEKHRSRPE 208
|
|
| RecA-like |
cd01393 |
RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA ... |
121-250 |
8.14e-24 |
|
RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange. While prokaryotes have a single RecA protein, eukaryotes have multiple RecA homologs such as Rad51, DMC1 and Rad55/57. Archaea have the RecA-like homologs RadA and RadB.
Pssm-ID: 410881 [Multi-domain] Cd Length: 185 Bit Score: 95.88 E-value: 8.14e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 121 ITEAFGEFRTGKTQLSHTLC--------------GEHQM---ELLDYVAAKF-----------------------HEEAG 160
Cdd:cd01393 3 ITEIYGPPGSGKTQLALQLAanalllgggvvwidTEGAFppsRLVQILEASPsselelaealsrllyfrppdtlaHLLAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 161 I-----------FKLLIIDSIMALFRVDF----SGRGELAERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGAtmTF 225
Cdd:cd01393 83 DslpeslfpppnTSLVVVDSVSALFRKAFprggDGDSSSSLRARLLSQLARALQKLAAQFNLAVVVTNQVTTKIRG--GS 160
|
170 180
....*....|....*....|....*
gi 2217338756 226 QADPKKPIGGHILAHASTTRISLRK 250
Cdd:cd01393 161 GASLVPPALGNTWEHSVSTRLLLYR 185
|
|
| archRadB |
cd01394 |
archaeal RadB; The archaeal protein RadB shares similarity RadA, the archaeal functional ... |
101-260 |
1.45e-22 |
|
archaeal RadB; The archaeal protein RadB shares similarity RadA, the archaeal functional homologue to the bacterial RecA. The precise function of RadB is unclear.
Pssm-ID: 410882 [Multi-domain] Cd Length: 216 Bit Score: 93.15 E-value: 1.45e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 101 ITTGSQEFDKLLGGGIESMAITEAFGEFRTGKTQLSHTL---------------------------CGEHQMELLDYV-- 151
Cdd:cd01394 1 LSTGSKSLDSLLGGGVERGTITQIYGPPGSGKTNICLQLaveaakqgkkvvyidteglsperfqqiAGERFESIASNIiv 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 152 --AAKFHEEA------------GIFKLLIIDSIMALFRVDfsgRGELAERQQKLAQMLSRLQKISEEYNVAVFVTNQMTA 217
Cdd:cd01394 81 fePYSFDEQGvaiqeaekllksDKVDLVVVDSATALYRLE---LGDDSEANRELSRQMSKLLSIARKYDIPVVITNQVYS 157
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 2217338756 218 DpgatmtFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKI 260
Cdd:cd01394 158 D------IDDDRLKPVGGTLLEHWSKAIIRLEKSPPGLRRATL 194
|
|
| XRCC3 |
cd19491 |
XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells ... |
108-250 |
3.85e-20 |
|
XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells 3) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC3, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC2, helps recruit RAD51 to the break site.
Pssm-ID: 410899 [Multi-domain] Cd Length: 250 Bit Score: 87.35 E-value: 3.85e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 108 FDKLLGGGIESMAITEAFGEFRTGKT----------QLSHTLCGE------------------HQM----ELLDYVAAKF 155
Cdd:cd19491 1 LDELLGGGIPVGGITEIAGESGAGKTqlclqlaltvQLPRELGGLgggavyictessfpskrlQQLasslPKRYHLEKAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 156 HEEAGIF---------------------------KLLIIDSIMALFRVDF-SGRGELAERQQKLAQMLSRLQKISEEYNV 207
Cdd:cd19491 81 NFLDNIFvehvadletlehclnyqlpallergpiRLVVIDSIAALFRSEFdTSRSDLVERAKYLRRLADHLKRLADKYNL 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217338756 208 AVFVTNQMTADPGA---------------TMTFQADP----KKPIGGHILAHASTTRISLRK 250
Cdd:cd19491 161 AVVVVNQVTDRFDSssdasglgvldylsqFSSFSGGVsgnrKVPALGLTWANLVNTRLMLSR 222
|
|
| Rad51B |
cd19493 |
RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair ... |
109-259 |
9.12e-20 |
|
RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51B, together with the other RAD51 paralogs, RAD51C, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site.
Pssm-ID: 410901 [Multi-domain] Cd Length: 222 Bit Score: 85.83 E-value: 9.12e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 109 DKLLGGGIESMAITEAFGEFRTGKTQLSHTLCGEHQME-----------------------LLDYVAAKFHEEAGIF--- 162
Cdd:cd19493 1 DTALAGGLPLGAITEITGASGSGKTQFALTLASSAAMParkggldggvlyidteskfsaerLAEIAEARFPEAFSGFmee 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 163 --------------------------------------KLLIIDSIMALFRVDFSG-RGELAERQQKLAQMLSRLQKISE 203
Cdd:cd19493 81 neraeemlkrvavvrvttlaqllerlpnleehilssgvRLVVIDSIAALVRREFGGsDGEVTERHNALAREASSLKRLAE 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 204 EYNVAVFVTNQMTADPGATMTFQADPKKPIgGHILAHASTTRISLRKGRGELR----IAK 259
Cdd:cd19493 161 EFRIAVLVTNQATTHFGDAGDGSSGVTAAL-GDAWAHAVNTRLRLERCLLQLRrvleIVK 219
|
|
| recomb_radB |
TIGR02237 |
DNA repair and recombination protein RadB; This family consists exclusively of archaeal RadB ... |
109-257 |
9.53e-16 |
|
DNA repair and recombination protein RadB; This family consists exclusively of archaeal RadB protein, a homolog of bacterial RecA (TIGR02012), eukaryotic RAD51 (TIGR02239) and DMC1 (TIGR02238), and archaeal RadA (TIGR02236).
Pssm-ID: 274047 [Multi-domain] Cd Length: 209 Bit Score: 74.37 E-value: 9.53e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 109 DKLLGGGIESMAITEAFGEFRTGKTQLSHTL---------------------------CGEHQMELLD----YVAAKFHE 157
Cdd:TIGR02237 2 DELLGGGVERGTITQIYGPPGSGKTNICMILavnaarqgkkvvyidteglsperfkqiAEDRPERALSnfivFEVFDFDE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 158 EAGI------------FKLLIIDSIMALFRVDFSGRGELAERQqkLAQMLSRLQKISEEYNVAVFVTNQMTADPGatmtf 225
Cdd:TIGR02237 82 QGVAiqktskfidrdsASLVVVDSFTALYRLELSDDRISRNRE--LARQLTLLLSLARKKNLAVVITNQVYTDVN----- 154
|
170 180 190
....*....|....*....|....*....|..
gi 2217338756 226 qADPKKPIGGHILAHASTTRISLRKGRGELRI 257
Cdd:TIGR02237 155 -NGTLRPLGGHLLEHWSKVILRLEKFRGRRLA 185
|
|
| Rad51C |
cd19492 |
RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair ... |
121-261 |
1.10e-13 |
|
RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51C, together with the other RAD51 paralogs, RAD51B, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site. Additionally, RAD51C acts as a mediator in the early steps of DNA damage signaling.
Pssm-ID: 410900 [Multi-domain] Cd Length: 172 Bit Score: 67.63 E-value: 1.10e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 121 ITEAFGEFRTGKTQLSHTLC-------------GE---------------------HQMELLDYVAAKFHEEAGIfKLLI 166
Cdd:cd19492 3 ITEICGVPGVGKTQLCMQLAvnvqipkcfgglaGEaiyidtegsfnihyfrvhdyvELLALINSLPKFLEDHPKV-KLIV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 167 IDSIMALFRVDFSGrgeLAERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGATMTFQAdpkKPIGGHILAHASTTRI 246
Cdd:cd19492 82 VDSIAFPFRHDFDD---LAQRTRLLNGLAQLLHSLARQHNLAVVLTNQVTTKISEDGQSQL---VPALGESWSHACTTRL 155
|
170
....*....|....*
gi 2217338756 247 SLRKGRGElRIAKIY 261
Cdd:cd19492 156 FLTWDEKQ-RFAHLY 169
|
|
| RecA |
COG0468 |
RecA/RadA recombinase [Replication, recombination and repair]; |
71-251 |
5.89e-13 |
|
RecA/RadA recombinase [Replication, recombination and repair];
Pssm-ID: 440236 [Multi-domain] Cd Length: 351 Bit Score: 68.27 E-value: 5.89e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 71 DKIKEAANKLIEPGFL--TAFEYSEKRKM-VFHITTGSQEFDKLLG-GGIESMAITEAFGEFRTGKTQLSHTLC------ 140
Cdd:COG0468 11 EKALEAALSQIEKQFGkgSIMRLGDKARQdVEVISTGSLALDIALGvGGLPRGRIVEIYGPESSGKTTLALHAIaeaqka 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 141 -----------------------------------GEHQMELLDYVAakfheEAGIFKLLIIDSIMALF-RVDFSGR--- 181
Cdd:COG0468 91 ggiaafidaehaldpeyakklgvdidnllvsqpdtGEQALEIAETLV-----RSGAVDLIVVDSVAALVpKAEIEGEmgd 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 182 GELAERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGatMTFqADPKKPIGGHILAHASTTRISLRKG 251
Cdd:COG0468 166 SHVGLQARLMSQALRKLTGAISKSNTTVIFINQLREKIG--VMF-GNPETTTGGNALKFYASVRLDIRRI 232
|
|
| Rad51D |
cd19489 |
RAD51D recombinase; RAD51D recombinase, a RAD51 paralog, plays an important role in DNA repair ... |
113-250 |
4.80e-07 |
|
RAD51D recombinase; RAD51D recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51D, together with the other RAD51 paralogs, RAD51B, RAD51C, XRCC3, and XRCC2, helps recruit RAD51 to the break site.
Pssm-ID: 410897 [Multi-domain] Cd Length: 209 Bit Score: 49.56 E-value: 4.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 113 GGGIESMAITEAFGEFRTGKTQLSHT------------------------------LCGEHQ------------------ 144
Cdd:cd19489 1 GGGLRTGEITELVGESSSGKTQLCLTaaanvasrsgqnvlyidtkssfsarrlaqiLKSRAQdaeeidkalqrirvvrvf 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 145 -----MELLDYVAAKFHEE----AGIFKLLIIDSIMALFRVDFSGrgelAERQQKLAQM--LSR-LQKISEEYNVAVFVT 212
Cdd:cd19489 81 dpyelLDLLEELRNTLSQQqenlYSRLKLVIIDSLSALISPLLGG----SKHSEGHALLasLARlLKKLAAEYQIAVLVT 156
|
170 180 190
....*....|....*....|....*....|....*...
gi 2217338756 213 NQMTADPGatMTFQADPkKPIGGHILAHASTTRISLRK 250
Cdd:cd19489 157 NLTVRGGD--GGQQGST-KPALGEYWESVPSTRLLLSR 191
|
|
| HHH_5 |
pfam14520 |
Helix-hairpin-helix domain; |
25-79 |
5.76e-05 |
|
Helix-hairpin-helix domain;
Pssm-ID: 434010 [Multi-domain] Cd Length: 57 Bit Score: 40.16 E-value: 5.76e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 2217338756 25 DLLQKHGINVADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVDKIKEAANK 79
Cdd:pfam14520 3 ELLSISGIGPKTALALLSAGIGTVEDLAEADVDELAEIPGIGEKTAQRIILELRD 57
|
|
| XRCC2 |
cd19490 |
XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells ... |
164-250 |
1.66e-04 |
|
XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells 2) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC2, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC3, helps recruit RAD51 to the break site.
Pssm-ID: 410898 [Multi-domain] Cd Length: 226 Bit Score: 41.95 E-value: 1.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 164 LLIIDSIMALFRVDFSGRGELAERQQK----LAQMLSRLQKISEEYNVAVFVTNQM-----------TADPGATMTFQAD 228
Cdd:cd19490 125 LLLIDSISAFYWQDRFSAELARAAPLLqeaaLRAILRELRRLRRRFQLVVIATKQAlfpgksastdnPAANNAVSKASAP 204
|
90 100
....*....|....*....|..
gi 2217338756 229 PKKPIGGHILAHASTTRISLRK 250
Cdd:cd19490 205 SHREYLPRPWQRLVTHRLVLSR 226
|
|
| RecA-like_protease |
cd19481 |
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ... |
130-213 |
8.67e-03 |
|
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.
Pssm-ID: 410889 [Multi-domain] Cd Length: 158 Bit Score: 36.11 E-value: 8.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217338756 130 TGKTQLSHTLCGEHQMEL----LDYVAAKFHEEAG-----IFKL--------LIIDSIMALFRvDFSGRGELAERQQKLA 192
Cdd:cd19481 37 TGKTLLAKALAGELGLPLivvkLSSLLSKYVGESEknlrkIFERarrlapciLFIDEIDAIGR-KRDSSGESGELRRVLN 115
|
90 100
....*....|....*....|..
gi 2217338756 193 QMLSRLQKISEEYNVAVF-VTN 213
Cdd:cd19481 116 QLLTELDGVNSRSKVLVIaATN 137
|
|
| |
