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Conserved domains on  [gi|2217324359|ref|XP_047295750|]
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putative zinc finger protein 826 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
109-130 1.51e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 1.51e-05
                          10        20
                  ....*....|....*....|..
gi 2217324359 109 KHRRTHTGEKPYKCEECGKAFT 130
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFK 25
Zn-ribbon_8 super family cl00993
Zinc ribbon domain; This entry represents a region of about 41 amino acids found in a number ...
 120-155 2.96e-04

Zinc ribbon domain; This entry represents a region of about 41 amino acids found in a number of small proteins in a wide range of bacteria. The region usually begins with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One protein in this entry has been noted as a putative regulatory protein, designated FmdB. Most proteins in this entry have a C-terminal region containing highly degenerate sequence.


The actual alignment was detected with superfamily member TIGR02605:

Pssm-ID: 470024  Cd Length: 52  Bit Score: 37.32  E-value: 2.96e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2217324359 120 YKCEECGKAFTASSTLSEyktihtgEKPCKCEECGK 155
Cdd:TIGR02605   6 YRCTACGHRFEVLQKMSD-------DPLATCPACGG 34
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
109-130 1.51e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 1.51e-05
                          10        20
                  ....*....|....*....|..
gi 2217324359 109 KHRRTHTGEKPYKCEECGKAFT 130
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFK 25
CxxC_CxxC_SSSS TIGR02605
putative regulatory protein, FmdB family; This model represents a region of about 50 amino ...
 120-155 2.96e-04

putative regulatory protein, FmdB family; This model represents a region of about 50 amino acids found in a number of small proteins in a wide range of bacteria. The region begins usually with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One member of this family is has been noted as a putative regulatory protein, designated FmdB (SP:Q50229, ). Most members of this family have a C-terminal region containing highly degenerate sequence, such as SSTSESTKSSGSSGSSGSSESKASGSTEKSTSSTTAAAAV in Mycobacterium tuberculosis and VAVGGSAPAPSPAPRAGGGGGGCCGGGCCG in Streptomyces avermitilis. These low complexity regions, which are not included in the model, resemble low-complexity C-terminal regions of some heterocycle-containing bacteriocin precursors. [Regulatory functions, DNA interactions]


Pssm-ID: 274226  Cd Length: 52  Bit Score: 37.32  E-value: 2.96e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2217324359 120 YKCEECGKAFTASSTLSEyktihtgEKPCKCEECGK 155
Cdd:TIGR02605   6 YRCTACGHRFEVLQKMSD-------DPLATCPACGG 34
CxxC_CXXC_SSSS smart00834
Putative regulatory protein; CxxC_CXXC_SSSS represents a region of about 41 amino acids found ...
 120-154 1.34e-03

Putative regulatory protein; CxxC_CXXC_SSSS represents a region of about 41 amino acids found in a number of small proteins in a wide range of bacteria. The region usually begins with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One protein in this entry has been noted as a putative regulatory protein, designated FmdB. Most proteins in this entry have a C-terminal region containing highly degenerate sequence.


Pssm-ID: 197903  Cd Length: 41  Bit Score: 35.22  E-value: 1.34e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2217324359  120 YKCEECGKAFTASSTLSEyktihtgEKPCKCEECG 154
Cdd:smart00834   6 YRCEDCGHTFEVLQKISD-------DPLTTCPECG 33
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
109-130 1.51e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 1.51e-05
                          10        20
                  ....*....|....*....|..
gi 2217324359 109 KHRRTHTGEKPYKCEECGKAFT 130
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFK 25
CxxC_CxxC_SSSS TIGR02605
putative regulatory protein, FmdB family; This model represents a region of about 50 amino ...
 120-155 2.96e-04

putative regulatory protein, FmdB family; This model represents a region of about 50 amino acids found in a number of small proteins in a wide range of bacteria. The region begins usually with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One member of this family is has been noted as a putative regulatory protein, designated FmdB (SP:Q50229, ). Most members of this family have a C-terminal region containing highly degenerate sequence, such as SSTSESTKSSGSSGSSGSSESKASGSTEKSTSSTTAAAAV in Mycobacterium tuberculosis and VAVGGSAPAPSPAPRAGGGGGGCCGGGCCG in Streptomyces avermitilis. These low complexity regions, which are not included in the model, resemble low-complexity C-terminal regions of some heterocycle-containing bacteriocin precursors. [Regulatory functions, DNA interactions]


Pssm-ID: 274226  Cd Length: 52  Bit Score: 37.32  E-value: 2.96e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2217324359 120 YKCEECGKAFTASSTLSEyktihtgEKPCKCEECGK 155
Cdd:TIGR02605   6 YRCTACGHRFEVLQKMSD-------DPLATCPACGG 34
CxxC_CXXC_SSSS smart00834
Putative regulatory protein; CxxC_CXXC_SSSS represents a region of about 41 amino acids found ...
 120-154 1.34e-03

Putative regulatory protein; CxxC_CXXC_SSSS represents a region of about 41 amino acids found in a number of small proteins in a wide range of bacteria. The region usually begins with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One protein in this entry has been noted as a putative regulatory protein, designated FmdB. Most proteins in this entry have a C-terminal region containing highly degenerate sequence.


Pssm-ID: 197903  Cd Length: 41  Bit Score: 35.22  E-value: 1.34e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2217324359  120 YKCEECGKAFTASSTLSEyktihtgEKPCKCEECG 154
Cdd:smart00834   6 YRCEDCGHTFEVLQKISD-------DPLTTCPECG 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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