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Conserved domains on  [gi|2217319650|ref|XP_047294255|]
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zinc finger protein 600 isoform X3 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
272-679 8.43e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 8.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 272 KPYKCNECDKAFNQQSNLARHRRIHTGEKPYKC--EECDKVFSRKSTLESHKRIHTGEKPYKC-KVCDTAFTWNSQLARH 348
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 349 KRIHTGEKTYKCNECGKTFSHKSSLVCHHRLHGGEKSYKCKVCDKAFAW----NSHLVRHTRIHSGGKPYKCNECGKTFG 424
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsNSLHPPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 425 QNSDLLIHKSIHTGEQPYKYeecekvfscgSTLETHKIIHTGEKPYKCKVCDKAFACHSYLAKHTRIHSGEKPYKCNECS 504
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSI----------PSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 505 KTFRL--RSYLASHRRVHSGE-----KPYKCNECSKTFSQRSYLHCHRR--LHSGE--KPYKCNE--CGKTFSHKPSLVH 571
Cdd:COG5048   262 RSSLPtaSSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 572 HRRLHTGEKSYKC--TVCDKAFVRNSYLARHTRIH-----TAEKPYKC--NECGKAFNQQSQLSLHHRIHA--GEKLYKC 640
Cdd:COG5048   342 HILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLsfRPYNCKN 421

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 2217319650 641 ETCDKVFSRKSHLKRHRRIHPGKKPYKCKVCDKTFGSDS 679
Cdd:COG5048   422 PPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
85-456 1.21e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650  85 DQLGSSFYSHLPELHIIQIKGKIGNQFEKSTSDAPSV-STSQRISPRPQIHISNNYGNNSPNSSLLPqkqEVYMREKSFQ 163
Cdd:COG5048    77 LELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSsSNSNDNNLLSSHSLPPSSRDPQLPDLLSI---SNLRNNPLPG 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 164 CNESGKAFNCSSLLRkHQIPHlgdkqykcDVCGKLFNHKQYLTCHCRCHTGEKPYKCNECGKSFSQVSSLTCHRRLHTAV 243
Cdd:COG5048   154 NNSSSVNTPQSNSLH-PPLPA--------NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSS 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 244 KSHKCNECGKIFGQNSALVIHKAIHTGEKPYKCNECDKAFNQQSNLARHRRIHTGE-------KPYKCEECDKVFSRKST 316
Cdd:COG5048   225 SSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSP 304

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 317 LESHKR--IHTGE--KPYKCKV--CDTAFTWNSQLARHKRIHTGEKTYKC--NECGKTFSHKS------SLVCHHRLHGG 382
Cdd:COG5048   305 LTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppqSLQQYKDLKND 384

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217319650 383 EKSYKCKVCDKAFAWNSHLV---RHTRIHSGGKPYKCNECGKTFGQNSDLLIHKSIHTGEQPYKYEECEKVFSCGST 456
Cdd:COG5048   385 KKSETLSNSCIRNFKRDSNLslhIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
680-705 8.38e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.38e-03
                          10        20
                  ....*....|....*....|....*.
gi 2217319650 680 HLKQHTGLHTGEKPYKCNECGKAFSK 705
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
272-679 8.43e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 8.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 272 KPYKCNECDKAFNQQSNLARHRRIHTGEKPYKC--EECDKVFSRKSTLESHKRIHTGEKPYKC-KVCDTAFTWNSQLARH 348
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 349 KRIHTGEKTYKCNECGKTFSHKSSLVCHHRLHGGEKSYKCKVCDKAFAW----NSHLVRHTRIHSGGKPYKCNECGKTFG 424
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsNSLHPPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 425 QNSDLLIHKSIHTGEQPYKYeecekvfscgSTLETHKIIHTGEKPYKCKVCDKAFACHSYLAKHTRIHSGEKPYKCNECS 504
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSI----------PSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 505 KTFRL--RSYLASHRRVHSGE-----KPYKCNECSKTFSQRSYLHCHRR--LHSGE--KPYKCNE--CGKTFSHKPSLVH 571
Cdd:COG5048   262 RSSLPtaSSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 572 HRRLHTGEKSYKC--TVCDKAFVRNSYLARHTRIH-----TAEKPYKC--NECGKAFNQQSQLSLHHRIHA--GEKLYKC 640
Cdd:COG5048   342 HILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLsfRPYNCKN 421

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 2217319650 641 ETCDKVFSRKSHLKRHRRIHPGKKPYKCKVCDKTFGSDS 679
Cdd:COG5048   422 PPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
85-456 1.21e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650  85 DQLGSSFYSHLPELHIIQIKGKIGNQFEKSTSDAPSV-STSQRISPRPQIHISNNYGNNSPNSSLLPqkqEVYMREKSFQ 163
Cdd:COG5048    77 LELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSsSNSNDNNLLSSHSLPPSSRDPQLPDLLSI---SNLRNNPLPG 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 164 CNESGKAFNCSSLLRkHQIPHlgdkqykcDVCGKLFNHKQYLTCHCRCHTGEKPYKCNECGKSFSQVSSLTCHRRLHTAV 243
Cdd:COG5048   154 NNSSSVNTPQSNSLH-PPLPA--------NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSS 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 244 KSHKCNECGKIFGQNSALVIHKAIHTGEKPYKCNECDKAFNQQSNLARHRRIHTGE-------KPYKCEECDKVFSRKST 316
Cdd:COG5048   225 SSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSP 304

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 317 LESHKR--IHTGE--KPYKCKV--CDTAFTWNSQLARHKRIHTGEKTYKC--NECGKTFSHKS------SLVCHHRLHGG 382
Cdd:COG5048   305 LTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppqSLQQYKDLKND 384

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217319650 383 EKSYKCKVCDKAFAWNSHLV---RHTRIHSGGKPYKCNECGKTFGQNSDLLIHKSIHTGEQPYKYEECEKVFSCGST 456
Cdd:COG5048   385 KKSETLSNSCIRNFKRDSNLslhIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
288-313 4.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.40e-04
                          10        20
                  ....*....|....*....|....*.
gi 2217319650 288 NLARHRRIHTGEKPYKCEECDKVFSR 313
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
208-229 7.23e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.23e-03
                          10        20
                  ....*....|....*....|..
gi 2217319650 208 HCRCHTGEKPYKCNECGKSFSQ 229
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
680-705 8.38e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.38e-03
                          10        20
                  ....*....|....*....|....*.
gi 2217319650 680 HLKQHTGLHTGEKPYKCNECGKAFSK 705
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
272-679 8.43e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 8.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 272 KPYKCNECDKAFNQQSNLARHRRIHTGEKPYKC--EECDKVFSRKSTLESHKRIHTGEKPYKC-KVCDTAFTWNSQLARH 348
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 349 KRIHTGEKTYKCNECGKTFSHKSSLVCHHRLHGGEKSYKCKVCDKAFAW----NSHLVRHTRIHSGGKPYKCNECGKTFG 424
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsNSLHPPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 425 QNSDLLIHKSIHTGEQPYKYeecekvfscgSTLETHKIIHTGEKPYKCKVCDKAFACHSYLAKHTRIHSGEKPYKCNECS 504
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSI----------PSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 505 KTFRL--RSYLASHRRVHSGE-----KPYKCNECSKTFSQRSYLHCHRR--LHSGE--KPYKCNE--CGKTFSHKPSLVH 571
Cdd:COG5048   262 RSSLPtaSSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 572 HRRLHTGEKSYKC--TVCDKAFVRNSYLARHTRIH-----TAEKPYKC--NECGKAFNQQSQLSLHHRIHA--GEKLYKC 640
Cdd:COG5048   342 HILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLsfRPYNCKN 421

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 2217319650 641 ETCDKVFSRKSHLKRHRRIHPGKKPYKCKVCDKTFGSDS 679
Cdd:COG5048   422 PPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
244-630 1.01e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 1.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 244 KSHKCNECGKIFGQNSALVIHKAIHTGEKPYKCN--ECDKAFNQQSNLARHRRIHTGEKPYkcEECDKVFSRKSTLESHK 321
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 322 RIHTG------EKPYKCKVCDTAFTWNSQLARHKRIHTGEKTYKCN-------------------ECGKTFSHKSSLVCH 376
Cdd:COG5048   110 LSSSSsnsndnNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNsssvntpqsnslhpplpanSLSKDPSSNLSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 377 HRLHGGEKSYKCKVCDKAFAWNSHLVRHTRIHSGGKPYKCNECGKTFGQNSDLLIHKSIHTGEQPYKYEECEKVFSCGST 456
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 457 LETHKIIHTGE-------KPYKCKVCDKAFACHSYLAKHTR--IHSGE--KPYKCNE--CSKTFRLRSYLASHRRVHSGE 523
Cdd:COG5048   270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 524 KPYKC--NECSKTFSQRS--YLHCHRRLHSGEKPYKCNECGKTFSHKPSLV-HHRRLHT------GEKSYKCTVCDKAFV 592
Cdd:COG5048   350 SPAKEklLNSSSKFSPLLnnEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRdSNLSLHIithlsfRPYNCKNPPCSKSFN 429

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 2217319650 593 RNSYLARHTRIHTAEKPYkCNECGKAFNQQSQLSLHHR 630
Cdd:COG5048   430 RHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
187-577 1.34e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 1.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 187 DKQYKCDVCGKLFNHKQYLTCHCRCHTGEKPYKCN--ECGKSFSQVSSLTCHRRLHTAVKSHKCN-ECGKIFGQNSALVI 263
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 264 HKAIHTGEKPYKCNECDKAFNQQSNLARHRRIHTgeKPYKCEECDKVFSRKSTLESHKRIHTGEKPYKCKvcdtAFTWNS 343
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS--NLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSK----DPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 344 QLARHKRIHTGEKTYKCNECGKTFSHKSSLVCHHRLHGGEKSYKCKVCDKAF------AWNSHLVRHTRIHSGGKPYKCN 417
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 418 ECGKTFGQNSDLLIHKSIHTG-EQPYKYEECEKVFSCGSTLETHK--IIHTGE--KPYKCKV--CDKAFACHSYLAKHTR 490
Cdd:COG5048   265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 491 IHSGEKPYKC--NECSKTFR--LRSYLASHRRVHSGEKPYKCNECS-----KTFSQRSYLHCHRRLHSGEKP--YKCNEC 559
Cdd:COG5048   345 LHTSISPAKEklLNSSSKFSplLNNEPPQSLQQYKDLKNDKKSETLsnsciRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                         410
                  ....*....|....*...
gi 2217319650 560 GKTFSHKPSLVHHRRLHT 577
Cdd:COG5048   425 SKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
113-516 1.37e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 1.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 113 KSTSDAPSVSTSQRISPRPQIHiSNNYGNNSPNSSLLPQKQEvymreKSFQCNESGKAFNCSSL--LRKHQIPHLGDKQY 190
Cdd:COG5048    19 TPKSTLKSLSNAPRPDSCPNCT-DSFSRLEHLTRHIRSHTGE-----KPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSD 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 191 KCDvcgKLFNHKQYLTCHCR----CHTGEKPYKCNECGKSFSQVSSLTCHRRLHTAVKSHKCNECGKIFGQ--------- 257
Cdd:COG5048    93 LNS---KSLPLSNSKASSSSlsssSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsnslhp 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 258 -------------NSALVIHKAIHTGEKPYKCNECDKAFNQQSNLARHRRIHTGEKPYKCEECDKVFSRKSTLESHKRIH 324
Cdd:COG5048   170 plpanslskdpssNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLS 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 325 TGEKPYKCKVCDTAFTWNSQLARHKRIHTGEKT-------YKCNECGKTFSHKSSLVCH--HRLHGGE--KSYKCKV--C 391
Cdd:COG5048   250 SSDSSSSASESPRSSLPTASSQSSSPNESDSSSekgfslpIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslC 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 392 DKAFAWNSHLVRHTRIHSGGKPYKC--NECGKTFGQNSD------LLIHKSIHTGEQPYK-YEECEKVFSCGSTLETHKI 462
Cdd:COG5048   330 GKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqsLQQYKDLKNDKKSETlSNSCIRNFKRDSNLSLHII 409

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217319650 463 IHTGEKP--YKCKVCDKAFACHSYLAKHTRIHSgEKPYKCNECSKTFRLRSYLASH 516
Cdd:COG5048   410 THLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
328-716 2.42e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 2.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 328 KPYKCKVCDTAFTWNSQLARHKRIHTGEKTYKCN--ECGKTFSHKSSLVCHHRLHGGEKSYKCkvCDKAFAWNSHLVRHT 405
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 406 RIHSGGKPYKCN-ECGKTFGQNSdllIHKSIHTGEQPYKYEECEKV---FSCGSTLETHKIIHTGEKPYKCKVCDKAFAC 481
Cdd:COG5048   110 LSSSSSNSNDNNlLSSHSLPPSS---RDPQLPDLLSISNLRNNPLPgnnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 482 HSylakHTRIHSGEKPYKCNECSKTFRLRSYLASHRRVHSGEKPYKCNECSKTFSQRSYLHCHRRLHSGEKPYKCNECG- 560
Cdd:COG5048   187 LI----SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPr 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 561 ----------KTFSHKPSLVHHRRLhtgeKSYKCTVCDKAFVRNSYLARHTR--IHTAE--KPYKCNE--CGKAFNQQSQ 624
Cdd:COG5048   263 sslptassqsSSPNESDSSSEKGFS----LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDA 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 625 LSLHHRIHAGEKLYKC--ETCDKVFSRKSHLKRH--RRIHPGKKPYKCKVCD-----KTFGSDSHLKQHTGLHTGEKP-- 693
Cdd:COG5048   339 LKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPqsLQQYKDLKNDKKSETLsnsciRNFKRDSNLSLHIITHLSFRPyn 418

                         410       420
                  ....*....|....*....|...
gi 2217319650 694 YKCNECGKAFSKQSTLIHHQAVH 716
Cdd:COG5048   419 CKNPPCSKSFNRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
272-434 1.81e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 272 KPYKCNECDKAFNQQSNLARHRR--IHTGE--KPYKCEE--CDKVFSRKSTLESHKRIHTGEKPYKCKVCDT-------A 338
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSsskfsplL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 339 FTWNSQLARHKRIHTGEKTYKC--NECGKTFSHKSSLVCHHRLH--GGEKSYKCKVCDKAFAWNSHLVRHTRIHSGGKPY 414
Cdd:COG5048   368 NNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHlsFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170       180
                  ....*....|....*....|
gi 2217319650 415 KCNECGKTFGQNSDLLIHKS 434
Cdd:COG5048   448 LCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
85-456 1.21e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650  85 DQLGSSFYSHLPELHIIQIKGKIGNQFEKSTSDAPSV-STSQRISPRPQIHISNNYGNNSPNSSLLPqkqEVYMREKSFQ 163
Cdd:COG5048    77 LELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSsSNSNDNNLLSSHSLPPSSRDPQLPDLLSI---SNLRNNPLPG 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 164 CNESGKAFNCSSLLRkHQIPHlgdkqykcDVCGKLFNHKQYLTCHCRCHTGEKPYKCNECGKSFSQVSSLTCHRRLHTAV 243
Cdd:COG5048   154 NNSSSVNTPQSNSLH-PPLPA--------NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSS 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 244 KSHKCNECGKIFGQNSALVIHKAIHTGEKPYKCNECDKAFNQQSNLARHRRIHTGE-------KPYKCEECDKVFSRKST 316
Cdd:COG5048   225 SSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSP 304

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 317 LESHKR--IHTGE--KPYKCKV--CDTAFTWNSQLARHKRIHTGEKTYKC--NECGKTFSHKS------SLVCHHRLHGG 382
Cdd:COG5048   305 LTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppqSLQQYKDLKND 384

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217319650 383 EKSYKCKVCDKAFAWNSHLV---RHTRIHSGGKPYKCNECGKTFGQNSDLLIHKSIHTGEQPYKYEECEKVFSCGST 456
Cdd:COG5048   385 KKSETLSNSCIRNFKRDSNLslhIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
288-313 4.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.40e-04
                          10        20
                  ....*....|....*....|....*.
gi 2217319650 288 NLARHRRIHTGEKPYKCEECDKVFSR 313
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 270-349 5.45e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 5.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 270 GEKPYKCN--ECDKAFNQQSNLARHRrIHTGEKPYKCEECDKvfsrkstlESHKRIHTGEKPYKCKVCDTAFTWNSQLAR 347
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM-LHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 2217319650 348 HK 349
Cdd:COG5189   417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 607-686 1.04e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 607 EKPYKCN--ECGKAFNQQSQLSlHHRIHAGEKLYKCETCDKVfsrkshlkRHRRIHPGKKPYKCKVCDKTFGSDSHLKQH 684
Cdd:COG5189   347 GKPYKCPveGCNKKYKNQNGLK-YHMLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417


                  ..
gi 2217319650 685 TG 686
Cdd:COG5189   418 RK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
596-621 1.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.66e-03
                          10        20
                  ....*....|....*....|....*.
gi 2217319650 596 YLARHTRIHTAEKPYKCNECGKAFNQ 621
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
652-675 1.92e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.92e-03
                          10        20
                  ....*....|....*....|....
gi 2217319650 652 HLKRHRRIHPGKKPYKCKVCDKTF 675
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
457-481 2.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.31e-03
                          10        20
                  ....*....|....*....|....*
gi 2217319650 457 LETHKIIHTGEKPYKCKVCDKAFAC 481
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
345-369 2.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.53e-03
                          10        20
                  ....*....|....*....|....*
gi 2217319650 345 LARHKRIHTGEKTYKCNECGKTFSH 369
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 410-493 3.60e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 3.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 410 GGKPYKCN--ECGKTFGQNSDLLIHKsihtgeqpyKYEECEKVFSCGSTLETHKIIHTGEKPYKCKVCDKAFACHSYLAK 487
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 2217319650 488 HtRIHS 493
Cdd:COG5189   417 H-RKHS 421
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 638-660 4.03e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 4.03e-03
                          10        20
                  ....*....|....*....|...
gi 2217319650 638 YKCETCDKVFSRKSHLKRHRRIH 660
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
260-285 4.74e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.74e-03
                          10        20
                  ....*....|....*....|....*.
gi 2217319650 260 ALVIHKAIHTGEKPYKCNECDKAFNQ 285
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 214-293 6.00e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 6.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 214 GEKPYKCN--ECGKSFSQVSSLTCHRrLHtavkshkcNECGKIFGQNSALVIHKAIHTGEKPYKCNECDKAFNQQSNLAR 291
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM-LH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 2217319650 292 HR 293
Cdd:COG5189   417 HR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
606-665 6.61e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 6.61e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217319650 606 AEKPYKCNECGKAFNQQSQLSLHHRIHAGEKLYKC--ETCDKVFSRKSHLKRHRRIHPGKKP 665
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPS 91
zf-H2C2_2 pfam13465
Zinc-finger double domain;
208-229 7.23e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.23e-03
                          10        20
                  ....*....|....*....|..
gi 2217319650 208 HCRCHTGEKPYKCNECGKSFSQ 229
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
680-705 8.38e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.38e-03
                          10        20
                  ....*....|....*....|....*.
gi 2217319650 680 HLKQHTGLHTGEKPYKCNECGKAFSK 705
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 515-600 9.90e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 9.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217319650 515 SHRRVHSGEKPYKCN--ECSKTFSQRSYLHCHRrLHSgekpykcnECGKTFSHKPSLVHHRRLHTGEKSYKCTVCDKAFV 592
Cdd:COG5189   339 SRMLKVKDGKPYKCPveGCNKKYKNQNGLKYHM-LHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYK 409


                  ....*...
gi 2217319650 593 RNSYLARH 600
Cdd:COG5189   410 NLNGLKYH 417
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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