chitinase domain-containing protein 1 isoform X11 [Homo sapiens]
Protein Classification
glycoside hydrolase family 18 protein( domain architecture ID 248)
glycoside hydrolase family 18 protein such as chitinase, which catalyzes the random endo-hydrolysis of the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| GH18_chitinase-like super family | cl10447 | The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant ... |
77-288 | 1.30e-115 | |||||
The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have been identified in viruses, bacteria, fungi, protozoan parasites, insects, and plants. The structure of the GH18 domain is an eight-stranded beta/alpha barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel. The GH18 family includes chitotriosidase, chitobiase, hevamine, zymocin-alpha, narbonin, SI-CLP (stabilin-1 interacting chitinase-like protein), IDGF (imaginal disc growth factor), CFLE (cortical fragment-lytic enzyme) spore hydrolase, the type III and type V plant chitinases, the endo-beta-N-acetylglucosaminidases, and the chitolectins. The GH85 (glycosyl hydrolase, family 85) ENGases (endo-beta-N-acetylglucosaminidases) are closely related to the GH18 chitinases and are included in this alignment model. The actual alignment was detected with superfamily member cd02876: Pssm-ID: 471972 [Multi-domain] Cd Length: 318 Bit Score: 335.43 E-value: 1.30e-115
|
|||||||||
| Name | Accession | Description | Interval | E-value | |||||
| GH18_SI-CLP | cd02876 | Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein ... |
77-288 | 1.30e-115 | |||||
Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl hydrolase family 18 (GH18) domain but lacks a chitin-binding domain. The catalytic amino acids of the GH18 domain are not conserved in SI-CLP, similar to the chitolectins YKL-39, YKL-40, and YM1/2. Human SI-CLP is sorted to late endosomes and secretory lysosomes in alternatively activated macrophages. Pssm-ID: 119355 [Multi-domain] Cd Length: 318 Bit Score: 335.43 E-value: 1.30e-115
|
|||||||||
| Glyco_18 | smart00636 | Glyco_18 domain; |
81-281 | 2.19e-25 | |||||
Glyco_18 domain; Pssm-ID: 214753 [Multi-domain] Cd Length: 334 Bit Score: 103.14 E-value: 2.19e-25
|
|||||||||
| Glyco_hydro_18 | pfam00704 | Glycosyl hydrolases family 18; |
214-281 | 1.19e-05 | |||||
Glycosyl hydrolases family 18; Pssm-ID: 425828 [Multi-domain] Cd Length: 311 Bit Score: 45.91 E-value: 1.19e-05
|
|||||||||
| ChiA | COG3325 | Chitinase, GH18 family [Carbohydrate transport and metabolism]; |
214-272 | 7.04e-05 | |||||
Chitinase, GH18 family [Carbohydrate transport and metabolism]; Pssm-ID: 442554 [Multi-domain] Cd Length: 391 Bit Score: 43.75 E-value: 7.04e-05
|
|||||||||
| Name | Accession | Description | Interval | E-value | |||||
| GH18_SI-CLP | cd02876 | Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein ... |
77-288 | 1.30e-115 | |||||
Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl hydrolase family 18 (GH18) domain but lacks a chitin-binding domain. The catalytic amino acids of the GH18 domain are not conserved in SI-CLP, similar to the chitolectins YKL-39, YKL-40, and YM1/2. Human SI-CLP is sorted to late endosomes and secretory lysosomes in alternatively activated macrophages. Pssm-ID: 119355 [Multi-domain] Cd Length: 318 Bit Score: 335.43 E-value: 1.30e-115
|
|||||||||
| Glyco_18 | smart00636 | Glyco_18 domain; |
81-281 | 2.19e-25 | |||||
Glyco_18 domain; Pssm-ID: 214753 [Multi-domain] Cd Length: 334 Bit Score: 103.14 E-value: 2.19e-25
|
|||||||||
| GH18_chitinase-like | cd00598 | The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant ... |
81-231 | 4.27e-18 | |||||
The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have been identified in viruses, bacteria, fungi, protozoan parasites, insects, and plants. The structure of the GH18 domain is an eight-stranded beta/alpha barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel. The GH18 family includes chitotriosidase, chitobiase, hevamine, zymocin-alpha, narbonin, SI-CLP (stabilin-1 interacting chitinase-like protein), IDGF (imaginal disc growth factor), CFLE (cortical fragment-lytic enzyme) spore hydrolase, the type III and type V plant chitinases, the endo-beta-N-acetylglucosaminidases, and the chitolectins. The GH85 (glycosyl hydrolase, family 85) ENGases (endo-beta-N-acetylglucosaminidases) are closely related to the GH18 chitinases and are included in this alignment model. Pssm-ID: 119349 [Multi-domain] Cd Length: 210 Bit Score: 80.88 E-value: 4.27e-18
|
|||||||||
| GH18_CFLE_spore_hydrolase | cd02874 | Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial ... |
81-293 | 2.57e-14 | |||||
Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the forespore inner membrane and is deposited as a mature enzyme in the cortex layer of the spore. As part of a sensory mechanism capable of initiating germination, CFLE degrades a spore-specific peptidoglycan constituent called muramic-acid delta-lactam that comprises the outer cortex. CFLE has a C-terminal glycosyl hydrolase family 18 (GH18) catalytic domain as well as two N-terminal LysM peptidoglycan-binding domains. In addition to SleB, this family includes YaaH, YdhD, and YvbX from Bacillus subtilis. Pssm-ID: 119353 [Multi-domain] Cd Length: 313 Bit Score: 71.91 E-value: 2.57e-14
|
|||||||||
| Glyco_hydro_18 | pfam00704 | Glycosyl hydrolases family 18; |
214-281 | 1.19e-05 | |||||
Glycosyl hydrolases family 18; Pssm-ID: 425828 [Multi-domain] Cd Length: 311 Bit Score: 45.91 E-value: 1.19e-05
|
|||||||||
| GH18_chitolectin_chitotriosidase | cd02872 | This conserved domain family includes a large number of catalytically inactive chitinase-like ... |
214-293 | 3.14e-05 | |||||
This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active chitotriosidases. The conserved domain is an eight-stranded alpha/beta barrel fold belonging to the family 18 glycosyl hydrolases. The fold has a pronounced active-site cleft at the C-terminal end of the beta-barrel. The chitolectins lack a key active site glutamate (the proton donor required for hydrolytic activity) but retain highly conserved residues involved in oligosaccharide binding. Chitotriosidase is a chitinolytic enzyme expressed in maturing macrophages, which suggests that it plays a part in antimicrobial defense. Chitotriosidase hydrolyzes chitotriose, as well as colloidal chitin to yield chitobiose and is therefore considered an exochitinase. Chitotriosidase occurs in two major forms, the large form being converted to the small form by either RNA or post-translational processing. Although the small form, containing the chitinase domain alone, is sufficient for the chitinolytic activity, the additional C-terminal chitin-binding domain of the large form plays a role in processing colloidal chitin. The chitotriosidase gene is nonessential in humans, as about 35% of the population are heterozygous and 6% homozygous for an inactivated form of the gene. HCGP39 is a 39-kDa human cartilage glycoprotein thought to play a role in connective tissue remodeling and defense against pathogens. Pssm-ID: 119351 [Multi-domain] Cd Length: 362 Bit Score: 44.86 E-value: 3.14e-05
|
|||||||||
| ChiA | COG3325 | Chitinase, GH18 family [Carbohydrate transport and metabolism]; |
214-272 | 7.04e-05 | |||||
Chitinase, GH18 family [Carbohydrate transport and metabolism]; Pssm-ID: 442554 [Multi-domain] Cd Length: 391 Bit Score: 43.75 E-value: 7.04e-05
|
|||||||||
| GH18_chitinase | cd06548 | The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant ... |
212-272 | 6.59e-03 | |||||
The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an eight-stranded alpha/beta barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel. Pssm-ID: 119365 [Multi-domain] Cd Length: 322 Bit Score: 37.61 E-value: 6.59e-03
|
|||||||||
| Blast search parameters | ||||
|
