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Conserved domains on  [gi|2217284210|ref|XP_047283394|]
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excitatory amino acid transporter 2 isoform X5 [Homo sapiens]

Protein Classification

dicarboxylate/amino acid:cation symporter( domain architecture ID 10448728)

dicarboxylate/amino acid:cation symporter facilitates H+ or Na+ symport with C4-dicarboxylates, dicarboxylic amino acids (aspartate, glutamate) or other amino acids; belongs to the sodium:dicarboxylate symporter family

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SDF pfam00375
Sodium:dicarboxylate symporter family;
37-487 1.47e-121

Sodium:dicarboxylate symporter family;


:

Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 363.38  E-value: 1.47e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210  37 LLTLTVFGVILGAVCGGLLrlaspihPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGL-DAKASGRLGTRAMVYY 115
Cdd:pfam00375   1 LLLQILIALVLGILIGLFF-------PELAAWLKPLGDLFIRLLKMIIVPLIFASIISGIASLgDGKKLGKLGGKTLLYF 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 116 MSTTIIAAVLGVILVLAIHPGNPKLKKQLGPgkKNDEVSSLDAFLDLIRNLFPENLVQACFQQiqtvtkkvlvapppdee 195
Cdd:pfam00375  74 LVTTAIAALIGLLVANVFQPGSGLALIAASL--KEAKAAEAPSLLDFILNIIPSNIFEALAEG----------------- 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 196 anatsavvsllnetvtevpeetkmvikkglefkdgmNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMI 275
Cdd:pfam00375 135 ------------------------------------NVLAVIVFAILFGIALAALGEKGEPLLNFIESLQEVMMKVIGWV 178

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 276 MWYSPLGIACLICgKIIAIKDLEVVArQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGTASS 355
Cdd:pfam00375 179 MKLAPIGVFALIA-NTVGTYGLGILS-SLAKFLLVVYLGLAIHLLIVYPLLIKFLGKVNPFKFLKKMLPALLTAFSTASS 256

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 356 AGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPS 435
Cdd:pfam00375 257 AATLPVTLECAEKNLGVSESIASFVLPLGATINMDGTAIYLAVAAIFIAQAYGVDLSFGQQLTLVLTATLASIGAAGVPG 336

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217284210 436 AGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIVYHL 487
Cdd:pfam00375 337 GGLVALGLVLSALGLPLEGIALILAIDRLLDMFRTAVNVTGDAAAAVIVAKL 388
 
Name Accession Description Interval E-value
SDF pfam00375
Sodium:dicarboxylate symporter family;
37-487 1.47e-121

Sodium:dicarboxylate symporter family;


Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 363.38  E-value: 1.47e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210  37 LLTLTVFGVILGAVCGGLLrlaspihPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGL-DAKASGRLGTRAMVYY 115
Cdd:pfam00375   1 LLLQILIALVLGILIGLFF-------PELAAWLKPLGDLFIRLLKMIIVPLIFASIISGIASLgDGKKLGKLGGKTLLYF 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 116 MSTTIIAAVLGVILVLAIHPGNPKLKKQLGPgkKNDEVSSLDAFLDLIRNLFPENLVQACFQQiqtvtkkvlvapppdee 195
Cdd:pfam00375  74 LVTTAIAALIGLLVANVFQPGSGLALIAASL--KEAKAAEAPSLLDFILNIIPSNIFEALAEG----------------- 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 196 anatsavvsllnetvtevpeetkmvikkglefkdgmNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMI 275
Cdd:pfam00375 135 ------------------------------------NVLAVIVFAILFGIALAALGEKGEPLLNFIESLQEVMMKVIGWV 178

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 276 MWYSPLGIACLICgKIIAIKDLEVVArQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGTASS 355
Cdd:pfam00375 179 MKLAPIGVFALIA-NTVGTYGLGILS-SLAKFLLVVYLGLAIHLLIVYPLLIKFLGKVNPFKFLKKMLPALLTAFSTASS 256

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 356 AGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPS 435
Cdd:pfam00375 257 AATLPVTLECAEKNLGVSESIASFVLPLGATINMDGTAIYLAVAAIFIAQAYGVDLSFGQQLTLVLTATLASIGAAGVPG 336

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217284210 436 AGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIVYHL 487
Cdd:pfam00375 337 GGLVALGLVLSALGLPLEGIALILAIDRLLDMFRTAVNVTGDAAAAVIVAKL 388
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
34-484 4.53e-120

Na+/H+-dicarboxylate symporter [Energy production and conversion];


Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 360.20  E-value: 4.53e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210  34 KNLLLTLTVFGVILGAVCGGLLrlaspiHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGL-DAKASGRLGTRAM 112
Cdd:COG1301     2 KLSLTLQILIALVLGILLGLLL------PELVAAVLKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 113 VYYMSTTIIAAVLGVILVLAIHPGNPkLKKQLGPGKKNDEVSSLDaFLDLIRNLFPENLVQAcfqqiqtvtkkvlvappp 192
Cdd:COG1301    76 LYFLVTTTIALVIGLVVANLFQPGAG-LNLDLADAAAAEAAEAPS-LLDFLLNIIPSNIFEA------------------ 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 193 deeanatsavvsllnetvtevpeetkmvikkgleFKDGmNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLV 272
Cdd:COG1301   136 ----------------------------------FAEG-NMLQIIFFAILFGIALAALGEKGKPLLDFFESLSEVMFKIV 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 273 IMIMWYSPLGIACLIcGKIIAIKDLEVVArQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGT 352
Cdd:COG1301   181 GWVMKLAPIGVFALI-AATVAKYGLDALG-SLGKLVLTVYLALLLHLFVVLPLILRLLTGLSPLKFLRAIRPALLLAFST 258

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 353 ASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAAS 432
Cdd:COG1301   259 SSSEATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAALFIAQAYGIDLSLGQQLTIVLTAVLASIGAAG 338

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217284210 433 IPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIV 484
Cdd:COG1301   339 VPGAGLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVNVTGDAVATVVV 390
gltP PRK11283
glutamate/aspartate:proton symporter; Provisional
 34-478 4.81e-40

glutamate/aspartate:proton symporter; Provisional


Pssm-ID: 183075 [Multi-domain]  Cd Length: 437  Bit Score: 151.07  E-value: 4.81e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210  34 KNLLLTLT---VFGVILGAVCGGLLRLASPIHPDVVMLIAFP-GDILMRMLKMLILPLIISSLITGLSGL-DAKASGRLG 108
Cdd:PRK11283    2 KNIKFSLAwqiLIALVLGILLGAYLHYHSDSRDWLVSNLLSPaGDIFIHLIKMIVVPIVISTLIVGIAGVgDAKQLGRIG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 109 TRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGP------GKKNDEVSSLD-AFLDLIRNLFPENLVQAcfqqiqt 181
Cdd:PRK11283   82 AKTIIYFEVITTVAIILGITLANVFQPGAGIDMSQLATvdiskyQSTTEEVQSHShGLMGTILSLIPTNIFAS------- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 182 vtkkvlvapppdeeanatsavvsllnetvtevpeetkmvIKKGlefkdgmNVLGLIGFFIAFGIAMGKMGDQAKL-MVDF 260
Cdd:PRK11283  155 ---------------------------------------MAKG-------EMLPIIFFSVLFGLGLSSLPATHREpLVTV 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 261 FNILNEIVMKLVIMIMWYSPLGIACLICgkiiaikdlevvarqlgmymVTVIIGLIIHggiFLPLIYFVVTRKNPFSFFA 340
Cdd:PRK11283  189 FRSVSETMFKVTHMVMRYAPVGVFALIA--------------------VTVANFGFAS---LWPLAKLVLLVYFAILFFA 245

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 341 GI----------FQAW----------ITALGTASSAGTLPvtfRCLE--ENLGIDKRVTRFVLPVGATINMDGTALYEAV 398
Cdd:PRK11283  246 LVvlgivarlcgLSIWilirilkdelILAYSTASSETVLP---RIIEkmEAYGAPKSITSFVVPTGYSFNLDGSTLYQSI 322

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 399 AAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDS 478
Cdd:PRK11283  323 AAIFIAQLYGIDLSIWQEIILVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVGNA 402
 
Name Accession Description Interval E-value
SDF pfam00375
Sodium:dicarboxylate symporter family;
37-487 1.47e-121

Sodium:dicarboxylate symporter family;


Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 363.38  E-value: 1.47e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210  37 LLTLTVFGVILGAVCGGLLrlaspihPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGL-DAKASGRLGTRAMVYY 115
Cdd:pfam00375   1 LLLQILIALVLGILIGLFF-------PELAAWLKPLGDLFIRLLKMIIVPLIFASIISGIASLgDGKKLGKLGGKTLLYF 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 116 MSTTIIAAVLGVILVLAIHPGNPKLKKQLGPgkKNDEVSSLDAFLDLIRNLFPENLVQACFQQiqtvtkkvlvapppdee 195
Cdd:pfam00375  74 LVTTAIAALIGLLVANVFQPGSGLALIAASL--KEAKAAEAPSLLDFILNIIPSNIFEALAEG----------------- 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 196 anatsavvsllnetvtevpeetkmvikkglefkdgmNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMI 275
Cdd:pfam00375 135 ------------------------------------NVLAVIVFAILFGIALAALGEKGEPLLNFIESLQEVMMKVIGWV 178

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 276 MWYSPLGIACLICgKIIAIKDLEVVArQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGTASS 355
Cdd:pfam00375 179 MKLAPIGVFALIA-NTVGTYGLGILS-SLAKFLLVVYLGLAIHLLIVYPLLIKFLGKVNPFKFLKKMLPALLTAFSTASS 256

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 356 AGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPS 435
Cdd:pfam00375 257 AATLPVTLECAEKNLGVSESIASFVLPLGATINMDGTAIYLAVAAIFIAQAYGVDLSFGQQLTLVLTATLASIGAAGVPG 336

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217284210 436 AGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIVYHL 487
Cdd:pfam00375 337 GGLVALGLVLSALGLPLEGIALILAIDRLLDMFRTAVNVTGDAAAAVIVAKL 388
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
34-484 4.53e-120

Na+/H+-dicarboxylate symporter [Energy production and conversion];


Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 360.20  E-value: 4.53e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210  34 KNLLLTLTVFGVILGAVCGGLLrlaspiHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGL-DAKASGRLGTRAM 112
Cdd:COG1301     2 KLSLTLQILIALVLGILLGLLL------PELVAAVLKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 113 VYYMSTTIIAAVLGVILVLAIHPGNPkLKKQLGPGKKNDEVSSLDaFLDLIRNLFPENLVQAcfqqiqtvtkkvlvappp 192
Cdd:COG1301    76 LYFLVTTTIALVIGLVVANLFQPGAG-LNLDLADAAAAEAAEAPS-LLDFLLNIIPSNIFEA------------------ 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 193 deeanatsavvsllnetvtevpeetkmvikkgleFKDGmNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLV 272
Cdd:COG1301   136 ----------------------------------FAEG-NMLQIIFFAILFGIALAALGEKGKPLLDFFESLSEVMFKIV 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 273 IMIMWYSPLGIACLIcGKIIAIKDLEVVArQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGT 352
Cdd:COG1301   181 GWVMKLAPIGVFALI-AATVAKYGLDALG-SLGKLVLTVYLALLLHLFVVLPLILRLLTGLSPLKFLRAIRPALLLAFST 258

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 353 ASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAAS 432
Cdd:COG1301   259 SSSEATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAALFIAQAYGIDLSLGQQLTIVLTAVLASIGAAG 338

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217284210 433 IPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIV 484
Cdd:COG1301   339 VPGAGLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVNVTGDAVATVVV 390
gltP PRK11283
glutamate/aspartate:proton symporter; Provisional
 34-478 4.81e-40

glutamate/aspartate:proton symporter; Provisional


Pssm-ID: 183075 [Multi-domain]  Cd Length: 437  Bit Score: 151.07  E-value: 4.81e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210  34 KNLLLTLT---VFGVILGAVCGGLLRLASPIHPDVVMLIAFP-GDILMRMLKMLILPLIISSLITGLSGL-DAKASGRLG 108
Cdd:PRK11283    2 KNIKFSLAwqiLIALVLGILLGAYLHYHSDSRDWLVSNLLSPaGDIFIHLIKMIVVPIVISTLIVGIAGVgDAKQLGRIG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 109 TRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGP------GKKNDEVSSLD-AFLDLIRNLFPENLVQAcfqqiqt 181
Cdd:PRK11283   82 AKTIIYFEVITTVAIILGITLANVFQPGAGIDMSQLATvdiskyQSTTEEVQSHShGLMGTILSLIPTNIFAS------- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 182 vtkkvlvapppdeeanatsavvsllnetvtevpeetkmvIKKGlefkdgmNVLGLIGFFIAFGIAMGKMGDQAKL-MVDF 260
Cdd:PRK11283  155 ---------------------------------------MAKG-------EMLPIIFFSVLFGLGLSSLPATHREpLVTV 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 261 FNILNEIVMKLVIMIMWYSPLGIACLICgkiiaikdlevvarqlgmymVTVIIGLIIHggiFLPLIYFVVTRKNPFSFFA 340
Cdd:PRK11283  189 FRSVSETMFKVTHMVMRYAPVGVFALIA--------------------VTVANFGFAS---LWPLAKLVLLVYFAILFFA 245

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 341 GI----------FQAW----------ITALGTASSAGTLPvtfRCLE--ENLGIDKRVTRFVLPVGATINMDGTALYEAV 398
Cdd:PRK11283  246 LVvlgivarlcgLSIWilirilkdelILAYSTASSETVLP---RIIEkmEAYGAPKSITSFVVPTGYSFNLDGSTLYQSI 322

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 399 AAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDS 478
Cdd:PRK11283  323 AAIFIAQLYGIDLSIWQEIILVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVGNA 402
PRK01663 PRK01663
C4-dicarboxylate transporter DctA; Reviewed
 43-494 8.39e-39

C4-dicarboxylate transporter DctA; Reviewed


Pssm-ID: 234968 [Multi-domain]  Cd Length: 428  Bit Score: 147.36  E-value: 8.39e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210  43 FGVILGAVCGGLLRLaspIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGL-DAKASGRLGTRAMVYYMSTTII 121
Cdd:PRK01663   11 FQVLVAIIIGILLGH---FYPELGAQMKPLGDGFIKLIKMIIAPIIFCTVVTGIAGMgDMKKVGRVGGKALLYFEIVSTI 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 122 AAVLGVILVLAIHPGNpklkkqlgpgKKNDEVSSLDA--------------FLDLIRNLFPENLVQAcfqqiqtvtkkvl 187
Cdd:PRK01663   88 ALIIGLIVVNVVQPGA----------GMNIDPATLDAkavaqyaaqaheqgTVDFLMDIIPTTVVGA------------- 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 188 vapppdeeanatsavvsllnetvtevpeetkmvikkgleFKDGmNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEI 267
Cdd:PRK01663  145 ---------------------------------------FASG-DILQVLLFAVLFGFALARLGEKGKPVFDFIESLSHV 184

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 268 VMKLVIMIMWYSPLG----IACLIcGKIiAIKDLevvaRQLGMYMVTViigliihggiFLPLIYFV------VTRKNPFS 337
Cdd:PRK01663  185 LFGIVNMIMKLAPIGafgaMAFTI-GKY-GVGSL----VQLGQLIGCF----------YITCILFVfvvlgaIARLTGFS 248

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 338 FFAgiFQAWITA-----LGTASSAGTLPVTFRCLEeNLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLD 412
Cdd:PRK01663  249 IFK--FIRYIKEellivLGTSSSESALPRMMEKME-KLGCKKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATNTPLS 325

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 413 GGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVG-LPTEDISLLVAVDWLLDRMRTSVNVVGDSFgAGIVYHLSKSE 491
Cdd:PRK01663  326 IGHQITLLAVLLLTSKGAAGVTGSGFIVLAATLSAVPhIPVAGLALILGIDRFMSEARALTNLIGNGV-ATVVVAKWEKE 404


                  ...
gi 2217284210 492 LDT 494
Cdd:PRK01663  405 LDR 407
PRK13027 PRK13027
C4-dicarboxylate transporter DctA; Reviewed
 42-477 6.76e-35

C4-dicarboxylate transporter DctA; Reviewed


Pssm-ID: 183850 [Multi-domain]  Cd Length: 421  Bit Score: 136.34  E-value: 6.76e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210  42 VFGVILGAVCGGLLrlaspihPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGL-DAKASGRLGTRAMVYYMSTTI 120
Cdd:PRK13027   13 VIALVLGVALGAFF-------PHFAESLKPLGDGFIKLIKMLIGPIVFCVVVSGIAGAgDLKKVGRVGLKAVIYFEVMTT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 121 IAAVLGVILVLAIHPG---NPKLKkQLGPGKKNDEVS---SLDAFLDLIRNLFPENLVQAcfqqiqtvtkkvlvapppde 194
Cdd:PRK13027   86 IALVIGLVLAYLTGPGvgmNIDLR-SLDAASLAGYAKnaqSLKGTAGFLLKLIPTTAVDA-------------------- 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 195 eanatsavvsllnetvtevpeetkmvikkgleFKDGmNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIM 274
Cdd:PRK13027  145 --------------------------------FAKG-DILQVLLFSVLFGSALSLLGERAKRVNRLIDELSHVLFRIMGF 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 275 IMWYSPLGIACLIC---GKIiAIKDLevvaRQLGMYMVTVIIGLIIhggiFLPLIYFVVTRKNPFSFFAGIF---QAWIT 348
Cdd:PRK13027  192 IIKLAPLGVLGAIAfttGKY-GVGSL----KQLGMLVAVFYLTCFV----FVVVVLGAVMRLAGFSVFKLIRylrEELLI 262

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 349 ALGTASSAGTLPVTFRCLEeNLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASV 428
Cdd:PRK13027  263 VLGTASSDAVLPQVMRKLE-HMGIKDSTVGLVIPTGYSFNLDGFSIYLTLAAVFIAQATNTPLSMHDLITILLVSLVTSK 341

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 2217284210 429 GAASIPSAGLVTMLLILTAVG-LPTEDISLLVAVDWLLDRMRTSVNVVGD 477
Cdd:PRK13027  342 GAHGIPGSAIVILAATLSAIPaIPVLGLVLILPVDWFMGIARALTNLIGN 391
TcyP COG1823
L-cystine transporter TcyP, sodium:dicarboxylate symporter family [Amino acid transport and ...
 34-484 2.53e-23

L-cystine transporter TcyP, sodium:dicarboxylate symporter family [Amino acid transport and metabolism];


Pssm-ID: 441428  Cd Length: 463  Bit Score: 102.98  E-value: 2.53e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210  34 KNLLLTLTVF-GVILGAVCGGLLRLA----SPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGL-DAKASGRL 107
Cdd:COG1823    26 KHVSFSKRVFtGLGLGILFGLILQLIygagSPVIKQSIDWFNIVGNGYVRLLQMIVMPLVFVSILSAITKLkNASSLGKI 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 108 GTRAMVYYMSTTIIAAVLGVILVLAIHpgnpklkkqlgpgkkndevssLDAfldlirnlfpENLVQAcfqqiqtvtkkvl 187
Cdd:COG1823   106 SGLIIGILLGTTAIAALVGILVALLFG---------------------LTA----------EGLTQG------------- 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 188 vappPDEEANATSavvslLNETVTEVPEETkmVIKKGLE------FKD--GMNVLGLIG--FFIAF-GIA----MGKMGD 252
Cdd:COG1823   142 ----AAETARGEA-----LEERLGEVEDLS--LPQQILSfiptnpFADltGARPTSTIAvvIFAAFlGIAalglRRKKPE 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 253 QAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICgKIIAIKDLEVVArQLGMYmvtVIIGLIIHGGIFL-PLIYFVVT 331
Cdd:COG1823   211 QAETFLKGIDALQAIVMRLVRLVLRLTPYGVLALMT-KVVATSDFADIL-NLGKF---VVASYVALIIMFIvHLLLLALA 285

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 332 RKNPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTA-LYEAVAAIFIAQMNGV- 409
Cdd:COG1823   286 GLNPLTYFKKVWPVLTFAFTSRSSAGTIPLNIETQTKRLGVPEGIANFAASFGATIGQNGCAgIYPAMLAVMIAPTVGIn 365

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217284210 410 VLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNvVGDSFGAGIV 484
Cdd:COG1823   366 PLDPSFILTLIAVVTISSFGVAGVGGGATFAALIVLSAMGLPVALAGLLISIEPLIDMGRTALN-VSGSMTAGTV 439
PRK14695 PRK14695
serine/threonine transporter SstT; Provisional
 232-478 3.50e-13

serine/threonine transporter SstT; Provisional


Pssm-ID: 173158  Cd Length: 319  Bit Score: 70.85  E-value: 3.50e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 232 NVLGLIGFFIAFGIAMGKMGDQAKlmvDFFNILNEIVMKLVIMIMWYSPLGIACLICgKIIAIKDLEVVArQLGMYMVTV 311
Cdd:PRK14695   60 NYIGILSWAVIFGIAMREASKNSK---ELLKTIADVTSKIVEWIINLAPFGILGLVF-KTISDKGVGSLA-NYGILLVLL 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 312 IIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQ-AWITALGTASSAGTLPVTFRcLEENLGIDKRVTRFVLPVGATINMD 390
Cdd:PRK14695  135 VTTMLFVAPVVNPLIAFFFMRRNPYPLVWNCLRvSGVTAFFTRSSATNIPVNMK-LCHDLGLNPDTYSVSIPLGSTINMA 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 391 GTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRT 470
Cdd:PRK14695  214 GVAITINLLTLVTVNTLGIPVDFATAFVLSVVAAISACGASGIAGGSLLLIPVACSLFGISNDIAIQIVGVGFVIGVIQD 293


                  ....*...
gi 2217284210 471 SVNVVGDS 478
Cdd:PRK14695  294 SCETALNS 301
PRK13628 PRK13628
serine/threonine transporter SstT; Provisional
 232-450 2.70e-11

serine/threonine transporter SstT; Provisional


Pssm-ID: 184190 [Multi-domain]  Cd Length: 402  Bit Score: 65.66  E-value: 2.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 232 NVLGLIGFFIAFGIAMGKMGDQAKlmvDFFNILNEIVMKLVIMIMWYSPLGIACLICGkIIAIKDLEVVARQLGMYMVTV 311
Cdd:PRK13628  146 NYIGILAWAIGLGLALRHASDTTK---NVVNDLSEAVSQIVKWVIRFAPIGIFGLVAS-TLAETGFSALAGYAQLLAVLV 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 312 IIGLIIHGGiFLPLIYFVVTRKNPFSF-FAGIFQAWITALGTASSAGTLPVTFRcLEENLGIDKRVTRFVLPVGATINMD 390
Cdd:PRK13628  222 GCMLFVALV-VNPLIVFWKIRRNPYPLvFTCLRESGVTAFFTRSSAANIPVNMA-LCEKLGLDEDTYSVSIPLGATINMA 299

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 391 GTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLvtmLLILTAVGL 450
Cdd:PRK13628  300 GAAITITVLTLAAVHTLGIPVDLPTALLLSVVAAISACGASGVAGGSL---LLIPLACSL 356
SstT COG3633
Na+/serine and Na+/threonine symporter SstT [Amino acid transport and metabolism];
45-450 1.89e-09

Na+/serine and Na+/threonine symporter SstT [Amino acid transport and metabolism];


Pssm-ID: 442850  Cd Length: 406  Bit Score: 59.80  E-value: 1.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210  45 VILGAVCGGLLRLASPihpDVVMLIAFPGDILMRMLK----MLILPLIISSLitglsgldakASGRLGTRA-----MVYY 115
Cdd:COG3633    19 ILIGLVLGILLALLSP---EAAKSVGLLGTLFVGALKavapILVFVLVMSAI----------ANHKQGQKTnmkpiIVLY 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 116 MSTTIIAAVLGVILvlaihpgnpklkkqlgpgkkndevssldAFLdlirnlFPENLVqacfqqiqtvtkkvLVAPppDEE 195
Cdd:COG3633    86 LLGTFLAALVAVVA----------------------------SFL------FPTTLT--------------LVAA--AAD 115

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 196 ANATSAVVSLLNETVTevpeetKMV------IKKGlefkdgmNVLGLIGFFIAFGIAMGKMGDQAKLMvdfFNILNEIVM 269
Cdd:COG3633   116 LTPPGGIGEVLKTLLL------NVVdnpvnaLANA-------NYIGILAWAIGLGLALRHASDTTKTV---LSDLSDAVS 179

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 270 KLVIMIMWYSPLGIACLICGKI------IAIKDLEVVARQLGMyMVTVIIGLIihggiflPLIYFVVTRKNPFSF-FAGI 342
Cdd:COG3633   180 KIVRWVIRFAPLGIFGLVASTVattgfsALLGYAHLLAVLVGC-MLFVALVVN-------PLIVFLKIRRNPYPLvFTCL 251

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284210 343 FQAWITALGTASSAGTLPVTFRcLEENLGIDKRVTRFVLPVGATINMDGtalyeavAAIFIAQMN-------GVVLDGGQ 415
Cdd:COG3633   252 RESGITAFFTRSSAANIPVNMA-LCEKLGLDEDTYSVSIPLGATINMAG-------AAITITVLTlaavhtlGIEVDLPT 323

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 2217284210 416 IVTVSLTATLASVGAASIPSAGLvtmLLILTAVGL 450
Cdd:COG3633   324 ALLLSVVAAVSACGASGVAGGSL---LLIPLACSL 355
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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