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Conserved domains on  [gi|2217378339|ref|XP_047279738|]
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snRNA-activating protein complex subunit 4 isoform X5 [Homo sapiens]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 11709750)

SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein binds DNA and may function as a transcription factor

CATH:  1.20.58.1880
Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  8882580
SCOP:  4000317

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
401-448 1.68e-12

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


:

Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 62.24  E-value: 1.68e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2217378339  401 KGYWAPEEDAKLLQAVAKYGEQDWFKIREEVPGRSDAQCRDRYLRRLH 448
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLK 48
PLN03091 super family cl33633
hypothetical protein; Provisional
 399-502 4.41e-09

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PLN03091:

Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 59.22  E-value: 4.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378339 399 LKKGYWAPEEDAKLLQAVAKYGEQDWfkirEEVPGRSDAQ-----CRDRYLRRLHFSLKKGRWNLKEEEQLIELIEKYGv 473
Cdd:PLN03091   12 LRKGLWSPEEDEKLLRHITKYGHGCW----SSVPKQAGLQrcgksCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLG- 86

                          90       100
                  ....*....|....*....|....*....
gi 2217378339 474 GHWAKIASELPHRSGSQCLSKWKIMMGKK 502
Cdd:PLN03091   87 NRWSQIAAQLPGRTDNEIKNLWNSCLKKK 115
SANT super family cl21498
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 290-339 3.61e-07

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


The actual alignment was detected with superfamily member cd11659:

Pssm-ID: 473887 [Multi-domain]  Cd Length: 53  Bit Score: 47.30  E-value: 3.61e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2217378339 290 PSINKQEWSREEEERLQAIaAAHGHLEWQKIAEELGtsRSAFQCLQKFQQ 339
Cdd:cd11659     1 PSIKKTEWTREEDEKLLHL-AKLLPTQWRTIAPIVG--RTAQQCLERYNK 47
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
346-397 2.42e-06

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


:

Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 44.91  E-value: 2.42e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2217378339  346 RKEWTEEEDRMLTQLVQEMRVGShipYRRIVYYMEGRDSMQLIYRWTKSLDP 397
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNN---WEKIAKELPGRTAEQCRERWRNLLKP 49
SANT super family cl21498
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 262-305 1.07e-03

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


The actual alignment was detected with superfamily member pfam13921:

Pssm-ID: 473887 [Multi-domain]  Cd Length: 60  Bit Score: 37.67  E-value: 1.07e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2217378339 262 DWEKISNInfEGSRSAEEIRKFWQNSEHPSINKQEWSREEEERL 305
Cdd:pfam13921  19 DWKQIAKE--LGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
 
Name Accession Description Interval E-value
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
401-448 1.68e-12

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 62.24  E-value: 1.68e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2217378339  401 KGYWAPEEDAKLLQAVAKYGEQDWFKIREEVPGRSDAQCRDRYLRRLH 448
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLK 48
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 404-447 1.71e-12

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 62.21  E-value: 1.71e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2217378339 404 WAPEEDAKLLQAVAKYGEQDWFKIREEVPGRSDAQCRDRYLRRL 447
Cdd:cd00167     2 WTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 401-447 3.83e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 58.28  E-value: 3.83e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2217378339 401 KGYWAPEEDAKLLQAVAKYGEqDWFKIREEVPGRSDAQCRDRYLRRL 447
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGN-RWKKIAKLLPGRTDNQCKNRWQNYL 46
PLN03091 PLN03091
hypothetical protein; Provisional
 399-502 4.41e-09

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 59.22  E-value: 4.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378339 399 LKKGYWAPEEDAKLLQAVAKYGEQDWfkirEEVPGRSDAQ-----CRDRYLRRLHFSLKKGRWNLKEEEQLIELIEKYGv 473
Cdd:PLN03091   12 LRKGLWSPEEDEKLLRHITKYGHGCW----SSVPKQAGLQrcgksCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLG- 86

                          90       100
                  ....*....|....*....|....*....
gi 2217378339 474 GHWAKIASELPHRSGSQCLSKWKIMMGKK 502
Cdd:PLN03091   87 NRWSQIAAQLPGRTDNEIKNLWNSCLKKK 115
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 290-339 3.61e-07

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 47.30  E-value: 3.61e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2217378339 290 PSINKQEWSREEEERLQAIaAAHGHLEWQKIAEELGtsRSAFQCLQKFQQ 339
Cdd:cd11659     1 PSIKKTEWTREEDEKLLHL-AKLLPTQWRTIAPIVG--RTAQQCLERYNK 47
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
294-342 5.14e-07

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 46.83  E-value: 5.14e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2217378339  294 KQEWSREEEERLQAIAAAHGHLEWQKIAEELGTsRSAFQCLQKFQQHNK 342
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPG-RTAEQCRERWRNLLK 48
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 297-357 6.25e-07

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 46.92  E-value: 6.25e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217378339 297 WSREEEERLQAIAAAHGhLEWQKIAEELGtSRSAFQCLQKFQQHNKA-LKRKEWTEEEDRML 357
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELG-RRTPKQCFDRWRRKLNPkISRGPWSKEEDQRL 60
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
346-397 2.42e-06

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 44.91  E-value: 2.42e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2217378339  346 RKEWTEEEDRMLTQLVQEMRVGShipYRRIVYYMEGRDSMQLIYRWTKSLDP 397
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNN---WEKIAKELPGRTAEQCRERWRNLLKP 49
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 256-357 3.60e-06

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 50.17  E-value: 3.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378339 256 NRLDShDWEKISNINFE------GSRSAEEIRKFWQNSEHPSINKQEWSREEEERLQAIAAAHGHLeWQKIAEELGtSRS 329
Cdd:COG5147    29 EDLKA-LVKKLGPNNWSkvasllISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQ-WSTIADYKD-RRT 105

                          90       100
                  ....*....|....*....|....*...
gi 2217378339 330 AFQCLQKFQQHNKALKRKEWTEEEDRML 357
Cdd:COG5147   106 AQQCVERYVNTLEDLSSTHDSKLQRRNE 133
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 470-496 1.99e-05

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 42.18  E-value: 1.99e-05
                          10        20
                  ....*....|....*....|....*..
gi 2217378339 470 KYGVGHWAKIASELPHRSGSQCLSKWK 496
Cdd:cd00167    16 KYGKNNWEKIAKELPGRTPKQCRERWR 42
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 349-412 3.67e-05

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 41.91  E-value: 3.67e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217378339 349 WTEEEDRMLTQLVQEMrvgsHIPYRRIVYYMEGRDSMQLIYRWTKSLDPGLKKGYWAPEEDAKL 412
Cdd:pfam13921   1 WTEEEDEKLLKLVEKY----GNDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
470-496 5.19e-05

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 41.06  E-value: 5.19e-05
                           10        20
                   ....*....|....*....|....*..
gi 2217378339  470 KYGVGHWAKIASELPHRSGSQCLSKWK 496
Cdd:smart00717  18 KYGKNNWEKIAKELPGRTAEQCRERWR 44
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 399-495 1.52e-04

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 44.78  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378339 399 LKKGYWAPEEDAKLLQAVAKYGEQDWFKIREEVPGRSDAQCRDRYLRRLHFSLKKGRWNLKEEEQLIELIEKYGVgHWAK 478
Cdd:COG5147    18 RKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGT-QWST 96

                          90
                  ....*....|....*..
gi 2217378339 479 IASELPHRSGSQCLSKW 495
Cdd:COG5147    97 IADYKDRRTAQQCVERY 113
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 262-305 1.07e-03

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 37.67  E-value: 1.07e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2217378339 262 DWEKISNInfEGSRSAEEIRKFWQNSEHPSINKQEWSREEEERL 305
Cdd:pfam13921  19 DWKQIAKE--LGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 343-443 8.27e-03

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 38.52  E-value: 8.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378339 343 ALKRKEWTEEEDRMLTQLVQEMRVGSHIPYRRIVYYMEGRDSMQLiyRWTKSLDPGLKKGYWAPEEDAKLLQAVAKYGEQ 422
Cdd:PLN03212   22 GMKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLLRCGKSCRL--RWMNYLRPSVKRGGITSDEEDLILRLHRLLGNR 99

                          90       100
                  ....*....|....*....|.
gi 2217378339 423 dWFKIREEVPGRSDAQCRDRY 443
Cdd:PLN03212  100 -WSLIAGRIPGRTDNEIKNYW 119
 
Name Accession Description Interval E-value
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
401-448 1.68e-12

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 62.24  E-value: 1.68e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2217378339  401 KGYWAPEEDAKLLQAVAKYGEQDWFKIREEVPGRSDAQCRDRYLRRLH 448
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLK 48
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 404-447 1.71e-12

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 62.21  E-value: 1.71e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2217378339 404 WAPEEDAKLLQAVAKYGEQDWFKIREEVPGRSDAQCRDRYLRRL 447
Cdd:cd00167     2 WTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 401-447 3.83e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 58.28  E-value: 3.83e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2217378339 401 KGYWAPEEDAKLLQAVAKYGEqDWFKIREEVPGRSDAQCRDRYLRRL 447
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGN-RWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 404-457 8.33e-10

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 55.01  E-value: 8.33e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217378339 404 WAPEEDAKLLQAVAKYGeQDWFKIREEVPGRSDAQCRDRYLRRLHFSLKKGRWN 457
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWS 53
PLN03091 PLN03091
hypothetical protein; Provisional
 399-502 4.41e-09

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 59.22  E-value: 4.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378339 399 LKKGYWAPEEDAKLLQAVAKYGEQDWfkirEEVPGRSDAQ-----CRDRYLRRLHFSLKKGRWNLKEEEQLIELIEKYGv 473
Cdd:PLN03091   12 LRKGLWSPEEDEKLLRHITKYGHGCW----SSVPKQAGLQrcgksCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLG- 86

                          90       100
                  ....*....|....*....|....*....
gi 2217378339 474 GHWAKIASELPHRSGSQCLSKWKIMMGKK 502
Cdd:PLN03091   87 NRWSQIAAQLPGRTDNEIKNLWNSCLKKK 115
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 290-339 3.61e-07

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 47.30  E-value: 3.61e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2217378339 290 PSINKQEWSREEEERLQAIaAAHGHLEWQKIAEELGtsRSAFQCLQKFQQ 339
Cdd:cd11659     1 PSIKKTEWTREEDEKLLHL-AKLLPTQWRTIAPIVG--RTAQQCLERYNK 47
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
294-342 5.14e-07

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 46.83  E-value: 5.14e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2217378339  294 KQEWSREEEERLQAIAAAHGHLEWQKIAEELGTsRSAFQCLQKFQQHNK 342
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPG-RTAEQCRERWRNLLK 48
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 297-357 6.25e-07

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 46.92  E-value: 6.25e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217378339 297 WSREEEERLQAIAAAHGhLEWQKIAEELGtSRSAFQCLQKFQQHNKA-LKRKEWTEEEDRML 357
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELG-RRTPKQCFDRWRRKLNPkISRGPWSKEEDQRL 60
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 296-340 2.21e-06

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 44.87  E-value: 2.21e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2217378339 296 EWSREEEERLQAIAAAHGHLEWQKIAEELGTsRSAFQCLQKFQQH 340
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPG-RTPKQCRERWRNL 44
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
346-397 2.42e-06

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 44.91  E-value: 2.42e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2217378339  346 RKEWTEEEDRMLTQLVQEMRVGShipYRRIVYYMEGRDSMQLIYRWTKSLDP 397
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNN---WEKIAKELPGRTAEQCRERWRNLLKP 49
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 256-357 3.60e-06

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 50.17  E-value: 3.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378339 256 NRLDShDWEKISNINFE------GSRSAEEIRKFWQNSEHPSINKQEWSREEEERLQAIAAAHGHLeWQKIAEELGtSRS 329
Cdd:COG5147    29 EDLKA-LVKKLGPNNWSkvasllISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQ-WSTIADYKD-RRT 105

                          90       100
                  ....*....|....*....|....*...
gi 2217378339 330 AFQCLQKFQQHNKALKRKEWTEEEDRML 357
Cdd:COG5147   106 AQQCVERYVNTLEDLSSTHDSKLQRRNE 133
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 334-453 8.82e-06

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 49.02  E-value: 8.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378339 334 LQKFQQHNKALKRKE--WTEEEDRMLTQLVQEM------RVGSHIPYRrivyyMEGRDSMqliyRWTKSLDPGLKKGYWA 405
Cdd:COG5147     6 NKELQIKLMQTKRKGgsWKRTEDEDLKALVKKLgpnnwsKVASLLISS-----TGKQSSN----RWNNHLNPQLKKKNWS 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2217378339 406 PEEDAKLLQAVAKYGEQdWFKIREEVPGRSDAQCRDRYLRRLHFSLKK 453
Cdd:COG5147    77 EEEDEQLIDLDKELGTQ-WSTIADYKDRRTAQQCVERYVNTLEDLSST 123
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 470-496 1.99e-05

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 42.18  E-value: 1.99e-05
                          10        20
                  ....*....|....*....|....*..
gi 2217378339 470 KYGVGHWAKIASELPHRSGSQCLSKWK 496
Cdd:cd00167    16 KYGKNNWEKIAKELPGRTPKQCRERWR 42
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 349-412 3.67e-05

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 41.91  E-value: 3.67e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217378339 349 WTEEEDRMLTQLVQEMrvgsHIPYRRIVYYMEGRDSMQLIYRWTKSLDPGLKKGYWAPEEDAKL 412
Cdd:pfam13921   1 WTEEEDEKLLKLVEKY----GNDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
470-496 5.19e-05

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 41.06  E-value: 5.19e-05
                           10        20
                   ....*....|....*....|....*..
gi 2217378339  470 KYGVGHWAKIASELPHRSGSQCLSKWK 496
Cdd:smart00717  18 KYGKNNWEKIAKELPGRTAEQCRERWR 44
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 397-443 9.63e-05

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 40.37  E-value: 9.63e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2217378339 397 PGLKKGYWAPEEDAKLLQAVAKYGEQdWFKIREEVpGRSDAQCRDRY 443
Cdd:cd11659     1 PSIKKTEWTREEDEKLLHLAKLLPTQ-WRTIAPIV-GRTAQQCLERY 45
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 399-495 1.52e-04

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 44.78  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378339 399 LKKGYWAPEEDAKLLQAVAKYGEQDWFKIREEVPGRSDAQCRDRYLRRLHFSLKKGRWNLKEEEQLIELIEKYGVgHWAK 478
Cdd:COG5147    18 RKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGT-QWST 96

                          90
                  ....*....|....*..
gi 2217378339 479 IASELPHRSGSQCLSKW 495
Cdd:COG5147    97 IADYKDRRTAQQCVERY 113
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 294-340 1.62e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 39.79  E-value: 1.62e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2217378339 294 KQEWSREEEERLQAIAAAHGHlEWQKIAEELGTsRSAFQCLQKFQQH 340
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGN-RWKKIAKLLPG-RTDNQCKNRWQNY 45
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 398-502 4.77e-04

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 42.37  E-value: 4.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378339 398 GLKKGYWAPEEDAKLLQAVAKYGEQDWFKIREEVP-GRSDAQCRDRYLRRLHFSLKKGRWNLKEEEQLIELIEKYGvGHW 476
Cdd:PLN03212   22 GMKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGlLRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLG-NRW 100

                          90       100
                  ....*....|....*....|....*.
gi 2217378339 477 AKIASELPHRSGSQCLSKWKIMMGKK 502
Cdd:PLN03212  101 SLIAGRIPGRTDNEIKNYWNTHLRKK 126
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 404-443 7.64e-04

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 37.93  E-value: 7.64e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2217378339 404 WAPEEDAKLLQAVAKYGEQDWFKIREE---VPGRSDAQCRDRY 443
Cdd:cd11660     3 WTDEEDEALVEGVEKYGVGNWAKILKDyffVNNRTSVDLKDKW 45
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 262-305 1.07e-03

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 37.67  E-value: 1.07e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2217378339 262 DWEKISNInfEGSRSAEEIRKFWQNSEHPSINKQEWSREEEERL 305
Cdd:pfam13921  19 DWKQIAKE--LGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 292-411 2.37e-03

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 41.31  E-value: 2.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378339 292 INKQEWSREEEERLQAIAAAHGHLEWQKIAEELgTSRSAFQC-LQKFQQHNKALKRKEWTEEEDRMLTQLVQEMrvGSHI 370
Cdd:COG5147    18 RKGGSWKRTEDEDLKALVKKLGPNNWSKVASLL-ISSTGKQSsNRWNNHLNPQLKKKNWSEEEDEQLIDLDKEL--GTQW 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2217378339 371 pyRRIVYYMEGRDSMQLIYRWTKSLDPGLKKGYWAPEEDAK 411
Cdd:COG5147    95 --STIADYKDRRTAQQCVERYVNTLEDLSSTHDSKLQRRNE 133
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 233-375 6.15e-03

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 39.77  E-value: 6.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378339 233 KQGREAEKEiQDINQLPE-----EALLGNRLDSHDWEKISNINFE----GSRSAEEIRKFWQNSEHPSINKQEWSREEEE 303
Cdd:COG5147   222 KKGETLALE-QEINEYKEkkglsRKQFCERIWSTDRDEDKFWPNIykklPYRDKKSIYKHLRRKYNIFEQRGKWTKEEEQ 300

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217378339 304 RLQAIAAAHGHLeWQKIAEELGTSRSafQCLQKFQQHNK---ALKRKEWTEEEDRMLTQLVQEMRVGSHiPYRRI 375
Cdd:COG5147   301 ELAKLVVEHGGS-WTEIGKLLGRMPN--DCRDRWRDYVKcgdTLKRNRWSIEEEELLDKVVNEMRLEAQ-QSSRI 371
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 343-443 8.27e-03

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 38.52  E-value: 8.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378339 343 ALKRKEWTEEEDRMLTQLVQEMRVGSHIPYRRIVYYMEGRDSMQLiyRWTKSLDPGLKKGYWAPEEDAKLLQAVAKYGEQ 422
Cdd:PLN03212   22 GMKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLLRCGKSCRL--RWMNYLRPSVKRGGITSDEEDLILRLHRLLGNR 99

                          90       100
                  ....*....|....*....|.
gi 2217378339 423 dWFKIREEVPGRSDAQCRDRY 443
Cdd:PLN03212  100 -WSLIAGRIPGRTDNEIKNYW 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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