|
Name |
Accession |
Description |
Interval |
E-value |
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
471-827 |
5.37e-115 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 363.69 E-value: 5.37e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 471 QALEQL----GHQAFRPGQERAVMRILSGISTLLVLPTGAGKSLCYQLPALLysrrSPCLTLVVSPLLSLMDDQVSGLpp 546
Cdd:COG0514 4 DALEVLkrvfGYDSFRPGQEEIIEAVLAGRDALVVMPTGGGKSLCYQLPALL----LPGLTLVVSPLIALMKDQVDALra 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 547 -cLKAACIHSGMTRKQRESVLQKIRAAQVHVLMLTPEALVGAGGLPPAAQLPPVAFAcIDEAHCLSQWSHNFRPCYLRVc 625
Cdd:COG0514 80 agIRAAFLNSSLSAEERREVLRALRAGELKLLYVAPERLLNPRFLELLRRLKISLFA-IDEAHCISQWGHDFRPDYRRL- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 626 KVLRERMGVHCFLGLTATATRRTASDVAQHLAVaEEPDLH--GPA-PvptNLHLSVS--MDRDTDQALLTLLqgKRFQNl 700
Cdd:COG0514 158 GELRERLPNVPVLALTATATPRVRADIAEQLGL-EDPRVFvgSFDrP---NLRLEVVpkPPDDKLAQLLDFL--KEHPG- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 701 DSIIIYCNRREDTERIAALLRtclhaawvpGSGGRApkttaEAYHAGMCSRERRRVQRAFMQGQLRVVVATVAFGMGLDR 780
Cdd:COG0514 231 GSGIVYCLSRKKVEELAEWLR---------EAGIRA-----AAYHAGLDAEEREANQDRFLRDEVDVIVATIAFGMGIDK 296
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 2217373813 781 PDVRAVLHLGLPPSFESYVQAVGRAGRDGQPAHCHLFLQPQGEDLRE 827
Cdd:COG0514 297 PDVRFVIHYDLPKSIEAYYQEIGRAGRDGLPAEALLLYGPEDVAIQR 343
|
|
| DEXHc_RecQ4-like |
cd18018 |
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ... |
470-667 |
2.03e-107 |
|
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.
Pssm-ID: 350776 [Multi-domain] Cd Length: 201 Bit Score: 332.68 E-value: 2.03e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 470 FQALEQL-GHQAFRPGQERAVMRILSGISTLLVLPTGAGKSLCYQLPALLYSRRSPCLTLVVSPLLSLMDDQVSGLPPCL 548
Cdd:cd18018 1 LKLLRRVfGHPSFRPGQEEAIARLLSGRSTLVVLPTGAGKSLCYQLPALLLRRRGPGLTLVVSPLIALMKDQVDALPRAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 549 KAACIHSGMTRKQRESVLQKIRAAQVHVLMLTPEALVGAGGLPPAAQLPPVAFACIDEAHCLSQWSHNFRPCYLRVCKVL 628
Cdd:cd18018 81 KAAALNSSLTREERRRILEKLRAGEVKILYVSPERLVNESFRELLRQTPPISLLVVDEAHCISEWSHNFRPDYLRLCRVL 160
|
170 180 190
....*....|....*....|....*....|....*....
gi 2217373813 629 RERMGVHCFLGLTATATRRTASDVAQHLAVAEEPDLHGP 667
Cdd:cd18018 161 RELLGAPPVLALTATATKRVVEDIASHLGIPESGVVRGP 199
|
|
| recQ |
TIGR01389 |
ATP-dependent DNA helicase RecQ; The ATP-dependent DNA helicase RecQ of E. coli is about 600 ... |
474-830 |
2.68e-92 |
|
ATP-dependent DNA helicase RecQ; The ATP-dependent DNA helicase RecQ of E. coli is about 600 residues long. This model represents bacterial proteins with a high degree of similarity in domain architecture and in primary sequence to E. coli RecQ. The model excludes eukaryotic and archaeal proteins with RecQ-like regions, as well as more distantly related bacterial helicases related to RecQ. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273594 [Multi-domain] Cd Length: 591 Bit Score: 306.61 E-value: 2.68e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 474 EQLGHQAFRPGQERAVMRILSGISTLLVLPTGAGKSLCYQLPALLYsrrsPCLTLVVSPLLSLMDDQVSGLPPC-LKAAC 552
Cdd:TIGR01389 7 RTFGYDDFRPGQEEIISHVLDGRDVLVVMPTGGGKSLCYQVPALLL----KGLTVVISPLISLMKDQVDQLRAAgVAAAY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 553 IHSGMTRKQRESVLQKIRAAQVHVLMLTPEALVGAGGLPPAAQLPPVAFAcIDEAHCLSQWSHNFRPCYLRVCkVLRERM 632
Cdd:TIGR01389 83 LNSTLSAKEQQDIEKALVNGELKLLYVAPERLEQDYFLNMLQRIPIALVA-VDEAHCVSQWGHDFRPEYQRLG-SLAERF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 633 GVHCFLGLTATATRRTASDVAQHLAVAEEPDLHGPAPVPtNLHLSVSMDRDTDQALLTLLQGKRFQnldSIIIYCNRRED 712
Cdd:TIGR01389 161 PQVPRIALTATADAETRQDIRELLRLADANEFITSFDRP-NLRFSVVKKNNKQKFLLDYLKKHRGQ---SGIIYASSRKK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 713 TERIAALLRTclhaawvpgsggraPKTTAEAYHAGMCSRERRRVQRAFMQGQLRVVVATVAFGMGLDRPDVRAVLHLGLP 792
Cdd:TIGR01389 237 VEELAERLES--------------QGISALAYHAGLSNKVRAENQEDFLYDDVKVMVATNAFGMGIDKPNVRFVIHYDMP 302
|
330 340 350
....*....|....*....|....*....|....*...
gi 2217373813 793 PSFESYVQAVGRAGRDGQPAHCHLFLQPQgeDLRELRR 830
Cdd:TIGR01389 303 GNLESYYQEAGRAGRDGLPAEAILLYSPA--DIALLKR 338
|
|
| recQ_fam |
TIGR00614 |
ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are ... |
477-830 |
5.55e-88 |
|
ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are known are 3'-5' DNA-DNA helicases. These proteins are used for recombination, recombinational repair, and possibly maintenance of chromosome stability. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129701 [Multi-domain] Cd Length: 470 Bit Score: 290.90 E-value: 5.55e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 477 GHQAFRPGQERAVMRILSGISTLLVLPTGAGKSLCYQLPALLysrrSPCLTLVVSPLLSLMDDQV-----SGLPpclkAA 551
Cdd:TIGR00614 8 GLSSFRPVQLEVINAVLLGRDCFVVMPTGGGKSLCYQLPALY----SDGITLVISPLISLMEDQVlqlqaLGIP----AT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 552 CIHSGMTRKQRESVLQKIRAAQVHVLMLTPEALVGAGGLppAAQLPP---VAFACIDEAHCLSQWSHNFRPCYlRVCKVL 628
Cdd:TIGR00614 80 FLNSAQTKEQQLNVLTDLKDGKIKLLYVTPEKISASNRL--LQTLEErkgITLIAVDEAHCISQWGHDFRPDY-KALGSL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 629 RERMGVHCFLGLTATATRRTASDVAQHLavaeepDLHGPAPVPT-----NLHLSVsMDRDTD--QALLTLLQGKrfQNLD 701
Cdd:TIGR00614 157 KQKFPNVPVMALTATASPSVREDILRQL------NLLNPQIFCTsfdrpNLYYEV-RRKTPKilEDLLRFIRKE--FEGK 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 702 SIIIYCNRREDTERIAALLRTC-LHAAwvpgsggrapkttaeAYHAGMCSRERRRVQRAFMQGQLRVVVATVAFGMGLDR 780
Cdd:TIGR00614 228 SGIIYCPSRKKVEQVAAELQKLgLAAG---------------AYHAGLEDSARDDVQHKFQRDEIQVVVATVAFGMGINK 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 2217373813 781 PDVRAVLHLGLPPSFESYVQAVGRAGRDGQPAHCHLFLQPQgeDLRELRR 830
Cdd:TIGR00614 293 PDVRFVIHYSLPKSMESYYQESGRAGRDGLPSECHLFYAPA--DMNRLRR 340
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
474-830 |
2.60e-81 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 276.98 E-value: 2.60e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 474 EQLGHQAFRPGQERAVMRILSGISTLLVLPTGAGKSLCYQLPALLYsrrsPCLTLVVSPLLSLMDDQVSGLPP-CLKAAC 552
Cdd:PRK11057 19 ETFGYQQFRPGQQEIIDAVLSGRDCLVVMPTGGGKSLCYQIPALVL----DGLTLVVSPLISLMKDQVDQLLAnGVAAAC 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 553 IHSGMTRKQRESVLQKIRAAQVHVLMLTPEALVGAGGLPPAAQLPPVAFAcIDEAHCLSQWSHNFRPCYlRVCKVLRERM 632
Cdd:PRK11057 95 LNSTQTREQQLEVMAGCRTGQIKLLYIAPERLMMDNFLEHLAHWNPALLA-VDEAHCISQWGHDFRPEY-AALGQLRQRF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 633 GVHCFLGLTATATRRTASDVAQHLavaeepDLHGPApvptnLHLSvSMDRD------------TDQaLLTLLQGKRFQnl 700
Cdd:PRK11057 173 PTLPFMALTATADDTTRQDIVRLL------GLNDPL-----IQIS-SFDRPnirytlvekfkpLDQ-LMRYVQEQRGK-- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 701 dSIIIYCNRREDTERIAALLRtclhaawvpgSGGrapkTTAEAYHAGMCSRERRRVQRAFMQGQLRVVVATVAFGMGLDR 780
Cdd:PRK11057 238 -SGIIYCNSRAKVEDTAARLQ----------SRG----ISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINK 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 2217373813 781 PDVRAVLHLGLPPSFESYVQAVGRAGRDGQPAHCHLFLQPQgeDLRELRR 830
Cdd:PRK11057 303 PNVRFVVHFDIPRNIESYYQETGRAGRDGLPAEAMLFYDPA--DMAWLRR 350
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
474-656 |
4.40e-69 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 229.34 E-value: 4.40e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 474 EQLGHQAFRPGQERAVMRILSGISTLLVLPTGAGKSLCYQLPALLysrrSPCLTLVVSPLLSLMDDQVSGLPP-CLKAAC 552
Cdd:cd17920 6 EVFGYDEFRPGQLEAINAVLAGRDVLVVMPTGGGKSLCYQLPALL----LDGVTLVVSPLISLMQDQVDRLQQlGIRAAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 553 IHSGMTRKQRESVLQKIRAAQVHVLMLTPEALVGAGGLPPAAQLP---PVAFACIDEAHCLSQWSHNFRPCYLRVCKvLR 629
Cdd:cd17920 82 LNSTLSPEEKREVLLRIKNGQYKLLYVTPERLLSPDFLELLQRLPerkRLALIVVDEAHCVSQWGHDFRPDYLRLGR-LR 160
|
170 180
....*....|....*....|....*..
gi 2217373813 630 ERMGVHCFLGLTATATRRTASDVAQHL 656
Cdd:cd17920 161 RALPGVPILALTATATPEVREDILKRL 187
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
673-817 |
1.65e-62 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 208.22 E-value: 1.65e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 673 NLHLSVSMDRDTDQALLTLLQGKRFQNLDSIIIYCNRREDTERIAALLRTCLHAAwvpgsggrapkttaEAYHAGMCSRE 752
Cdd:cd18794 3 NLFYSVRPKDKKDEKLDLLKRIKVEHLGGSGIIYCLSRKECEQVAARLQSKGISA--------------AAYHAGLEPSD 68
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217373813 753 RRRVQRAFMQGQLRVVVATVAFGMGLDRPDVRAVLHLGLPPSFESYVQAVGRAGRDGQPAHCHLF 817
Cdd:cd18794 69 RRDVQRKWLRDKIQVIVATVAFGMGIDKPDVRFVIHYSLPKSMESYYQESGRAGRDGLPSECILF 133
|
|
| PLN03137 |
PLN03137 |
ATP-dependent DNA helicase; Q4-like; Provisional |
477-817 |
6.66e-52 |
|
ATP-dependent DNA helicase; Q4-like; Provisional
Pssm-ID: 215597 [Multi-domain] Cd Length: 1195 Bit Score: 198.97 E-value: 6.66e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 477 GHQAFRPGQERAVMRILSGISTLLVLPTGAGKSLCYQLPALLysrrSPCLTLVVSPLLSLMDDQVSGLPPC-LKAACIHS 555
Cdd:PLN03137 457 GNHSFRPNQREIINATMSGYDVFVLMPTGGGKSLTYQLPALI----CPGITLVISPLVSLIQDQIMNLLQAnIPAASLSA 532
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 556 GMTRKQRESVLQKIRA--AQVHVLMLTPEALVGAGGLP------PAAQLppVAFACIDEAHCLSQWSHNFRPCYlRVCKV 627
Cdd:PLN03137 533 GMEWAEQLEILQELSSeySKYKLLYVTPEKVAKSDSLLrhlenlNSRGL--LARFVIDEAHCVSQWGHDFRPDY-QGLGI 609
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 628 LRERMGVHCFLGLTATATRRTASDVAQHLAVAE----EPDLHGPapvptNLHLSVSmdRDTDQALLTLLQGKRFQNLDSI 703
Cdd:PLN03137 610 LKQKFPNIPVLALTATATASVKEDVVQALGLVNcvvfRQSFNRP-----NLWYSVV--PKTKKCLEDIDKFIKENHFDEC 682
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 704 -IIYCNRREDTERIAALLRTCLHaawvpgsggrapktTAEAYHAGMCSRERRRVQRAFMQGQLRVVVATVAFGMGLDRPD 782
Cdd:PLN03137 683 gIIYCLSRMDCEKVAERLQEFGH--------------KAAFYHGSMDPAQRAFVQKQWSKDEINIICATVAFGMGINKPD 748
|
330 340 350
....*....|....*....|....*....|....*
gi 2217373813 783 VRAVLHLGLPPSFESYVQAVGRAGRDGQPAHCHLF 817
Cdd:PLN03137 749 VRFVIHHSLPKSIEGYHQECGRAGRDGQRSSCVLY 783
|
|
| DEXHc_RecQ1 |
cd18015 |
DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ ... |
459-660 |
1.38e-36 |
|
DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350773 [Multi-domain] Cd Length: 209 Bit Score: 137.11 E-value: 1.38e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 459 SGQLAETPAEVFQAleqlghQAFRPGQERAVMRILSGISTLLVLPTGAGKSLCYQLPALLysrrSPCLTLVVSPLLSLMD 538
Cdd:cd18015 3 SGKVKDTLKNVFKL------EKFRPLQLETINATMAGRDVFLVMPTGGGKSLCYQLPALC----SDGFTLVVSPLISLME 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 539 DQVSGLPPC-LKAACIHSGMTRKQRESVLQKIR--AAQVHVLMLTPEALVGA----GGLPPAAQLPPVAFACIDEAHCLS 611
Cdd:cd18015 73 DQLMALKKLgISATMLNASSSKEHVKWVHAALTdkNSELKLLYVTPEKIAKSkrfmSKLEKAYNAGRLARIAIDEVHCCS 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 2217373813 612 QWSHNFRPCY--LRVCKVLRERMGVhcfLGLTATATRRTASDVAQHLAVAE 660
Cdd:cd18015 153 QWGHDFRPDYkkLGILKRQFPNVPI---LGLTATATSKVLKDVQKILCIQK 200
|
|
| DEXHc_RecQ5 |
cd18014 |
DEAH-box helicase domain of RecQ5; ATP-dependent DNA helicase Q5 (RecQ5) is part of the RecQ ... |
477-656 |
2.45e-36 |
|
DEAH-box helicase domain of RecQ5; ATP-dependent DNA helicase Q5 (RecQ5) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350772 [Multi-domain] Cd Length: 205 Bit Score: 136.45 E-value: 2.45e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 477 GHQAFR-PGQERAVMRILSGISTLLV-LPTGAGKSLCYQLPALLYSRrspcLTLVVSPLLSLMDDQVSGLPPC-LKAACI 553
Cdd:cd18014 9 GHSDFKsPLQEKATMAVVKGNKDVFVcMPTGAGKSLCYQLPALLAKG----ITIVISPLIALIQDQVDHLKTLkIRVDSL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 554 HSGMTRKQRESVLQKIRAA--QVHVLMLTPEALVGAGGLPPAAQLPP---VAFACIDEAHCLSQWSHNFRPCYLRVcKVL 628
Cdd:cd18014 85 NSKLSAQERKRIIADLESEkpQTKFLYITPEMAATSSFQPLLSSLVSrnlLSYLVVDEAHCVSQWGHDFRPDYLRL-GAL 163
|
170 180
....*....|....*....|....*...
gi 2217373813 629 RERMGVHCFLGLTATATRRTASDVAQHL 656
Cdd:cd18014 164 RSRYGHVPWVALTATATPQVQEDIFAQL 191
|
|
| DpdF |
NF041063 |
protein DpdF; |
435-816 |
3.76e-35 |
|
protein DpdF;
Pssm-ID: 468990 [Multi-domain] Cd Length: 813 Bit Score: 144.67 E-value: 3.76e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 435 PSPQPVPEVPSLDPTvLPLYSLGPSGQLAETPAEVFqaLEQ-LGHQAFR-PGQERAVMRILS---GiSTLLV-LPTGAGK 508
Cdd:NF041063 96 WRPEWLDAAADDPPF-EDVFAERLRRTLEPVPGDPF--LAEaLGFTHYRsPGQREAVRAALLappG-STLIVnLPTGSGK 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 509 SLCYQLPALLYSRRSPcLTLVVSPLLSLMDDQVSGLPPCLKAACI--------HSGMTRKQRESVLQKIRAAQVHVLMLT 580
Cdd:NF041063 172 SLVAQAPALLASRQGG-LTLVVVPTVALAIDQERRARELLRRAGPdlggplawHGGLSAEERAAIRQRIRDGTQRILFTS 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 581 PEALVGagGLPP----AAQLPPVAFACIDEAHCLSQWSHNFRPCYLRVCKVLRERMGV----HCF--LGLTATATRRT-- 648
Cdd:NF041063 251 PESLTG--SLRPalfdAAEAGLLRYLVVDEAHLVDQWGDGFRPEFQLLAGLRRSLLRLapsgRPFrtLLLSATLTESTld 328
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 649 -------ASDVAQHLAVAE---EPDlhgpapvpTNLHLSVSMDRDTDQALLTLLQGKRfqnldSIIIYCNRREDTERIAA 718
Cdd:NF041063 329 tletlfgPPGPFIVVSAVQlrpEPA--------YWVAKCDSEEERRERVLEALRHLPR-----PLILYVTKVEDAEAWLQ 395
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 719 LLR-------TCLHaawvpGsggrapKTTAEayhagmcsrERRRVQRAFMQGQLRVVVATVAFGMGLDRPDVRAVLHLGL 791
Cdd:NF041063 396 RLRaagfrrvALFH-----G------DTPDA---------ERERLIEQWRENELDIVVATSAFGLGMDKSDVRTVIHACV 455
|
410 420
....*....|....*....|....*
gi 2217373813 792 PPSFESYVQAVGRAGRDGQPAHCHL 816
Cdd:NF041063 456 PETLDRFYQEVGRGGRDGKASLSLL 480
|
|
| DEXHc_RecQ3 |
cd18017 |
DEAH-box helicase domain of RecQ3; DEAD-like helicase RecQ3 (also called Werner syndrome ... |
474-656 |
1.40e-34 |
|
DEAH-box helicase domain of RecQ3; DEAD-like helicase RecQ3 (also called Werner syndrome ATP-dependent helicase or WRN) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Werner's syndrome.
Pssm-ID: 350775 [Multi-domain] Cd Length: 193 Bit Score: 131.05 E-value: 1.40e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 474 EQLGHQAFRPGQERAVMRIL-SGISTLLVLPTGAGKSLCYQLPALLYSRrspcLTLVVSPLLSLMDDQV-----SGLPPC 547
Cdd:cd18017 6 EYFGHSSFRPVQWKVIRSVLeERRDNLVVMATGYGKSLCYQYPSVLLNS----LTLVISPLISLMEDQVlqlvmSNIPAC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 548 LkaacihsgMTRKQRESVLQKIRAAQVHVLMLTPEALVGAGGLPPAAQLPPVAFAcIDEAHCLSQWSHNFRPCYlRVCKV 627
Cdd:cd18017 82 F--------LGSAQSQNVLDDIKMGKIRVIYVTPEFVSKGLELLQQLRNGITLIA-IDEAHCVSQWGHDFRSSY-RHLGS 151
|
170 180
....*....|....*....|....*....
gi 2217373813 628 LRERMGVHCFLGLTATATRRTASDVAQHL 656
Cdd:cd18017 152 IRNRLPNVPIVALTATATPSVRDDIIKNL 180
|
|
| DEXHc_RecQ2_BLM |
cd18016 |
DEAH-box helicase domain of RecQ2; ATP-dependent DNA helicase Q2 (RecQ2, also called Bloom ... |
475-656 |
3.30e-30 |
|
DEAH-box helicase domain of RecQ2; ATP-dependent DNA helicase Q2 (RecQ2, also called Bloom syndrome protein homolog or BLM) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations in RecQ2 cause Bloom syndrome.
Pssm-ID: 350774 [Multi-domain] Cd Length: 208 Bit Score: 118.78 E-value: 3.30e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 475 QLGHQAFRPGQERAVMRILSGISTLLVLPTGAGKSLCYQLPALLysrrSPCLTLVVSPLLSLMDDQVSGLPPcLKAACih 554
Cdd:cd18016 12 KFGLHQFRTNQLEAINAALLGEDCFVLMPTGGGKSLCYQLPACV----SPGVTVVISPLRSLIVDQVQKLTS-LDIPA-- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 555 SGMTRKQRESVLQKIRA------AQVHVLMLTPEALVGAGGLPPAAQ----LPPVAFACIDEAHCLSQWSHNFRPCYLRV 624
Cdd:cd18016 85 TYLTGDKTDAEATKIYLqlskkdPIIKLLYVTPEKISASNRLISTLEnlyeRKLLARFVIDEAHCVSQWGHDFRPDYKRL 164
|
170 180 190
....*....|....*....|....*....|..
gi 2217373813 625 cKVLRERMGVHCFLGLTATATRRTASDVAQHL 656
Cdd:cd18016 165 -NMLRQKFPSVPMMALTATATPRVQKDILNQL 195
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
466-812 |
1.57e-23 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 107.23 E-value: 1.57e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 466 PAEVFQALEQLGHQAFRPGQERAVMRILSGISTLLVLPTGAGKSLCYQLPAL--LYSRRSPClTLVVSPLLSLMDDQVS- 542
Cdd:COG1205 42 PPELRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLeaLLEDPGAT-ALYLYPTKALARDQLRr 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 543 ------GLPPCLKAACIHSGMTRKQResvlQKIRAaQVHVLMLTPEALvGAGGLPPAAQLPPVaFAC-----IDEAHCL- 610
Cdd:COG1205 121 lrelaeALGLGVRVATYDGDTPPEER----RWIRE-HPDIVLTNPDML-HYGLLPHHTRWARF-FRNlryvvIDEAHTYr 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 611 ----SQWSHNFRPcYLRVCkvlrERMGVHC-FLGLTAT-------ATRRTASDVAqhlAVAEEPDLHGPA------PVPT 672
Cdd:COG1205 194 gvfgSHVANVLRR-LRRIC----RHYGSDPqFILASATignpaehAERLTGRPVT---VVDEDGSPRGERtfvlwnPPLV 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 673 NLHLSVSMDRDTDQALLTLL-QGKRFqnldsiIIYCNRREDTERIAALLRtclHAAWVPGSGGRApkttaEAYHAGMCSR 751
Cdd:COG1205 266 DDGIRRSALAEAARLLADLVrEGLRT------LVFTRSRRGAELLARYAR---RALREPDLADRV-----AAYRAGYLPE 331
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217373813 752 ERRRVQRAFMQGQLRVVVATVAFGMGLDRPDVRAVLHLGLPPSFESYVQAVGRAGRDGQPA 812
Cdd:COG1205 332 ERREIERGLRSGELLGVVSTNALELGIDIGGLDAVVLAGYPGTRASFWQQAGRAGRRGQDS 392
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
482-646 |
3.95e-23 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 96.93 E-value: 3.95e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 482 RPGQERAVMRILSGISTLLVLPTGAGKSLCYQLPAL--LYSRRSPCLTLVVSPLLSLMDDQVS-----GLPPCLKAACIH 554
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALeaLDKLDNGPQALVLAPTRELAEQIYEelkklGKGLGLKVASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 555 SGMTRKQRESVLQKIraaqvHVLMLTPEALvgAGGLPPAAQLPPVAFACIDEAHCLSQWShnFRPCYLRVCKVLRERmgv 634
Cdd:pfam00270 81 GGDSRKEQLEKLKGP-----DILVGTPGRL--LDLLQERKLLKNLKLLVLDEAHRLLDMG--FGPDLEEILRRLPKK--- 148
|
170
....*....|..
gi 2217373813 635 HCFLGLTATATR 646
Cdd:pfam00270 149 RQILLLSATLPR 160
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
473-656 |
3.22e-21 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 92.94 E-value: 3.22e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 473 LEQLGHQAFRPGQERAVMRILSGI-STLLVLPTGAGKSLCYQLPALLY-SRRSPCLTLVVSPLLSLMDDQVS-----GLP 545
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGLrDVILAAPTGSGKTLAALLPALEAlKRGKGGRVLVLVPTRELAEQWAEelkklGPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 546 PCLKAACIHSGMTRKQResvLQKIRAAQVHVLMLTPEALVGAgGLPPAAQLPPVAFACIDEAHCLSQWshNFRPCYLRVC 625
Cdd:smart00487 81 LGLKVVGLYGGDSKREQ---LRKLESGKTDILVTTPGRLLDL-LENDKLSLSNVDLVILDEAHRLLDG--GFGDQLEKLL 154
|
170 180 190
....*....|....*....|....*....|.
gi 2217373813 626 KVLRErmgVHCFLGLTATATRRTASDVAQHL 656
Cdd:smart00487 155 KLLPK---NVQLLLLSATPPEEIENLLELFL 182
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
741-809 |
8.45e-20 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 84.57 E-value: 8.45e-20
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217373813 741 AEAYHAGMCSRERRRVQRAFMQGQLRVVVATVAFGMGLDRPDVRAVLHLGLPPSFESYVQAVGRAGRDG 809
Cdd:smart00490 14 VARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
704-812 |
1.47e-17 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 80.38 E-value: 1.47e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 704 IIYCNRREDTERIAALLRTCLhaawvpGSGGRAPKTTAeAYHAGMCSRERRRVQRAFMQGQLRVVVATVAFGMGLDRPDV 783
Cdd:cd18797 39 IVFCRSRKLAELLLRYLKARL------VEEGPLASKVA-SYRAGYLAEDRREIEAELFNGELLGVVATNALELGIDIGGL 111
|
90 100
....*....|....*....|....*....
gi 2217373813 784 RAVLHLGLPPSFESYVQAVGRAGRDGQPA 812
Cdd:cd18797 112 DAVVLAGYPGSLASLWQQAGRAGRRGKDS 140
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
681-818 |
1.78e-17 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 79.86 E-value: 1.78e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 681 DRDTDQALLTLLQGKRFQNldSIIIYCNRREDTERIAALLRTClhaawvpgsggrapKTTAEAYHAGMCSRERRRVQRAF 760
Cdd:cd18787 10 EEEKKLLLLLLLLEKLKPG--KAIIFVNTKKRVDRLAELLEEL--------------GIKVAALHGDLSQEERERALKKF 73
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 2217373813 761 MQGQLRVVVAT-VAfGMGLDRPDVRAVLHLGLPPSFESYVQAVGRAGRDGQPAHCHLFL 818
Cdd:cd18787 74 RSGKVRVLVATdVA-ARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
686-809 |
3.18e-17 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 78.41 E-value: 3.18e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 686 QALLTLLQGKRFqnlDSIIIYCNRREDTEriAALLRtclhaawvpgsggRAPKTTAEAYHAGMCSRERRRVQRAFMQGQL 765
Cdd:pfam00271 4 EALLELLKKERG---GKVLIFSQTKKTLE--AELLL-------------EKEGIKVARLHGDLSQEEREEILEDFRKGKI 65
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 2217373813 766 RVVVATVAFGMGLDRPDVRAVLHLGLPPSFESYVQAVGRAGRDG 809
Cdd:pfam00271 66 DVLVATDVAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
466-830 |
7.48e-16 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 80.96 E-value: 7.48e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 466 PAEVFQALEQLGHQAFRPGQERAVMRILSGISTLLVLPTGAGKSLCYQLPA---LLYSRRSPCLTLVVSPL--LSLmddQ 540
Cdd:COG0513 10 SPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLlqrLDPSRPRAPQALILAPTreLAL---Q 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 541 VS--------GLPpcLKAACIHSGMT-RKQRESvLQKiraaQVHVLMLTP---EALVGAGGLppaaQLPPVAFACIDEA- 607
Cdd:COG0513 87 VAeelrklakYLG--LRVATVYGGVSiGRQIRA-LKR----GVDIVVATPgrlLDLIERGAL----DLSGVETLVLDEAd 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 608 HCLSQwshNFRPCYLRVCKVL---RERMgvhCFlglTATATRRTASDVAQHLAVAEEPDLHGPAPVPTNLHLSVSM--DR 682
Cdd:COG0513 156 RMLDM---GFIEDIERILKLLpkeRQTL---LF---SATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLvdKR 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 683 DTDQALLTLLqgkRFQNLDSIIIYCNRREDTERIAALLRTCLHAAwvpgsggrapkttaEAYHAGMCSRERRRVQRAFMQ 762
Cdd:COG0513 227 DKLELLRRLL---RDEDPERAIVFCNTKRGADRLAEKLQKRGISA--------------AALHGDLSQGQRERALDAFRN 289
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217373813 763 GQLRVVVAT-VAfGMGLDRPDVRAVLHLGLPPSFESYVQAVGRAGRDGQPAHCHLFLQPqgEDLRELRR 830
Cdd:COG0513 290 GKIRVLVATdVA-ARGIDIDDVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTP--DERRLLRA 355
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
498-643 |
3.03e-14 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 70.90 E-value: 3.03e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 498 TLLVLPTGAGKSLCYQLPALLYSRRSPCLTLVVSPLLSLMDDQVSGL----PPCLKAACIHSGMTRKQREsvlqKIRAAQ 573
Cdd:cd00046 4 VLITAPTGSGKTLAALLAALLLLLKKGKKVLVLVPTKALALQTAERLrelfGPGIRVAVLVGGSSAEERE----KNKLGD 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 574 VHVLMLTPEALVGAGGLPPAAQLPPVAFACIDEAHCLSQWSHNFRPCYLRVCKVLRERMGVhcfLGLTAT 643
Cdd:cd00046 80 ADIIIATPDMLLNLLLREDRLFLKDLKLIIVDEAHALLIDSRGALILDLAVRKAGLKNAQV---ILLSAT 146
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
482-831 |
4.28e-12 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 70.05 E-value: 4.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 482 RPGQERAVMRILSGIST-----LLVLPTGAGKSLcyqLPALLYSR-RSPCLTLVVSPLLSLMDDQVSGLPPCLKAACIHS 555
Cdd:COG1061 82 RPYQQEALEALLAALERgggrgLVVAPTGTGKTV---LALALAAElLRGKRVLVLVPRRELLEQWAEELRRFLGDPLAGG 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 556 GmtRKQRESvlqkiraaqvHVLMLTPEALVGAGGLppaAQLPP-VAFACIDEAHclsqwsHNFRPCYLRVckvlRERMGV 634
Cdd:COG1061 159 G--KKDSDA----------PITVATYQSLARRAHL---DELGDrFGLVIIDEAH------HAGAPSYRRI----LEAFPA 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 635 HCFLGLTATATRRTASDVAQHL------------AVAE----EPDLHgpaPVPTNL---------------HLSVSMDRD 683
Cdd:COG1061 214 AYRLGLTATPFRSDGREILLFLfdgivyeyslkeAIEDgylaPPEYY---GIRVDLtderaeydalserlrEALAADAER 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 684 TDQALLTLLQGKRfqNLDSIIIYCNRREDTERIAALLRtclhaawvpgsggrAPKTTAEAYHAGMCSRERRRVQRAFMQG 763
Cdd:COG1061 291 KDKILRELLREHP--DDRKTLVFCSSVDHAEALAELLN--------------EAGIRAAVVTGDTPKKEREEILEAFRDG 354
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217373813 764 QLRVVVATVAFGMGLDRPDVRAVLHLGlppSFES---YVQAVGRA---GRDGQPAHCHLFLQPQGEDLRELRRH 831
Cdd:COG1061 355 ELRILVTVDVLNEGVDVPRLDVAILLR---PTGSpreFIQRLGRGlrpAPGKEDALVYDFVGNDVPVLEELAKD 425
|
|
| RecQL4_SLD2_NTD |
cd22289 |
N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA ... |
2-50 |
8.67e-12 |
|
N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins; RecQL4, also called ATP-dependent DNA helicase Q4, or DNA helicase, RecQ-like type 4 (RecQ4), or RTS, is a DNA-dependent ATPase that may modulate chromosome segregation. This family also includes fungal DNA replication regulator SLD2, also known as DNA replication and checkpoint protein 1 (DRC1), which functions with DPB11 to control DNA replication and the S-phase checkpoint. It is also required for the proper activation of RAD53 in response to DNA damage and replication blocks. This model corresponds to the N-terminal domain of RecQL4 and SLD2, which is a homeodomain-like DNA interaction motif.
Pssm-ID: 412085 Cd Length: 49 Bit Score: 60.72 E-value: 8.67e-12
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 2217373813 2 ERLRDVRERLQAWERAFRRQRGRRPSQDDVEAAPEETRALYREYRTLKR 50
Cdd:cd22289 1 ERLQELKIALKTWERAFAKKHGRKPTKDDIKAAPEEIKDLYKEYAKLKK 49
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
661-812 |
2.64e-11 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 62.67 E-value: 2.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 661 EPDLHGPAPVPTNLHLSVSMDRDTDQALLTLLQGKrfqnldSIIIYCNRREDTERIAALLRTcLHAAWVPGSggrapktt 740
Cdd:cd18796 5 DIKVILPVAPEIFPWAGESGADAYAEVIFLLERHK------STLVFTNTRSQAERLAQRLRE-LCPDRVPPD-------- 69
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217373813 741 AEAYHAGMCSRE-RRRVQRAFMQGQLRVVVATVAFGMGLDRPDVRAVLHLGLPPSFESYVQAVGRAGRDGQPA 812
Cdd:cd18796 70 FIALHHGSLSRElREEVEAALKRGDLKVVVATSSLELGIDIGDVDLVIQIGSPKSVARLLQRLGRSGHRPGAA 142
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
700-817 |
6.84e-11 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 59.25 E-value: 6.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 700 LDSIIIYCNRREDTERIAAllrtclhaawvpgsggrapkttaeayhagmcsrerrrvqrafmqgQLRVVVATVAFGMGLD 779
Cdd:cd18785 3 VVKIIVFTNSIEHAEEIAS---------------------------------------------SLEILVATNVLGEGID 37
|
90 100 110
....*....|....*....|....*....|....*....
gi 2217373813 780 RPDVRAVLHLGLPPSFESYVQAVGRAGRDGQ-PAHCHLF 817
Cdd:cd18785 38 VPSLDTVIFFDPPSSAASYIQRVGRAGRGGKdEGEVILF 76
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
704-831 |
3.39e-10 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 63.31 E-value: 3.39e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 704 IIYCNRREDTERIAALLRTCLHaawvpgsggrapktTAEAYHAGMCSRERRRVQRAFMQGQLRVVVATVAFGMGLDRPDV 783
Cdd:PTZ00424 271 IIYCNTRRKVDYLTKKMHERDF--------------TVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQV 336
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 2217373813 784 RAVLHLGLPPSFESYVQAVGRAGRDGQPAHCHLFLQPQG-EDLRELRRH 831
Cdd:PTZ00424 337 SLVINYDLPASPENYIHRIGRSGRFGRKGVAINFVTPDDiEQLKEIERH 385
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
479-817 |
3.77e-10 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 63.97 E-value: 3.77e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 479 QAFRPGQERAVMRILSGISTLLVLPTGAGKSLCYQLPALL-YSRRSP-------CLTLVVSPLLSL-------------- 536
Cdd:COG1201 23 GAPTPPQREAWPAIAAGESTLLIAPTGSGKTLAAFLPALDeLARRPRpgelpdgLRVLYISPLKALandiernlraplee 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 537 MDDQVSGLPPCLKAAcIHSGMTrkqresvLQKIRAAQV----HVLMLTPE----ALVGAGGlppAAQLPPVAFACIDEAH 608
Cdd:COG1201 103 IGEAAGLPLPEIRVG-VRTGDT-------PASERQRQRrrppHILITTPEslalLLTSPDA---RELLRGVRTVIVDEIH 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 609 CL------SQWS------HNFRPCYLRVckvlrermgvhcfLGLTATAtrRTASDVAQHLAVAEEPD----LHGPAPVPT 672
Cdd:COG1201 172 ALagskrgVHLAlslerlRALAPRPLQR-------------IGLSATV--GPLEEVARFLVGYEDPRpvtiVDAGAGKKP 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 673 NLHLSVSMDRDTD-------------QALLTLLQGKRfqnldSIIIYCNRREDTERIAALLRTcLHAAWVpgsggrapkT 739
Cdd:COG1201 237 DLEVLVPVEDLIErfpwaghlwphlyPRVLDLIEAHR-----TTLVFTNTRSQAERLFQRLNE-LNPEDA---------L 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 740 TAEAYHAGMcSRE-RRRVQRAFMQGQLRVVVATVAFGMGLDRPDVRAVLHLGLPPSFESYVQAVGRAG-RDGQPAHCHLF 817
Cdd:COG1201 302 PIAAHHGSL-SREqRLEVEEALKAGELRAVVATSSLELGIDIGDVDLVIQVGSPKSVARLLQRIGRAGhRVGEVSKGRLV 380
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
466-825 |
2.14e-09 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 61.34 E-value: 2.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 466 PAEVFQALEQLGHQAFRPGQERAVMRILSGISTLLVLPTGAGKSLCYQLPAL----------LYSRRSPcLTLVVSP--- 532
Cdd:PLN00206 129 PPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIIsrcctirsghPSEQRNP-LAMVLTPtre 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 533 LLSLMDDQVS----GLPpcLKAACIHSGMTRKQresvlqkiraaQVHVLMLTPEALVGAGG------LPPAAQLPPVAFA 602
Cdd:PLN00206 208 LCVQVEDQAKvlgkGLP--FKTALVVGGDAMPQ-----------QLYRIQQGVELIVGTPGrlidllSKHDIELDNVSVL 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 603 CIDEAHCLSQwsHNFRPCYLRVCKVLRERMgVHCFLGLTATATRRTASDVAQHLAVAEEPDLHGPAPVPTNLHLSVSmDR 682
Cdd:PLN00206 275 VLDEVDCMLE--RGFRDQVMQIFQALSQPQ-VLLFSATVSPEVEKFASSLAKDIILISIGNPNRPNKAVKQLAIWVE-TK 350
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 683 DTDQALLTLLQGK-RFQnlDSIIIYCNRREDTERIAALLRTclhaawvpgsggrAPKTTAEAYHAGMCSRERRRVQRAFM 761
Cdd:PLN00206 351 QKKQKLFDILKSKqHFK--PPAVVFVSSRLGADLLANAITV-------------VTGLKALSIHGEKSMKERREVMKSFL 415
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217373813 762 QGQLRVVVATVAFGMGLDRPDVRAVLHLGLPPSFESYVQAVGRAGRDGQPAHCHLFLQPQGEDL 825
Cdd:PLN00206 416 VGEVPVIVATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFVNEEDRNL 479
|
|
| COG1202 |
COG1202 |
Superfamily II helicase, archaea-specific [Replication, recombination and repair]; |
704-807 |
2.14e-09 |
|
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
Pssm-ID: 440815 [Multi-domain] Cd Length: 790 Bit Score: 61.45 E-value: 2.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 704 IIYCNRREDTERIAallrtclhaawvpgsggRAPKTTAEAYHAGMCSRERRRVQRAFMQGQLRVVVATVAFGMGLDRPDV 783
Cdd:COG1202 431 IIFTNSRRRCHEIA-----------------RALGYKAAPYHAGLDYGERKKVERRFADQELAAVVTTAALAAGVDFPAS 493
|
90 100 110
....*....|....*....|....*....|....*.
gi 2217373813 784 RAVlhlglppsFES------------YVQAVGRAGR 807
Cdd:COG1202 494 QVI--------FDSlamgiewlsvqeFHQMLGRAGR 521
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
681-809 |
1.90e-08 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 54.48 E-value: 1.90e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 681 DRDTDQALLTLLQGKRFQNLDSIIIYCNRREDTERIAALLRtclhaawvpGSGgrapkttaeAYHAGMCSRERRRVQRAF 760
Cdd:cd18795 24 MNKFDSDIIVLLKIETVSEGKPVLVFCSSRKECEKTAKDLA---------GIA---------FHHAGLTREDRELVEELF 85
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 2217373813 761 MQGQLRVVVATVAFGMGLDRPDVRAVLhLGLP----------PSFEsYVQAVGRAGRDG 809
Cdd:cd18795 86 REGLIKVLVATSTLAAGVNLPARTVII-KGTQrydgkgyrelSPLE-YLQMIGRAGRPG 142
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
485-608 |
2.38e-08 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 54.90 E-value: 2.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 485 QERAVMRILSGISTLLVLPTGAGKSLCYQLPAL--LYSRRSPClTLVVSPLLSLMDDQVSGL----PPCL---KAACIHs 555
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILeaLLRDPGSR-ALYLYPTKALAQDQLRSLrellEQLGlgiRVATYD- 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 2217373813 556 GMTrkqRESVLQKIRAAQVHVLMLTPEALvGAGGLPPAAQLPP----VAFACIDEAH 608
Cdd:cd17923 83 GDT---PREERRAIIRNPPRILLTNPDML-HYALLPHHDRWARflrnLRYVVLDEAH 135
|
|
| PRK09751 |
PRK09751 |
putative ATP-dependent helicase Lhr; Provisional |
702-806 |
3.85e-08 |
|
putative ATP-dependent helicase Lhr; Provisional
Pssm-ID: 137505 [Multi-domain] Cd Length: 1490 Bit Score: 57.63 E-value: 3.85e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 702 SIIIYCNRREDTERIAALLR---------------TCLHAAWVPGSGGR----APKTTAEAYHAGMCSRERRRVQRAFMQ 762
Cdd:PRK09751 246 STIVFTNSRGLAEKLTARLNelyaarlqrspsiavDAAHFESTSGATSNrvqsSDVFIARSHHGSVSKEQRAITEQALKS 325
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 2217373813 763 GQLRVVVATVAFGMGLDRPDVRAVLHLGLPPSFESYVQAVGRAG 806
Cdd:PRK09751 326 GELRCVVATSSLELGIDMGAVDLVIQVATPLSVASGLQRIGRAG 369
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
466-810 |
1.38e-07 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 55.29 E-value: 1.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 466 PAEVFQALEQLGHQAFRPGQERAVMR-ILSGISTLLVLPTGAGKSLCYQLpALLYSRRSPCLTLVVSPLLSLMDDQVSGL 544
Cdd:COG1204 8 LEKVIEFLKERGIEELYPPQAEALEAgLLEGKNLVVSAPTASGKTLIAEL-AILKALLNGGKALYIVPLRALASEKYREF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 545 PPCLKAACIHSGMTRKQRESVLQkiRAAQVHVLMLTPE---ALVGAGGLPpaaqLPPVAFACIDEAH------------- 608
Cdd:COG1204 87 KRDFEELGIKVGVSTGDYDSDDE--WLGRYDILVATPEkldSLLRNGPSW----LRDVDLVVVDEAHliddesrgptlev 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 609 CLSQwshnfrpcYLRVCKVLRermgvhcFLGLTATAtrRTASDVAQHLavaeepdlhGPAPV-----PTNLHLSVSMDRD 683
Cdd:COG1204 161 LLAR--------LRRLNPEAQ-------IVALSATI--GNAEEIAEWL---------DAELVksdwrPVPLNEGVLYDGV 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 684 TDQALLTLLQGKRFQNL--------DSIIIYCNRREDTERIAALLRTCLHAAWVPGSGGRAPKTTAE------------- 742
Cdd:COG1204 215 LRFDDGSRRSKDPTLALaldlleegGQVLVFVSSRRDAESLAKKLADELKRRLTPEEREELEELAEEllevseethtnek 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 743 ---------AYH-AGMCSRERRRVQRAFMQGQLRVVVAT--VAFGMGLdrPdVRAVL-----HLGLPP--SFEsYVQAVG 803
Cdd:COG1204 295 ladclekgvAFHhAGLPSELRRLVEDAFREGLIKVLVATptLAAGVNL--P-ARRVIirdtkRGGMVPipVLE-FKQMAG 370
|
....*..
gi 2217373813 804 RAGRDGQ 810
Cdd:COG1204 371 RAGRPGY 377
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
434-820 |
5.74e-07 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 53.62 E-value: 5.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 434 VPSPqpvpeVPSLDPTVLPLYslgpsgqlaetpaeVFQALEQLGHQAFRPGQERAVMRILSGISTLLVLPTGAGKSLCYQ 513
Cdd:PTZ00110 125 VPKP-----VVSFEYTSFPDY--------------ILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFL 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 514 LPALLYSRRSPCL-------TLVVSPLLSLMDD-----QVSGLPPCLKAACIHSGMTRKQRESVLQKiraaQVHVLMLTP 581
Cdd:PTZ00110 186 LPAIVHINAQPLLrygdgpiVLVLAPTRELAEQireqcNKFGASSKIRNTVAYGGVPKRGQIYALRR----GVEILIACP 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 582 EALVGAggLPP-AAQLPPVAFACIDEA-------------HCLSQ---------WSHNFRPCYLRVCKVLRERMGVHCFL 638
Cdd:PTZ00110 262 GRLIDF--LESnVTNLRRVTYLVLDEAdrmldmgfepqirKIVSQirpdrqtlmWSATWPKEVQSLARDLCKEEPVHVNV 339
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 639 G-LTATATRRtasdVAQHLAVAEEPDlhgpapvptnlhlsvsmdrdtDQALLTLLQGKRFQNLDSIIIYCnrreDTERIA 717
Cdd:PTZ00110 340 GsLDLTACHN----IKQEVFVVEEHE---------------------KRGKLKMLLQRIMRDGDKILIFV----ETKKGA 390
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 718 ALLRTCLHAAWVPgsggrapkttAEAYHAGMCSRERRRVQRAFMQGQLRVVVATVAFGMGLDRPDVRAVLHLGLPPSFES 797
Cdd:PTZ00110 391 DFLTKELRLDGWP----------ALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPNQIED 460
|
410 420
....*....|....*....|...
gi 2217373813 798 YVQAVGRAGRDGQPAHCHLFLQP 820
Cdd:PTZ00110 461 YVHRIGRTGRAGAKGASYTFLTP 483
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
481-806 |
1.20e-06 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 52.58 E-value: 1.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 481 FRPGQERAVMRILSGISTLLVLPTGAGKSLCYQLPAL--LYSR-RSPCL-----TLVVSPLLSLMDDQVSGL-------- 544
Cdd:PRK13767 33 FTPPQRYAIPLIHEGKNVLISSPTGSGKTLAAFLAIIdeLFRLgREGELedkvyCLYVSPLRALNNDIHRNLeeplteir 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 545 ---------PPCLKAACIHSGMTRKQRESVLQKiraaQVHVLMLTPEALVGAGGLPPAAQ-LPPVAFACIDEAHCLSQws 614
Cdd:PRK13767 113 eiakergeeLPEIRVAIRTGDTSSYEKQKMLKK----PPHILITTPESLAILLNSPKFREkLRTVKWVIVDEIHSLAE-- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 615 hNFRPCYLRVCKVLRERMGVHCF--LGLTATATrrTASDVAQHLAVAEepDLHGPAPVptnLHLSVSMDRDTDQALLT-- 690
Cdd:PRK13767 187 -NKRGVHLSLSLERLEELAGGEFvrIGLSATIE--PLEEVAKFLVGYE--DDGEPRDC---EIVDARFVKPFDIKVISpv 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 691 ---------LLQGKRFQNLDSII-------IYCNRREDTERIAALLRTCLhaawvpgsGGRAPKTTAEAYHAGMcSRERR 754
Cdd:PRK13767 259 ddlihtpaeEISEALYETLHELIkehrttlIFTNTRSGAERVLYNLRKRF--------PEEYDEDNIGAHHSSL-SREVR 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 2217373813 755 -RVQRAFMQGQLRVVVATVAFGMGLDRPDVRAVLHLGLPPSFESYVQAVGRAG 806
Cdd:PRK13767 330 lEVEEKLKRGELKVVVSSTSLELGIDIGYIDLVVLLGSPKSVSRLLQRIGRAG 382
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
481-643 |
3.10e-05 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 44.99 E-value: 3.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 481 FRPGQERAVMRILSGIST---LLVLPTGAGKSLC-YQLPALLYSRRspclTLVVSPLLSLMDDQVSGLppcLKAACIHSg 556
Cdd:cd17926 1 LRPYQEEALEAWLAHKNNrrgILVLPTGSGKTLTaLALIAYLKELR----TLIVVPTDALLDQWKERF---EDFLGDSS- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 557 mtRKQRESVLQKIRAAQVHVLMlTPEALVgagGLPPAAQLPPVAFACI--DEAHCLS--QWSHnfrpcylrvckvLRERM 632
Cdd:cd17926 73 --IGLIGGGKKKDFDDANVVVA-TYQSLS---NLAEEEKDLFDQFGLLivDEAHHLPakTFSE------------ILKEL 134
|
170
....*....|.
gi 2217373813 633 GVHCFLGLTAT 643
Cdd:cd17926 135 NAKYRLGLTAT 145
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
698-876 |
4.11e-05 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 47.21 E-value: 4.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 698 QNLDSIIIYCNRREDTERIAALLrtclhaawvpgsggrapktTAEAYHAGMCSRE-----RRRVQRAFMQGQLRVVVATV 772
Cdd:PRK01297 333 NPWERVMVFANRKDEVRRIEERL-------------------VKDGINAAQLSGDvpqhkRIKTLEGFREGKIRVLVATD 393
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 773 AFGMGLDRPDVRAVLHLGLPPSFESYVQAVGRAGRDGQPAHCHLFLqpqGEDlrelrrhvhaDSTDFLAVKRLVQRvfpa 852
Cdd:PRK01297 394 VAGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISFA---GED----------DAFQLPEIEELLGR---- 456
|
170 180
....*....|....*....|....
gi 2217373813 853 cTCTCTRPPSEQegavggERPVPK 876
Cdd:PRK01297 457 -KISCEMPPAEL------LKPVPR 473
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
681-810 |
4.34e-05 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 47.10 E-value: 4.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 681 DRDTDQALLTLLQGKRFQnldSIIIYCNRREDTERIAALLRtclhaawvpgsggrAPKTTAEAYHAGMCSRERRRVQRAF 760
Cdd:PRK11776 226 PDERLPALQRLLLHHQPE---SCVVFCNTKKECQEVADALN--------------AQGFSALALHGDLEQRDRDQVLVRF 288
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 2217373813 761 MQGQLRVVVAT-VAfGMGLDRPDVRAVLHLGLPPSFESYVQAVGRAGRDGQ 810
Cdd:PRK11776 289 ANRSCSVLVATdVA-ARGLDIKALEAVINYELARDPEVHVHRIGRTGRAGS 338
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
686-818 |
6.63e-05 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 44.12 E-value: 6.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 686 QALLTLLQgKRFQNLDSI--IIYCNRREDTERIAALLRTC------LHAAWVPGSGgrapkTTAEAYHAGMCSRERRRVQ 757
Cdd:cd18802 10 QKLIEILR-EYFPKTPDFrgIIFVERRATAVVLSRLLKEHpstlafIRCGFLIGRG-----NSSQRKRSLMTQRKQKETL 83
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217373813 758 RAFMQGQLRVVVATVAFGMGLDRPDVRAVLHLGLPPSFESYVQAVGRAGRDGqpAHCHLFL 818
Cdd:cd18802 84 DKFRDGELNLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGRARAPN--SKYILMV 142
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
481-612 |
7.88e-05 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 44.56 E-value: 7.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 481 FRPGQERAVMRI-LSGISTLLVLPTGAGKSLCYQLPALLYSRRSPCLTLVVSPLLSLMDDQVSGLPPCLKAACIHSGMtr 559
Cdd:cd17921 2 LNPIQREALRALyLSGDSVLVSAPTSSGKTLIAELAILRALATSGGKAVYIAPTRALVNQKEADLRERFGPLGKNVGL-- 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 2217373813 560 KQRESVLQKIRAAQVHVLMLTPEALVGAGGLPPAAQLPPVAFACIDEAHCLSQ 612
Cdd:cd17921 80 LTGDPSVNKLLLAEADILVATPEKLDLLLRNGGERLIQDVRLVVVDEAHLIGD 132
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
751-813 |
9.17e-05 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 46.12 E-value: 9.17e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217373813 751 RERRRVQRAFMQGQLRVVVATVAFGMGLDRPDVRAVLHLGLPPSFESYVQAVGRAGRDGQPAH 813
Cdd:PRK04837 292 KKRLRILEEFTRGDLDILVATDVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGH 354
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
495-610 |
1.76e-04 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 43.34 E-value: 1.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 495 GISTLLVLPTGAGKSLCYQLPAL--LYSRRSPCL-TLVVSPLLSLMDDQ-------VSGLPPCLKAACIHSGMTRKQRes 564
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALssLADEPEKGVqVLYISPLKALINDQerrleepLDEIDLEIPVAVRHGDTSQSEK-- 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 2217373813 565 vlQKIRAAQVHVLMLTPEAL----VGAGGLPpaaQLPPVAFACIDEAHCL 610
Cdd:cd17922 79 --AKQLKNPPGILITTPESLelllVNKKLRE---LFAGLRYVVVDEIHAL 123
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
469-607 |
2.68e-04 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 43.22 E-value: 2.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 469 VFQALEQLGHQAFRPGQERAVMRILSGISTLLVLPTGAGKSLCYQLPALLYSRRSPCL--------TLVVSPLLSL---M 537
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDLQPIPreqrngpgVLVLTPTRELalqI 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217373813 538 DDQVSG-LPPCLKAACIHSGMTRKQRESVLQKiraaQVHVLMLTP---EALVGAGglppAAQLPPVAFACIDEA 607
Cdd:cd17958 81 EAECSKySYKGLKSVCVYGGGNRNEQIEDLSK----GVDIIIATPgrlNDLQMNN----VINLKSITYLVLDEA 146
|
|
| DDXDc_reverse_gyrase |
cd17924 |
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of ... |
491-580 |
4.60e-04 |
|
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350682 [Multi-domain] Cd Length: 189 Bit Score: 42.31 E-value: 4.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 491 RILSGISTLLVLPTGAGKS---LCYQLPALLYSRRSpcltLVVSPLLSLM-------DDQVSGLPPCLKAACIHSGMTRK 560
Cdd:cd17924 28 RLLRGKSFAIIAPTGVGKTtfgLATSLYLASKGKRS----YLIFPTKSLVkqayerlSKYAEKAGVEVKILVYHSRLKKK 103
|
90 100
....*....|....*....|
gi 2217373813 561 QRESVLQKIRAAQVHVLMLT 580
Cdd:cd17924 104 EKEELLEKIEKGDFDILVTT 123
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
471-585 |
6.66e-04 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 42.04 E-value: 6.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 471 QALEQLGHQAFRPGQERAVMRILSGISTLLVLPTGAGKSLCYQLPAL-------LYSRRSPcLTLVVSPL--LSLmddQV 541
Cdd:cd00268 3 KALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILekllpepKKKGRGP-QALVLAPTreLAM---QI 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 2217373813 542 S------GLPPCLKAACIHSGMTRKQRESVLQKiraaQVHVLMLTPEALV 585
Cdd:cd00268 79 AevarklGKGTGLKVAAIYGGAPIKKQIEALKK----GPDIVVGTPGRLL 124
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
481-643 |
1.08e-03 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 40.73 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 481 FRPGQERAVMRILSGIST-----LLVLPTGAGKSLCY-QLPALLYSRRSPCLTLVVSPLLSLMDDQVSGLPPCLKAACIH 554
Cdd:pfam04851 4 LRPYQIEAIENLLESIKNgqkrgLIVMATGSGKTLTAaKLIARLFKKGPIKKVLFLVPRKDLLEQALEEFKKFLPNYVEI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 555 SG--MTRKQRESVLQKiraaqvHVLMLTPEALVGAGGLPPaAQLPPVAFACI--DEAHCL--SQWSH---NFRPCYLrvc 625
Cdd:pfam04851 84 GEiiSGDKKDESVDDN------KIVVTTIQSLYKALELAS-LELLPDFFDVIiiDEAHRSgaSSYRNileYFKPAFL--- 153
|
170
....*....|....*...
gi 2217373813 626 kvlrermgvhcfLGLTAT 643
Cdd:pfam04851 154 ------------LGLTAT 159
|
|
| PRK02362 |
PRK02362 |
ATP-dependent DNA helicase; |
744-823 |
1.37e-03 |
|
ATP-dependent DNA helicase;
Pssm-ID: 235032 [Multi-domain] Cd Length: 737 Bit Score: 42.64 E-value: 1.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 744 YHAGMCSRERRRVQRAFMQGQLRVVVATVAFGMGLDRPDVRAVLH--------LGLPP-SFESYVQAVGRAGRDGqpahc 814
Cdd:PRK02362 309 HHAGLSREHRELVEDAFRDRLIKVISSTPTLAAGLNLPARRVIIRdyrrydggAGMQPiPVLEYHQMAGRAGRPG----- 383
|
....*....
gi 2217373813 815 hlfLQPQGE 823
Cdd:PRK02362 384 ---LDPYGE 389
|
|
| PRK01172 |
PRK01172 |
ATP-dependent DNA helicase; |
744-809 |
1.48e-03 |
|
ATP-dependent DNA helicase;
Pssm-ID: 100801 [Multi-domain] Cd Length: 674 Bit Score: 42.56 E-value: 1.48e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217373813 744 YHAGMCSRERRRVQRAFMQGQLRVVVATVAFGMGLDRP-------DVRAVLHLGLPP-SFESYVQAVGRAGRDG 809
Cdd:PRK01172 291 HHAGLSNEQRRFIEEMFRNRYIKVIVATPTLAAGVNLParlvivrDITRYGNGGIRYlSNMEIKQMIGRAGRPG 364
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
467-585 |
2.27e-03 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 40.38 E-value: 2.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 467 AEVFQALEQLGHQAFRPGQERAVMRILSGISTLLVLPTGAGKSLCYQLPAL--LYSRRSPCLTLVVSPLLSLMdDQVS-- 542
Cdd:cd17954 9 EELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILqaLLENPQRFFALVLAPTRELA-QQISeq 87
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 2217373813 543 ----GLPPCLKAACIHSGMtrkqrESVLQKIRAAQ-VHVLMLTPEALV 585
Cdd:cd17954 88 fealGSSIGLKSAVLVGGM-----DMMAQAIALAKkPHVIVATPGRLV 130
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
514-577 |
2.96e-03 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 38.35 E-value: 2.96e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217373813 514 LPALLYSRRSPClTLVVSPLLSLMDDQVSGLPPCLKAACIHSGMTRKQRESVLQKIRAAQVHVL 577
Cdd:pfam00271 6 LLELLKKERGGK-VLIFSQTKKTLEAELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVL 68
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
740-807 |
3.62e-03 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 40.95 E-value: 3.62e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217373813 740 TAEAYHAGMCSRERRRVQRAFMQGQLRVVVATVAFGMGLDRPDVRAVLHLGLPPSFESYVQAVGRAGR 807
Cdd:PRK10590 271 RSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHVVNYELPNVPEDYVHRIGRTGR 338
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
686-818 |
5.63e-03 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 38.23 E-value: 5.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 686 QALLTLLQGKRFQNlDSIIIYCNRREDTERIAALLRTClhaawvpgsggrapKTTAEAYHAGMCSRERRRVQRAFM--QG 763
Cdd:cd18793 14 EALLELLEELREPG-EKVLIFSQFTDTLDILEEALRER--------------GIKYLRLDGSTSSKERQKLVDRFNedPD 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217373813 764 QLRVVVATVAFGMGL-----DRpdvraVLHLGLP--PSFESyvQAVGRAGRDGQ--PAHCHLFL 818
Cdd:cd18793 79 IRVFLLSTKAGGVGLnltaaNR-----VILYDPWwnPAVEE--QAIDRAHRIGQkkPVVVYRLI 135
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
469-584 |
6.92e-03 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 39.27 E-value: 6.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 469 VFQALEQLGHQAFRPGQERAVMRILSGISTLLVLPTGAGKSLCYQLP--------ALLYSR--RSPcLTLVVSPLLSLMd 538
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPiiqrllryKLLAEGpfNAP-RGLVITPSRELA- 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 2217373813 539 DQVS--------GLPpcLKAACIHSGMTRKQresvLQKIRAAQVHVLMLTPEAL 584
Cdd:cd17948 79 EQIGsvaqslteGLG--LKVKVITGGRTKRQ----IRNPHFEEVDILVATPGAL 126
|
|
| SF2_C_RecG |
cd18811 |
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a ... |
745-816 |
7.34e-03 |
|
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. RecG helps process Holliday junction intermediates to mature products by catalyzing branch migration. It is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350198 [Multi-domain] Cd Length: 159 Bit Score: 38.48 E-value: 7.34e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217373813 745 HAGMCSRERRRVQRAFMQGQLRVVVATVAFGMGLDRPD--VRAVLH---LGLppsfESYVQAVGRAGRDGQPAHCHL 816
Cdd:cd18811 68 HGRLKSDEKDAVMAEFREGEVDILVSTTVIEVGVDVPNatVMVIEDaerFGL----SQLHQLRGRVGRGDHQSYCLL 140
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
548-577 |
8.79e-03 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 37.49 E-value: 8.79e-03
10 20 30
....*....|....*....|....*....|
gi 2217373813 548 LKAACIHSGMTRKQRESVLQKIRAAQVHVL 577
Cdd:cd18787 52 IKVAALHGDLSQEERERALKKFRSGKVRVL 81
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
505-643 |
9.01e-03 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 38.32 E-value: 9.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217373813 505 GAGK-----SLCYQLpalLYSRRSPCLTLVVSPlLSLMD---DQVSGLPPCLKAACIHSgmTRKQRESVLQKIRAAQVHV 576
Cdd:cd17919 29 GLGKtlqaiAFLAYL---LKEGKERGPVLVVCP-LSVLEnweREFEKWTPDLRVVVYHG--SQRERAQIRAKEKLDKFDV 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217373813 577 LMLTPEALVGagglpPAAQLPPVAFACI--DEAHCL----SQWShnfrpcylrvcKVLReRMGVHCFLGLTAT 643
Cdd:cd17919 103 VLTTYETLRR-----DKASLRKFRWDLVvvDEAHRLknpkSQLS-----------KALK-ALRAKRRLLLTGT 158
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
548-590 |
9.18e-03 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 36.42 E-value: 9.18e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 2217373813 548 LKAACIHSGMTRKQRESVLQKIRAAQVHVLMLTPealVGAGGL 590
Cdd:smart00490 12 IKVARLHGGLSQEEREEILDKFNNGKIKVLVATD---VAERGL 51
|
|
| |
