NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2217371527|ref|XP_047277583|]
View 

zinc finger protein ZFPM2 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PR-SET_ZFPM2 cd19216
PR-SET domain found in zinc finger protein ZFPM2 and similar proteins; ZFPM2 (also termed ...
 12-118 5.47e-71

PR-SET domain found in zinc finger protein ZFPM2 and similar proteins; ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


:

Pssm-ID: 380993  Cd Length: 111  Bit Score: 230.93  E-value: 5.47e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217371527   12 GELEVFQKDGERKIQSRQQLPVGTTWGPFPGKMDLNNNSLKTKAQVPMVLTAGPKWLLDVTWQGVEDNKNNCIVYSKGGQ 91
Cdd:cd19216      5 GELEVFQKDGERKIHSRQQLPVGTTWGPFPGKIDLNNNSLKTKAPVPLVLTAGPKWLLDVTWQGTEDNKNNCIVYSKGGQ 84

                           90       100
                   ....*....|....*....|....*..
gi 2217371527   92 LWCTTTKAISEGEELIAFVVDFDSRLQ 118
Cdd:cd19216     85 LWCTTTKNISEGEELIAFVVDFDSRLQ 111
 
Name Accession Description Interval E-value
PR-SET_ZFPM2 cd19216
PR-SET domain found in zinc finger protein ZFPM2 and similar proteins; ZFPM2 (also termed ...
 12-118 5.47e-71

PR-SET domain found in zinc finger protein ZFPM2 and similar proteins; ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380993  Cd Length: 111  Bit Score: 230.93  E-value: 5.47e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217371527   12 GELEVFQKDGERKIQSRQQLPVGTTWGPFPGKMDLNNNSLKTKAQVPMVLTAGPKWLLDVTWQGVEDNKNNCIVYSKGGQ 91
Cdd:cd19216      5 GELEVFQKDGERKIHSRQQLPVGTTWGPFPGKIDLNNNSLKTKAPVPLVLTAGPKWLLDVTWQGTEDNKNNCIVYSKGGQ 84

                           90       100
                   ....*....|....*....|....*..
gi 2217371527   92 LWCTTTKAISEGEELIAFVVDFDSRLQ 118
Cdd:cd19216     85 LWCTTTKNISEGEELIAFVVDFDSRLQ 111
 
Name Accession Description Interval E-value
PR-SET_ZFPM2 cd19216
PR-SET domain found in zinc finger protein ZFPM2 and similar proteins; ZFPM2 (also termed ...
 12-118 5.47e-71

PR-SET domain found in zinc finger protein ZFPM2 and similar proteins; ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380993  Cd Length: 111  Bit Score: 230.93  E-value: 5.47e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217371527   12 GELEVFQKDGERKIQSRQQLPVGTTWGPFPGKMDLNNNSLKTKAQVPMVLTAGPKWLLDVTWQGVEDNKNNCIVYSKGGQ 91
Cdd:cd19216      5 GELEVFQKDGERKIHSRQQLPVGTTWGPFPGKIDLNNNSLKTKAPVPLVLTAGPKWLLDVTWQGTEDNKNNCIVYSKGGQ 84

                           90       100
                   ....*....|....*....|....*..
gi 2217371527   92 LWCTTTKAISEGEELIAFVVDFDSRLQ 118
Cdd:cd19216     85 LWCTTTKNISEGEELIAFVVDFDSRLQ 111
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 12-115 5.76e-27

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 106.66  E-value: 5.76e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217371527   12 GELEVFQKDG----ERKIQSRQQLPVGTTWGPFPGKMDLNNNSLKTKAQV-----------PMVLTAGPKWLLDVTWQGv 76
Cdd:cd19201      5 GELELRKPSQdagrSGGVWAKQPLPEGTRFGPYPGKLVKEPLDPSYEWKVeaqgskggeglLLLTEDSGTWLKLVRSAD- 83

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2217371527   77 EDNKNNCIVYSKGGQLWCTTTKAISEGEELIAFVVDFDS 115
Cdd:cd19201     84 DEDEANLILYFKGGQIWCEVTKDIPPGEELILVLREPLL 122
PR-SET_ZFPM1 cd19215
PR-SET domain found in zinc finger protein ZFPM1 and similar proteins; ZFPM1 (also termed ...
 13-111 1.84e-18

PR-SET domain found in zinc finger protein ZFPM1 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation.


Pssm-ID: 380992  Cd Length: 110  Bit Score: 81.75  E-value: 1.84e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217371527   13 ELEVFQKDGERKIQSRQQLPVGTTWGPFPGKMDLNNNSLKTKAQ---VPMVLTAGPKWLLDVTwQGVEDNKNNCIVYSKG 89
Cdd:cd19215      6 ELELVGSSGQRRVRARQSLSEGLSWGPYHGSIQSSASSPGQAEEspaVTLLLVDEDCWLRRLP-LVSTEAEANCTIYRKG 84

                           90       100
                   ....*....|....*....|..
gi 2217371527   90 GQLWCTTTKAISEGEELIAFVV 111
Cdd:cd19215     85 DAIWCKTTKPVPEGELLSAILV 106
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 13-109 2.00e-05

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 43.73  E-value: 2.00e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217371527   13 ELEVFQ---KDGERKIQSRQQLPVGTTWGPFPGK---MDLNNNSLKTKAQvpmvltagpkwlldvtwqgvednknNCIVY 86
Cdd:cd10534      4 GLELVLssiPEGGLGVFARRTIPAGTRFGPLEGVvnwMRFVRPARNEEEQ-------------------------NLVAY 58

                           90       100
                   ....*....|....*....|...
gi 2217371527   87 SKGGQLWCTTTKAISEGEELIAF 109
Cdd:cd10534     59 QHGGQIYFRTTRDIPPGEELLVW 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH