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Conserved domains on  [gi|2217366902|ref|XP_047276265|]
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zinc finger protein 680 isoform X1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 18089471)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217|GO:0003700
PubMed:  8183940|22803940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB super family cl42959
krueppel associated box;
1-32 9.62e-12

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 59.91  E-value: 9.62e-12
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2217366902    1 MFENYRNLVFLGIAVSKPHLITCLEQGKEPWN 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
111-472 3.74e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 3.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366902 111 KIFQCDKYVKVFHKFSNSNSHKKRNTGKKVFKC--KECGKSFCMLSHLTQHIRIHTRENSYKCE-ECGKVLNWFSELIKH 187
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366902 188 KGIHMGEKPYKCEECGKAFNQSSTLIK--HKKIHIEEKPFK-----CEECGKAFSLFSILSKHKIIHTGDKPYKCDECH- 259
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgnnssSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSn 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366902 260 KAFNWFATLTNHKRIHTGEKPFKCEECGKDfNQFSNLTKHKKIHTGEKPYKCE---------------ECGKAFNQFANL 324
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLE-NSSSSLPLTTNSQLSPKSLLSQspsslsssdssssasESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366902 325 TRHKKIHTGE-------KSYKCEECGKAFIQSSNLTEHMR--IHTGE--KPYKCEE--CGKAFNGCSSLTRHKRIHT--R 389
Cdd:COG5048   271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTsiS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366902 390 ENTYKCEECGKGFTLFST-----LTNHKVIHTGEKSYKCD--ECGNVFNWPATLANHKRIHAREKPY--KCEECGKAFNR 460
Cdd:COG5048   351 PAKEKLLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNR 430

                         410
                  ....*....|..
gi 2217366902 461 SSHLTRHKKIHT 472
Cdd:COG5048   431 HYNLIPHKKIHT 442
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
1-32 9.62e-12

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 59.91  E-value: 9.62e-12
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2217366902    1 MFENYRNLVFLGIAVSKPHLITCLEQGKEPWN 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
111-472 3.74e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 3.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366902 111 KIFQCDKYVKVFHKFSNSNSHKKRNTGKKVFKC--KECGKSFCMLSHLTQHIRIHTRENSYKCE-ECGKVLNWFSELIKH 187
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366902 188 KGIHMGEKPYKCEECGKAFNQSSTLIK--HKKIHIEEKPFK-----CEECGKAFSLFSILSKHKIIHTGDKPYKCDECH- 259
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgnnssSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSn 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366902 260 KAFNWFATLTNHKRIHTGEKPFKCEECGKDfNQFSNLTKHKKIHTGEKPYKCE---------------ECGKAFNQFANL 324
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLE-NSSSSLPLTTNSQLSPKSLLSQspsslsssdssssasESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366902 325 TRHKKIHTGE-------KSYKCEECGKAFIQSSNLTEHMR--IHTGE--KPYKCEE--CGKAFNGCSSLTRHKRIHT--R 389
Cdd:COG5048   271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTsiS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366902 390 ENTYKCEECGKGFTLFST-----LTNHKVIHTGEKSYKCD--ECGNVFNWPATLANHKRIHAREKPY--KCEECGKAFNR 460
Cdd:COG5048   351 PAKEKLLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNR 430

                         410
                  ....*....|..
gi 2217366902 461 SSHLTRHKKIHT 472
Cdd:COG5048   431 HYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
351-375 5.84e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 5.84e-05
                          10        20
                  ....*....|....*....|....*
gi 2217366902 351 NLTEHMRIHTGEKPYKCEECGKAFN 375
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
1-32 9.62e-12

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 59.91  E-value: 9.62e-12
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2217366902    1 MFENYRNLVFLGIAVSKPHLITCLEQGKEPWN 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
111-472 3.74e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 3.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366902 111 KIFQCDKYVKVFHKFSNSNSHKKRNTGKKVFKC--KECGKSFCMLSHLTQHIRIHTRENSYKCE-ECGKVLNWFSELIKH 187
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366902 188 KGIHMGEKPYKCEECGKAFNQSSTLIK--HKKIHIEEKPFK-----CEECGKAFSLFSILSKHKIIHTGDKPYKCDECH- 259
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgnnssSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSn 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366902 260 KAFNWFATLTNHKRIHTGEKPFKCEECGKDfNQFSNLTKHKKIHTGEKPYKCE---------------ECGKAFNQFANL 324
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLE-NSSSSLPLTTNSQLSPKSLLSQspsslsssdssssasESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366902 325 TRHKKIHTGE-------KSYKCEECGKAFIQSSNLTEHMR--IHTGE--KPYKCEE--CGKAFNGCSSLTRHKRIHT--R 389
Cdd:COG5048   271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTsiS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366902 390 ENTYKCEECGKGFTLFST-----LTNHKVIHTGEKSYKCD--ECGNVFNWPATLANHKRIHAREKPY--KCEECGKAFNR 460
Cdd:COG5048   351 PAKEKLLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNR 430

                         410
                  ....*....|..
gi 2217366902 461 SSHLTRHKKIHT 472
Cdd:COG5048   431 HYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
133-301 2.72e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 2.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366902 133 KRNTGKKVFKCKECGKSFCMLSHLTQHIR--IHTRENSYKCEE----CGKVLNWFSELIKHKGIHMGEKPYKC--EECGK 204
Cdd:COG5048   282 SEKGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSISPAKEklLNSSS 361

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366902 205 AFNQSST-----LIKHKKIHIEEKPFKCE--ECGKAFSLFSILSKHKIIHTGDKPY--KCDECHKAFNWFATLTNHKRIH 275
Cdd:COG5048   362 KFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIH 441

                         170       180
                  ....*....|....*....|....*.
gi 2217366902 276 TGEKPFKCEECGKdFNQFSNLTKHKK 301
Cdd:COG5048   442 TNHAPLLCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
307-469 9.80e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 9.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366902 307 KPYKCEECGKAFNQFANLTRHK--KIHTGE--KSYKCEE--CGKAFIQSSNLTEHMRIHTGEKPYKCEEC------GKAF 374
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366902 375 NGCSSLTRHKRIHTRENTYKC---EECGKGFTLFSTLTNHKVIHTGEKS--YKCDECGNVFNWPATLANHKRIHAREKPY 449
Cdd:COG5048   368 NNEPPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170       180
                  ....*....|....*....|
gi 2217366902 450 KCEECGKaFNRSSHLTRHKK 469
Cdd:COG5048   448 LCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
195-478 1.23e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366902 195 KPYKCEECGKAFNQSSTLIKHKKIHIEEKPFKC--EECGKAFSLFSILSKHKIIHTGDKPYKC-DECHKAFNWFATLTNH 271
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366902 272 KRIHTGEKPFKCEECGKDFNQFSNLTK--HKKIHTGEKPYK---------------------CEECGKAFNQFANLTRHK 328
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366902 329 KIHTGEKSYKCEECGKAFIQSSNLTEHMRIHTgEKPYKCEECGKAFNGCSSLTRHKRIHTRENTYKCEECGKGFTLFSTL 408
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366902 409 TNHKVIHTGE-------KSYKCDECGNVFNWPATLANHKR--IHARE--KPYKCEE--CGKAFNRSSHLTRHKKIHTGEK 475
Cdd:COG5048   271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350


                  ...
gi 2217366902 476 LYK 478
Cdd:COG5048   351 PAK 353
zf-H2C2_2 pfam13465
Zinc-finger double domain;
351-375 5.84e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 5.84e-05
                          10        20
                  ....*....|....*....|....*
gi 2217366902 351 NLTEHMRIHTGEKPYKCEECGKAFN 375
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
295-320 1.38e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.38e-04
                          10        20
                  ....*....|....*....|....*.
gi 2217366902 295 NLTKHKKIHTGEKPYKCEECGKAFNQ 320
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
323-348 3.48e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.48e-04
                          10        20
                  ....*....|....*....|....*.
gi 2217366902 323 NLTRHKKIHTGEKSYKCEECGKAFIQ 348
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
268-292 7.05e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.05e-04
                          10        20
                  ....*....|....*....|....*
gi 2217366902 268 LTNHKRIHTGEKPFKCEECGKDFNQ 292
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
250-323 8.60e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 8.60e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217366902 250 DKPYKCDECHKAFNWFATLTNHKRIHTGEKPFKCEECGKDFNQF--SNLTKHKKIHTGEKPYKCEECGKAFNQFAN 323
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPLSNSKAS 106
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 192-262 2.18e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.18e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217366902 192 MGEKPYKCE--ECGKAFNQSSTLIKHKKiHIEEKPFKCEECGKafslfsilSKHKIIHTGDKPYKCDECHKAF 262
Cdd:COG5189   345 KDGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRY 408
zf-H2C2_2 pfam13465
Zinc-finger double domain;
240-263 2.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.53e-03
                          10        20
                  ....*....|....*....|....
gi 2217366902 240 LSKHKIIHTGDKPYKCDECHKAFN 263
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 337-359 3.10e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.10e-03
                          10        20
                  ....*....|....*....|...
gi 2217366902 337 YKCEECGKAFIQSSNLTEHMRIH 359
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
183-208 3.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.53e-03
                          10        20
                  ....*....|....*....|....*.
gi 2217366902 183 ELIKHKGIHMGEKPYKCEECGKAFNQ 208
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 449-471 4.63e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.63e-03
                          10        20
                  ....*....|....*....|...
gi 2217366902 449 YKCEECGKAFNRSSHLTRHKKIH 471
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
436-460 9.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.34e-03
                          10        20
                  ....*....|....*....|....*
gi 2217366902 436 LANHKRIHAREKPYKCEECGKAFNR 460
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 141-163 9.86e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 9.86e-03
                          10        20
                  ....*....|....*....|...
gi 2217366902 141 FKCKECGKSFCMLSHLTQHIRIH 163
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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