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Conserved domains on  [gi|2201821980|ref|XP_046780374|]
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guanine nucleotide-binding protein subunit beta-4 [Gallus gallus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-340 1.99e-86

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 261.89  E-value: 1.99e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980  48 RRTLRGHLAKIYAMHWGSDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLK 127
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980 128 TREgnvrVSRELPGHTGYLSCCRFLDDNQIVTSSG-DTTCALWDIETGQQTTTFTGHTGDVMSLSLSPDmRTFVSGAC-D 205
Cdd:cd00200    82 TGE----CVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSqD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980 206 ASSKLWDIRDGMCRQSFTGHVSDINAVCFFPNGHAFATGSDDATCRLFDLRADQELMMY-SHDNIICgitSVAFSKSGRL 284
Cdd:cd00200   157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLrGHENGVN---SVAFSPDGYL 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2201821980 285 LLAGYDDFNCNVWDTLKGERAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Cdd:cd00200   234 LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
YhaN super family cl34808
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1-58 7.59e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


The actual alignment was detected with superfamily member COG4717:

Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 38.21  E-value: 7.59e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2201821980   1 MSELEQLRQEAEQLRNQIRDARKACSDTTLAQITTSLDSVGRIQMRtRRTLRGHLAKI 58
Cdd:COG4717   162 EEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQR-LAELEEELEEA 218
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-340 1.99e-86

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 261.89  E-value: 1.99e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980  48 RRTLRGHLAKIYAMHWGSDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLK 127
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980 128 TREgnvrVSRELPGHTGYLSCCRFLDDNQIVTSSG-DTTCALWDIETGQQTTTFTGHTGDVMSLSLSPDmRTFVSGAC-D 205
Cdd:cd00200    82 TGE----CVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSqD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980 206 ASSKLWDIRDGMCRQSFTGHVSDINAVCFFPNGHAFATGSDDATCRLFDLRADQELMMY-SHDNIICgitSVAFSKSGRL 284
Cdd:cd00200   157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLrGHENGVN---SVAFSPDGYL 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2201821980 285 LLAGYDDFNCNVWDTLKGERAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Cdd:cd00200   234 LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
46-340 1.99e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 206.69  E-value: 1.99e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980  46 RTRRTLRGHLAKIYAMHWGSDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 125
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980 126 LKTRegnvRVSRELPGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLSPDMRTFVSGAC 204
Cdd:COG2319   191 LATG----KLLRTLTGHTGAVRSVAFSPDGKlLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980 205 DASSKLWDIRDGMCRQSFTGHVSDINAVCFFPNGHAFATGSDDATCRLFDLRADQELmmYSHDNIICGITSVAFSKSGRL 284
Cdd:COG2319   267 DGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKT 344

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2201821980 285 LLAGYDDFNCNVWDTLKGERAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Cdd:COG2319   345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 40-171 6.08e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 54.32  E-value: 6.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980  40 VGRIQMRTRrtLRGHLAKIYAMHWGS-DSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSwvMTCAYAPS--GNYVACGG 116
Cdd:PLN00181  562 VARSQLVTE--MKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN--ICCVQFPSesGRSLAFGS 637

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980 117 LDNICSIYNLKtregnvrvSRELP-----GHTGYLSCCRFLDDNQIVTSSGDTTCALWDI 171
Cdd:PLN00181  638 ADHKVYYYDLR--------NPKLPlctmiGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 215-254 5.32e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 5.32e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2201821980  215 DGMCRQSFTGHVSDINAVCFFPNGHAFATGSDDATCRLFD 254
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
216-254 3.81e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 3.81e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2201821980 216 GMCRQSFTGHVSDINAVCFFPNGHAFATGSDDATCRLFD 254
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1-58 7.59e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 38.21  E-value: 7.59e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2201821980   1 MSELEQLRQEAEQLRNQIRDARKACSDTTLAQITTSLDSVGRIQMRtRRTLRGHLAKI 58
Cdd:COG4717   162 EEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQR-LAELEEELEEA 218
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-340 1.99e-86

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 261.89  E-value: 1.99e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980  48 RRTLRGHLAKIYAMHWGSDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLK 127
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980 128 TREgnvrVSRELPGHTGYLSCCRFLDDNQIVTSSG-DTTCALWDIETGQQTTTFTGHTGDVMSLSLSPDmRTFVSGAC-D 205
Cdd:cd00200    82 TGE----CVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSqD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980 206 ASSKLWDIRDGMCRQSFTGHVSDINAVCFFPNGHAFATGSDDATCRLFDLRADQELMMY-SHDNIICgitSVAFSKSGRL 284
Cdd:cd00200   157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLrGHENGVN---SVAFSPDGYL 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2201821980 285 LLAGYDDFNCNVWDTLKGERAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Cdd:cd00200   234 LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
46-340 1.99e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 206.69  E-value: 1.99e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980  46 RTRRTLRGHLAKIYAMHWGSDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 125
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980 126 LKTRegnvRVSRELPGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLSPDMRTFVSGAC 204
Cdd:COG2319   191 LATG----KLLRTLTGHTGAVRSVAFSPDGKlLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980 205 DASSKLWDIRDGMCRQSFTGHVSDINAVCFFPNGHAFATGSDDATCRLFDLRADQELmmYSHDNIICGITSVAFSKSGRL 284
Cdd:COG2319   267 DGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKT 344

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2201821980 285 LLAGYDDFNCNVWDTLKGERAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Cdd:COG2319   345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
46-340 4.61e-60

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 197.83  E-value: 4.61e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980  46 RTRRTLRGHLAKIYAMHWGSDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 125
Cdd:COG2319    69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980 126 LKTRegnvRVSRELPGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLSPDMRTFVSGAC 204
Cdd:COG2319   149 LATG----KLLRTLTGHSGAVTSVAFSPDGKlLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSA 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980 205 DASSKLWDIRDGMCRQSFTGHVSDINAVCFFPNGHAFATGSDDATCRLFDLRADQELMMYSHDNiiCGITSVAFSKSGRL 284
Cdd:COG2319   225 DGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHS--GGVNSVAFSPDGKL 302

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2201821980 285 LLAGYDDFNCNVWDTLKGERAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Cdd:COG2319   303 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
64-340 2.83e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 159.31  E-value: 2.83e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980  64 GSDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNIcsiyNLKTREGNVRVSRELPGHT 143
Cdd:COG2319     3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLT----LLLLDAAAGALLATLLGHT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980 144 GYLSCCRFL-DDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSF 222
Cdd:COG2319    79 AAVLSVAFSpDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980 223 TGHVSDINAVCFFPNGHAFATGSDDATCRLFDLRADQELMMYS-HDNiicGITSVAFSKSGRLLLAGYDDFNCNVWDTLK 301
Cdd:COG2319   159 TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTG---AVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2201821980 302 GERAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Cdd:COG2319   236 GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274
WD40 COG2319
WD40 repeat [General function prediction only];
46-256 2.59e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 153.91  E-value: 2.59e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980  46 RTRRTLRGHLAKIYAMHWGSDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 125
Cdd:COG2319   195 KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980 126 LKTREgnvrVSRELPGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLSPDMRTFVSGAC 204
Cdd:COG2319   275 LATGE----LLRTLTGHSGGVNSVAFSPDGKlLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSD 350

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2201821980 205 DASSKLWDIRDGMCRQSFTGHVSDINAVCFFPNGHAFATGSDDATCRLFDLR 256
Cdd:COG2319   351 DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
46-215 3.49e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.48  E-value: 3.49e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980  46 RTRRTLRGHLAKIYAMHWGSDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 125
Cdd:COG2319   237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980 126 LKTRegnvRVSRELPGHTGYLSCCRFL-DDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLSPDMRTFVSGAC 204
Cdd:COG2319   317 LATG----KLLRTLTGHTGAVRSVAFSpDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392

                         170
                  ....*....|.
gi 2201821980 205 DASSKLWDIRD 215
Cdd:COG2319   393 DGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
150-340 6.76e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.84  E-value: 6.76e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980 150 RFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDI 229
Cdd:COG2319     2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980 230 NAVCFFPNGHAFATGSDDATCRLFDLRADQELM-MYSHDNiicGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGERAGVL 308
Cdd:COG2319    82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRtLTGHTG---AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2201821980 309 AGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Cdd:COG2319   159 TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 218-340 1.73e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.01  E-value: 1.73e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980 218 CRQSFTGHVSDINAVCFFPNGHAFATGSDDATCRLFDLRADQELM-MYSHDNiicGITSVAFSKSGRLLLAGYDDFNCNV 296
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRtLKGHTG---PVRDVAASADGTYLASGSSDKTIRL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2201821980 297 WDTLKGERAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Cdd:cd00200    78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD 121
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 40-171 6.08e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 54.32  E-value: 6.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980  40 VGRIQMRTRrtLRGHLAKIYAMHWGS-DSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSwvMTCAYAPS--GNYVACGG 116
Cdd:PLN00181  562 VARSQLVTE--MKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN--ICCVQFPSesGRSLAFGS 637

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980 117 LDNICSIYNLKtregnvrvSRELP-----GHTGYLSCCRFLDDNQIVTSSGDTTCALWDI 171
Cdd:PLN00181  638 ADHKVYYYDLR--------NPKLPlctmiGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 215-254 5.32e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 5.32e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2201821980  215 DGMCRQSFTGHVSDINAVCFFPNGHAFATGSDDATCRLFD 254
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 97-331 1.78e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 49.70  E-value: 1.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980  97 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKT-----REGNVRVSrELPGHTGYLSCC-RFLDDNQIVTSSGDTTCALWD 170
Cdd:PLN00181  483 SNLVCAIGFDRDGEFFATAGVNKKIKIFECESiikdgRDIHYPVV-ELASRSKLSGICwNSYIKSQVASSNFEGVVQVWD 561

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980 171 IETGQQTTTFTGHTGDVMSLSL-SPDMRTFVSGACDASSKLWDIRDGMcrqSFTGHVSDINAVCF-FPN--GHAFATGSD 246
Cdd:PLN00181  562 VARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGV---SIGTIKTKANICCVqFPSesGRSLAFGSA 638

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201821980 247 DATCRLFDLRADQELM--MYSHDNIicgITSVAFSKSGRLLLAGYDDfNCNVWDtLKGERAGV-------LAGHDNRVSC 317
Cdd:PLN00181  639 DHKVYYYDLRNPKLPLctMIGHSKT---VSYVRFVDSSTLVSSSTDN-TLKLWD-LSMSISGInetplhsFMGHTNVKNF 713

                         250
                  ....*....|....
gi 2201821980 318 LGVTDDGMAVATGS 331
Cdd:PLN00181  714 VGLSVSDGYIATGS 727
WD40 pfam00400
WD domain, G-beta repeat;
216-254 3.81e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 3.81e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2201821980 216 GMCRQSFTGHVSDINAVCFFPNGHAFATGSDDATCRLFD 254
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 49-83 4.22e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 4.22e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2201821980   49 RTLRGHLAKIYAMHWGSDSRLLVSASQDGKLIIWD 83
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
49-83 1.36e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.36e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2201821980  49 RTLRGHLAKIYAMHWGSDSRLLVSASQDGKLIIWD 83
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
302-340 7.69e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 7.69e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2201821980 302 GERAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 301-340 1.83e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 1.83e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2201821980  301 KGERAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 311-339 3.92e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.51  E-value: 3.92e-03
                          10        20
                  ....*....|....*....|....*....
gi 2201821980 311 HDNRVSCLGVTDDGMAVATGSWDSFLRIW 339
Cdd:pfam20426 123 HKDVVSCVAVTSDGSILATGSYDTTVMVW 151
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 134-170 4.24e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 4.24e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2201821980  134 RVSRELPGHTGYLSCCRFL-DDNQIVTSSGDTTCALWD 170
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSpDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 183-212 5.53e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 5.53e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2201821980  183 HTGDVMSLSLSPDMRTFVSGACDASSKLWD 212
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
183-212 6.45e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.86  E-value: 6.45e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 2201821980 183 HTGDVMSLSLSPDMRTFVSGACDASSKLWD 212
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1-58 7.59e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 38.21  E-value: 7.59e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2201821980   1 MSELEQLRQEAEQLRNQIRDARKACSDTTLAQITTSLDSVGRIQMRtRRTLRGHLAKI 58
Cdd:COG4717   162 EEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQR-LAELEEELEEA 218
WD40 pfam00400
WD domain, G-beta repeat;
137-170 7.93e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.86  E-value: 7.93e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2201821980 137 RELPGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWD 170
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKlLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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