NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2201819285|ref|XP_046779606|]
View 

beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1 [Gallus gallus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 690)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor (CMP-NeuA) instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.99.-
Gene Ontology:  GO:0008373|GO:0006486
PubMed:  9334165

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 143-408 0e+00

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467713  Cd Length: 266  Bit Score: 589.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 143 PEQLLCRLRDRVNVTMIRGSDGPFNSSEWQHYLPDKSLNETVGRLGRCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPV 222
Cdd:cd23985     1 AEELLCELKDKVNVSMLEGTDFPFNTSEWEGYLPKKSLREEVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 223 KGFQEDVGQKTTIRLVNSQLVTVEEQQFLKDALYNTGILIVWDPAPYHAEIHEWYRKPDYKFFEAYKSYRIRHPEQPFYI 302
Cdd:cd23985    81 AGFQQDVGTKTTIRLINSQLVTTEKHKFLKDSLYNEGILIVWDPAPYHSDIPEWYKNPDYNFFENYKTYRRLNPNQPFYI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 303 LNPKMQWQLWDILQENSLEHIQPNPPSSGMLGIVIMMTLCDEVDVYEFLPSKRQTDICHYYQKFHDHACTMGAYHPLLFE 382
Cdd:cd23985   161 LHPQMQWELWDIIQENSPEEIQPNPPSSGMLGIILMMTLCDQVDVYEFLPSKRKTDVCHYYQKFFDRACTMGAYHPLLYE 240

                         250       260
                  ....*....|....*....|....*.
gi 2201819285 383 KNLVKHLNQGTDEDIYTHGKVTLPGF 408
Cdd:cd23985   241 KNLVKHLNQGTDEDIYLLGKVTLPGF 266
 
Name Accession Description Interval E-value
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 143-408 0e+00

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 589.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 143 PEQLLCRLRDRVNVTMIRGSDGPFNSSEWQHYLPDKSLNETVGRLGRCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPV 222
Cdd:cd23985     1 AEELLCELKDKVNVSMLEGTDFPFNTSEWEGYLPKKSLREEVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 223 KGFQEDVGQKTTIRLVNSQLVTVEEQQFLKDALYNTGILIVWDPAPYHAEIHEWYRKPDYKFFEAYKSYRIRHPEQPFYI 302
Cdd:cd23985    81 AGFQQDVGTKTTIRLINSQLVTTEKHKFLKDSLYNEGILIVWDPAPYHSDIPEWYKNPDYNFFENYKTYRRLNPNQPFYI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 303 LNPKMQWQLWDILQENSLEHIQPNPPSSGMLGIVIMMTLCDEVDVYEFLPSKRQTDICHYYQKFHDHACTMGAYHPLLFE 382
Cdd:cd23985   161 LHPQMQWELWDIIQENSPEEIQPNPPSSGMLGIILMMTLCDQVDVYEFLPSKRKTDVCHYYQKFFDRACTMGAYHPLLYE 240

                         250       260
                  ....*....|....*....|....*.
gi 2201819285 383 KNLVKHLNQGTDEDIYTHGKVTLPGF 408
Cdd:cd23985   241 KNLVKHLNQGTDEDIYLLGKVTLPGF 266
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 166-391 1.87e-33

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 125.80  E-value: 1.87e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 166 FNSSEWQHY----LPDKSLNETV-----------GRLGRCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKGFQEDVG 230
Cdd:pfam00777   7 FPLGEWIRYsewwLPFTVTEELLellpkvspfdnKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 231 QKTTIRLVNSQLVTVEEQQFLK-DALYNTGILIV----------WDPAP-YHAEIhewyrKPDYKFFEAYKSYRIRHPEQ 298
Cdd:pfam00777  87 SKTTLRTMNPESAIDSKYGNLGfSHPRDPFVEFVlvpfkgrdllWLPAFlTKGNV-----SRSLRVLYTLKEVKIPVDPD 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 299 PFYILNPKMQWQLWDILQENSLehIQPNPPSSGMLGIVIMMTLCDEVDVYEFLP---SKRQTDicHYYQKFHDHACTMGA 375
Cdd:pfam00777 162 KVLFLHPDFLRYVANFWLRSHG--LKGRRPSTGLLMLSLALHLCDEVSLYGFGPfldSRGNSH--HYYDNVLMKKGGFYG 237

                         250
                  ....*....|....*.
gi 2201819285 376 YHPLLFEKNLVKHLNQ 391
Cdd:pfam00777 238 VHDMPFEFKLLQKLHK 253
 
Name Accession Description Interval E-value
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 143-408 0e+00

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 589.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 143 PEQLLCRLRDRVNVTMIRGSDGPFNSSEWQHYLPDKSLNETVGRLGRCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPV 222
Cdd:cd23985     1 AEELLCELKDKVNVSMLEGTDFPFNTSEWEGYLPKKSLREEVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 223 KGFQEDVGQKTTIRLVNSQLVTVEEQQFLKDALYNTGILIVWDPAPYHAEIHEWYRKPDYKFFEAYKSYRIRHPEQPFYI 302
Cdd:cd23985    81 AGFQQDVGTKTTIRLINSQLVTTEKHKFLKDSLYNEGILIVWDPAPYHSDIPEWYKNPDYNFFENYKTYRRLNPNQPFYI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 303 LNPKMQWQLWDILQENSLEHIQPNPPSSGMLGIVIMMTLCDEVDVYEFLPSKRQTDICHYYQKFHDHACTMGAYHPLLFE 382
Cdd:cd23985   161 LHPQMQWELWDIIQENSPEEIQPNPPSSGMLGIILMMTLCDQVDVYEFLPSKRKTDVCHYYQKFFDRACTMGAYHPLLYE 240

                         250       260
                  ....*....|....*....|....*.
gi 2201819285 383 KNLVKHLNQGTDEDIYTHGKVTLPGF 408
Cdd:cd23985   241 KNLVKHLNQGTDEDIYLLGKVTLPGF 266
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 144-408 7.21e-148

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 420.14  E-value: 7.21e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 144 EQLLCRLRDRVNVTMIRGSDGPFNSSEWQHYLPDKSLNETVGRLGRCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVK 223
Cdd:cd23968     2 EDLLCRLKKAAPFSTLRKTTSPFKDLLSLRYPFPESSLENTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 224 GFQEDVGQKTTIRLVNSQLVTVEEQQFLKDALYNTGILIVWDPAPYHAEIHEWYRKPDYKFFEAYKSYRIRHPEQPFYIL 303
Cdd:cd23968    82 GFEKDVGSKTTLRLINSQILSKPEFNFLTDPLYRNVTLLVWDPSSYNVNLEKWYKKPDFDFFPNYIKYRRRHPEEPFYLI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 304 NPKMQWQLWDILQENSLEHIQPNPPSSGMLGIVIMMTLCDEVDVYEFLPSKRQTDICHYYQKFHDHACTMGAYHPLLFEK 383
Cdd:cd23968   162 DPRFLWRLWDILQEYTPEKIKPNPPSSGFIGIVLMLHLCDWVDVYEYVPSVRQTDRCHYYDVEKDLACTLGAWHPLAAEK 241

                         250       260
                  ....*....|....*....|....*
gi 2201819285 384 NLVKHLNQGTDEDIYTHGKVTLPGF 408
Cdd:cd23968   242 LLVRHLNVGSDDDIFRKGRATLPGF 266
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 140-408 5.64e-141

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 403.06  E-value: 5.64e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 140 KLSPEQLLCRLRDRVNVTMIRGSDGPFNSSEWQHYLPDKSLNETVGR-LGRCAVVSSAGSLKSSHLGPEIDSHDAVLRFN 218
Cdd:cd23986     1 KLSRQELLCELKKRVQVRTLDGKEAPFSALGWEKYVPKIPLSKLHLRgFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 219 GAPVKGFQEDVGQKTTIRLVNSQLVTVEEQQFLKDALYNTGILIVWDPAPYHAEIHEWYRKPDYKFFEAYKSYRIRHPEQ 298
Cdd:cd23986    81 SAPTRGYEKDVGNKTTIRIINSQILTNPNHHFIDSSLYKDVILVAWDPAPYSANLHKWYKKPDYNLFTPYVQYRKRNPNQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 299 PFYILNPKMQWQLWDILQENSLEHIQPNPPSSGMLGIVIMMTLCDEVDVYEFLPSKRQTDICHYYQKFHDHACTMGAYHP 378
Cdd:cd23986   161 PFYILHPKFIWQLWDIIQENTQEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTDLCHYHERYYDAACTLGAYHP 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 2201819285 379 LLFEKNLVKHLNQGTDEDIYTHGKVTLPGF 408
Cdd:cd23986   241 LLYEKLLIQRMNKGTEDDLYRKGKVILPGF 270
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 190-389 6.69e-50

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 167.15  E-value: 6.69e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 190 CAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKGFQEDVGQKTTIRLVNSQLVTVeeqqflkdalYNTGILIVWDPAPY 269
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGF----------YLRGPRCGCHPLPL 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 270 HAEIHEWYRKPDYKFFEAYKSYRIRHPEQPFYILN--PKMQWQLWDILQ-ENSLEHIQPNPPSSGMLGIVIMMTLCDEVD 346
Cdd:cd19952    71 EEEVVLILSRAAAADFKRLKRRKKRHDNAVLLLTDpaPDLLSYVRKRLEkLGLKSFFGGNAPSSGLLAVLLALQLCDSVD 150

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2201819285 347 VYEF--LPSKRQTDICHYYQKFHDHActMGAYHPLLFEKNLVKHL 389
Cdd:cd19952   151 LYGFgvDSGHAPKVPYHYYDLVEAEE--GTAVHSFDLEAELLRAL 193
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 166-391 1.87e-33

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 125.80  E-value: 1.87e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 166 FNSSEWQHY----LPDKSLNETV-----------GRLGRCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKGFQEDVG 230
Cdd:pfam00777   7 FPLGEWIRYsewwLPFTVTEELLellpkvspfdnKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 231 QKTTIRLVNSQLVTVEEQQFLK-DALYNTGILIV----------WDPAP-YHAEIhewyrKPDYKFFEAYKSYRIRHPEQ 298
Cdd:pfam00777  87 SKTTLRTMNPESAIDSKYGNLGfSHPRDPFVEFVlvpfkgrdllWLPAFlTKGNV-----SRSLRVLYTLKEVKIPVDPD 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 299 PFYILNPKMQWQLWDILQENSLehIQPNPPSSGMLGIVIMMTLCDEVDVYEFLP---SKRQTDicHYYQKFHDHACTMGA 375
Cdd:pfam00777 162 KVLFLHPDFLRYVANFWLRSHG--LKGRRPSTGLLMLSLALHLCDEVSLYGFGPfldSRGNSH--HYYDNVLMKKGGFYG 237

                         250
                  ....*....|....*.
gi 2201819285 376 YHPLLFEKNLVKHLNQ 391
Cdd:pfam00777 238 VHDMPFEFKLLQKLHK 253
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 135-365 8.09e-32

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 121.98  E-value: 8.09e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 135 KMNAAKLSPEQLLCRLRDRVNVTMIRGSDGPFNSSEWQHyLPDKSLNETvGRLGRCAVVSSAGSLKSSHLGPEIDSHDAV 214
Cdd:cd23963    13 LLNTRKLFLTQKNTPLGDVLYYSYFKKKTFKITKSLYEL-LPKTSPFSH-KRYKTCAVVGNSGILLGSGCGKEIDSHDFV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 215 LRFNGAPVKGFQEDVGQKT--------TIRLVNSQLVTVEEQQFLKDAL--YNTGILivWdpapYHAEIHEWYRKPdykF 284
Cdd:cd23963    91 IRCNLPPIKGFEKDVGRKTnlttlnpsILKRRYNSLKKNRDRDKFLNRLkeYNGSIL--W----YPKFSFKSSTNL---L 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 285 FEAYKSYRIRHPEQPFYILNPKMQWQLWDILQENSLEHiqpnPPSSGMLGIVIMMTLCDEVDVYEFLPSkrQTDI----- 359
Cdd:cd23963   162 LKAARALKKNGLNLTVVYSNPEHFLAVQKFWKRRGLEK----RPSTGLYLVSLALTFCDEIHLYGFWPF--PTDPngrpv 235


                  ....*..
gi 2201819285 360 -CHYYQK 365
Cdd:cd23963   236 pYHYYDD 242
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 189-365 3.91e-29

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 112.77  E-value: 3.91e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 189 RCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKGFQEDVGQKTTIRLVnsqlvtVEEQQFLKDALYNTGILIVWdpAP 268
Cdd:cd23967     4 RCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMF------YPESAFRDPEEYDSDWLLVL--VP 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 269 YHAEIHEWY------RKPDYKFFeAYKSYRIRHPEQP--FYILNPKmqwqlwdILQENSLEHIQ--------PNPPSSGM 332
Cdd:cd23967    76 FKSMDLLWLqavikgKKPNGKGG-FWKKIATSVPKPPkkIRILNPY-------ILQEAAFDLIGlpmngkqgKNVPTTGI 147

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2201819285 333 LGIVIMMTLCDEVDV--YEFLPSKRQTDIcHYYQK 365
Cdd:cd23967   148 IAIVMALHYCDEVDIagFGYDPSDPNAPL-HYYDS 181
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 188-377 1.38e-25

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 103.48  E-value: 1.38e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 188 GRCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKGFQEDVGQKTTIRLV---NSQLVtVEEQQFLKDALYNTGILIVW 264
Cdd:cd23965     2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVshsSLPRL-LRNAILLLAGTRAPTVVVFW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 265 DPAPYhaeihewYRKPDYKFFEAYKSYRIRHPEQPFYILNP-KMQWQLWDILQENSLEHIQPNP-PSSGMLGIVIMMTLC 342
Cdd:cd23965    81 GPETK-------MNKDGAGKYNLLRSLSKKYPDVEFYSLTPeKMDYADELFEKETGKSRIKSGTwLSTGWFTMLLALDVC 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2201819285 343 DEVDVYEFLPSkrqtDIC----------HYYQKFHDHACTMGAYH 377
Cdd:cd23965   154 DEIKVYGMVPE----NYCrehpnskvpyHYYEPGGLKECTYYNYH 194
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 189-391 9.30e-24

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 100.02  E-value: 9.30e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 189 RCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKGFQEDVGQKTTI------RLVNSQLVTVEEQqflKDALYntgILI 262
Cdd:cd23964    84 RCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFytffpeSLHNSLLKHVPQD---KDTKY---LFI 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 263 VWDPAPYH--AEIHEWYRKPDYKffEAYKSYRIRHPEQP----FYILNPkmqwqlwDI---LQENSLEHIQPNPPSSGML 333
Cdd:cd23964   158 PFKIRDYDylDAVLSGKPVPDGC--DKGKRPPPLFGPKLnatnVRLLHP-------DFiryLFNRWLNSSTSYRPTTGAL 228

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2201819285 334 GIVIMMTLCDEVDVYEFLPSKRQTDicHYY-QKFHDHACTMGAyHPLLFEKNLVKHLNQ 391
Cdd:cd23964   229 MLLTALHTCDQVSVYGFGYDPRFSL--HYYdKTFVKFTVFYAN-HDFTNERKLWRKLHE 284
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 184-366 3.90e-22

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 95.04  E-value: 3.90e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 184 VGRLGRCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKGFQEDVGQKTTIRLV----------NSQLVTVEEQ----Q 249
Cdd:cd23966    74 PNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMypesavdldpGVHLVLVPFKvldlQ 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 250 FLKDALYNTGIlivwdpapyhaeIHEWYRKPdyKFFEAYKS-YRIRHPEQPFYIlnpkmqwqlwdilQENSLEHiQPNPP 328
Cdd:cd23966   154 WLISALTTGEI------------TRTYTPVK--RFIKADKDkVLVINPAFIKYV-------------HDNWTEH-HGRYP 205

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2201819285 329 SSGMLGIVIMMTLCDEVDVYEF-LPSKRQTDicHYYQKF 366
Cdd:cd23966   206 STGFLALIFALHICDEVSVFGFgADSKGNWH--HYWEKN 242
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 189-389 9.57e-21

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 89.72  E-value: 9.57e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 189 RCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKGFQEDVGQKTTIRL-------VNSQ--------LVTVE----EQQ 249
Cdd:cd23982     4 RCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLfypesaqFDPGiendpdtlLVLVPfkplDFY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 250 FLKDALYNTGIL--IVWDPAPyhaeiHEWYRKPDykffeayksyRIRhpeqpfyILNPKMQWQLWDILQENSLEHIQPNP 327
Cdd:cd23982    84 WLYEILSNEKRVrkGFWKQPP-----RIWDANPK----------QIR-------ILNPYYTYVAATKLLQVPGQRKKKQK 141

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2201819285 328 PSSGMLGIVIMMTLCDEVDVYEF-LP-SKRQTDICHYYQKFhdhacTM----GAYHPLLFEKNLVKHL 389
Cdd:cd23982   142 PTTGLLAITLALHLCDEVHIAGFgYPdNGNSNQPIHYYNQI-----TLksmaNSGHNLNAEAQAIQRL 204
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 188-377 4.67e-20

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 88.38  E-value: 4.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 188 GRCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKGFQEDVGQKTTIRLVNSQLVT--VEEQQFL----KDALYntgil 261
Cdd:cd23977     2 RRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPllLRNQGYFfqqsRDTKY----- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 262 IVWDPApyhaeihewyRKPDY----KFFEAYKSYRIRHPEQPFYILNPKMQWQLWDILQENSLEHIQPNPP--SSGMLGI 335
Cdd:cd23977    77 VIWGPE----------RNMDRdgggKTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMKSGSflSTGWFTM 146

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2201819285 336 VIMMTLCDEVDVY-----EFLPSKRQTDI-CHYYQKFHDHACTMGAYH 377
Cdd:cd23977   147 ILALELCEEILVYgmvsdSYCRNKNHSSVpYHYYEKGRLDECRMYLVH 194
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 189-389 6.69e-20

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 87.11  E-value: 6.69e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 189 RCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKGFQEDVGQKTTIRLVNSQLVTVEEQQFLKDAlynTGILIVWDPAP 268
Cdd:cd23984     4 KCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNT---TVVLIPFKPHD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 269 YH----------AEIHEWYRKPDYKFFeaYKSYRIRhpeqpfyILNP---KMQWQLWDILQENSLEHIQPNPPSSGMLGI 335
Cdd:cd23984    81 LRwlldllmgkkVSAKGFWKKPALNLI--YKPNQIR-------ILNPfilRIAAYELLHFPKRFPKEKKPKHPTTGIIAI 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2201819285 336 VIMMTLCDEVDV----YEFLPSkrqTDICHYYQKFHDHACTMGAYHPLLFEKNLVKHL 389
Cdd:cd23984   152 TLALHICNEVHIagfkYDFSNL---NSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 189-389 3.45e-19

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 85.56  E-value: 3.45e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 189 RCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKGFQEDVGQKTTIRLVNSQLVTVEEQQFLKDALYNTGIL----IVW 264
Cdd:cd23983     4 RCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFksvdFAW 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 265 DPAPYHAEIHEWYRKpdyKFFeaYKSYRIRHPEQP--FYILNPkmqwqlwDILQENSLEHIQ-PNP-----------PSS 330
Cdd:cd23983    84 LKAMVKKEPLSFWSR---LFF--WKEVADSIPLKPsqFRILNP-------LIIKETALDILQyPEPqsrlwgwdknvPTL 151

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 331 GMLGIVIMMTLCDEVDVYEFLPSKRQTDI-CHYYQKFHDHACTMGAYHPLLFEKNLVKHL 389
Cdd:cd23983   152 GVTAVVLATHLCDEVSLAGFGYDLSQPHApLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 189-389 4.70e-18

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 82.28  E-value: 4.70e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 189 RCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKGFQEDVGQKTTIRLVNSQLVTVEEQQFLKDALYntgILIVWDPAP 268
Cdd:cd23981     4 RCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLF---VLAGFKWQD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 269 YhaeihEWYRKPDYK--------FfeaYKSYRIRHPEQP--FYILNPKMqwqlwdiLQENSLEHI----------QPNPP 328
Cdd:cd23981    81 F-----KWLKYIVYKekvsasdgF---WKSVATRVPREPheIRILNPYF-------IQEAAFSFIglpfnnglmgRGNIP 145

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2201819285 329 SSGMLGIVIMMTLCDEVDVYEF-----LPSKRqtdiCHYYQKFHDHACTMGAYHPLLFEKNLVKHL 389
Cdd:cd23981   146 TLGSVAITMALHNCDEVAVAGFgydmnTPNAP----LHYYETIKMSAIKESWTHNIQREKEFLRKL 207
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 189-350 2.01e-17

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 81.85  E-value: 2.01e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 189 RCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKGFQEDVGQKTTIRLVNSQLVtveeqqflKDALYNTGILIVwdpaP 268
Cdd:cd23980    83 RCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESF--------RELAQNVSMILV----P 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 269 YHAEIHEW------YRKPDYKFFEAYKSYRIRHPEqpFYILNPKMQWQLWDILQENSLEHiqpnpPSSGMLGIVIMMTLC 342
Cdd:cd23980   151 FKTLDLEWvisattTGTISHTYVPVPRKIKVKKEK--ILIYHPAFIKYVFDRWLQGHGRY-----PSTGILSVIFSLHVC 223


                  ....*...
gi 2201819285 343 DEVDVYEF 350
Cdd:cd23980   224 DEVDLYGF 231
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 175-389 2.32e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 81.67  E-value: 2.32e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 175 LPDKSLNETVgRLGRCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKGFQEDVGQKTTIRLVN--------SQLVTVE 246
Cdd:cd23970    57 LPEVSPFQNK-HYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNpsilekyyNNLLTIQ 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 247 EQQ-FLKDaLYNTGILIVWDPAPYHAEIHEWYRKPDYKFFEayksyrirHPEQpfyiLNPKMQWqLWDILQENS----LE 321
Cdd:cd23970   136 DRNnFFLS-LKKLDGAILWIPAFFFHTSATVTRTLVDFFVE--------HRGQ----LKVQLAW-PGNIMQHVNrywkTK 201

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2201819285 322 HIQPNPPSSGMLGIVIMMTLCDEVDVYEFLP---SKRQTDIC-HYYQKFhDHACTMG--AYHPLLFEKNLVKHL 389
Cdd:cd23970   202 HLSPKRLSTGILMYTLASAICEEIHLYGFWPfgfDPTGTPLPyHYYDKK-GTKFTTKwqESHQLPAEFVLLYKM 274
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 189-397 2.50e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 82.11  E-value: 2.50e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 189 RCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKGFQEDVGQKTTIRLVNSQLVTVEEQQFLKDALYNtgilivwdpAP 268
Cdd:cd23973    85 RCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSSLMILQKRGFKN---------IP 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 269 YHAEIH-----EWYRkpDYKFFEAY--------KSYRIRHP---------EQPFYILNPK-MQWQLWDILQENSLE--HI 323
Cdd:cd23973   156 QDKDIKyilfpEGPR--DYQWLEALlknktipsGAYYGRRPrsyfsgdftEDKYLVLHPDfLRYVKNRFLRSKTLKgkYW 233

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2201819285 324 QPNPPSSGMLGIVIMMTLCDEVDVYEFLPSKRQTDICHYYQKFHDHACTMGAyHPLLFEKNLVKHLNqgtDEDI 397
Cdd:cd23973   234 AIYRPTTGAFLLLTALHLCDTVSAYGFITEDYRKYPDHYYDKKKTKLVFYIN-HDFRLEKKLWKRLH---DEKI 303
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 190-383 9.87e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 78.74  E-value: 9.87e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 190 CAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKGFQEDVGQKTTIRLV--NSQLVTVEEQQFLKDALYNTgILIVWDPa 267
Cdd:cd23978     4 CALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVahSSVYRVLRRPQEFLNRTPET-TLIFWGP- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 268 pyHAEIHEWYRKPDYKFFEAYKSYrirHPEQPFYILNPKMQWQLWDILQENSLEHIQPNPP--SSGMLGIVIMMTLCDEV 345
Cdd:cd23978    82 --PNKMQKDGKSNLFRIIQRASMT---FPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSwlSTGWFTMVIAVELCDNV 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2201819285 346 DVYEFLP----SKRQTD---ICHYYQKFHDHACT---------MGAYHPLLFEK 383
Cdd:cd23978   157 HVYGMVPpnycSKRPTPkkmPYHYYEPKGPDECVtyiqnehgrRGNHHRFITEK 210
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 189-390 3.01e-16

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 78.71  E-value: 3.01e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 189 RCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKGFQEDVGQKT-----TIRLVNSQLVTVEEQQFL-----KDALYnt 258
Cdd:cd23972    84 RCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTsfygfTVNTMKNSLISYWNLGFTrtpqgQDLQY-- 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 259 gILIVWDPAPY---HAEIH-----EWYRKPD--YKFF---EAYKSYRIRHPEQPFYILNPKMQWQLWDilqensLEHIQP 325
Cdd:cd23972   162 -IFIPSDIRDYvmlRSAILgvpvpEGLDKGDrpHKYFgpeASAKKFKLLHPDFISYLTDRFLKSKLLN------THYGHL 234

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2201819285 326 NPPSSGMLGIVIMMTLCDEVDVYEFLPSKrqtdichyYQKFHDH-------ACTMGAYHPLLFEKNLVKHLN 390
Cdd:cd23972   235 YMPSTGALMLLTALHTCDQVSAYGFITSN--------YWKFSDHyyerkkkPLVFYANHDMLLEAALWRRLH 298
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 189-391 1.26e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 77.10  E-value: 1.26e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 189 RCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKGFQEDVGQKT------TIRLVNS----------QLVTVEEQQFL- 251
Cdd:cd23974    86 RCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTsfytfsTNTLMNSlrayagvgfnGPPQSKETRYIf 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 252 -----------KDALYNTGIlivwDPAPyhaeihEWYRKPDYKFFE--AYKSYRIRHPEQPFYILN-----PKMQWQLWD 313
Cdd:cd23974   166 lpdhdrdyllvKAALTHTPI----DRGR------DKSKRPSKYFGKdvTAEKFKIYHPDFIRYLRNrflwsPILNTKQRD 235

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2201819285 314 ILQenslehiqpnpPSSGMLGIVIMMTLCDEVDVYEFLPSKRQTDICHYYQKFHdHACTMGAYHPLLFEKNLVKHLNQ 391
Cdd:cd23974   236 IYR-----------PSTGAVMLLAALHTCDQVSAYGFMTPDYGKYSDHYYDKTY-HKVVFYANHDLRLEMQLWQKLHK 301
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 186-391 2.08e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 76.13  E-value: 2.08e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 186 RLGRCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKGFQEDVGQKTTIRLVN--------SQLVTVEEQQFLKDALYN 257
Cdd:cd23987    63 HFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNpsvvqrafEDLVNETWKEKFLQRLQS 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 258 TGILIVWDPApYHA----EIHEWYR----KPDYKFFEAYKSYRIRHPEQPFYILNpkmqwqlwdilqensleHIQPNPPS 329
Cdd:cd23987   143 LNGSILWIPA-FMAkggeERVEWVNdlilKHHINVRTAYPSLRLLHAVRGYWLTN-----------------KVHIKRPT 204

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2201819285 330 SGMLGIVIMMTLCDEVDVYEFLPSKRQTD----ICHYYQKFHDHACTMGAYHPLLFEKNLVKHLNQ 391
Cdd:cd23987   205 TGLLMYTLATRFCNRIHLYGFWPFPRDQNqnpvKYHYYDSLKYGYTSQASPHTMPLEFKALKNLHQ 270
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 186-352 2.35e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 75.76  E-value: 2.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 186 RLGRCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKGFQEDVGQKTTIRLVNSQLV----------TVEEQQFLKDAL 255
Cdd:cd23988    63 RFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVqrafggfrneSDREKFVHRLSM 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 256 YNTGILivWDPA------PYHAE-IHEWYRKPDYKFFEAYKSYRIRHPEQPFYILNpkmqwqlwdilqensleHIQPNPP 328
Cdd:cd23988   143 LNDSVL--WIPAfmvkggEKHVEwVNALILKNKLKVRTAYPSLRLIHAVRGYWLTN-----------------KVNIKRP 203

                         170       180
                  ....*....|....*....|....
gi 2201819285 329 SSGMLGIVIMMTLCDEVDVYEFLP 352
Cdd:cd23988   204 STGLLMYTLATRFCDEIHLYGFWP 227
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 186-363 1.61e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 73.22  E-value: 1.61e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 186 RLGRCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKGFQEDVGQKTTIRLVNSQLV----------TVEEQqfLKDAL 255
Cdd:cd23969    63 HFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSVIphaygdlvnaTDKEK--FVERL 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 256 YNTGILIVWDPA---PYHAEIHEW----YRKPDYKFFEAYKSYRIRHpeqpfyilnpkMQWQLWdilqenSLEHIQPNPP 328
Cdd:cd23969   141 RQLGDSILWIPAfvsKGGEEHVQWtneiILKHKLNVKTAYPPLRLNH-----------AIRGYW------LTTKFRIKRP 203

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2201819285 329 SSGMLGIVIMMTLCDEVDVYEFLPSK---RQTDI-CHYY 363
Cdd:cd23969   204 STGLLMYTLATRFCDEIHLYGFYPFSedgNGRAVkYHYY 242
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 190-383 4.60e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 71.44  E-value: 4.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 190 CAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKGFQEDVGQKTTIRLVNSQLVtveeQQFLKD--ALYNTG---ILIVW 264
Cdd:cd23976    18 CALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSI----QRILRNrnELLNVSqgtVFIFW 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 265 DPAPyhaeihewYRKPDYKFFeAYKSYRIRHPEQP----FYILNPKMqWQLWDIL-QENSLEHIQPNP-PSSGMLGIVIM 338
Cdd:cd23976    94 GPSN--------YMRRDGKGL-VYNNLQLMNQILPklkvYTITRHKM-LQFDELFkRETGKDRKISNTwLSTGWFTMIIA 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2201819285 339 MTLCDEVDVYEFLPSkrqtDIC----------HYYQKFHDHACTM---------GAYHPLLFEK 383
Cdd:cd23976   164 LELCDRINVYGMVPP----DFCrdpnhpsvpyHYYEPSGPDECTMyishergrkGSHHRFITEK 223
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 190-266 2.17e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 69.19  E-value: 2.17e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 190 CAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKGFQEDVGQKTTIRLVNSQ---LVTVEEQQFLKDAlyNTGILIVWDP 266
Cdd:cd23975     4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTsvpLLLKNPDYFFKET--NETIYVIWGP 81
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 189-363 8.55e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 68.24  E-value: 8.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 189 RCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKG-FQEDVGQKTTIRLVNSQLVTVEEQQ-------FLKD-ALYNTG 259
Cdd:cd23991    66 QCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNLVTANPSIISIKYAKlnerrkpFLETvSVYGDA 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 260 ILIVwdPAPYhaeihewYRKPDYKFFEAYKSYRIRHPEQPFYILNPKMqwqLWDILQENSLEHIQPNPPSSGMLGIVIMM 339
Cdd:cd23991   146 FLLL--PAFS-------YRSNTALSFKVYYTLEDFKAKQKVIFFHPIY---LKHLAQFWRSKGVQVYRLSTGLMITSAAL 213

                         170       180
                  ....*....|....*....|....*..
gi 2201819285 340 TLCDEVDVYEFLPSKRQTD---ICHYY 363
Cdd:cd23991   214 ELCEEVKLYGFWPFSKNTEgkpISHHY 240
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 189-350 6.11e-12

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 65.66  E-value: 6.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 189 RCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKGFQEDVGQKTTIRLVNSQLVtveeqqflKDALYNTGILIVwdpaP 268
Cdd:cd23979    82 RCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESA--------KNLPANVSFVLV----P 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 269 YHAEIHEWYRKP----DYKFFEAYKSYRIRHPEQPFYILNPKmqwqLWDILQENSLEHiQPNPPSSGMLGIVIMMTLCDE 344
Cdd:cd23979   150 FKTLDLLWITSAlstgQIRFTYAPVKQFLRVDKDKVQIYNPA----FFKYIHDRWTEH-HGRYPSTGMLVLFFALHVCDE 224


                  ....*.
gi 2201819285 345 VDVYEF 350
Cdd:cd23979   225 VNVYGF 230
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 187-352 1.10e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 64.97  E-value: 1.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 187 LGRCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKgFQEDVGQKTtirlvnsQLVTVeeqqflkdalyNTGILIVwdp 266
Cdd:cd23971    64 LKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKT-------NLVTA-----------NPSILRE--- 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 267 apYHAEIHEWyRKPDYKFFEAYK-----------------SYRIRHPEQPF------YILNPKMQWQLWDILQENSLEHI 323
Cdd:cd23971   122 --KFHNLKKR-RRPFVERMKVYGnallllpafsytsntepSLRALYTLEDFgspqkvLFFNPEYLRNLSRYWKSKGLKAR 198

                         170       180
                  ....*....|....*....|....*....
gi 2201819285 324 QpnpPSSGMLGIVIMMTLCDEVDVYEFLP 352
Cdd:cd23971   199 R---LSTGLMLVSAALELCENVHLYGFWP 224
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 189-350 1.43e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 61.39  E-value: 1.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 189 RCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPV-KGFQEDVGQKTTIRLVNSQLVTVEEQQFLK---------DALYNT 258
Cdd:cd23990    66 KCAVVGNGGILKNSKCGREIDSADFVFRCNLPPIsEKYVRDVGVKTDVVTINPSIITERFHKLEKwrrpfyevlQVYENA 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 259 GILIvwdPAPYHAeihewyRKPDYKF--------FEAYKSYRIRHPEqpfYILNPKMQWqlwdilqenSLEHIQPNPPSS 330
Cdd:cd23990   146 SVVL---PAFYNT------RNTDVSIrvkyvlddFESQQAVYYFHPQ---YLLNVSRFW---------LRQGVRAKRISS 204

                         170       180
                  ....*....|....*....|
gi 2201819285 331 GMLGIVIMMTLCDEVDVYEF 350
Cdd:cd23990   205 GLMLVTAALELCEEVHLYGF 224
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 186-379 7.08e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 53.30  E-value: 7.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 186 RLGRCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPV-KGFQEDVGQKTTIRLVNSQLVTVEEQQFLkdalyntgilivw 264
Cdd:cd23989    62 PLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLsREYTDDVGTKTQLVTANPSIIDKRFQNLL------------- 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201819285 265 dpapyhaeiheWYRKpdyKFFEAYKSYRIRHPEQPFYILNPKMQWQLW------DILQENSLEHIQPN------------ 326
Cdd:cd23989   129 -----------WSRK---SFVESMKVYGRSYIYMPAFSMKTGTDPSLRvyytlaDVGANQTVLFANPNflrnvgkfwksk 194

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2201819285 327 -----PPSSGMLGIVIMMTLCDEVDVYEFLPSKRQTD---ICHYYqkfHDHACTMGAYHPL 379
Cdd:cd23989   195 gvhakRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDertISHHY---YDNVLPDSGFHAM 252
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH