NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2194924128|ref|XP_046602189|]
View 

synaptic vesicle glycoprotein 2C isoform X1 [Neodiprion lecontei]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
synapt_SV2 super family cl31090
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 16-352 2.25e-37

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


The actual alignment was detected with superfamily member TIGR01299:

Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 146.66  E-value: 2.25e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  16 ELKKVRDYSSGDKPSELKSADEEV--DLERAIELTGFGWYHIGLIAICGGILVATVCETMGMSFVHPAAQCDLALTTVKK 93
Cdd:TIGR01299 125 ELKDGEGPPGGEGEAERRADEEELaqQYELIIQECGHGRFQWALFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGK 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  94 GYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLFCSNQ-STVYAYITEFL 172
Cdd:TIGR01299 205 GMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAiPIVFSYFAEFL 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 173 PTSKRASIITWTCGFMAIGYLLIPGLAWLLIPlEVNWDLGF---VVYTSWRVYLAAIGSLSFATGFLLPFFPESPKFLMS 249
Cdd:TIGR01299 285 AQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIP-HYGWSFQMgsaYQFHSWRVFVIVCAFPCVFAIGALTFMPESPRFFLE 363

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 250 VGRKREALNVLRLVYNRN---SGNSNVEYPVKNLK--------FDVHDTPGHVTTALSFTLQGLFKLMWHQTATLFRPPY 318
Cdd:TIGR01299 364 NGKHDEAWMILKLIHDTNmraKGHPEKVFSVNHIKtihqedelIEIESDTGTWYQRCFVRALSEGGGIWGNFLRCFNPEV 443

                         330       340       350
                  ....*....|....*....|....*....|....
gi 2194924128 319 GWTTLLFCLIQFGICVTSMGMYIWIPNLLNMIKS 352
Cdd:TIGR01299 444 REITIKLMGVWFTLSFGYYGLSVWFPDMIKHLQA 477
AraJ super family cl43718
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
388-504 3.24e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


The actual alignment was detected with superfamily member COG2814:

Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.96  E-value: 3.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 388 SEVYTSTLVTGVFSVVAFGTL--GGLVAILRKKTVLVSALFLSGIAGFGNYFATNEITVAVLISVSVAVAGSCSTVSNTI 465
Cdd:COG2814    43 SPAQAGLVVTAYLLGAALGAPlaGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALAL 122

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2194924128 466 AVEVYPTNLRAMAVSLAFTIGRLGIALAGNTIGILIESY 504
Cdd:COG2814   123 IADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
 
Name Accession Description Interval E-value
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 16-352 2.25e-37

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 146.66  E-value: 2.25e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  16 ELKKVRDYSSGDKPSELKSADEEV--DLERAIELTGFGWYHIGLIAICGGILVATVCETMGMSFVHPAAQCDLALTTVKK 93
Cdd:TIGR01299 125 ELKDGEGPPGGEGEAERRADEEELaqQYELIIQECGHGRFQWALFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGK 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  94 GYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLFCSNQ-STVYAYITEFL 172
Cdd:TIGR01299 205 GMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAiPIVFSYFAEFL 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 173 PTSKRASIITWTCGFMAIGYLLIPGLAWLLIPlEVNWDLGF---VVYTSWRVYLAAIGSLSFATGFLLPFFPESPKFLMS 249
Cdd:TIGR01299 285 AQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIP-HYGWSFQMgsaYQFHSWRVFVIVCAFPCVFAIGALTFMPESPRFFLE 363

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 250 VGRKREALNVLRLVYNRN---SGNSNVEYPVKNLK--------FDVHDTPGHVTTALSFTLQGLFKLMWHQTATLFRPPY 318
Cdd:TIGR01299 364 NGKHDEAWMILKLIHDTNmraKGHPEKVFSVNHIKtihqedelIEIESDTGTWYQRCFVRALSEGGGIWGNFLRCFNPEV 443

                         330       340       350
                  ....*....|....*....|....*....|....
gi 2194924128 319 GWTTLLFCLIQFGICVTSMGMYIWIPNLLNMIKS 352
Cdd:TIGR01299 444 REITIKLMGVWFTLSFGYYGLSVWFPDMIKHLQA 477
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 60-281 1.02e-30

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 124.65  E-value: 1.02e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  60 ICGGILVATVCETMGMSFVHPAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSS 139
Cdd:cd17438     3 VLGLALMADGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 140 FSPTTNLFIVLRFLTGL-FCSNQSTVYAYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLIPlevNWDLGFVVYT- 217
Cdd:cd17438    83 FVQGYGAFLFCRLISGFgIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIP---HYGWGFSMGTn 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2194924128 218 ----SWRVYLAAIGSLSFATGFLLPFFPESPKFLMSVGRKREALNVLRLVYNRN---SGNSNVEYPVKNLK 281
Cdd:cd17438   160 yhfhSWRVFVIICALPCIASIIALKFMPESPRFLLEMGKHDEAWMILKNIHDTNmraKGTPEKVFTVSNIK 230
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
57-493 1.78e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 80.79  E-value: 1.78e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  57 LIAICGGILVATVCETMGMSFVHPAAQcDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSF 136
Cdd:COG2814    12 LLALALGAFLSGLGIGIVLPALPLIAA-DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 137 MSSFSPTTNLFIVLRFLTGLFCS-NQSTVYAYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLIPLeVNWDLGFVV 215
Cdd:COG2814    91 LCALAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL-FGWRWVFLV 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 216 ytswrvyLAAIGSLSFAtgFLLPFFPESPKflmsVGRKREALNVLRLVYNRnsgnsnveypvknlkfdvhdtpghvttal 295
Cdd:COG2814   170 -------NAVLALLALL--LLLRLLPESRP----AARARLRGSLRELLRRP----------------------------- 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 296 sftlqglfklmwhqtatlfrppygwTTLLFCLIQFGICVTSMGMYIWIPnllnmiksgagigaticeLVLANQANLTLNS 375
Cdd:COG2814   208 -------------------------RLLLLLLLAFLLGFGFFALFTYLP------------------LYLQEVLGLSASA 244

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 376 ASesadcsslirsevyTSTLVTGVFSVVAFGTLGGLVAILRKKTVLVSALFLSGIAGFGNYFATNEITVAVLISVSVAVA 455
Cdd:COG2814   245 AG--------------LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGF 310

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 2194924128 456 GSCSTVSNTIAVEVYPTNLRAMAVSLAFTIGRLGIALA 493
Cdd:COG2814   311 GLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
Sugar_tr pfam00083
Sugar (and other) transporter;
52-261 1.28e-13

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 73.07  E-value: 1.28e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  52 WYHIGLIaicGGILVATVCETMgmsFVHPAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGT 131
Cdd:pfam00083  13 GYDTGVI---GAFLTLIDFFKN---FGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLF 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 132 WAFSFMSSFSPTTNLFIVL---RFLTGLFC-SNQSTVYAYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLIPlev 207
Cdd:pfam00083  87 VIGAVLQGAAKGKWSVYQLivgRVLVGIGVgGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNK--- 163

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2194924128 208 nwdlgFVVYTSWRVYLAAIGSLSFATGFLLPFFPESPKFLMSVGRKREALNVLR 261
Cdd:pfam00083 164 -----TSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLA 212
xylE PRK10077
D-xylose transporter XylE; Provisional
 53-261 1.30e-08

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 57.40  E-value: 1.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  53 YHIGLIAICGGIL-------VATVCETMGMSFVHPAaQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVL- 124
Cdd:PRK10077   11 FSITLVATLGGLLfgydtavISGTVESLNTVFVAPQ-NLSESAANSLLGFCVASALIGCIIGGALGGYCSNRFGRRDSLk 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 125 ------LISTIGTWA--FSFMSSFSPTTNL---FIVLRFLTGLFCSNQSTVYA-YITEFLPTSKRASIITWTcGFMAI-G 191
Cdd:PRK10077   90 iaavlfFISALGSAWpeFGFTSIGPDNTGYvpeFVIYRIIGGIGVGLASMLSPmYIAEIAPAHIRGKLVSFN-QFAIIfG 168

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2194924128 192 YLLIPGLAWLLIPLEvnwDLGFVVYTSWRVYLA--AIGSLSFatGFLLPFFPESPKFLMSVGRKREALNVLR 261
Cdd:PRK10077  169 QLVVYFVNYFIARSG---DASWLNTDGWRYMFAseAIPALLF--LMLLYFVPETPRYLMSRGKQEQAEGILR 235
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
388-504 3.24e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.96  E-value: 3.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 388 SEVYTSTLVTGVFSVVAFGTL--GGLVAILRKKTVLVSALFLSGIAGFGNYFATNEITVAVLISVSVAVAGSCSTVSNTI 465
Cdd:COG2814    43 SPAQAGLVVTAYLLGAALGAPlaGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALAL 122

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2194924128 466 AVEVYPTNLRAMAVSLAFTIGRLGIALAGNTIGILIESY 504
Cdd:COG2814   123 IADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
 
Name Accession Description Interval E-value
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 16-352 2.25e-37

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 146.66  E-value: 2.25e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  16 ELKKVRDYSSGDKPSELKSADEEV--DLERAIELTGFGWYHIGLIAICGGILVATVCETMGMSFVHPAAQCDLALTTVKK 93
Cdd:TIGR01299 125 ELKDGEGPPGGEGEAERRADEEELaqQYELIIQECGHGRFQWALFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGK 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  94 GYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLFCSNQ-STVYAYITEFL 172
Cdd:TIGR01299 205 GMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAiPIVFSYFAEFL 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 173 PTSKRASIITWTCGFMAIGYLLIPGLAWLLIPlEVNWDLGF---VVYTSWRVYLAAIGSLSFATGFLLPFFPESPKFLMS 249
Cdd:TIGR01299 285 AQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIP-HYGWSFQMgsaYQFHSWRVFVIVCAFPCVFAIGALTFMPESPRFFLE 363

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 250 VGRKREALNVLRLVYNRN---SGNSNVEYPVKNLK--------FDVHDTPGHVTTALSFTLQGLFKLMWHQTATLFRPPY 318
Cdd:TIGR01299 364 NGKHDEAWMILKLIHDTNmraKGHPEKVFSVNHIKtihqedelIEIESDTGTWYQRCFVRALSEGGGIWGNFLRCFNPEV 443

                         330       340       350
                  ....*....|....*....|....*....|....
gi 2194924128 319 GWTTLLFCLIQFGICVTSMGMYIWIPNLLNMIKS 352
Cdd:TIGR01299 444 REITIKLMGVWFTLSFGYYGLSVWFPDMIKHLQA 477
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 60-281 1.02e-30

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 124.65  E-value: 1.02e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  60 ICGGILVATVCETMGMSFVHPAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSS 139
Cdd:cd17438     3 VLGLALMADGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 140 FSPTTNLFIVLRFLTGL-FCSNQSTVYAYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLIPlevNWDLGFVVYT- 217
Cdd:cd17438    83 FVQGYGAFLFCRLISGFgIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIP---HYGWGFSMGTn 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2194924128 218 ----SWRVYLAAIGSLSFATGFLLPFFPESPKFLMSVGRKREALNVLRLVYNRN---SGNSNVEYPVKNLK 281
Cdd:cd17438   160 yhfhSWRVFVIICALPCIASIIALKFMPESPRFLLEMGKHDEAWMILKNIHDTNmraKGTPEKVFTVSNIK 230
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 60-302 3.29e-30

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 123.37  E-value: 3.29e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  60 ICGGILVATVCETMGMSFVHPAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSS 139
Cdd:cd17363     3 VLGLALMADGVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 140 FSPTTNLFIVLRFLTGLFCSNQ-STVYAYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLIPlevNWDLGFVVYT- 217
Cdd:cd17363    83 FVQGYGFFLFCRLLSGIGIGGSiPIVFSYFAEFLAREKRGEHLSWLCMFWMIGGLYASAMAWAIIP---HYGWGFSMGTa 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 218 ----SWRVYLAAIGSLSFATGFLLPFFPESPKFLMSVGRKREALNVLRLVYNRN---SGNSNVEYPVKNLKFDVHDTPGH 290
Cdd:cd17363   160 yqfhSWRVFVIVCALPSVASVVALTFMPESPRFLLEVGKHDEAWMILKQVHDTNmraKGHPERVFTVSHIKRMNTLFLAI 239

                         250
                  ....*....|..
gi 2194924128 291 VTTALSFTLQGL 302
Cdd:cd17363   240 VWFTMSFSYYGL 251
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 92-489 7.85e-30

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 122.43  E-value: 7.85e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  92 KKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLFCSNQSTV-YAYITE 170
Cdd:TIGR00898 128 KVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQaVVLNTE 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 171 FLPTSKRASIITWTCGFMAIGYLLIPGLAWlLIPlevnwdlgfvvytSWRVYLAAIGSLSFATGFLLPFFPESPKFLMSV 250
Cdd:TIGR00898 208 FLPKKQRAIVGTLIQVFFSLGLVLLPLVAY-FIP-------------DWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQ 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 251 GRKREALNVLRLVYNRNSgnsnveypvKNLKFDVHDtpghvttaLSFTLQGLFKLMWHQTATLFRPP-YGWTTLLFCLIQ 329
Cdd:TIGR00898 274 GRIEEALKILQRIAKING---------KKLPAEVLS--------LSLEKDLSSSKKQYSFLDLFRTPnLRKTTLCLMMLW 336

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 330 FGICVTSMGMYIWIPNLlnmiksgagigaticelvlanQANLTLNSASesadcSSLIRSEVYTSTLVTgvfsvvaFGTLG 409
Cdd:TIGR00898 337 FTTAFSYYGLVLDLGNL---------------------GGNIYLDLFI-----SGLVELPAKLITLLL-------IDRLG 383

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 410 glvailRKKTvLVSALFLSGIAGFGNYFATNEITVAVLISVSVAVAGSCSTVSNTIAV--EVYPTNLRAMAVSLAFTIGR 487
Cdd:TIGR00898 384 ------RRYT-MAASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMVYLYtaELYPTVVRNLGVGVCSTMAR 456


                  ..
gi 2194924128 488 LG 489
Cdd:TIGR00898 457 VG 458
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 60-497 1.70e-26

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 112.31  E-value: 1.70e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  60 ICGGILVATVCETMGMSFVHPAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSS 139
Cdd:cd17440     3 VLGMALMADGVEVFVVGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 140 FSPTTNLFIVLRFLTGLFCSNQ-STVYAYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLIPlEVNWDLGF---VV 215
Cdd:cd17440    83 FVQGYGLFLFCRLLSGFGIGGAvPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIP-HYGWSFSMgsaYQ 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 216 YTSWRVYLAAIGSLSFATGFLLPFFPESPKFLMSVGRKREALNVLRLVYNRN---SGNSNVEYPVKNLKFDVHDTPGHVT 292
Cdd:cd17440   162 FHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKQIHDTNmraRGQPEKVFTVNRIKKDNTIKLTIVW 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 293 TALSFTLQGLFklMWHQTATlfrPPYGWTTLLFCLIQFGIC----VTSMGMYIWIPNLLNMIKSGAGIGATicELVLANQ 368
Cdd:cd17440   242 LTLSFGYYGLS--VWFPDVI---KHLQFKSVTFEDSLFKSCffedVTSVNTYFRNCTFIETVFYNTDLEDY--KFIDSDF 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 369 ANLTLNSASESADCSSlirSEVYTSTLvtgVFSVVAFGTL----GGLVAILR-----KKTVLVSALFLSGIAGFGNYFAT 439
Cdd:cd17440   315 INCTFFHNKTGCQITF---DDDYSAYW---IYFVNFLGTLavlpGNIVSALLmdrigRLTMLGGSMVLSGISCFFLWFGT 388

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2194924128 440 NEITVAVLISVSVAVAGSCSTVSNTIAVEVYPTNLRAMAVSLAFTIGRLGiALAGNTI 497
Cdd:cd17440   389 SESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAA-AVLGNLI 445
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 60-302 3.15e-25

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 108.58  E-value: 3.15e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  60 ICGGILVATVCETMGMSFVHPAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSS 139
Cdd:cd17439     3 VLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 140 FSPTTNLFIVLRFLTGL-FCSNQSTVYAYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLIPlEVNWDLGF---VV 215
Cdd:cd17439    83 FVQGYGTFLFCRLLSGVgIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIP-HYGWSFQMgsaYQ 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 216 YTSWRVYLAAIGSLSFATGFLLPFFPESPKFLMSVGRKREALNVLRLVYNRN---SGNSNVEYPVKNLKFDVHDTPGHVT 292
Cdd:cd17439   162 FHSWRVFVLVCAFPSVFAIGALTTMPESPRFFLENGKHDEAWMVLKQVHDTNmraKGHPERVFSVTHIKRRITLMMMAVW 241

                         250
                  ....*....|
gi 2194924128 293 TALSFTLQGL 302
Cdd:cd17439   242 FTMSFSYYGL 251
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 59-235 4.55e-21

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 94.91  E-value: 4.55e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  59 AICGGILVATVCETMGMSFVHPAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMS 138
Cdd:cd17372     2 AYAGMGWVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 139 SFSPTTNLFIVLRFLTGLFCSNQSTVYAYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLIPlEVNWdlgfvvytS 218
Cdd:cd17372    82 AFAPNYMWLIILRCLVGLGLGGGPQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMP-RLGW--------R 152

                         170
                  ....*....|....*..
gi 2194924128 219 WRVYLAAIGSLSFATGF 235
Cdd:cd17372   153 WLLAFSSVPSSLLLVFY 169
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 53-501 3.37e-19

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 89.72  E-value: 3.37e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  53 YHIGLIAICGGILVATVCETMGMSFVHPAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTW 132
Cdd:TIGR00895  14 YQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFS 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 133 AFSFMSSFSPTTNLFIVLRFLTGL-FCSNQSTVYAYITEFLPTSKRASIIT-WTCGFmAIGYLLIPGLAWLLIPlevnwD 210
Cdd:TIGR00895  94 VFTLLCALATNVTQLLILRFLAGLgLGGLMPNLNALVSEYAPKRFRGTAVGlMFCGY-PIGAAVGGFLAGWLIP-----V 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 211 LGfvvytsWRV--YLAAIGSLSFATgFLLPFFPESPKFLMSVGRK--REALNVLRLVYNRNSGNSNVEYPVKnlkfdvhd 286
Cdd:TIGR00895 168 FG------WRSlfYVGGIAPLLLLL-LLMRFLPESIDFLVSKRPEtvRRIVNAIAPQMQAEAQSALPEQKST-------- 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 287 tpghvttalSFTLQGLFKLmwhqtatLFRPPYGWTTLLFCLIQFGICVTSMGMYIWIPNLL-----NMIKSGAGIGATIC 361
Cdd:TIGR00895 233 ---------QGTKRSVFKA-------LFQGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMvelgfSLSLAATGGALFNF 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 362 ELVLanqanltlnSASESADCSSLIRSEVYTS-TLVTGVFSVVAFGTLGglvailrKKTVLVSALFLSGIAGFGNYfatn 440
Cdd:TIGR00895 297 GGVI---------GSIIFGWLADRLGPRVTALlLLLGAVFAVLVGSTLF-------SPTLLLLLGAIAGFFVNGGQ---- 356

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2194924128 441 eitvavlisvsvavagscsTVSNTIAVEVYPTNLRAMAVSLAFTIGRLGIALAGNTIGILI 501
Cdd:TIGR00895 357 -------------------SGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 81-512 1.36e-18

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 87.27  E-value: 1.36e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  81 AAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLFCSN 160
Cdd:cd17316    26 AAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGG 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 161 QSTV-YAYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLIPLevnwdlgFVVYTSWRVYLAAIGSLSFATGFLlpf 239
Cdd:cd17316   106 EYPGaSTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPL-------LSGDWGWRILFLIGALPALLALLL--- 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 240 fpespkflmsvgRKRealnvlrlvynrnsgnsnveypvknlkfdvhdtpghvttalsftlqglfklmwhqtatlfrppyg 319
Cdd:cd17316   176 ------------RRR----------------------------------------------------------------- 178

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 320 wtTLLFCLIQFGICVTSMGMYIWIPNLLNMIKSGAGigaticelvlanqanltlnsasesadcsslirSEVYTSTLVTGV 399
Cdd:cd17316   179 --TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSP--------------------------------ATSSLYLLLISL 224

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 400 FSVVAFGTLGGLVAILRKKTVLVSALFLSGIAG--FGNYFATNEITVAVLISVSVAVAGSCSTVSNTIAVEVYPTNLRAM 477
Cdd:cd17316   225 GALVGALIAGLLSDRIGRKKTLVIGLILSGILAlpLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRAT 304

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 2194924128 478 AVSLAFTIGRLGIALAGNTIGILIESYCDFTLIGL 512
Cdd:cd17316   305 GVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPAL 339
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 57-204 3.68e-17

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 83.32  E-value: 3.68e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  57 LIAICGGILVATVCETMGMSFVHPAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSF 136
Cdd:cd17442     2 LFLIMGSTGVAEAMEIMLLAVVSPEIRCEWHLEDWQVALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFSL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2194924128 137 MSSFSPTTNLFIVLRFLTGLFCSNQSTVYAYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLIP 204
Cdd:cd17442    82 LTSFAPSYIWFVFLRCMVGCGVSGHSQGLIIKTEFLPTKYRGYMLPLSQIFWLAGSLLIIGLASVVIP 149
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
57-493 1.78e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 80.79  E-value: 1.78e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  57 LIAICGGILVATVCETMGMSFVHPAAQcDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSF 136
Cdd:COG2814    12 LLALALGAFLSGLGIGIVLPALPLIAA-DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 137 MSSFSPTTNLFIVLRFLTGLFCS-NQSTVYAYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLIPLeVNWDLGFVV 215
Cdd:COG2814    91 LCALAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL-FGWRWVFLV 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 216 ytswrvyLAAIGSLSFAtgFLLPFFPESPKflmsVGRKREALNVLRLVYNRnsgnsnveypvknlkfdvhdtpghvttal 295
Cdd:COG2814   170 -------NAVLALLALL--LLLRLLPESRP----AARARLRGSLRELLRRP----------------------------- 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 296 sftlqglfklmwhqtatlfrppygwTTLLFCLIQFGICVTSMGMYIWIPnllnmiksgagigaticeLVLANQANLTLNS 375
Cdd:COG2814   208 -------------------------RLLLLLLLAFLLGFGFFALFTYLP------------------LYLQEVLGLSASA 244

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 376 ASesadcsslirsevyTSTLVTGVFSVVAFGTLGGLVAILRKKTVLVSALFLSGIAGFGNYFATNEITVAVLISVSVAVA 455
Cdd:COG2814   245 AG--------------LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGF 310

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 2194924128 456 GSCSTVSNTIAVEVYPTNLRAMAVSLAFTIGRLGIALA 493
Cdd:COG2814   311 GLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
48-504 4.67e-16

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 79.53  E-value: 4.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  48 TGFGWYHIGLIAICGGILVATVcetMGMSFVHPAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLIS 127
Cdd:COG2271     5 SRYRWRILALLFLAYFLNYLDR---SNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 128 TIGTWAFSFMSSFSPTTNLFIVLRFLTGLFCS-NQSTVYAYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLIPle 206
Cdd:COG2271    82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAgFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA-- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 207 vnwdlgfvvYTSWRVYLAAIGSLSFATGFLlpffpespkflmsvgrkrealnvlrlvynrnsgnsnveypvknlkfdvhd 286
Cdd:COG2271   160 ---------AFGWRAAFLILGLPGLLLALL-------------------------------------------------- 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 287 tpghvttalsftlqglfklmwhqtatlfrppygwTTLLFCLIQFGICVTSMGMYIWIPNLlnmiksgagigaticelvLA 366
Cdd:COG2271   181 ----------------------------------RFWLLALAYFLVYFALYGFLTWLPTY------------------LV 208

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 367 NQANLTLNSAsesadcsslirSEVYTSTLVTGVFSVVAFGTLGGLVaILRKKTVLVSALFLSGIAGFGNYFATNEITVAV 446
Cdd:COG2271   209 EVRGLSLAQA-----------GLLLSLPFLAGIVGSLLGGWLSDRL-GRRRKLVLAIGLLLAALALLLLALLPSPALAIA 276

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2194924128 447 LISVSVAVAGSCSTVSNTIAVEVYPTNLRAMAVSLAFTIGRLGIALAGNTIGILIESY 504
Cdd:COG2271   277 LLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT 334
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 47-250 2.66e-15

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 77.55  E-value: 2.66e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  47 LTGFGWyhigliaicggilVATVCETMGMSFVHPAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLI 126
Cdd:cd17441     3 LTGLAW-------------MADAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKI 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 127 STIGTWAFSFMSSFSPTTNLFIVLRFLTG--LFCSNQS-TVYAyitEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLI 203
Cdd:cd17441    70 SVLWTLYYGILSAFAPIYSWILVLRGLVGfgIGGVPQSvTLYA---EFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVM 146

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2194924128 204 PlevnwdlgfvvYTSWR--VYLAAIGSLSFAtgFLLPFFPESPKFLMSV 250
Cdd:cd17441   147 P-----------TLGWRwlLILSALPLLIFA--VLCFWLPESARYWTTI 182
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 54-253 3.43e-14

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 74.14  E-value: 3.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  54 HIGLIAICGGILVATvcETMGMSFVHPAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWA 133
Cdd:cd17359     1 LISLVAALGGLLFGY--DTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 134 FSFMSSFSPTTNLFIVLRFLTGLFCSNQST-VYAYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLIPLevnWDLG 212
Cdd:cd17359    79 SALGSAFSPNFTIFIIARIIGGLAVGGASAlVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANA---GGAD 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2194924128 213 FVVYTSWRVYLAAIGSLSFATGFLLPFFPESPKFLMSVGRK 253
Cdd:cd17359   156 WLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRWLVSKGKP 196
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 101-241 4.70e-14

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 73.38  E-value: 4.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 101 FLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLFCSNQSTV-YAYITEFLPTSKRAS 179
Cdd:cd17317    35 FLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVgFVLGMEIVGPKYRSF 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2194924128 180 IITWTCGFMAIGYLLIPGLAWLLiplevnwdlgfvvyTSWRVYLAAIGSLSFATGFLLPFFP 241
Cdd:cd17317   115 VGILFGLFWALGYMLLALLAYLI--------------RDWRWLQLAISLPGLLFLLLLWWLP 162
Sugar_tr pfam00083
Sugar (and other) transporter;
52-261 1.28e-13

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 73.07  E-value: 1.28e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  52 WYHIGLIaicGGILVATVCETMgmsFVHPAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGT 131
Cdd:pfam00083  13 GYDTGVI---GAFLTLIDFFKN---FGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLF 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 132 WAFSFMSSFSPTTNLFIVL---RFLTGLFC-SNQSTVYAYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLIPlev 207
Cdd:pfam00083  87 VIGAVLQGAAKGKWSVYQLivgRVLVGIGVgGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNK--- 163

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2194924128 208 nwdlgFVVYTSWRVYLAAIGSLSFATGFLLPFFPESPKFLMSVGRKREALNVLR 261
Cdd:pfam00083 164 -----TSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLA 212
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 85-251 6.79e-13

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 69.91  E-value: 6.79e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  85 DLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLFCSNQSTV 164
Cdd:cd17315    28 GFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 165 YA-YITEFLPTSKRASIITWTCGFMAIGyllipglawLLIPLEVNWDLGFVVYTSWRVYLAAIGSLSFATGFLLPFFPES 243
Cdd:cd17315   108 VPlYISEIAPAKIRGALGTLNQLMITFG---------ILLAYLLGLALSLSPPGWWRLMFALAAVPALLQLLLMFFLPES 178


                  ....*...
gi 2194924128 244 PKFLMSVG 251
Cdd:cd17315   179 RALLVGVG 186
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 57-243 1.74e-12

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 67.91  E-value: 1.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  57 LIAICGGILVATVcETMGMSFVHPAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSF 136
Cdd:COG0477    16 LLALALGTFLEGL-DFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 137 MSSFSPTTNLFIVLRFLTGLFCS-NQSTVYAYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLIPlevnwdlgfvv 215
Cdd:COG0477    95 LCGLAPSPELLIAARALQGIGAGgLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA----------- 163

                         170       180
                  ....*....|....*....|....*...
gi 2194924128 216 YTSWRVYLAAIGSLSFATGFLLPFFPES 243
Cdd:COG0477   164 ALGWRWIFLINAPLGLLALVLRLRLPES 191
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 64-205 2.21e-12

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 68.37  E-value: 2.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  64 ILVATVCETMGMSFVHP------AAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFM 137
Cdd:cd17330     1 LFLVVFLDALGFGIVFPvlpfyvREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2194924128 138 SSFSPTTNLFIVLRFLTGLFCSNQSTVYAYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLIPL 205
Cdd:cd17330    81 LGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTP 148
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 58-200 7.98e-12

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 66.84  E-value: 7.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  58 IAICGGILVATVCETMGMSFVHPAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFM 137
Cdd:cd17365     1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2194924128 138 SSFSPTTNLFIVLRFLTGL-FCSNQSTVYAYITEFLPTSKRASIITWT-CGF---MAIGYLL----IPGLAW 200
Cdd:cd17365    81 TAFAQSVLQLALLRFLTGLgLGAAMPNAITLVSEYAPARRRSLAVTLMfCGYplgAALGGFLaaalIPAFGW 152
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 92-251 4.37e-11

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 64.30  E-value: 4.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  92 KKGYLSGAMFLGIVVSANAWGFFADT-FGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLFCSNQ-STVYAYIT 169
Cdd:cd17378    34 LVGLPQSSFFVGCLIGSGVLGHLADSsLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIgTCALVLAT 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 170 EFLPTSKRASIITWTCGFMAIGYLLIPGLAwlliplevnwdlgFVVYTSWRVYLAAIGSLSFATGFLLPFFPESPKFLMS 249
Cdd:cd17378   114 EPVGPKWRGQVGMSTFFFFVLGFMSLPGIA-------------YLNGSSWRVLYFWTSIPALIYCILVYLFARRLLAVMV 180


                  ..
gi 2194924128 250 VG 251
Cdd:cd17378   181 IG 182
MFS_1 pfam07690
Major Facilitator Superfamily;
60-493 4.73e-11

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 64.36  E-value: 4.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  60 ICGGILVATVCETMGMSFVHPAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSS 139
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 140 FSPTTNLFIVLRFLTGLFCS-NQSTVYAYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLIplevnwdlgfvVYTS 218
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA-----------SLFG 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 219 WRVYLAAIGSLSFAtGFLLPFFPESPKFLMSVGRKREALNVLRLVYNRnsgnsnveypvknlkfdvhdtpghvttalsft 298
Cdd:pfam07690 150 WRAAFLILAILSLL-AAVLLLLPRPPPESKRPKPAEEARLSLIVAWKA-------------------------------- 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 299 lqglfklmwhqtatLFRPPYGWTTLLFCLIQFGIcvtsMGMYIWIPnllnmiksgagigaticelVLANQANLTLNSASE 378
Cdd:pfam07690 197 --------------LLRDPVLWLLLALLLFGFAF----FGLLTYLP-------------------LYQEVLGLSALLAGL 239

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 379 SADCSSLIrsevytstlvtGVFSVVAFGTLGGLVAILRKKTVLVSALFLSGIAGFGNYFATNEITVAVLISVSVAVAGSC 458
Cdd:pfam07690 240 LLGLGGLL-----------GAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLV 308

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 2194924128 459 STVSNTIAVEVYPTNLRAMAVSLAFTIGRLGIALA 493
Cdd:pfam07690 309 FPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 95-217 6.53e-11

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 63.85  E-value: 6.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  95 YLSGAMFL-GIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLFCSNQST-VYAYITEFL 172
Cdd:cd17374    38 SVAQSIFMaGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISInTLILGTEWT 117

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2194924128 173 PTSKRASIITWTCGFMAIGYLLIPGLAWLLipleVNWDLGFVVYT 217
Cdd:cd17374   118 TPRHRALAITLTSCFFSIGQMLLAGLAYAI----RDWRLLQLVVS 158
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 101-267 6.61e-11

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 64.20  E-value: 6.61e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 101 FLGIVVSANAWGFFADTFGRKKVLLISTIGTWA---FSFMSSFSPTTNLFIVLRFLTGLFCS-NQSTVYAYITEFLPTSK 176
Cdd:cd17357    59 FIGGAIGSFISAFLANRFGRKNGLLISNALLVVsslLMFLSKSAKSPELLIFGRFLVGIACGlSTGFVPMYLQEISPSEL 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 177 RASIITWTCGFMAIGYLLIPGLAWLLIplevnwdLGFVvyTSWRVYLAAIGSLSFATGFLLPFFPESPKFLMSV-GRKRE 255
Cdd:cd17357   139 RGALGSLTQIGVTLGILLGQVFGLPSV-------LGTE--TLWPYLLFFPGIPALLQLAALPFFPESPKFLLISkGDEEE 209

                         170
                  ....*....|..
gi 2194924128 256 ALNVLRLVYNRN 267
Cdd:cd17357   210 AEKSLKFLRGIE 221
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 85-202 1.20e-10

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 63.14  E-value: 1.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  85 DLALTTVKKGYLSGAMFLGivvsanawgFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLFC-SNQST 163
Cdd:cd17379    36 DLFQSSLNLGFLIGSIVIG---------YLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGkGGWMT 106

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2194924128 164 VYAYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLL 202
Cdd:cd17379   107 GYVLVTEFVGSKYRRTVGIVYQMFFTLGLLILPGIAYFI 145
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 57-287 2.76e-10

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 62.21  E-value: 2.76e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  57 LIAICGGILVATVCetmGMSFVHPAA-----QCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGT 131
Cdd:cd17358     5 FVANLGSFSFGIAV---GWSSPALPSlmsdnSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 132 WAFSFMSSFSPTTNLFIVLRFLTG----LFCSnqsTVYAYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLiplev 207
Cdd:cd17358    82 ILGWLLIAFAKDVWMLYLGRFLAGfgggAASV---VVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFL----- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 208 nwdlgfvvytSWRVYLAAIGSLSFATGFLLPFFPESPKFLMSVGRKREALNVLRlvYNRNSgNSNVEYPVKNLKFDVHDT 287
Cdd:cd17358   154 ----------PWRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQ--FLRGK-DADISKEAAEIQEELAEL 220
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 73-515 3.72e-10

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 61.67  E-value: 3.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  73 MGMSFVHPAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRF 152
Cdd:cd06174    13 GLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRF 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 153 LTGLFCSNQ-STVYAYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLIPLevnwdlgfvVYTSWRVYLAAIGSLSF 231
Cdd:cd06174    93 LLGLGSGLIdPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASS---------LGFGWRAVFLIAAALAL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 232 ATGFLLPFFPESPKFLMSVGRKREAlnvlrlvynrnsgnsnveypvknlkfdvhdtpghvttalsftlqglFKLMWHQTA 311
Cdd:cd06174   164 LAAILLLLVVPDPPESARAKNEEAS----------------------------------------------SKSVLKLLK 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 312 TLFRPPYGWTTLLFCLIQFGICVTSMGMYIWIpnllnmiksgagigaticelvlanqanltlnsASESADCSSLIRSEVY 391
Cdd:cd06174   198 RVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLF--------------------------------LLDLGGLSVAVAGLLL 245

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 392 TSTLVTGVFSVVAFGTLGGLvaILRKKTVLVSALFLSGIAGFGNYFATNEITVAVLISVSVAVAGSCSTVSNTIAVEVYP 471
Cdd:cd06174   246 SLFGLAGALGSLLLGLLSDR--LIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFP 323

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 2194924128 472 TNLRAMAVSLAFTIGRLGIALAGNTIGILIESYCDFTLIGLGCV 515
Cdd:cd06174   324 PEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLA 367
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 50-261 2.08e-09

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 59.66  E-value: 2.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  50 FGwYHIGLIAICGGILVATVCETMGMSFVHPAAQcdLALTTVKKgyLSGAMF-LGIVVSANAWGFFADTFGRKKVLLIST 128
Cdd:cd17431    13 FG-YNTGVINAPQKVIEEFYNKTLGDRYGEPISP--ETLTTLWS--LSVAIFsVGGMIGSFSVGLFVNRFGRRNSMLYNN 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 129 IGTWAFSFMSSFSPTTNLFIVL---RFLTGLFCS-NQSTVYAYITEFLPTSKRASIITWTCGFMAIGYLL--IPGLAWLL 202
Cdd:cd17431    88 LLAFAGAALMGLSKLAKSYEMLilgRFIIGLYCGlTTGLVPMYIGEISPTALRGALGTLHQLGIVVGILIsqIFGLEFIL 167

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 203 ipleVNWDLgfvvytsWRVYLAAIGSLSFATGFLLPFFPESPKFLMSVGRKRE-ALNVLR 261
Cdd:cd17431   168 ----GTEEL-------WPLLLGFTIVPAILQLALLPFCPESPRYLLINRNEEEeAKSVLK 216
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 71-255 4.82e-09

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 58.47  E-value: 4.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  71 ETMGMSFVHPAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVL 150
Cdd:cd17371    14 DLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLIL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 151 RFLTGL-FCSNQSTVYAYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLIPLevnwdlgFVVYTSWRV--YLAAIG 227
Cdd:cd17371    94 RALAGLgFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPL-------LPPEIAWRVlfLLGALP 166

                         170       180
                  ....*....|....*....|....*...
gi 2194924128 228 SLSFAtgFLLPFFPESPKFLMSVGRKRE 255
Cdd:cd17371   167 ALLVL--FIRRFVKEPPQWQAARAARRH 192
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 94-504 9.63e-09

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 57.20  E-value: 9.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  94 GYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLFCSNQSTV-YAYITEFL 172
Cdd:cd17325    34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAaMALIADIA 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 173 PTSKRASIITWTCGFMAIGYLLIPGLAWLLIPLevnwdlgfvvyTSWRVYLAAIGSLSFATGFLLPFFPESPKflmsvgr 252
Cdd:cd17325   114 PPEERGRAMGIFSSAIGLGFLIGPLLGGLLADA-----------LGYRAPFLVCAALALLALVLALLLLPEPR------- 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 253 krealnvlrlvynrnsgnsnveypvknlkfdvhdTPGHVTTALSFTLQGLFKLMwhqtatLFRPPYgwttLLFCLIqfgI 332
Cdd:cd17325   176 ----------------------------------PPPNKRAVSAARLRSGLRLL------LRDRRL----LALFLA---I 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 333 CVTSMGMYIWIPNLLNMIKSGAGIGATICELVLAnqanltlnsasesadcsslirsevytstlVTGVFSVVAFGTLGGLV 412
Cdd:cd17325   209 FVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFG-----------------------------AQGLASALSQPPAGKLS 259

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 413 AILRKKTVLVSALFLSGIAGFGNYFATNEITVAVLISVSVAVAGSCSTVSNTIAVEVYPTNLRAMAVSLAFTIGRLGIAL 492
Cdd:cd17325   260 DRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVL 339

                         410
                  ....*....|..
gi 2194924128 493 AGNTIGILIESY 504
Cdd:cd17325   340 GPLLGGFLYDAF 351
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
80-241 1.00e-08

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 57.17  E-value: 1.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  80 PAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGL-FC 158
Cdd:COG0738    32 PALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLgLG 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 159 SNQSTVYAYITEfLPTSKRASIITWTCGFMAIGYLLIPGLAWLLIPLEVNwdlgfvvyTSWRVYLAAIGSLSFATGFLLP 238
Cdd:COG0738   112 LLDVAANPYVAA-LGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLS--------LSWHLPYLILAVLLLLLALLFL 182


                  ...
gi 2194924128 239 FFP 241
Cdd:COG0738   183 RSK 185
xylE PRK10077
D-xylose transporter XylE; Provisional
 53-261 1.30e-08

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 57.40  E-value: 1.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  53 YHIGLIAICGGIL-------VATVCETMGMSFVHPAaQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVL- 124
Cdd:PRK10077   11 FSITLVATLGGLLfgydtavISGTVESLNTVFVAPQ-NLSESAANSLLGFCVASALIGCIIGGALGGYCSNRFGRRDSLk 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 125 ------LISTIGTWA--FSFMSSFSPTTNL---FIVLRFLTGLFCSNQSTVYA-YITEFLPTSKRASIITWTcGFMAI-G 191
Cdd:PRK10077   90 iaavlfFISALGSAWpeFGFTSIGPDNTGYvpeFVIYRIIGGIGVGLASMLSPmYIAEIAPAHIRGKLVSFN-QFAIIfG 168

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2194924128 192 YLLIPGLAWLLIPLEvnwDLGFVVYTSWRVYLA--AIGSLSFatGFLLPFFPESPKFLMSVGRKREALNVLR 261
Cdd:PRK10077  169 QLVVYFVNYFIARSG---DASWLNTDGWRYMFAseAIPALLF--LMLLYFVPETPRYLMSRGKQEQAEGILR 235
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 105-231 5.81e-08

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 54.54  E-value: 5.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 105 VVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLFCSNQSTVYAYITEFLPTSKRASIITWT 184
Cdd:cd17390    45 LFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRF 124

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2194924128 185 CGFMAIGYLLIPGLAWLLipleVNWDLGFvvytswrVYLAAIGSLSF 231
Cdd:cd17390   125 NAASSLGFILGPVVGGHL----AETDGGF-------YYVALLCSAIF 160
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 97-202 9.79e-08

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 54.01  E-value: 9.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  97 SGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLF-CSNQSTVYAYITEFLPTS 175
Cdd:cd17376    41 TSLFFVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSPSWEMFTVLFVIVGMGqISNYVVAFVLGTEILGKS 120

                          90       100
                  ....*....|....*....|....*...
gi 2194924128 176 KRASIITW-TCGFMAIGYLLIPGLAWLL 202
Cdd:cd17376   121 VRILFSTLgVCIFYAIGYMLLPLFAYFI 148
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 75-202 1.14e-07

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 53.73  E-value: 1.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  75 MSFVHPAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLT 154
Cdd:cd17319    22 ISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLL 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2194924128 155 GLF-CSNQSTVYAYITEFLPTSKRASIITWTCGFMAIGYLLI-PGLAWLL 202
Cdd:cd17319   102 GVAeAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGpPLSGWLL 151
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 103-202 6.20e-07

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 51.65  E-value: 6.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 103 GIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLFCSNQS-TVYAYITEFLPTSKRASII 181
Cdd:cd17446    45 GVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVlNSVSLNVEWMPTRVRAVVG 124

                          90       100
                  ....*....|....*....|.
gi 2194924128 182 TWTCGFMAIGYLLIPGLAWLL 202
Cdd:cd17446   125 TLLGYCYTLGQLILAGVAYAI 145
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 101-202 7.90e-07

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 51.27  E-value: 7.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 101 FLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLFCSNQS-TVYAYITEFLPTSKRAS 179
Cdd:cd17447    45 FAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFALTGFSiISMVLCVEWVDIEHRTV 124

                          90       100
                  ....*....|....*....|...
gi 2194924128 180 IITWTCGFMAIGYLLIPGLAWLL 202
Cdd:cd17447   125 AGVLISLFWTVGNMLLALVAYLI 147
2_A_01_02 TIGR00880
Multidrug resistance protein;
112-242 1.34e-06

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 48.03  E-value: 1.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 112 GFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLFCS-NQSTVYAYITEFLPTSKRASIITWTCGFMAI 190
Cdd:TIGR00880  19 GLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAfALVAGAALIADIYPPEERGVALGLMSAGIAL 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2194924128 191 GYLLIPGLAWLLIPlevnwdlgfvvYTSWRVYLAAIGSLSFATGFLLPFFPE 242
Cdd:TIGR00880  99 GPLLGPPLGGVLAQ-----------FLGWRAPFLFLAILALAAFILLAFLLP 139
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 55-246 1.52e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 50.24  E-value: 1.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  55 IGLIAICGGILVATvcETMGMSFVHPAAQcDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAF 134
Cdd:cd17324     1 LLALALAAFAIGTT--EYVIQGLLPDIAR-DFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 135 SFMSSFSPTTNLFIVLRFLTGLFCSN-QSTVYAYITEFLPTSKRASIITWTCGFMAIGYLL-IPGLAWLLiplevnwdlg 212
Cdd:cd17324    78 NLLAALAPSFALLLLARALAGLAHGGfWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLgRPLGGLLG---------- 147

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2194924128 213 fvVYTSWRVYLAAIGSLSFATGFLL-PFFPESPKF 246
Cdd:cd17324   148 --QLLGWRAAFLAIAVLALLAALLLwRLLPSLPPK 180
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
73-216 1.86e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 50.26  E-value: 1.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  73 MGMSFVHPAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRF 152
Cdd:COG2223    22 YLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGL 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2194924128 153 LTGLFC-SNQSTVYAYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLIpLEVNWDLGFVVY 216
Cdd:COG2223   102 LLGIGGgGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLI-AAFGWRNAFLIL 165
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
55-241 3.30e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 49.48  E-value: 3.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  55 IGLIAICGGILVATVCETMGMSFVHPAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGR--KKVLLISTIGTW 132
Cdd:COG2271   180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAA 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 133 AFSFMSSFSPTTNLFIVLRFLTGLFC-SNQSTVYAYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAwlliplevnwdl 211
Cdd:COG2271   260 LALLLLALLPSPALAIALLFLAGFGLgGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLV------------ 327

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2194924128 212 GFVV-YTSWRVYLAAIGSLSFATGFLLPFFP 241
Cdd:COG2271   328 GYLLdATGYQAAFLLLAALALLAALLALLLL 358
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
59-215 8.18e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 48.34  E-value: 8.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  59 AICGGILVATVCETMGMSFVHPAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMS 138
Cdd:COG2223   209 LLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLL 288

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2194924128 139 SFSPTT-NLFIVLRFLTGLFCS-NQSTVYAYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLIPLEVNWDLGFVV 215
Cdd:COG2223   289 ALALGSlWLFLVLFLLLGLALGgGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLV 367
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 101-245 1.04e-05

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 47.96  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 101 FLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLFCSNQSTV-YAYITEFLPTSKRAS 179
Cdd:cd17320    44 LLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVaRAIVRDLYSGAELAK 123

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2194924128 180 IItwtcGFMAIGYLLIPGLAwlliPLevnwdLG--FVVYTSWR---VYLAAIGSLSFATGFLlpFFPESPK 245
Cdd:cd17320   124 IF----SLLMMILAIAPALA----PL-----LGglLLLFFGWRaifVFLALLGLLLLLLVLL--FLPETLP 179
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 98-242 1.39e-05

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 47.18  E-value: 1.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  98 GAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLFCSN-QSTVYAYITEFLPTSK 176
Cdd:cd17323    41 SLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSpLAIGAGTIADLFTPEE 120

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2194924128 177 RASIITWTCGFMAIGYLLIPGLAWLLIplevnwdlgfvVYTSWRV--YLAAIGSLsFATGFLLPFFPE 242
Cdd:cd17323   121 RGKAMGVYSLGPLLGPALGPIIGGFIT-----------QSLGWRWifWFLAIISG-FCLILIFLFLPI 176
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 88-245 1.42e-05

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 47.26  E-value: 1.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  88 LTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLFCSNQS-TVYA 166
Cdd:cd17360    32 LSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASmTVPL 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2194924128 167 YITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLIPLEVNWdlgfvvytSWRVYLAAIGSLSFATGFLlpFFPESPK 245
Cdd:cd17360   112 YIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLPGGW--------RWMLGLAAVPAVLQFIGLL--FLPESPR 180
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 112-248 1.52e-05

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 47.61  E-value: 1.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 112 GFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLF---IVLRFLTGlFCS--NQSTVYAYITEFLPTSKRASIITWTCG 186
Cdd:cd17432    71 GPLVIRLGRKGTLLLNNIFAIVAAILMGLSKIAKSFemiIVGRFLVG-INAgiSLNVVPMYLGESAPKNLRGAVGLVPAI 149

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2194924128 187 FMAIGYLL--IPGLAWLLIPLEvnwdlgfvvytSWRVYLAAIGSLSFATGFLLPFFPESPKFLM 248
Cdd:cd17432   150 FITLGILLgqVLGLRELLGNEE-----------GWPLLLALTGVPALLQLLTLPFFPESPRYLL 202
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
 99-201 1.95e-05

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 46.77  E-value: 1.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  99 AMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGlFCSNQS--TVYAYITEFLPTSK 176
Cdd:cd17444    44 SLLVGLIFGYLITGCLADWFGRRPVLLFSVVFILIFGLTVALSVNVTMFSTLRFFEG-FCLAGIilSLYALRIELCPPGH 122

                          90       100
                  ....*....|....*....|....*.
gi 2194924128 177 RASiITWTCGFMAI-GYLLIPGLAWL 201
Cdd:cd17444   123 RFM-ITMVASFIAMaGQFLMPGLAAL 147
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 99-236 2.19e-05

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 46.75  E-value: 2.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  99 AMFLGIVVSANA---WGFFADTFGRKKVLLISTIGT--WAFSFMSSFSPTTNLFIVLRFLTGLFCSnQSTVY----AYIT 169
Cdd:cd17369   269 AVLIASVVAAITiplFGWLSDRVGRRPVYLAGALLAalFAFPFFWLLDTGSTWLIVLAAVVVLGVL-HGMMYgpqaAFLA 347

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2194924128 170 EFLPTSKRASiitwtcGfMAIGYLLIPGLAWLLIPLEVNWdLGFVVYTSWRV--YLAAIGSLSFATGFL 236
Cdd:cd17369   348 ELFPTRVRYT------G-ASLGYQLGAILGGGFAPLIATA-LVAATGSWWPValYLAALAVISLVAALF 408
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 85-245 2.22e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 46.82  E-value: 2.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  85 DLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLFCSNQSTV 164
Cdd:cd17489    25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 165 -YAYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLIPlevNWDLGFVVYTSwrvylAAIGSLSFATGFLLPFFPES 243
Cdd:cd17489   105 aATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQ---HLGFAVLFIVA-----AVLALLALLLVFLVKDPPPV 176


                  ..
gi 2194924128 244 PK 245
Cdd:cd17489   177 AA 178
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 73-156 3.07e-05

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 46.46  E-value: 3.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  73 MGMSFVH-------PAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTN 145
Cdd:cd17475     6 AAASLVAqgipalaPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYP 85

                          90
                  ....*....|.
gi 2194924128 146 LFIVLRFLTGL 156
Cdd:cd17475    86 VLLVLLFLVGA 96
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 88-238 3.27e-05

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 46.04  E-value: 3.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  88 LTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTT-NLFIVLRFLTGLFC-SNQSTVY 165
Cdd:cd17365   203 YSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASlVLLYVLVFLAGACVnGAQVGLY 282

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2194924128 166 AYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLIPLEVNWDLGFVVytswrvyLAAIGSLSFATGFLLP 238
Cdd:cd17365   283 ALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLA-------LAIPAALGALAVLLLR 348
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 102-202 3.86e-05

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 45.90  E-value: 3.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 102 LGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLFCSNQSTV-YAYITEFLPTSKRasi 180
Cdd:cd17375    46 LGVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGIAVAFTFDYYSFVIVRFLLAMVSSGYLVVvFVYVTEFTGIKAR--- 122

                          90       100
                  ....*....|....*....|....*.
gi 2194924128 181 iTWTC----GFMAIGYLLIPGLAWLL 202
Cdd:cd17375   123 -TWASmhvhAFFAVGIMVVALVGYLV 147
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 78-245 5.02e-05

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 45.69  E-value: 5.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  78 VHPAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLF 157
Cdd:cd17328    21 VLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIG 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 158 CSNQSTV-YAYITEFLPTSKRASiitwtcgFMAIGYLLIP---GLAWLLIPLEVNWDLGfvvytsWRVYLAAIGSLSFAT 233
Cdd:cd17328   101 EASYSPIaPTIIADLFPKEKRTR-------ALGVFYFAIPlgsGLGYVVGGLVAQATGG------WRWAFRVTGVLGVLL 167

                         170
                  ....*....|..
gi 2194924128 234 GFLLPFFPESPK 245
Cdd:cd17328   168 AILLLLFVREPP 179
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 76-215 5.59e-05

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 45.44  E-value: 5.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  76 SFVHPAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTG 155
Cdd:TIGR00881  15 ALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNG 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2194924128 156 LFCS-NQSTVYAYITEFLPTSKRASIIT-WTCGfMAIGYLLIPGLAWLLIPLEVNWDLGFVV 215
Cdd:TIGR00881  95 IFQGmGWPPCGRTVTKWFSRSERGTWVSfWNCS-HNVGGGLLPPLVLFGIAELYSWHWVFIV 155
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 55-216 8.34e-05

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 44.87  E-value: 8.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  55 IGLIAICGGILVATVCETMGMSFV-HPAAQCDLALTTVkkgylsgamFLGIVVSANAWGFFADTFGRKKVLLISTIGTWA 133
Cdd:cd17473     7 ASTLTVMAGAAIAPALPAIAQHFVpNSELLVPLLLTLP---------ALFIALFAPLAGWLADRFGRKRLLIAGLLLYGI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 134 FSFMSSFSPTTNLFIVLRFLTGLFCSNQSTV-YAYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLipLEVNWDLG 212
Cdd:cd17473    78 GGVAGLFLDSLYALLASRALLGIGVAGIMTLaTALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGAL--AEIGWRAP 155


                  ....
gi 2194924128 213 FVVY 216
Cdd:cd17473   156 FLVY 159
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 87-247 1.14e-04

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 44.55  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  87 ALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTW-AFSFMSSFSPTTNLFIVLRFLTGLFCSNQS-TV 164
Cdd:cd17356    41 YPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIiGAIIQVAAIGKWYQLIVGRIIAGLGVGFASvLV 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 165 YAYITEFLPTSKRASIITWTCGFMAIGYLLipgLAWllipleVNWDLGFVVYT-SWRV--YLAAIGSLSFATGFLlpFFP 241
Cdd:cd17356   121 PVYQSEVAPKHIRGTLVSLYQLAITIGILV---AYC------INYGTHKLDGSaQWRIplGLQIVWGLLLLIGMF--FLP 189


                  ....*.
gi 2194924128 242 ESPKFL 247
Cdd:cd17356   190 ESPRWL 195
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 85-235 1.49e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 44.13  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  85 DLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGT---WAFSFMSSFSPTTNLFIVLRFLTGLFCSNQ 161
Cdd:cd17316   207 VLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSgilALPLFYLLSGSPTLLLLLLFILSFFVGGVW 286

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2194924128 162 STVYAYITEFLPTSKRASIITWTcgfMAIGYLLIPGLAWLLIPLEVNWDlgfvVYTSWRVYLAAIGSLSFATGF 235
Cdd:cd17316   287 GALYAYLAELFPTEVRATGVGLS---YNLGRLGGGGAPPLIALLLASTG----GTGVPALILALLAIVALIVAL 353
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 99-179 1.57e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 44.22  E-value: 1.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  99 AMFLGIVvsanAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTN-LFIVLRFLTGLFCSNQSTVY-AYITEFLPTSK 176
Cdd:cd17371   257 GGFLGYL----AGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPtLILILGFPLGFFASGPFSGMgAYLTELFPTAV 332


                  ...
gi 2194924128 177 RAS 179
Cdd:cd17371   333 RAT 335
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 86-248 1.91e-04

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 43.63  E-value: 1.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  86 LALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLFCSNQSTVY 165
Cdd:cd17435    31 LALSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGRIAIGVSISLSSIAT 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 166 A-YITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLIPlevnwdlgfvVYTSWRVYLAAIGSLSFATGFLLPFFPESP 244
Cdd:cd17435   111 CvYIAEIAPQHRRGLLVSLNELMIVIGILLAYISNYAFAN----------VSNGWKYMFGLVIPLAALQAIAMYFLPPSP 180


                  ....
gi 2194924128 245 KFLM 248
Cdd:cd17435   181 RFLV 184
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 81-269 2.33e-04

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 43.71  E-value: 2.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  81 AAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIgtwafSFMSSFSPTTN-----LFIVLRFLTG 155
Cdd:cd17433    31 IADPALRLDDAAASWFGSVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSV-----PFIAGFTVITAaqnvwMLYVGRLLTG 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 156 LFCSNQSTVYA-YITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLiplevnwdlgfvvytSWRvYLAAIGSLSFATG 234
Cdd:cd17433   106 LASGVTSLVVPvYISEIAHPRVRGTLGSCVQLMVVIGIMGAYLAGLVL---------------DWR-WLAVLGSIPPTLM 169

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2194924128 235 FLLP-FFPESPKFLMSVGRKREALNVLRLVYNRNSG 269
Cdd:cd17433   170 LLLMcFMPETPRFLLTQHRRQEAMAALRFLRGPDQG 205
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 94-201 2.83e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 43.31  E-value: 2.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  94 GYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLrFLTGLF-CSNQSTVYAYITEFL 172
Cdd:cd17478   233 GLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILL-VLAGFLlFASFPVTVVLAQELL 311

                          90       100       110
                  ....*....|....*....|....*....|
gi 2194924128 173 PTSKR-ASIITWTCGFmAIGYLLIPGLAWL 201
Cdd:cd17478   312 PGNVGlASGLMMGLSF-GLGGIGAPVLGAL 340
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
 94-199 3.67e-04

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 42.84  E-value: 3.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  94 GYLSGAMFLGivvsanawgFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTG-LFCSNQSTVYAYITEFL 172
Cdd:cd17445    48 GFASGYLCLG---------YTADRLGRRRTLLLSLTLAVPFGVLVAVAASPSLFMAMRFLLGaALAGVYLTLYLTRLELC 118

                          90       100
                  ....*....|....*....|....*..
gi 2194924128 173 PTSKRASIITWTCGFMAIGYLLIPGLA 199
Cdd:cd17445   119 DPPQRLLVAMAGGLTMVGGHFLLLGLA 145
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 94-252 5.51e-04

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 42.26  E-value: 5.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  94 GYLSGAMF-LGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLFCSNQSTVYAYITEFL 172
Cdd:cd17389    66 GGLIGSLFsLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVT 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 173 PTSKR----ASI-ITWTCGFMaIGYLLIPGLAWLLIPLEVNWDLgfvvytswrvyLAAIGSLSFATG---FLLPFFPES- 243
Cdd:cd17389   146 SPKKRskgmALIgVAFSLGFI-IGPMIGAYFASFTRSLGEVFFS-----------MPALFALVLALAdllFIFFFLPETl 213


                  ....*....
gi 2194924128 244 PKFLMSVGR 252
Cdd:cd17389   214 PSNLRRLGL 222
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 87-246 5.73e-04

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 42.34  E-value: 5.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  87 ALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLFCSNQSTVY- 165
Cdd:cd17362    35 NLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAp 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 166 AYITEFLPTSKRASIITWTCGFMAIGYLLipglAWLLIPLEVNWDLGfvvytsWRVYLAAIGSLSFATGFLLPFFPESPK 245
Cdd:cd17362   115 VYIAETSPSHIRGLLVSLKELFIVLGILL----GYVSGYAFADVVGG------WRYMYGLAAPPALLLGIGMWFLPPSPR 184


                  .
gi 2194924128 246 F 246
Cdd:cd17362   185 W 185
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 76-240 6.25e-04

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 42.26  E-value: 6.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  76 SFVHPAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTG 155
Cdd:cd17312    23 SVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNG 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 156 LFcsnQST----VYAYITEFLPTSKRASIITWTCGFMAIGylliPGLAWLLIplevnwdLGFVVYTSWRVYLAAIGSLSF 231
Cdd:cd17312   103 LF---QSMgwppCVKLLGNWFSKKERGTVYGIWSTSHNFG----GILAPILA-------ASLASYYGWRAAFLVPGIVGL 168


                  ....*....
gi 2194924128 232 ATGFLLPFF 240
Cdd:cd17312   169 VVAIILFFF 177
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 63-245 7.14e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 41.79  E-value: 7.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  63 GILVATVCETMGMSFVHPA---AQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSS 139
Cdd:cd17474     3 AVFFATLLAVLGVSIVDPIlpaIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 140 FSPTTNLFIVLRFLTGLFCSN-QSTVYAYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAwlliplevnwdlGFVVYTS 218
Cdd:cd17474    83 LSDSFALLLAGRALQGIGAAGlGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLG------------GLLAAIS 150

                         170       180
                  ....*....|....*....|....*..
gi 2194924128 219 WRVYLAAIGSLSFATGFLLPFFPESPK 245
Cdd:cd17474   151 WRYPFFLLAALIPVAFLAILFLLPEPK 177
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 63-199 7.92e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 41.79  E-value: 7.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  63 GILVATVCETMGMSFVHPA----AQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMS 138
Cdd:cd17325   203 ALFLAIFVLAFAFGALEPFlplyAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLL 282

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2194924128 139 SFSPTTNLFIVLRFLTGLFCS-NQSTVYAYITEFLPTSKRASIITWTCGFMAIGYLLIPGLA 199
Cdd:cd17325   283 PLATSFWLLLLLLALLGLGLGlVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLG 344
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
56-191 8.93e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 41.50  E-value: 8.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  56 GLIAICGGILVATVCETMGMSFVHPAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFS 135
Cdd:COG2814   208 RLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGL 287

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2194924128 136 FMSSFSPTTNLFIVLRFLTGLFCS-NQSTVYAYITEFLPTSKRASIITWTCGFMAIG 191
Cdd:COG2814   288 LLLALAGSLWLLLLALFLLGFGFGlLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
 85-252 9.83e-04

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 41.62  E-value: 9.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  85 DLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGL---FCSNQ 161
Cdd:cd17437    26 DLKISDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVGRFVAGIgvgFALMI 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 162 STVyaYITEFLPTSKRASIITWTCGFMAIGYLL--IPGLAWLLIPLEVNWDLGFVVytswrvylAAIGSLSFATGFLlpF 239
Cdd:cd17437   106 APV--YTAEVAPASSRGFLTSFPEIFINIGILLgyVSNYAFSGLPLHVGWRLMLGV--------GAVPSLFLAIGVL--A 173

                         170
                  ....*....|...
gi 2194924128 240 FPESPKFLMSVGR 252
Cdd:cd17437   174 MPESPRWTPAVRR 186
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 89-191 1.04e-03

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 41.30  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  89 TTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLFCSNQSTV-YAY 167
Cdd:cd17377    37 AAYKVSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNGGMSLVaFVL 116

                          90       100
                  ....*....|....*....|....
gi 2194924128 168 ITEFLPTSKRASIITWTCGFMAIG 191
Cdd:cd17377   117 LNECVGKSYWALAGSLGGLFFAVG 140
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
111-164 1.10e-03

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 41.44  E-value: 1.10e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2194924128 111 WGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLFCSNQSTV 164
Cdd:PRK11102   46 YGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASVV 99
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
 94-201 1.15e-03

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 41.35  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  94 GYLSGAMFLGIVvsanawgffADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTG-LFCSNQSTVYAYITEFL 172
Cdd:cd17373    37 GLIFGYLILGCI---------ADRFGRRPVLLFSLILILIFGLTVALAVSVTMFSTLRFLEGfCLAGIILTLYLLRLELC 107

                          90       100
                  ....*....|....*....|....*....
gi 2194924128 173 PTSKRASIITWTCGFMAIGYLLIPGLAWL 201
Cdd:cd17373   108 DPGKRLMITMVASLVAVAGQFLMPGLAAL 136
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 94-159 1.23e-03

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 41.03  E-value: 1.23e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2194924128  94 GYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTN--LFIVLRFLTGLFCS 159
Cdd:cd17335    35 GILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFFVAQIfwLLLLLVILGAFFSA 102
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
33-198 1.24e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 41.38  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  33 KSADEEVDLERAIELTGFGWYHIGLIAICGGILVATVCETMGMSFVHPAAQCDLALTTVKKGYLSGAMFLGIVVSANAWG 112
Cdd:COG0738   188 EIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGG 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 113 FFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLFCSNQ-STVYAYITEFLP--TSKRASIITWtcgFMA 189
Cdd:COG0738   268 FLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMfPTIFSLALDGLGkrTAAAVSAVLI---MGI 344


                  ....*....
gi 2194924128 190 IGYLLIPGL 198
Cdd:COG0738   345 VGGAIGPPL 353
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 85-156 1.43e-03

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 41.10  E-value: 1.43e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2194924128  85 DLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGL 156
Cdd:PRK11551   44 EFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGV 115
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 101-159 1.46e-03

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 40.83  E-value: 1.46e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2194924128 101 FLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLFCS 159
Cdd:TIGR00710  50 LLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGAS 108
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 80-245 2.41e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 40.38  E-value: 2.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128  80 PAAQCDLALTTVKKGYLSGAMFLGIVVSANAWGFFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNLFIVLRFLTGLFCS 159
Cdd:cd17333    20 PSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAG 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 160 -NQSTVYAYITEFLPtSKRASIITWTCGFMAIGYLLIPGLAWLLIPLEVNWDLGFVVytswrvylaaIGSLSFATG--FL 236
Cdd:cd17333   100 iLDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLI----------IGLIYLLLAilIL 168


                  ....*....
gi 2194924128 237 LPFFPESPK 245
Cdd:cd17333   169 LTLFPELPS 177
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 101-232 2.58e-03

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 40.23  E-value: 2.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 101 FLGIVVSANAWG---------FFADTFGRKKVLLISTIGTWAFSFMSSFSPTTNL--FIVLRFLTGLFcsnQS----TVY 165
Cdd:cd17380    35 DQGLVLSSFFWGyaltqvlggYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLplLILSRILLGLG---EGvhfpSMT 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2194924128 166 AYITEFLPTSKRASIITWTCGFMAIGYLLIPGLAWLLIPLeVNWD--------LGFVVYTSWRVYLAAIGSLSFA 232
Cdd:cd17380   112 SLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEY-YGWPsvfyffglLGLLWALVWLIYLPPVWAIIVA 185
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
388-504 3.24e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.96  E-value: 3.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2194924128 388 SEVYTSTLVTGVFSVVAFGTL--GGLVAILRKKTVLVSALFLSGIAGFGNYFATNEITVAVLISVSVAVAGSCSTVSNTI 465
Cdd:COG2814    43 SPAQAGLVVTAYLLGAALGAPlaGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALAL 122

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2194924128 466 AVEVYPTNLRAMAVSLAFTIGRLGIALAGNTIGILIESY 504
Cdd:COG2814   123 IADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH