|
Name |
Accession |
Description |
Interval |
E-value |
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
633-775 |
2.03e-28 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 110.88 E-value: 2.03e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 633 QFHVFISYSEHDsaWVKHALIPNLEKEDGSILICFHEGNSDPGKNITEDVIKCIEKSYKSIFVLSPNFVQSEWCHYELYF 712
Cdd:smart00255 1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2165539796 713 AHHNLFHESSDNIiiillepiplycIPIRY-----------PKLKALMeKKAYLEWPKDRRKcgLFWTNLRAAI 775
Cdd:smart00255 79 ALENALEEGGLRV------------IPIFYevipsdvrkqpGKFRKVF-KKNYLKWPEDEKE--QFWKKALYAV 137
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
351-541 |
2.18e-15 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 79.21 E-value: 2.18e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 351 KYLNFANNILTDdvFKTPI-QLPHLKTLILKDNKLETLSLVscFASNTSLKHLDLSQNLLQHENDE--NClwpETLISMN 427
Cdd:COG4886 139 KELDLSNNQLTD--LPEPLgNLTNLKSLDLSNNQLTDLPEE--LGNLTNLKELDLSNNQITDLPEPlgNL---TNLEELD 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 428 LSSNKFTD---SVFRClpRNIQILDMNDNKIQTVPkEIIHLTSLRELNLAFNLLTDLPGCSHFGRLSVLNVEMNLILSPS 504
Cdd:COG4886 212 LSGNQLTDlpePLANL--TNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK 288
|
170 180 190
....*....|....*....|....*....|....*..
gi 2165539796 505 LDFFQSCQEVKILNAGRNPFRCTCELRDFIQLEKYSE 541
Cdd:COG4886 289 LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLL 325
|
|
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
634-710 |
1.63e-13 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 68.93 E-value: 1.63e-13
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2165539796 634 FHVFISYSEHDS-AWVKHALIPNLEKEdgSILICFHEGNSDPGKNITEDVIKCIEKSYKSIFVLSPNFVQSEWCHYEL 710
Cdd:pfam01582 1 YDVFLSFRGSDTrEWFVSHLLKELKQK--GIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDEL 76
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
72-129 |
5.92e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 52.91 E-value: 5.92e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2165539796 72 SKLKVLILCHNRIQELDIRTFEFNTELRYLDVSYNRLK---MVTWYSLAGLRHLDLSFNDF 129
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTtlsPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
31-269 |
7.14e-09 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 58.79 E-value: 7.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 31 TINCSNMSLRKVPTDLTPSA--TMLDLSYNLLFQLQRSdFHSVSKLKVLILCHNRIQELDiRTFEFNTELRYLDVSYNRL 108
Cdd:COG4886 163 SLDLSNNQLTDLPEELGNLTnlKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQL 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 109 KMVTW-YSLAGLRHLDLSFNDFDTIPiceETGNMSHLEILGLSGAKIRKSDFQKISHLHLNTVFLGLRSLSHYEEGSLPI 187
Cdd:COG4886 241 TDLPElGNLTNLEELDLSNNQLTDLP---PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILL 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 188 LNTTKLHIVLPMNTNFWVLLRDGIKTSKILEMTNIDGKSQSTSYETQQNLTLENAKTSILLLNKVDLLWGDLLLIFQFVW 267
Cdd:COG4886 318 LLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTT 397
|
..
gi 2165539796 268 HT 269
Cdd:COG4886 398 AG 399
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
326-482 |
4.21e-06 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 50.47 E-value: 4.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 326 MDIENLTisdaQMPHMLfpiyPMRFKYLNFANNILTddvfKTPIQLPH-LKTLILKDNKLETL------SLVSCFASNTS 398
Cdd:PRK15370 248 LSINRIT----ELPERL----PSALQSLDLFHNKIS----CLPENLPEeLRYLSVYDNSIRTLpahlpsGITHLNVQSNS 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 399 LKHLdlsqnllqhendenclwPETLiSMNLSSNKFTDSVFRCLPRNI----QILDMNDNKIQTVPKEIIhlTSLRELNLA 474
Cdd:PRK15370 316 LTAL-----------------PETL-PPGLKTLEAGENALTSLPASLppelQVLDVSKNQITVLPETLP--PTITTLDVS 375
|
....*...
gi 2165539796 475 FNLLTDLP 482
Cdd:PRK15370 376 RNALTNLP 383
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
522-574 |
1.50e-05 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 42.80 E-value: 1.50e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 2165539796 522 NPFRCTCELRDFIQLEKYSEgmMVGWSDSYICEYPLNLKGtQLKDVHLPELSC 574
Cdd:smart00082 1 NPFICDCELRWLLRWLQANE--HLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
372-433 |
1.14e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 40.59 E-value: 1.14e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2165539796 372 PHLKTLILKDNKLETLSlVSCFASNTSLKHLDLSQNLLQHENdENCLWPETLISM-NLSSNKF 433
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLD-DGAFKGLSNLKVLDLSNNLLTTLS-PGAFSGLPSLRYlDLSGNRL 61
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
28-133 |
4.05e-04 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 43.92 E-value: 4.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 28 RELTINCSNMSlrKVPTDLTPSATMLDLSYNLLFQLQRsdfHSVSKLKVLILCHNRIQELDIRTFEfntELRYLDVSYNR 107
Cdd:PRK15370 223 KTLYANSNQLT--SIPATLPDTIQEMELSINRITELPE---RLPSALQSLDLFHNKISCLPENLPE---ELRYLSVYDNS 294
|
90 100
....*....|....*....|....*.
gi 2165539796 108 LKMVTWYSLAGLRHLDLSFNDFDTIP 133
Cdd:PRK15370 295 IRTLPAHLPSGITHLNVQSNSLTALP 320
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
53-155 |
8.11e-04 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 42.61 E-value: 8.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 53 LDLSYNLLFQLQRSDFHSVSKLKVLILCHNRiqeldirTFEFNTELRYLDVSYNRLKMVTW--YSLAGLRHLDLSFNDFD 130
Cdd:COG4886 77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEelANLTNLKELDLSNNQLT 149
|
90 100
....*....|....*....|....*
gi 2165539796 131 TIPicEETGNMSHLEILGLSGAKIR 155
Cdd:COG4886 150 DLP--EPLGNLTNLKSLDLSNNQLT 172
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
51-156 |
8.73e-04 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 41.70 E-value: 8.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 51 TMLDLSYNLLFQLQrsDFHSVSKLKVLILCHNRI------------QELDIR--------TFEFNTE--------LRYLD 102
Cdd:cd21340 49 THLYLQNNQIEKIE--NLENLVNLKKLYLGGNRIsvveglenltnlEELHIEnqrlppgeKLTFDPRslaalsnsLRVLN 126
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 2165539796 103 VSYNRLKMVTW-YSLAGLRHLDLSFNDFDTI-PICEETGNMSHLEILGLSG---AKIRK 156
Cdd:cd21340 127 ISGNNIDSLEPlAPLRNLEQLDASNNQISDLeELLDLLSSWPSLRELDLTGnpvCKKPK 185
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
347-481 |
2.43e-03 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 40.80 E-value: 2.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 347 PMRFKYLNFANNILT----DDVFKTPIQLPHLKTLILKDNKLE---TLSLVSCFASNTSLKHLDLSQNLLQHENDenclw 419
Cdd:cd00116 136 PPALEKLVLGRNRLEgascEALAKALRANRDLKELNLANNGIGdagIRALAEGLKANCNLEVLDLNNNGLTDEGA----- 210
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2165539796 420 peTLISMNLSSNKFtdsvfrclprnIQILDMNDNKIQTVPKEIIH------LTSLRELNLAFNLLTDL 481
Cdd:cd00116 211 --SALAETLASLKS-----------LEVLNLGDNNLTDAGAAALAsallspNISLLTLSLSCNDITDD 265
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
16-501 |
4.24e-03 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 40.60 E-value: 4.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 16 SVRGGASKLLEERELTincSNMSLRKVPTDLT--PSATMLDLSYNLLFQLQRSDFHSVSKLKVLILCHNRIQELDIRTFE 93
Cdd:PLN00113 133 SIPRGSIPNLETLDLS---NNMLSGEIPNDIGsfSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELG 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 94 FNTELRYLDVSYNRLKMVTWYSLAGL---RHLDLSFNDFdTIPICEETGNMSHLEILGLSGAK----IRKSDF--QKISH 164
Cdd:PLN00113 210 QMKSLKWIYLGYNNLSGEIPYEIGGLtslNHLDLVYNNL-TGPIPSSLGNLKNLQYLFLYQNKlsgpIPPSIFslQKLIS 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 165 LHLNTVFLglrslshyeEGSLP--ILNTTKLHIVLPMNTNFWVLLRDGIKTSKILEMTNIdgKSQSTSYETQQNLTLENA 242
Cdd:PLN00113 289 LDLSDNSL---------SGEIPelVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQL--WSNKFSGEIPKNLGKHNN 357
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 243 KTSIlllnkvDLLWGDLLLIFQFVWHTSVEYFqvqhvtfggKVYLDHNSFD-------YSNTVMRTIKLEHVHFRiFSIP 315
Cdd:PLN00113 358 LTVL------DLSTNNLTGEIPEGLCSSGNLF---------KLILFSNSLEgeipkslGACRSLRRVRLQDNSFS-GELP 421
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 316 QErvyllFTKMDIENltisdaqmphmlfpiypmrfkYLNFANNILTDDVFKTPIQLPHLKTLILKDNK------------ 383
Cdd:PLN00113 422 SE-----FTKLPLVY---------------------FLDISNNNLQGRINSRKWDMPSLQMLSLARNKffgglpdsfgsk 475
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 384 -LETLSLV---------SCFASNTSLKHLDLSQNLLQHENDENCLWPETLISMNLSSNKFTDSV---FRCLPRnIQILDM 450
Cdd:PLN00113 476 rLENLDLSrnqfsgavpRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIpasFSEMPV-LSQLDL 554
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 2165539796 451 NDNKIQ-TVPKEIIHLTSLRELNLAFNLL-TDLPGCSHFGRLSVLNVEMNLIL 501
Cdd:PLN00113 555 SQNQLSgEIPKNLGNVESLVQVNISHNHLhGSLPSTGAFLAINASAVAGNIDL 607
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
633-775 |
2.03e-28 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 110.88 E-value: 2.03e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 633 QFHVFISYSEHDsaWVKHALIPNLEKEDGSILICFHEGNSDPGKNITEDVIKCIEKSYKSIFVLSPNFVQSEWCHYELYF 712
Cdd:smart00255 1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2165539796 713 AHHNLFHESSDNIiiillepiplycIPIRY-----------PKLKALMeKKAYLEWPKDRRKcgLFWTNLRAAI 775
Cdd:smart00255 79 ALENALEEGGLRV------------IPIFYevipsdvrkqpGKFRKVF-KKNYLKWPEDEKE--QFWKKALYAV 137
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
351-541 |
2.18e-15 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 79.21 E-value: 2.18e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 351 KYLNFANNILTDdvFKTPI-QLPHLKTLILKDNKLETLSLVscFASNTSLKHLDLSQNLLQHENDE--NClwpETLISMN 427
Cdd:COG4886 139 KELDLSNNQLTD--LPEPLgNLTNLKSLDLSNNQLTDLPEE--LGNLTNLKELDLSNNQITDLPEPlgNL---TNLEELD 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 428 LSSNKFTD---SVFRClpRNIQILDMNDNKIQTVPkEIIHLTSLRELNLAFNLLTDLPGCSHFGRLSVLNVEMNLILSPS 504
Cdd:COG4886 212 LSGNQLTDlpePLANL--TNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK 288
|
170 180 190
....*....|....*....|....*....|....*..
gi 2165539796 505 LDFFQSCQEVKILNAGRNPFRCTCELRDFIQLEKYSE 541
Cdd:COG4886 289 LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLL 325
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
351-524 |
6.61e-15 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 77.67 E-value: 6.61e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 351 KYLNFANNILTDdVFKTPIQLPHLKTLILKDNKLETLSlvSCFASNTSLKHLDLSQNLLQHENDENCLWPEtLISMNLSS 430
Cdd:COG4886 116 ESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLP--EPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELDLSN 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 431 NKFTD--SVFRCLPrNIQILDMNDNKIQTVPKEIIHLTSLRELNLAFNLLTDLPGCSHFGRLSVLNVEMNLIlsPSLDFF 508
Cdd:COG4886 192 NQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQL--TDLPPL 268
|
170
....*....|....*.
gi 2165539796 509 QSCQEVKILNAGRNPF 524
Cdd:COG4886 269 ANLTNLKTLDLSNNQL 284
|
|
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
634-710 |
1.63e-13 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 68.93 E-value: 1.63e-13
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2165539796 634 FHVFISYSEHDS-AWVKHALIPNLEKEdgSILICFHEGNSDPGKNITEDVIKCIEKSYKSIFVLSPNFVQSEWCHYEL 710
Cdd:pfam01582 1 YDVFLSFRGSDTrEWFVSHLLKELKQK--GIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDEL 76
|
|
| TIR_2 |
pfam13676 |
TIR domain; This is a family of Toll-like receptors. |
636-715 |
9.19e-12 |
|
TIR domain; This is a family of Toll-like receptors.
Pssm-ID: 463954 [Multi-domain] Cd Length: 118 Bit Score: 62.72 E-value: 9.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 636 VFISYSEHDSAWVKHaLIPNLEKEDgsILICFHEGNSDPGKNITEDVIKCIEKSYKSIFVLSPNFVQSEWCHYELYFAHH 715
Cdd:pfam13676 1 VFISYAGEDRAWAEW-LADALEAAG--YRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALA 77
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
72-129 |
5.92e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 52.91 E-value: 5.92e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2165539796 72 SKLKVLILCHNRIQELDIRTFEFNTELRYLDVSYNRLK---MVTWYSLAGLRHLDLSFNDF 129
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTtlsPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
31-269 |
7.14e-09 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 58.79 E-value: 7.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 31 TINCSNMSLRKVPTDLTPSA--TMLDLSYNLLFQLQRSdFHSVSKLKVLILCHNRIQELDiRTFEFNTELRYLDVSYNRL 108
Cdd:COG4886 163 SLDLSNNQLTDLPEELGNLTnlKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQL 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 109 KMVTW-YSLAGLRHLDLSFNDFDTIPiceETGNMSHLEILGLSGAKIRKSDFQKISHLHLNTVFLGLRSLSHYEEGSLPI 187
Cdd:COG4886 241 TDLPElGNLTNLEELDLSNNQLTDLP---PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILL 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 188 LNTTKLHIVLPMNTNFWVLLRDGIKTSKILEMTNIDGKSQSTSYETQQNLTLENAKTSILLLNKVDLLWGDLLLIFQFVW 267
Cdd:COG4886 318 LLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTT 397
|
..
gi 2165539796 268 HT 269
Cdd:COG4886 398 AG 399
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
48-108 |
3.35e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 50.60 E-value: 3.35e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2165539796 48 PSATMLDLSYNLLFQLQRSDFHSVSKLKVLILCHNRIQELDIRTFEFNTELRYLDVSYNRL 108
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
330-524 |
2.02e-06 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 51.09 E-value: 2.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 330 NLTISDAQMPHMLFPIYPMRFKYLNFANNILTDDVFKTPIQLPHLKTLILKDNKLETLSLVSCFASNTSLKHLDLSQNLL 409
Cdd:COG4886 5 LLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 410 QHENDENCLWPETLISMNLSSNKFTDSVfrclpRNIQILDMNDNKIQTVPKEIIHLTSLRELNLAFNLLTDLP-GCSHFG 488
Cdd:COG4886 85 LLLGLTDLGDLTNLTELDLSGNEELSNL-----TNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPePLGNLT 159
|
170 180 190
....*....|....*....|....*....|....*...
gi 2165539796 489 RLSVLNVEMNLI--LSPSLdffQSCQEVKILNAGRNPF 524
Cdd:COG4886 160 NLKSLDLSNNQLtdLPEEL---GNLTNLKELDLSNNQI 194
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
326-482 |
4.21e-06 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 50.47 E-value: 4.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 326 MDIENLTisdaQMPHMLfpiyPMRFKYLNFANNILTddvfKTPIQLPH-LKTLILKDNKLETL------SLVSCFASNTS 398
Cdd:PRK15370 248 LSINRIT----ELPERL----PSALQSLDLFHNKIS----CLPENLPEeLRYLSVYDNSIRTLpahlpsGITHLNVQSNS 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 399 LKHLdlsqnllqhendenclwPETLiSMNLSSNKFTDSVFRCLPRNI----QILDMNDNKIQTVPKEIIhlTSLRELNLA 474
Cdd:PRK15370 316 LTAL-----------------PETL-PPGLKTLEAGENALTSLPASLppelQVLDVSKNQITVLPETLP--PTITTLDVS 375
|
....*...
gi 2165539796 475 FNLLTDLP 482
Cdd:PRK15370 376 RNALTNLP 383
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
522-574 |
1.50e-05 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 42.80 E-value: 1.50e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 2165539796 522 NPFRCTCELRDFIQLEKYSEgmMVGWSDSYICEYPLNLKGtQLKDVHLPELSC 574
Cdd:smart00082 1 NPFICDCELRWLLRWLQANE--HLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
372-433 |
1.14e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 40.59 E-value: 1.14e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2165539796 372 PHLKTLILKDNKLETLSlVSCFASNTSLKHLDLSQNLLQHENdENCLWPETLISM-NLSSNKF 433
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLD-DGAFKGLSNLKVLDLSNNLLTTLS-PGAFSGLPSLRYlDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
351-409 |
1.31e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 40.59 E-value: 1.31e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2165539796 351 KYLNFANNILT---DDVFKTpiqLPHLKTLILKDNKLETLSLVScFASNTSLKHLDLSQNLL 409
Cdd:pfam13855 4 RSLDLSNNRLTsldDGAFKG---LSNLKVLDLSNNLLTTLSPGA-FSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
425-478 |
2.22e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 39.82 E-value: 2.22e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 2165539796 425 SMNLSSNKFT---DSVFRCLPrNIQILDMNDNKIQTV-PKEIIHLTSLRELNLAFNLL 478
Cdd:pfam13855 5 SLDLSNNRLTsldDGAFKGLS-NLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
28-133 |
4.05e-04 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 43.92 E-value: 4.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 28 RELTINCSNMSlrKVPTDLTPSATMLDLSYNLLFQLQRsdfHSVSKLKVLILCHNRIQELDIRTFEfntELRYLDVSYNR 107
Cdd:PRK15370 223 KTLYANSNQLT--SIPATLPDTIQEMELSINRITELPE---RLPSALQSLDLFHNKISCLPENLPE---ELRYLSVYDNS 294
|
90 100
....*....|....*....|....*.
gi 2165539796 108 LKMVTWYSLAGLRHLDLSFNDFDTIP 133
Cdd:PRK15370 295 IRTLPAHLPSGITHLNVQSNSLTALP 320
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
337-493 |
6.21e-04 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 43.30 E-value: 6.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 337 QMPHMLFPIyPMRFKYLNFANNILTDDVFKTPIqlPHLKTLILKDNKLeTLSLVSCFASNTSLKHLDLSQNLLQHENDEN 416
Cdd:PLN00113 108 PIPDDIFTT-SSSLRYLNLSNNNFTGSIPRGSI--PNLETLDLSNNML-SGEIPNDIGSFSSLKVLDLGGNVLVGKIPNS 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 417 CLWPETLISMNLSSNKFTDSVFRCLP--RNIQILDMNDNKIQ-TVPKEIIHLTSLRELNLAFNLLT-DLPgcSHFGRLSV 492
Cdd:PLN00113 184 LTNLTSLEFLTLASNQLVGQIPRELGqmKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLTgPIP--SSLGNLKN 261
|
.
gi 2165539796 493 L 493
Cdd:PLN00113 262 L 262
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
374-515 |
6.63e-04 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 42.85 E-value: 6.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 374 LKTLILKDNKLE---TLSLVSCFASNTSLKHLDLSQN------------LLQHENdenclwpeTLISMNLSSNKFTDSVF 438
Cdd:COG5238 266 VETLYLSGNQIGaegAIALAKALQGNTTLTSLDLSVNrigdegaialaeGLQGNK--------TLHTLNLAYNGIGAQGA 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 439 RCLP------RNIQILDMNDNKIQTV-PKEIIHL----TSLRELNLAFNLLTD-----LPGCSHFGRLSVLNVEMNLILS 502
Cdd:COG5238 338 IALAkalqenTTLHSLDLSDNQIGDEgAIALAKYlegnTTLRELNLGKNNIGKqgaeaLIDALQTNRLHTLILDGNLIGA 417
|
170
....*....|....
gi 2165539796 503 PSLD-FFQSCQEVK 515
Cdd:COG5238 418 EAQQrLEQLLERIK 431
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
53-155 |
8.11e-04 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 42.61 E-value: 8.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 53 LDLSYNLLFQLQRSDFHSVSKLKVLILCHNRiqeldirTFEFNTELRYLDVSYNRLKMVTW--YSLAGLRHLDLSFNDFD 130
Cdd:COG4886 77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEelANLTNLKELDLSNNQLT 149
|
90 100
....*....|....*....|....*
gi 2165539796 131 TIPicEETGNMSHLEILGLSGAKIR 155
Cdd:COG4886 150 DLP--EPLGNLTNLKSLDLSNNQLT 172
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
51-156 |
8.73e-04 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 41.70 E-value: 8.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 51 TMLDLSYNLLFQLQrsDFHSVSKLKVLILCHNRI------------QELDIR--------TFEFNTE--------LRYLD 102
Cdd:cd21340 49 THLYLQNNQIEKIE--NLENLVNLKKLYLGGNRIsvveglenltnlEELHIEnqrlppgeKLTFDPRslaalsnsLRVLN 126
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 2165539796 103 VSYNRLKMVTW-YSLAGLRHLDLSFNDFDTI-PICEETGNMSHLEILGLSG---AKIRK 156
Cdd:cd21340 127 ISGNNIDSLEPlAPLRNLEQLDASNNQISDLeELLDLLSSWPSLRELDLTGnpvCKKPK 185
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
347-481 |
2.43e-03 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 40.80 E-value: 2.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 347 PMRFKYLNFANNILT----DDVFKTPIQLPHLKTLILKDNKLE---TLSLVSCFASNTSLKHLDLSQNLLQHENDenclw 419
Cdd:cd00116 136 PPALEKLVLGRNRLEgascEALAKALRANRDLKELNLANNGIGdagIRALAEGLKANCNLEVLDLNNNGLTDEGA----- 210
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2165539796 420 peTLISMNLSSNKFtdsvfrclprnIQILDMNDNKIQTVPKEIIH------LTSLRELNLAFNLLTDL 481
Cdd:cd00116 211 --SALAETLASLKS-----------LEVLNLGDNNLTDAGAAALAsallspNISLLTLSLSCNDITDD 265
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
370-479 |
3.10e-03 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 41.37 E-value: 3.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 370 QLPHLKTLILKDNKLETLSLVSCFASNTSLKHLDLSQNLLQHENDENCLwpETLISMNLSSNKFTDSVFRCLP--RNIQI 447
Cdd:PLN00113 91 RLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSI--PNLETLDLSNNMLSGEIPNDIGsfSSLKV 168
|
90 100 110
....*....|....*....|....*....|...
gi 2165539796 448 LDMNDNKIQ-TVPKEIIHLTSLRELNLAFNLLT 479
Cdd:PLN00113 169 LDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLV 201
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
372-482 |
3.14e-03 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 40.42 E-value: 3.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 372 PHLKTLILKDNKLETLS---LVSCFASNTSLKHLDLSQNLLQHEN--------DENCLwpetLISMNLSSNKFTDsvfrc 440
Cdd:cd00116 137 PALEKLVLGRNRLEGASceaLAKALRANRDLKELNLANNGIGDAGiralaeglKANCN----LEVLDLNNNGLTD----- 207
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 2165539796 441 lpRNIQILDMndnkiqTVPkeiiHLTSLRELNLAFNLLTDLP 482
Cdd:cd00116 208 --EGASALAE------TLA----SLKSLEVLNLGDNNLTDAG 237
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
16-501 |
4.24e-03 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 40.60 E-value: 4.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 16 SVRGGASKLLEERELTincSNMSLRKVPTDLT--PSATMLDLSYNLLFQLQRSDFHSVSKLKVLILCHNRIQELDIRTFE 93
Cdd:PLN00113 133 SIPRGSIPNLETLDLS---NNMLSGEIPNDIGsfSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELG 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 94 FNTELRYLDVSYNRLKMVTWYSLAGL---RHLDLSFNDFdTIPICEETGNMSHLEILGLSGAK----IRKSDF--QKISH 164
Cdd:PLN00113 210 QMKSLKWIYLGYNNLSGEIPYEIGGLtslNHLDLVYNNL-TGPIPSSLGNLKNLQYLFLYQNKlsgpIPPSIFslQKLIS 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 165 LHLNTVFLglrslshyeEGSLP--ILNTTKLHIVLPMNTNFWVLLRDGIKTSKILEMTNIdgKSQSTSYETQQNLTLENA 242
Cdd:PLN00113 289 LDLSDNSL---------SGEIPelVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQL--WSNKFSGEIPKNLGKHNN 357
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 243 KTSIlllnkvDLLWGDLLLIFQFVWHTSVEYFqvqhvtfggKVYLDHNSFD-------YSNTVMRTIKLEHVHFRiFSIP 315
Cdd:PLN00113 358 LTVL------DLSTNNLTGEIPEGLCSSGNLF---------KLILFSNSLEgeipkslGACRSLRRVRLQDNSFS-GELP 421
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 316 QErvyllFTKMDIENltisdaqmphmlfpiypmrfkYLNFANNILTDDVFKTPIQLPHLKTLILKDNK------------ 383
Cdd:PLN00113 422 SE-----FTKLPLVY---------------------FLDISNNNLQGRINSRKWDMPSLQMLSLARNKffgglpdsfgsk 475
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 384 -LETLSLV---------SCFASNTSLKHLDLSQNLLQHENDENCLWPETLISMNLSSNKFTDSV---FRCLPRnIQILDM 450
Cdd:PLN00113 476 rLENLDLSrnqfsgavpRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIpasFSEMPV-LSQLDL 554
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 2165539796 451 NDNKIQ-TVPKEIIHLTSLRELNLAFNLL-TDLPGCSHFGRLSVLNVEMNLIL 501
Cdd:PLN00113 555 SQNQLSgEIPKNLGNVESLVQVNISHNHLhGSLPSTGAFLAINASAVAGNIDL 607
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
370-504 |
6.59e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 39.00 E-value: 6.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2165539796 370 QLPHLKTLILKDNKLETLS-LVSCfasnTSLKHLDLSQNLLQH-ENDENClwpETLISMNLS------SNKFTDSVF--R 439
Cdd:cd21340 44 FLTNLTHLYLQNNQIEKIEnLENL----VNLKKLYLGGNRISVvEGLENL---TNLEELHIEnqrlppGEKLTFDPRslA 116
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2165539796 440 CLPRNIQILDMNDNKIQTVpKEIIHLTSLRELNLAFNLLTDLPGC----SHFGRLSVLNVEMNLILSPS 504
Cdd:cd21340 117 ALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELldllSSWPSLRELDLTGNPVCKKP 184
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
443-500 |
7.18e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 35.58 E-value: 7.18e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2165539796 443 RNIQILDMNDNKIQTVPKEII-HLTSLRELNLAFNLLTDLPG--CSHFGRLSVLNVEMNLI 500
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFkGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
|
|
| |
